Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8SGR

human liver mitochondrial Isovaleryl-CoA dehydrogenase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003995	molecular_function	acyl-CoA dehydrogenase activity
A	0004085	molecular_function	butyryl-CoA dehydrogenase activity
A	0005515	molecular_function	protein binding
A	0005654	cellular_component	nucleoplasm
A	0005739	cellular_component	mitochondrion
A	0005759	cellular_component	mitochondrial matrix
A	0006552	biological_process	L-leucine catabolic process
A	0006631	biological_process	fatty acid metabolic process
A	0008470	molecular_function	isovaleryl-CoA dehydrogenase activity
A	0009083	biological_process	branched-chain amino acid catabolic process
A	0016491	molecular_function	oxidoreductase activity
A	0016627	molecular_function	oxidoreductase activity, acting on the CH-CH group of donors
A	0016937	molecular_function	short-chain fatty acyl-CoA dehydrogenase activity
A	0033539	biological_process	fatty acid beta-oxidation using acyl-CoA dehydrogenase
A	0042802	molecular_function	identical protein binding
A	0050660	molecular_function	flavin adenine dinucleotide binding
B	0003995	molecular_function	acyl-CoA dehydrogenase activity
B	0004085	molecular_function	butyryl-CoA dehydrogenase activity
B	0005515	molecular_function	protein binding
B	0005654	cellular_component	nucleoplasm
B	0005739	cellular_component	mitochondrion
B	0005759	cellular_component	mitochondrial matrix
B	0006552	biological_process	L-leucine catabolic process
B	0006631	biological_process	fatty acid metabolic process
B	0008470	molecular_function	isovaleryl-CoA dehydrogenase activity
B	0009083	biological_process	branched-chain amino acid catabolic process
B	0016491	molecular_function	oxidoreductase activity
B	0016627	molecular_function	oxidoreductase activity, acting on the CH-CH group of donors
B	0016937	molecular_function	short-chain fatty acyl-CoA dehydrogenase activity
B	0033539	biological_process	fatty acid beta-oxidation using acyl-CoA dehydrogenase
B	0042802	molecular_function	identical protein binding
B	0050660	molecular_function	flavin adenine dinucleotide binding
C	0003995	molecular_function	acyl-CoA dehydrogenase activity
C	0004085	molecular_function	butyryl-CoA dehydrogenase activity
C	0005515	molecular_function	protein binding
C	0005654	cellular_component	nucleoplasm
C	0005739	cellular_component	mitochondrion
C	0005759	cellular_component	mitochondrial matrix
C	0006552	biological_process	L-leucine catabolic process
C	0006631	biological_process	fatty acid metabolic process
C	0008470	molecular_function	isovaleryl-CoA dehydrogenase activity
C	0009083	biological_process	branched-chain amino acid catabolic process
C	0016491	molecular_function	oxidoreductase activity
C	0016627	molecular_function	oxidoreductase activity, acting on the CH-CH group of donors
C	0016937	molecular_function	short-chain fatty acyl-CoA dehydrogenase activity
C	0033539	biological_process	fatty acid beta-oxidation using acyl-CoA dehydrogenase
C	0042802	molecular_function	identical protein binding
C	0050660	molecular_function	flavin adenine dinucleotide binding
D	0003995	molecular_function	acyl-CoA dehydrogenase activity
D	0004085	molecular_function	butyryl-CoA dehydrogenase activity
D	0005515	molecular_function	protein binding
D	0005654	cellular_component	nucleoplasm
D	0005739	cellular_component	mitochondrion
D	0005759	cellular_component	mitochondrial matrix
D	0006552	biological_process	L-leucine catabolic process
D	0006631	biological_process	fatty acid metabolic process
D	0008470	molecular_function	isovaleryl-CoA dehydrogenase activity
D	0009083	biological_process	branched-chain amino acid catabolic process
D	0016491	molecular_function	oxidoreductase activity
D	0016627	molecular_function	oxidoreductase activity, acting on the CH-CH group of donors
D	0016937	molecular_function	short-chain fatty acyl-CoA dehydrogenase activity
D	0033539	biological_process	fatty acid beta-oxidation using acyl-CoA dehydrogenase
D	0042802	molecular_function	identical protein binding
D	0050660	molecular_function	flavin adenine dinucleotide binding

Functional Information from PROSITE/UniProt

site_id	PS00072
Number of Residues	13
Details	ACYL_COA_DH_1 Acyl-CoA dehydrogenases signature 1. AMSEpnAGSDvvS

Chain	Residue	Details
A	ALA166-SER178

site_id	PS00073
Number of Residues	20
Details	ACYL_COA_DH_2 Acyl-CoA dehydrogenases signature 2. QcFGGnGYinDfpmgRflrD

Chain	Residue	Details
A	GLN380-ASP399

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: Proton acceptor => ECO:0000269\|PubMed:7640268, ECO:0007744\|PDB:1IVH

Chain	Residue	Details
A	GLU286
B	GLU286
C	GLU286
D	GLU286

site_id	SWS_FT_FI2
Number of Residues	44
Details	BINDING: BINDING => ECO:0000269\|PubMed:9214289, ECO:0007744\|PDB:1IVH

Chain	Residue	Details
A	LEU165
A	ALA407
A	THR409
B	LEU165
B	SER174
B	TRP198
B	SER222
B	TYR277
B	ASP284
B	ARG312
B	GLN323
A	SER174
B	GLN380
B	ALA407
B	THR409
C	LEU165
C	SER174
C	TRP198
C	SER222
C	TYR277
C	ASP284
C	ARG312
A	TRP198
C	GLN323
C	GLN380
C	ALA407
C	THR409
D	LEU165
D	SER174
D	TRP198
D	SER222
D	TYR277
D	ASP284
A	SER222
D	ARG312
D	GLN323
D	GLN380
D	ALA407
D	THR409
A	TYR277
A	ASP284
A	ARG312
A	GLN323
A	GLN380

site_id	SWS_FT_FI3
Number of Residues	16
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000250\|UniProtKB:Q9JHI5

Chain	Residue	Details
A	LYS58
C	LYS67
C	LYS78
C	LYS262
D	LYS58
D	LYS67
D	LYS78
D	LYS262
A	LYS67
A	LYS78
A	LYS262
B	LYS58
B	LYS67
B	LYS78
B	LYS262
C	LYS58

site_id	SWS_FT_FI4
Number of Residues	4
Details	MOD_RES: N6-acetyllysine => ECO:0000250\|UniProtKB:Q9JHI5

Chain	Residue	Details
A	LYS241
B	LYS241
C	LYS241
D	LYS241

site_id	SWS_FT_FI5
Number of Residues	4
Details	MOD_RES: N6-succinyllysine => ECO:0000250\|UniProtKB:Q9JHI5

Chain	Residue	Details
A	LYS318
B	LYS318
C	LYS318
D	LYS318

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	4
Details	M-CSA 68

Chain	Residue	Details
A	ALA164	electrostatic stabiliser, hydrogen bond donor
A	LEU165	electrostatic stabiliser, hydrogen bond donor
A	LEU283	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, steric role
A	VAL416	electrostatic stabiliser

site_id	MCSA2
Number of Residues	4
Details	M-CSA 68

Chain	Residue	Details
B	ALA164	electrostatic stabiliser, hydrogen bond donor
B	LEU165	electrostatic stabiliser, hydrogen bond donor
B	LEU283	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, steric role
B	VAL416	electrostatic stabiliser

site_id	MCSA3
Number of Residues	4
Details	M-CSA 68

Chain	Residue	Details
C	ALA164	electrostatic stabiliser, hydrogen bond donor
C	LEU165	electrostatic stabiliser, hydrogen bond donor
C	LEU283	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, steric role
C	VAL416	electrostatic stabiliser

site_id	MCSA4
Number of Residues	4
Details	M-CSA 68

Chain	Residue	Details
D	ALA164	electrostatic stabiliser, hydrogen bond donor
D	LEU165	electrostatic stabiliser, hydrogen bond donor
D	LEU283	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, steric role
D	VAL416	electrostatic stabiliser

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)