8S8P

Restriction on Ku Inward Translocation Caps Telomere Ends

Functional Information from GO Data

Chain	GOid	namespace	contents
K	0000166	molecular_function	nucleotide binding
K	0000723	biological_process	telomere maintenance
K	0000724	biological_process	double-strand break repair via homologous recombination
K	0000725	biological_process	recombinational repair
K	0000727	biological_process	double-strand break repair via break-induced replication
K	0000781	cellular_component	chromosome, telomeric region
K	0003677	molecular_function	DNA binding
K	0003678	molecular_function	DNA helicase activity
K	0003690	molecular_function	double-stranded DNA binding
K	0004386	molecular_function	helicase activity
K	0005515	molecular_function	protein binding
K	0005524	molecular_function	ATP binding
K	0005634	cellular_component	nucleus
K	0005635	cellular_component	nuclear envelope
K	0006281	biological_process	DNA repair
K	0006303	biological_process	double-strand break repair via nonhomologous end joining
K	0006310	biological_process	DNA recombination
K	0006325	biological_process	chromatin organization
K	0006974	biological_process	DNA damage response
K	0016787	molecular_function	hydrolase activity
K	0016887	molecular_function	ATP hydrolysis activity
K	0030466	biological_process	silent mating-type cassette heterochromatin formation
K	0031509	biological_process	subtelomeric heterochromatin formation
K	0042162	molecular_function	telomeric DNA binding
K	0043564	cellular_component	Ku70:Ku80 complex
K	0070034	molecular_function	telomerase RNA binding
K	0097552	biological_process	mitochondrial double-strand break repair via homologous recombination
K	0097695	biological_process	establishment of protein-containing complex localization to telomere
L	0000166	molecular_function	nucleotide binding
L	0000723	biological_process	telomere maintenance
L	0000724	biological_process	double-strand break repair via homologous recombination
L	0000725	biological_process	recombinational repair
L	0000781	cellular_component	chromosome, telomeric region
L	0003677	molecular_function	DNA binding
L	0003678	molecular_function	DNA helicase activity
L	0003690	molecular_function	double-stranded DNA binding
L	0004386	molecular_function	helicase activity
L	0005515	molecular_function	protein binding
L	0005524	molecular_function	ATP binding
L	0005634	cellular_component	nucleus
L	0006281	biological_process	DNA repair
L	0006303	biological_process	double-strand break repair via nonhomologous end joining
L	0006310	biological_process	DNA recombination
L	0006325	biological_process	chromatin organization
L	0006974	biological_process	DNA damage response
L	0007535	biological_process	donor selection
L	0016787	molecular_function	hydrolase activity
L	0016887	molecular_function	ATP hydrolysis activity
L	0031509	biological_process	subtelomeric heterochromatin formation
L	0034502	biological_process	protein localization to chromosome
L	0042162	molecular_function	telomeric DNA binding
L	0043564	cellular_component	Ku70:Ku80 complex
L	0070034	molecular_function	telomerase RNA binding
L	0097695	biological_process	establishment of protein-containing complex localization to telomere

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	437
Details	Domain: {"description":"Ku"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17287358","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	23
Details	DNA binding: {"description":"H-T-H motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU00625","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"17330950","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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