8SB6
Structure of human BRD2-BD1 bound to a histone H4 acetyl-methyllysine peptide
Functional Information from PROSITE/UniProt
| site_id | PS00633 |
| Number of Residues | 60 |
| Details | BROMODOMAIN_1 Bromodomain signature. AwpFrqpvDavklglpDYHkiIkqpMdmgtIkrrlenny..Ywaasecmqdfnt.MftNCyiY |
| Chain | Residue | Details |
| A | ALA96-TYR155 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 12 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:37731000, ECO:0007744|PDB:8SB6 |
| Chain | Residue | Details |
| A | ASP112 | |
| C | TYR155 | |
| C | ASN156 | |
| C | LYS157 | |
| A | TYR155 | |
| A | ASN156 | |
| A | LYS157 | |
| B | ASP112 | |
| B | TYR155 | |
| B | ASN156 | |
| B | LYS157 | |
| C | ASP112 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:20048151, ECO:0007744|PDB:2DVQ, ECO:0007744|PDB:2DVS |
| Chain | Residue | Details |
| A | ASP160 | |
| A | ASP161 | |
| B | ASP160 | |
| B | ASP161 | |
| C | ASP160 | |
| C | ASP161 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-lactoyllysine; alternate => ECO:0000269|PubMed:31645732 |
| Chain | Residue | Details |
| D | 7QK5 | |
| E | 7QK5 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-propionyllysine; alternate => ECO:0000269|PubMed:17267393 |
| Chain | Residue | Details |
| D | LYS8 | |
| E | LYS8 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-succinyllysine; alternate => ECO:0000269|PubMed:22389435 |
| Chain | Residue | Details |
| D | 7QK12 | |
| E | 7QK12 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:25218447 |
| Chain | Residue | Details |
| D | 7QK12 | |
| E | 7QK12 |
