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8SDU

Structure of rat organic anion transporter 1 (OAT1)

Functional Information from GO Data
ChainGOidnamespacecontents
A0005452molecular_functionsolute:inorganic anion antiporter activity
A0005515molecular_functionprotein binding
A0005886cellular_componentplasma membrane
A0005901cellular_componentcaveola
A0006820biological_processmonoatomic anion transport
A0008514molecular_functionorganic anion transmembrane transporter activity
A0009925cellular_componentbasal plasma membrane
A0014070biological_processresponse to organic cyclic compound
A0015132molecular_functionprostaglandin transmembrane transporter activity
A0015139molecular_functionalpha-ketoglutarate transmembrane transporter activity
A0015297molecular_functionantiporter activity
A0015347molecular_functionsodium-independent organic anion transmembrane transporter activity
A0015698biological_processinorganic anion transport
A0015711biological_processorganic anion transport
A0015732biological_processprostaglandin transport
A0015742biological_processalpha-ketoglutarate transport
A0016020cellular_componentmembrane
A0016323cellular_componentbasolateral plasma membrane
A0022857molecular_functiontransmembrane transporter activity
A0031404molecular_functionchloride ion binding
A0032991cellular_componentprotein-containing complex
A0042802molecular_functionidentical protein binding
A0042908biological_processxenobiotic transport
A0042910molecular_functionxenobiotic transmembrane transporter activity
A0043252biological_processsodium-independent organic anion transport
A0055085biological_processtransmembrane transport
A0072237biological_processmetanephric proximal tubule development
A0097254biological_processrenal tubular secretion
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues131
DetailsTOPO_DOM: Cytoplasmic => ECO:0000255
ChainResidueDetails
AMET1-GLN9
AASP157-VAL164
AHIS217-THR224
AGLU270-HIS337
AASN390-ARG395
AGLU447-SER484

site_idSWS_FT_FI2
Number of Residues222
DetailsTRANSMEM: Helical => ECO:0000255
ChainResidueDetails
AVAL10-LEU30
ALEU426-GLY446
AMET485-PRO505
ALEU136-ALA156
ALEU165-VAL187
AGLY196-ILE216
ALEU225-PRO245
AHIS249-ILE269
ALEU338-MET358
ALEU369-ILE389
APRO396-PRO416

site_idSWS_FT_FI3
Number of Residues175
DetailsTOPO_DOM: Extracellular => ECO:0000255
ChainResidueDetails
AMET31-GLN135
ATYR188-SER195
AHIS246-ARG248
AASP359-TYR368
ALYS417-SER425
AGLU506-LEU551

site_idSWS_FT_FI4
Number of Residues4
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AASN39
AASN56
AASN92
AASN113

227111

PDB entries from 2024-11-06

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