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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

8SHS

human liver mitochondrial Aldehyde dehydrogenase ALDH2

Functional Information from GO Data
ChainGOidnamespacecontents
A0001758molecular_functionretinal dehydrogenase (NAD+) activity
A0004029molecular_functionaldehyde dehydrogenase (NAD+) activity
A0005739cellular_componentmitochondrion
A0005759cellular_componentmitochondrial matrix
A0006067biological_processethanol metabolic process
A0006068biological_processethanol catabolic process
A0008957molecular_functionphenylacetaldehyde dehydrogenase (NAD+) activity
A0016491molecular_functionoxidoreductase activity
A0018937biological_processnitroglycerin metabolic process
A0042420biological_processdopamine catabolic process
A0046185biological_processaldehyde catabolic process
A0046857molecular_functionoxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor
A0051287molecular_functionNAD binding
A0070062cellular_componentextracellular exosome
A0106435molecular_functioncarboxylesterase activity
A0110095biological_processcellular detoxification of aldehyde
A0140087molecular_functionacetaldehyde dehydrogenase (NAD+) activity
B0001758molecular_functionretinal dehydrogenase (NAD+) activity
B0004029molecular_functionaldehyde dehydrogenase (NAD+) activity
B0005739cellular_componentmitochondrion
B0005759cellular_componentmitochondrial matrix
B0006067biological_processethanol metabolic process
B0006068biological_processethanol catabolic process
B0008957molecular_functionphenylacetaldehyde dehydrogenase (NAD+) activity
B0016491molecular_functionoxidoreductase activity
B0018937biological_processnitroglycerin metabolic process
B0042420biological_processdopamine catabolic process
B0046185biological_processaldehyde catabolic process
B0046857molecular_functionoxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor
B0051287molecular_functionNAD binding
B0070062cellular_componentextracellular exosome
B0106435molecular_functioncarboxylesterase activity
B0110095biological_processcellular detoxification of aldehyde
B0140087molecular_functionacetaldehyde dehydrogenase (NAD+) activity
C0001758molecular_functionretinal dehydrogenase (NAD+) activity
C0004029molecular_functionaldehyde dehydrogenase (NAD+) activity
C0005739cellular_componentmitochondrion
C0005759cellular_componentmitochondrial matrix
C0006067biological_processethanol metabolic process
C0006068biological_processethanol catabolic process
C0008957molecular_functionphenylacetaldehyde dehydrogenase (NAD+) activity
C0016491molecular_functionoxidoreductase activity
C0018937biological_processnitroglycerin metabolic process
C0042420biological_processdopamine catabolic process
C0046185biological_processaldehyde catabolic process
C0046857molecular_functionoxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor
C0051287molecular_functionNAD binding
C0070062cellular_componentextracellular exosome
C0106435molecular_functioncarboxylesterase activity
C0110095biological_processcellular detoxification of aldehyde
C0140087molecular_functionacetaldehyde dehydrogenase (NAD+) activity
D0001758molecular_functionretinal dehydrogenase (NAD+) activity
D0004029molecular_functionaldehyde dehydrogenase (NAD+) activity
D0005739cellular_componentmitochondrion
D0005759cellular_componentmitochondrial matrix
D0006067biological_processethanol metabolic process
D0006068biological_processethanol catabolic process
D0008957molecular_functionphenylacetaldehyde dehydrogenase (NAD+) activity
D0016491molecular_functionoxidoreductase activity
D0018937biological_processnitroglycerin metabolic process
D0042420biological_processdopamine catabolic process
D0046185biological_processaldehyde catabolic process
D0046857molecular_functionoxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor
D0051287molecular_functionNAD binding
D0070062cellular_componentextracellular exosome
D0106435molecular_functioncarboxylesterase activity
D0110095biological_processcellular detoxification of aldehyde
D0140087molecular_functionacetaldehyde dehydrogenase (NAD+) activity
Functional Information from PROSITE/UniProt
site_idPS00070
Number of Residues12
DetailsALDEHYDE_DEHYDR_CYS Aldehyde dehydrogenases cysteine active site. FfNQGQCCCAGS
ChainResidueDetails
APHE312-SER323
site_idPS00539
Number of Residues6
DetailsPYROKININ Pyrokinins signature. FGPRLG
ChainResidueDetails
APHE8-GLY13
site_idPS00687
Number of Residues8
DetailsALDEHYDE_DEHYDR_GLU Aldehyde dehydrogenases glutamic acid active site. LELGGKSP
ChainResidueDetails
ALEU284-PRO291
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsActive site: {"description":"Proton acceptor"}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues4
DetailsActive site: {"description":"Nucleophile"}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues20
DetailsBinding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues4
DetailsSite: {"description":"Transition state stabilizer","evidences":[{"source":"UniProtKB","id":"P20000","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues36
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P47738","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
Catalytic Information from CSA
site_idMCSA1
Number of Residues4
DetailsM-CSA 803
ChainResidueDetails
ALYS209electrostatic stabiliser
AGLU285electrostatic stabiliser, proton acceptor, proton donor
ACYS319covalently attached, electrostatic stabiliser, nucleofuge, nucleophile, proton acceptor, proton donor
AGLU416electrostatic stabiliser
site_idMCSA2
Number of Residues4
DetailsM-CSA 803
ChainResidueDetails
BLYS209electrostatic stabiliser
BGLU285electrostatic stabiliser, proton acceptor, proton donor
BCYS319covalently attached, electrostatic stabiliser, nucleofuge, nucleophile, proton acceptor, proton donor
BGLU416electrostatic stabiliser
site_idMCSA3
Number of Residues4
DetailsM-CSA 803
ChainResidueDetails
CLYS209electrostatic stabiliser
CGLU285electrostatic stabiliser, proton acceptor, proton donor
CCYS319covalently attached, electrostatic stabiliser, nucleofuge, nucleophile, proton acceptor, proton donor
CGLU416electrostatic stabiliser
site_idMCSA4
Number of Residues4
DetailsM-CSA 803
ChainResidueDetails
DLYS209electrostatic stabiliser
DGLU285electrostatic stabiliser, proton acceptor, proton donor
DCYS319covalently attached, electrostatic stabiliser, nucleofuge, nucleophile, proton acceptor, proton donor
DGLU416electrostatic stabiliser

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PDB entries from 2026-06-03

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