8S9P

1:1:1 agrin/LRP4/MuSK complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005509	molecular_function	calcium ion binding
A	0043113	biological_process	receptor clustering
A	0043236	molecular_function	laminin binding
B	0005509	molecular_function	calcium ion binding
C	0004672	molecular_function	protein kinase activity
C	0004713	molecular_function	protein tyrosine kinase activity
C	0005524	molecular_function	ATP binding
C	0006468	biological_process	protein phosphorylation

Functional Information from PROSITE/UniProt

site_id	PS00010
Number of Residues	12
Details	ASX_HYDROXYL Aspartic acid and asparagine hydroxylation site. CtNsegaFqCwC

Chain	Residue	Details
B	CYS409-CYS420

---

site_id	PS00022
Number of Residues	12
Details	EGF_1 EGF-like domain signature 1. CsCrpGvgGLrC

Chain	Residue	Details
A	CYS812-CYS823
A	CYS866-CYS877
A	CYS1355-CYS1366
A	CYS1574-CYS1585
A	CYS1613-CYS1624
A	CYS1845-CYS1856

---

site_id	PS00107
Number of Residues	29
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGEGAFGRVFqArapgllpyepftm.....VAVK

Chain	Residue	Details
C	ILE581-LYS609

---

site_id	PS00109
Number of Residues	13
Details	PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. FVHrDLATRNCLV

Chain	Residue	Details
C	PHE721-VAL733

---

site_id	PS00228
Number of Residues	4
Details	TUBULIN_B_AUTOREG Tubulin-beta mRNA autoregulation signal. MREL

Chain	Residue	Details
C	MET1-LEU4

---

site_id	PS01148
Number of Residues	25
Details	UPF0033 Uncharacterized protein family UPF0033 signature. LDaeGsnCPaTkVfqgvlelegveG

Chain	Residue	Details
A	LEU1121-GLY1145

---

site_id	PS01186
Number of Residues	12
Details	EGF_2 EGF-like domain signature 2. ClCpgGFsgph....C

Chain	Residue	Details
A	CYS1845-CYS1856
B	CYS378-CYS393
B	CYS418-CYS433
B	CYS722-CYS736

---

site_id	PS01187
Number of Residues	24
Details	EGF_CA Calcium-binding EGF-like domain signature. DvNECaeegy.........Csqg....CtNsegaFqC

Chain	Residue	Details
B	ASP395-CYS418

---

site_id	PS01209
Number of Residues	23
Details	LDLRA_1 LDL-receptor class A (LDLRA) domain signature. CIpaqwq.CDgdnDCgdhsDEDg....C

Chain	Residue	Details
B	CYS44-CYS66
B	CYS83-CYS105
B	CYS122-CYS143
B	CYS160-CYS182
B	CYS203-CYS225
B	CYS243-CYS265
B	CYS282-CYS304
B	CYS324-CYS349

---

site_id	PS01248
Number of Residues	36
Details	EGF_LAM_1 Laminin-type EGF-like (LE) domain signature. Cs.CrpgvgGlrCdrCepgfWnfrgivtdgrsgctpC

Chain	Residue	Details
A	CYS812-CYS847

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	471
Details	TOPO_DOM: Extracellular => ECO:0000255

Chain	Residue	Details
C	LEU24-THR495
A	LEU1957
A	GLN2007
A	ASP2009

---

site_id	SWS_FT_FI2
Number of Residues	20
Details	TRANSMEM: Helical => ECO:0000255

Chain	Residue	Details
C	VAL496-TYR516

---

site_id	SWS_FT_FI3
Number of Residues	352
Details	TOPO_DOM: Cytoplasmic => ECO:0000255

Chain	Residue	Details
C	CYS517-VAL869

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028

Chain	Residue	Details
C	ASP725
B	ASN498
B	ASN719
B	ASN901
B	ASN1077
B	ASN1415
B	ASN1467

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159

Chain	Residue	Details
C	ILE581
C	LYS609

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000250|UniProtKB:Q61006

Chain	Residue	Details
C	TYR554

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	MOD_RES: Phosphoserine; by CK2 => ECO:0000250|UniProtKB:Q61006

Chain	Residue	Details
C	SER681
C	SER698

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	MOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000250|UniProtKB:Q62838

Chain	Residue	Details
C	TYR755

---

site_id	SWS_FT_FI9
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
C	ASN222
A	SER676

---

site_id	SWS_FT_FI10
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000250

Chain	Residue	Details
C	ASN338

---

site_id	SWS_FT_FI11
Number of Residues	3
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN250
A	ASN777
A	ASN932

---

site_id	SWS_FT_FI12
Number of Residues	1
Details	CARBOHYD: O-linked (Fuc...) serine => ECO:0000250|UniProtKB:P25304

Chain	Residue	Details
A	SER1835

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