8SGP

human liver mitochondrial Medium-chain specific acyl-CoA dehydrogenase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001889	biological_process	liver development
A	0003995	molecular_function	acyl-CoA dehydrogenase activity
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005759	cellular_component	mitochondrial matrix
A	0005978	biological_process	glycogen biosynthetic process
A	0006082	biological_process	organic acid metabolic process
A	0006111	biological_process	regulation of gluconeogenesis
A	0006631	biological_process	fatty acid metabolic process
A	0006635	biological_process	fatty acid beta-oxidation
A	0007507	biological_process	heart development
A	0009409	biological_process	response to cold
A	0009437	biological_process	carnitine metabolic process
A	0009791	biological_process	post-embryonic development
A	0016491	molecular_function	oxidoreductase activity
A	0019254	biological_process	carnitine metabolic process, CoA-linked
A	0030424	cellular_component	axon
A	0031966	cellular_component	mitochondrial membrane
A	0033539	biological_process	fatty acid beta-oxidation using acyl-CoA dehydrogenase
A	0042594	biological_process	response to starvation
A	0042802	molecular_function	identical protein binding
A	0045329	biological_process	carnitine biosynthetic process
A	0051791	biological_process	medium-chain fatty acid metabolic process
A	0051793	biological_process	medium-chain fatty acid catabolic process
A	0055007	biological_process	cardiac muscle cell differentiation
A	0070991	molecular_function	medium-chain fatty acyl-CoA dehydrogenase activity
B	0001889	biological_process	liver development
B	0003995	molecular_function	acyl-CoA dehydrogenase activity
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005759	cellular_component	mitochondrial matrix
B	0005978	biological_process	glycogen biosynthetic process
B	0006082	biological_process	organic acid metabolic process
B	0006111	biological_process	regulation of gluconeogenesis
B	0006631	biological_process	fatty acid metabolic process
B	0006635	biological_process	fatty acid beta-oxidation
B	0007507	biological_process	heart development
B	0009409	biological_process	response to cold
B	0009437	biological_process	carnitine metabolic process
B	0009791	biological_process	post-embryonic development
B	0016491	molecular_function	oxidoreductase activity
B	0019254	biological_process	carnitine metabolic process, CoA-linked
B	0030424	cellular_component	axon
B	0031966	cellular_component	mitochondrial membrane
B	0033539	biological_process	fatty acid beta-oxidation using acyl-CoA dehydrogenase
B	0042594	biological_process	response to starvation
B	0042802	molecular_function	identical protein binding
B	0045329	biological_process	carnitine biosynthetic process
B	0051791	biological_process	medium-chain fatty acid metabolic process
B	0051793	biological_process	medium-chain fatty acid catabolic process
B	0055007	biological_process	cardiac muscle cell differentiation
B	0070991	molecular_function	medium-chain fatty acyl-CoA dehydrogenase activity
C	0001889	biological_process	liver development
C	0003995	molecular_function	acyl-CoA dehydrogenase activity
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0005759	cellular_component	mitochondrial matrix
C	0005978	biological_process	glycogen biosynthetic process
C	0006082	biological_process	organic acid metabolic process
C	0006111	biological_process	regulation of gluconeogenesis
C	0006631	biological_process	fatty acid metabolic process
C	0006635	biological_process	fatty acid beta-oxidation
C	0007507	biological_process	heart development
C	0009409	biological_process	response to cold
C	0009437	biological_process	carnitine metabolic process
C	0009791	biological_process	post-embryonic development
C	0016491	molecular_function	oxidoreductase activity
C	0019254	biological_process	carnitine metabolic process, CoA-linked
C	0030424	cellular_component	axon
C	0031966	cellular_component	mitochondrial membrane
C	0033539	biological_process	fatty acid beta-oxidation using acyl-CoA dehydrogenase
C	0042594	biological_process	response to starvation
C	0042802	molecular_function	identical protein binding
C	0045329	biological_process	carnitine biosynthetic process
C	0051791	biological_process	medium-chain fatty acid metabolic process
C	0051793	biological_process	medium-chain fatty acid catabolic process
C	0055007	biological_process	cardiac muscle cell differentiation
C	0070991	molecular_function	medium-chain fatty acyl-CoA dehydrogenase activity
D	0001889	biological_process	liver development
D	0003995	molecular_function	acyl-CoA dehydrogenase activity
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005739	cellular_component	mitochondrion
D	0005759	cellular_component	mitochondrial matrix
D	0005978	biological_process	glycogen biosynthetic process
D	0006082	biological_process	organic acid metabolic process
D	0006111	biological_process	regulation of gluconeogenesis
D	0006631	biological_process	fatty acid metabolic process
D	0006635	biological_process	fatty acid beta-oxidation
D	0007507	biological_process	heart development
D	0009409	biological_process	response to cold
D	0009437	biological_process	carnitine metabolic process
D	0009791	biological_process	post-embryonic development
D	0016491	molecular_function	oxidoreductase activity
D	0019254	biological_process	carnitine metabolic process, CoA-linked
D	0030424	cellular_component	axon
D	0031966	cellular_component	mitochondrial membrane
D	0033539	biological_process	fatty acid beta-oxidation using acyl-CoA dehydrogenase
D	0042594	biological_process	response to starvation
D	0042802	molecular_function	identical protein binding
D	0045329	biological_process	carnitine biosynthetic process
D	0051791	biological_process	medium-chain fatty acid metabolic process
D	0051793	biological_process	medium-chain fatty acid catabolic process
D	0055007	biological_process	cardiac muscle cell differentiation
D	0070991	molecular_function	medium-chain fatty acyl-CoA dehydrogenase activity

Functional Information from PROSITE/UniProt

site_id	PS00072
Number of Residues	13
Details	ACYL_COA_DH_1 Acyl-CoA dehydrogenases signature 1. CVTEpgAGSDvaG

Chain	Residue	Details
A	CYS159-GLY171

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site_id	PS00073
Number of Residues	20
Details	ACYL_COA_DH_2 Acyl-CoA dehydrogenases signature 2. QiLGGnGFntEypveKlmrD

Chain	Residue	Details
A	GLN374-ASP393

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: Proton acceptor => ECO:0000269|PubMed:1970566, ECO:0000269|PubMed:8823176

Chain	Residue	Details
A	GLU401
B	GLU401
C	GLU401
D	GLU401

---

site_id	SWS_FT_FI2
Number of Residues	12
Details	BINDING: in other chain => ECO:0000269|PubMed:15159392, ECO:0000269|PubMed:15975918, ECO:0000269|PubMed:8823176, ECO:0000269|Ref.23, ECO:0007744|PDB:1EGC, ECO:0007744|PDB:1EGD, ECO:0007744|PDB:1EGE, ECO:0007744|PDB:1T9G, ECO:0007744|PDB:2A1T, ECO:0007744|PDB:4P13

Chain	Residue	Details
A	TYR158
A	TRP191
A	HIS316
B	TYR158
B	TRP191
B	HIS316
C	TYR158
C	TRP191
C	HIS316
D	TYR158
D	TRP191
D	HIS316

---

site_id	SWS_FT_FI3
Number of Residues	16
Details	BINDING: BINDING => ECO:0000269|PubMed:8823176, ECO:0007744|PDB:1EGC

Chain	Residue	Details
A	SER167
A	ASP278
A	ARG281
A	GLU401
B	SER167
B	ASP278
B	ARG281
B	GLU401
C	SER167
C	ASP278
C	ARG281
C	GLU401
D	SER167
D	ASP278
D	ARG281
D	GLU401

---

site_id	SWS_FT_FI4
Number of Residues	8
Details	BINDING: BINDING => ECO:0000269|PubMed:15159392, ECO:0000269|PubMed:15975918, ECO:0000269|PubMed:8823176, ECO:0000269|Ref.23, ECO:0007744|PDB:1EGC, ECO:0007744|PDB:1EGD, ECO:0007744|PDB:1EGE, ECO:0007744|PDB:1T9G, ECO:0007744|PDB:2A1T, ECO:0007744|PDB:4P13

Chain	Residue	Details
A	ARG306
A	GLN374
B	ARG306
B	GLN374
C	ARG306
C	GLN374
D	ARG306
D	GLN374

---

site_id	SWS_FT_FI5
Number of Residues	20
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P45952

Chain	Residue	Details
A	LYS69
A	LYS212
A	LYS217
A	LYS259
A	LYS271
B	LYS69
B	LYS212
B	LYS217
B	LYS259
B	LYS271
C	LYS69
C	LYS212
C	LYS217
C	LYS259
C	LYS271
D	LYS69
D	LYS212
D	LYS217
D	LYS259
D	LYS271

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	MOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:P45952

Chain	Residue	Details
A	LYS179
B	LYS179
C	LYS179
D	LYS179

---

site_id	SWS_FT_FI7
Number of Residues	8
Details	MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861

Chain	Residue	Details
A	LYS279
A	LYS301
B	LYS279
B	LYS301
C	LYS279
C	LYS301
D	LYS279
D	LYS301

---

site_id	SWS_FT_FI8
Number of Residues	4
Details	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P45952

Chain	Residue	Details
A	THR351
B	THR351
C	THR351
D	THR351

---