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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

8SE1

Structure of Full-length Human Protein Kinase C Beta 2 (PKCBII) in the Inactive Conformation

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0002250biological_processadaptive immune response
A0002376biological_processimmune system process
A0003682molecular_functionchromatin binding
A0003713molecular_functiontranscription coactivator activity
A0004674molecular_functionprotein serine/threonine kinase activity
A0004697molecular_functiondiacylglycerol-dependent serine/threonine kinase activity
A0004698molecular_functioncalcium,diacylglycerol-dependent serine/threonine kinase activity
A0005080molecular_functionprotein kinase C binding
A0005246molecular_functioncalcium channel regulator activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0006325biological_processchromatin organization
A0006338biological_processchromatin remodeling
A0006357biological_processregulation of transcription by RNA polymerase II
A0006468biological_processprotein phosphorylation
A0006915biological_processapoptotic process
A0007077biological_processmitotic nuclear membrane disassembly
A0007165biological_processsignal transduction
A0007207biological_processphospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway
A0008091cellular_componentspectrin
A0008270molecular_functionzinc ion binding
A0010827biological_processregulation of D-glucose transmembrane transport
A0010829biological_processnegative regulation of D-glucose transmembrane transport
A0016020cellular_componentmembrane
A0016301molecular_functionkinase activity
A0016740molecular_functiontransferase activity
A0030949biological_processpositive regulation of vascular endothelial growth factor receptor signaling pathway
A0035403molecular_functionhistone H3T6 kinase activity
A0035556biological_processintracellular signal transduction
A0042113biological_processB cell activation
A0042393molecular_functionhistone binding
A0042953biological_processlipoprotein transport
A0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
A0044305cellular_componentcalyx of Held
A0045766biological_processpositive regulation of angiogenesis
A0045893biological_processpositive regulation of DNA-templated transcription
A0046627biological_processnegative regulation of insulin receptor signaling pathway
A0046872molecular_functionmetal ion binding
A0050681molecular_functionnuclear androgen receptor binding
A0050853biological_processB cell receptor signaling pathway
A0051049biological_processregulation of transport
A0070062cellular_componentextracellular exosome
A0070528biological_processprotein kinase C signaling
A0099523cellular_componentpresynaptic cytosol
A0106310molecular_functionprotein serine kinase activity
A2000300biological_processregulation of synaptic vesicle exocytosis
B0000166molecular_functionnucleotide binding
B0002250biological_processadaptive immune response
B0002376biological_processimmune system process
B0003682molecular_functionchromatin binding
B0003713molecular_functiontranscription coactivator activity
B0004674molecular_functionprotein serine/threonine kinase activity
B0004697molecular_functiondiacylglycerol-dependent serine/threonine kinase activity
B0004698molecular_functioncalcium,diacylglycerol-dependent serine/threonine kinase activity
B0005080molecular_functionprotein kinase C binding
B0005246molecular_functioncalcium channel regulator activity
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0006325biological_processchromatin organization
B0006338biological_processchromatin remodeling
B0006357biological_processregulation of transcription by RNA polymerase II
B0006468biological_processprotein phosphorylation
B0006915biological_processapoptotic process
B0007077biological_processmitotic nuclear membrane disassembly
B0007165biological_processsignal transduction
B0007207biological_processphospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway
B0008091cellular_componentspectrin
B0008270molecular_functionzinc ion binding
B0010827biological_processregulation of D-glucose transmembrane transport
B0010829biological_processnegative regulation of D-glucose transmembrane transport
B0016020cellular_componentmembrane
B0016301molecular_functionkinase activity
B0016740molecular_functiontransferase activity
B0030949biological_processpositive regulation of vascular endothelial growth factor receptor signaling pathway
B0035403molecular_functionhistone H3T6 kinase activity
B0035556biological_processintracellular signal transduction
B0042113biological_processB cell activation
B0042393molecular_functionhistone binding
B0042953biological_processlipoprotein transport
B0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
B0044305cellular_componentcalyx of Held
B0045766biological_processpositive regulation of angiogenesis
B0045893biological_processpositive regulation of DNA-templated transcription
B0046627biological_processnegative regulation of insulin receptor signaling pathway
B0046872molecular_functionmetal ion binding
B0050681molecular_functionnuclear androgen receptor binding
B0050853biological_processB cell receptor signaling pathway
B0051049biological_processregulation of transport
B0070062cellular_componentextracellular exosome
B0070528biological_processprotein kinase C signaling
B0099523cellular_componentpresynaptic cytosol
B0106310molecular_functionprotein serine kinase activity
B2000300biological_processregulation of synaptic vesicle exocytosis
Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues24
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGKGSFGKVMlSerkgtdel..........YAVK
ChainResidueDetails
ALEU348-LYS371
site_idPS00108
Number of Residues13
DetailsPROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IiYrDLKldNVML
ChainResidueDetails
AILE462-LEU474
site_idPS00479
Number of Residues50
DetailsZF_DAG_PE_1 Zinc finger phorbol-ester/DAG-type signature. HkFtarffkqptf.CshCtdfIwgfgkqgfq.CqvCcfvvHkrChefvtfs..C
ChainResidueDetails
AHIS37-CYS86
AHIS102-CYS151
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues234
DetailsDomain: {"description":"C2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00041","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues100
DetailsZinc finger: {"description":"Phorbol-ester/DAG-type 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00226","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues100
DetailsZinc finger: {"description":"Phorbol-ester/DAG-type 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00226","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues2
DetailsActive site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10027","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues18
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"P68403","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues18
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues3
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues2
DetailsModified residue: {"description":"Phosphothreonine; by autocatalysis","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues2
DetailsModified residue: {"description":"Phosphothreonine; by PDPK1","evidences":[{"source":"PubMed","id":"17115692","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues2
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"19369195","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues2
DetailsModified residue: {"description":"Phosphothreonine; by autocatalysis","evidences":[{"source":"UniProtKB","id":"P68403","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues2
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"17115692","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues2
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"19369195","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19369195","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues1
DetailsModified residue: {"description":"Phosphothreonine; by autocatalysis","evidences":[{"source":"UniProtKB","id":"P68403","evidenceCode":"ECO:0000250"},{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

246031

PDB entries from 2025-12-10

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