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8SH7

TUBB4B and TUBA1A Heterodimer from Human Respiratory Doublet Microtubules

Functional Information from GO Data
ChainGOidnamespacecontents
A0000226biological_processmicrotubule cytoskeleton organization
A0000278biological_processmitotic cell cycle
A0000793cellular_componentcondensed chromosome
A0001764biological_processneuron migration
A0001964biological_processstartle response
A0005198molecular_functionstructural molecule activity
A0005200molecular_functionstructural constituent of cytoskeleton
A0005515molecular_functionprotein binding
A0005525molecular_functionGTP binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005856cellular_componentcytoskeleton
A0005874cellular_componentmicrotubule
A0005879cellular_componentaxonemal microtubule
A0005881cellular_componentcytoplasmic microtubule
A0005886cellular_componentplasma membrane
A0006886biological_processintracellular protein transport
A0007017biological_processmicrotubule-based process
A0007098biological_processcentrosome cycle
A0007224biological_processsmoothened signaling pathway
A0007613biological_processmemory
A0007626biological_processlocomotory behavior
A0008344biological_processadult locomotory behavior
A0008542biological_processvisual learning
A0009612biological_processresponse to mechanical stimulus
A0010001biological_processglial cell differentiation
A0010467biological_processgene expression
A0015630cellular_componentmicrotubule cytoskeleton
A0016787molecular_functionhydrolase activity
A0021542biological_processdentate gyrus development
A0021696biological_processcerebellar cortex morphogenesis
A0021766biological_processhippocampus development
A0021859biological_processpyramidal neuron differentiation
A0021987biological_processcerebral cortex development
A0022008biological_processneurogenesis
A0030182biological_processneuron differentiation
A0030534biological_processadult behavior
A0030705biological_processcytoskeleton-dependent intracellular transport
A0031594cellular_componentneuromuscular junction
A0034612biological_processresponse to tumor necrosis factor
A0035641biological_processlocomotory exploration behavior
A0036464cellular_componentcytoplasmic ribonucleoprotein granule
A0042802molecular_functionidentical protein binding
A0044877molecular_functionprotein-containing complex binding
A0045202cellular_componentsynapse
A0046785biological_processmicrotubule polymerization
A0046872molecular_functionmetal ion binding
A0046982molecular_functionprotein heterodimerization activity
A0048853biological_processforebrain morphogenesis
A0048873biological_processhomeostasis of number of cells within a tissue
A0050807biological_processregulation of synapse organization
A0050808biological_processsynapse organization
A0051301biological_processcell division
A0051402biological_processneuron apoptotic process
A0055037cellular_componentrecycling endosome
A0061744biological_processmotor behavior
A0070062cellular_componentextracellular exosome
A0071277biological_processcellular response to calcium ion
A0072384biological_processorganelle transport along microtubule
A0140058biological_processneuron projection arborization
A1902065biological_processresponse to L-glutamate
B0000226biological_processmicrotubule cytoskeleton organization
B0000278biological_processmitotic cell cycle
B0003725molecular_functiondouble-stranded RNA binding
B0005200molecular_functionstructural constituent of cytoskeleton
B0005515molecular_functionprotein binding
B0005525molecular_functionGTP binding
B0005576cellular_componentextracellular region
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0005856cellular_componentcytoskeleton
B0005874cellular_componentmicrotubule
B0005879cellular_componentaxonemal microtubule
B0015630cellular_componentmicrotubule cytoskeleton
B0035578cellular_componentazurophil granule lumen
B0042267biological_processnatural killer cell mediated cytotoxicity
B0042288molecular_functionMHC class I protein binding
B0045171cellular_componentintercellular bridge
B0046872molecular_functionmetal ion binding
B0051082molecular_functionunfolded protein binding
B0070062cellular_componentextracellular exosome
B0072686cellular_componentmitotic spindle
B1903561cellular_componentextracellular vesicle
Functional Information from PROSITE/UniProt
site_idPS00227
Number of Residues7
DetailsTUBULIN Tubulin subunits alpha, beta, and gamma signature. GGGTGSG
ChainResidueDetails
BGLY140-GLY146
AGLY142-GLY148

site_idPS00228
Number of Residues4
DetailsTUBULIN_B_AUTOREG Tubulin-beta mRNA autoregulation signal. MREI
ChainResidueDetails
BMET1-ILE4

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues7
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:Q13509
ChainResidueDetails
BGLN11
BSER138
BGLY142
BTHR143
BGLY144
BASN204
BASN226

site_idSWS_FT_FI2
Number of Residues1
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:P68363
ChainResidueDetails
BGLU69
AGLU71
ASER140
AGLY144
ATHR145
ATHR179
AASN206
AASN228

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163
ChainResidueDetails
BTHR55

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
BLYS58

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: Phosphoserine; by CDK1 => ECO:0000269|PubMed:16371510
ChainResidueDetails
BSER172

site_idSWS_FT_FI6
Number of Residues1
DetailsMOD_RES: 5-glutamyl polyglutamate => ECO:0000250|UniProtKB:Q2T9S0
ChainResidueDetails
BGLU438

site_idSWS_FT_FI7
Number of Residues1
DetailsMOD_RES: 5-glutamyl polyglutamate => ECO:0000269|PubMed:32747782
ChainResidueDetails
AGLU443

site_idSWS_FT_FI8
Number of Residues1
DetailsMOD_RES: 5-glutamyl polyglutamate => ECO:0000250|UniProtKB:P68369
ChainResidueDetails
AGLU445

site_idSWS_FT_FI9
Number of Residues1
DetailsMOD_RES: 3'-nitrotyrosine => ECO:0000269|PubMed:10339593
ChainResidueDetails
ATYR451

222415

PDB entries from 2024-07-10

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