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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

8SGR

human liver mitochondrial Isovaleryl-CoA dehydrogenase

Functional Information from GO Data
ChainGOidnamespacecontents
A0003995molecular_functionacyl-CoA dehydrogenase activity
A0005515molecular_functionprotein binding
A0005654cellular_componentnucleoplasm
A0005739cellular_componentmitochondrion
A0005759cellular_componentmitochondrial matrix
A0006552biological_processL-leucine catabolic process
A0006629biological_processlipid metabolic process
A0006631biological_processfatty acid metabolic process
A0008470molecular_function3-methylbutanoyl-CoA dehydrogenase activity
A0009083biological_processbranched-chain amino acid catabolic process
A0016491molecular_functionoxidoreductase activity
A0016627molecular_functionoxidoreductase activity, acting on the CH-CH group of donors
A0016937molecular_functionshort-chain fatty acyl-CoA dehydrogenase activity
A0033539biological_processfatty acid beta-oxidation using acyl-CoA dehydrogenase
A0042802molecular_functionidentical protein binding
A0050660molecular_functionflavin adenine dinucleotide binding
B0003995molecular_functionacyl-CoA dehydrogenase activity
B0005515molecular_functionprotein binding
B0005654cellular_componentnucleoplasm
B0005739cellular_componentmitochondrion
B0005759cellular_componentmitochondrial matrix
B0006552biological_processL-leucine catabolic process
B0006629biological_processlipid metabolic process
B0006631biological_processfatty acid metabolic process
B0008470molecular_function3-methylbutanoyl-CoA dehydrogenase activity
B0009083biological_processbranched-chain amino acid catabolic process
B0016491molecular_functionoxidoreductase activity
B0016627molecular_functionoxidoreductase activity, acting on the CH-CH group of donors
B0016937molecular_functionshort-chain fatty acyl-CoA dehydrogenase activity
B0033539biological_processfatty acid beta-oxidation using acyl-CoA dehydrogenase
B0042802molecular_functionidentical protein binding
B0050660molecular_functionflavin adenine dinucleotide binding
C0003995molecular_functionacyl-CoA dehydrogenase activity
C0005515molecular_functionprotein binding
C0005654cellular_componentnucleoplasm
C0005739cellular_componentmitochondrion
C0005759cellular_componentmitochondrial matrix
C0006552biological_processL-leucine catabolic process
C0006629biological_processlipid metabolic process
C0006631biological_processfatty acid metabolic process
C0008470molecular_function3-methylbutanoyl-CoA dehydrogenase activity
C0009083biological_processbranched-chain amino acid catabolic process
C0016491molecular_functionoxidoreductase activity
C0016627molecular_functionoxidoreductase activity, acting on the CH-CH group of donors
C0016937molecular_functionshort-chain fatty acyl-CoA dehydrogenase activity
C0033539biological_processfatty acid beta-oxidation using acyl-CoA dehydrogenase
C0042802molecular_functionidentical protein binding
C0050660molecular_functionflavin adenine dinucleotide binding
D0003995molecular_functionacyl-CoA dehydrogenase activity
D0005515molecular_functionprotein binding
D0005654cellular_componentnucleoplasm
D0005739cellular_componentmitochondrion
D0005759cellular_componentmitochondrial matrix
D0006552biological_processL-leucine catabolic process
D0006629biological_processlipid metabolic process
D0006631biological_processfatty acid metabolic process
D0008470molecular_function3-methylbutanoyl-CoA dehydrogenase activity
D0009083biological_processbranched-chain amino acid catabolic process
D0016491molecular_functionoxidoreductase activity
D0016627molecular_functionoxidoreductase activity, acting on the CH-CH group of donors
D0016937molecular_functionshort-chain fatty acyl-CoA dehydrogenase activity
D0033539biological_processfatty acid beta-oxidation using acyl-CoA dehydrogenase
D0042802molecular_functionidentical protein binding
D0050660molecular_functionflavin adenine dinucleotide binding
Functional Information from PROSITE/UniProt
site_idPS00072
Number of Residues13
DetailsACYL_COA_DH_1 Acyl-CoA dehydrogenases signature 1. AMSEpnAGSDvvS
ChainResidueDetails
AALA166-SER178
site_idPS00073
Number of Residues20
DetailsACYL_COA_DH_2 Acyl-CoA dehydrogenases signature 2. QcFGGnGYinDfpmgRflrD
ChainResidueDetails
AGLN380-ASP399
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsActive site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"7640268","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1IVH","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues104
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"9214289","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1IVH","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues16
DetailsModified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"Q9JHI5","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues4
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q9JHI5","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues4
DetailsModified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"Q9JHI5","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
Catalytic Information from CSA
site_idMCSA1
Number of Residues4
DetailsM-CSA 68
ChainResidueDetails
AALA164electrostatic stabiliser, hydrogen bond donor
ALEU165electrostatic stabiliser, hydrogen bond donor
ALEU283hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, steric role
AVAL416electrostatic stabiliser
site_idMCSA2
Number of Residues4
DetailsM-CSA 68
ChainResidueDetails
BALA164electrostatic stabiliser, hydrogen bond donor
BLEU165electrostatic stabiliser, hydrogen bond donor
BLEU283hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, steric role
BVAL416electrostatic stabiliser
site_idMCSA3
Number of Residues4
DetailsM-CSA 68
ChainResidueDetails
CALA164electrostatic stabiliser, hydrogen bond donor
CLEU165electrostatic stabiliser, hydrogen bond donor
CLEU283hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, steric role
CVAL416electrostatic stabiliser
site_idMCSA4
Number of Residues4
DetailsM-CSA 68
ChainResidueDetails
DALA164electrostatic stabiliser, hydrogen bond donor
DLEU165electrostatic stabiliser, hydrogen bond donor
DLEU283hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, steric role
DVAL416electrostatic stabiliser

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PDB entries from 2025-07-30

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