8SC3

Human OCT1 bound to fenoterol in inward-open conformation

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005277	molecular_function	acetylcholine transmembrane transporter activity
A	0005326	molecular_function	neurotransmitter transmembrane transporter activity
A	0005330	molecular_function	dopamine:sodium symporter activity
A	0005334	molecular_function	norepinephrine:sodium symporter activity
A	0005515	molecular_function	protein binding
A	0005886	cellular_component	plasma membrane
A	0006805	biological_process	xenobiotic metabolic process
A	0006811	biological_process	monoatomic ion transport
A	0006812	biological_process	monoatomic cation transport
A	0006836	biological_process	neurotransmitter transport
A	0006837	biological_process	serotonin transport
A	0008504	molecular_function	monoamine transmembrane transporter activity
A	0008514	molecular_function	obsolete organic anion transmembrane transporter activity
A	0009925	cellular_component	basal plasma membrane
A	0010248	biological_process	establishment or maintenance of transmembrane electrochemical gradient
A	0015101	molecular_function	obsolete organic cation transmembrane transporter activity
A	0015132	molecular_function	prostaglandin transmembrane transporter activity
A	0015214	molecular_function	pyrimidine nucleoside transmembrane transporter activity
A	0015234	molecular_function	thiamine transmembrane transporter activity
A	0015489	molecular_function	putrescine transmembrane transporter activity
A	0015606	molecular_function	spermidine transmembrane transporter activity
A	0015651	molecular_function	quaternary ammonium group transmembrane transporter activity
A	0015695	biological_process	organic cation transport
A	0015697	biological_process	quaternary ammonium group transport
A	0015732	biological_process	prostaglandin transport
A	0015844	biological_process	monoamine transport
A	0015847	biological_process	putrescine transport
A	0015848	biological_process	spermidine transport
A	0015870	biological_process	acetylcholine transport
A	0015872	biological_process	dopamine transport
A	0015874	biological_process	norepinephrine transport
A	0015888	biological_process	thiamine transport
A	0016020	cellular_component	membrane
A	0016323	cellular_component	basolateral plasma membrane
A	0016324	cellular_component	apical plasma membrane
A	0016328	cellular_component	lateral plasma membrane
A	0019534	molecular_function	toxin transmembrane transporter activity
A	0022857	molecular_function	transmembrane transporter activity
A	0042802	molecular_function	identical protein binding
A	0042908	biological_process	xenobiotic transport
A	0042910	molecular_function	xenobiotic transmembrane transporter activity
A	0048241	biological_process	epinephrine transport
A	0051610	biological_process	serotonin uptake
A	0051620	biological_process	norepinephrine uptake
A	0055085	biological_process	transmembrane transport
A	0071934	biological_process	thiamine transmembrane transport
A	0072237	biological_process	metanephric proximal tubule development
A	0072530	biological_process	purine-containing compound transmembrane transport
A	0090494	biological_process	dopamine uptake
A	0098655	biological_process	monoatomic cation transmembrane transport
A	0098793	cellular_component	presynapse
A	0150104	biological_process	transport across blood-brain barrier
A	1901235	molecular_function	(R)-carnitine transmembrane transporter activity
A	1902270	biological_process	(R)-carnitine transmembrane transport
A	1902616	biological_process	O-acyl-L-carnitine transmembrane transport
A	1903711	biological_process	spermidine transmembrane transport
A	1990748	biological_process	cellular detoxification
A	1990962	biological_process	xenobiotic transport across blood-brain barrier

Functional Information from PROSITE/UniProt

site_id	PS00216
Number of Residues	17
Details	SUGAR_TRANSPORT_1 Sugar transport proteins signature 1. VGYFADRFGRKlcllg.T

Chain	Residue	Details
A	VAL166-THR182

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	222
Details	Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	139
Details	Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	25
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"O08966","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---