Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8S5L

Full-length human cystathionine beta-synthase, basal state, partially degraded tetramer

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001958	biological_process	endochondral ossification
A	0001974	biological_process	blood vessel remodeling
A	0003824	molecular_function	catalytic activity
A	0004122	molecular_function	cystathionine beta-synthase activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006534	biological_process	cysteine metabolic process
A	0006535	biological_process	cysteine biosynthetic process from serine
A	0006563	biological_process	L-serine metabolic process
A	0006565	biological_process	L-serine catabolic process
A	0006801	biological_process	superoxide metabolic process
A	0008652	biological_process	amino acid biosynthetic process
A	0009069	biological_process	serine family amino acid metabolic process
A	0010749	biological_process	regulation of nitric oxide mediated signal transduction
A	0016829	molecular_function	lyase activity
A	0019343	biological_process	cysteine biosynthetic process via cystathionine
A	0019344	biological_process	cysteine biosynthetic process
A	0019346	biological_process	transsulfuration
A	0019448	biological_process	L-cysteine catabolic process
A	0019825	molecular_function	oxygen binding
A	0019899	molecular_function	enzyme binding
A	0020037	molecular_function	heme binding
A	0021587	biological_process	cerebellum morphogenesis
A	0030170	molecular_function	pyridoxal phosphate binding
A	0031625	molecular_function	ubiquitin protein ligase binding
A	0031667	biological_process	response to nutrient levels
A	0042262	biological_process	DNA protection
A	0042802	molecular_function	identical protein binding
A	0042803	molecular_function	protein homodimerization activity
A	0043066	biological_process	negative regulation of apoptotic process
A	0043418	biological_process	homocysteine catabolic process
A	0044272	biological_process	sulfur compound biosynthetic process
A	0046328	biological_process	regulation of JNK cascade
A	0046872	molecular_function	metal ion binding
A	0050421	molecular_function	nitrite reductase (NO-forming) activity
A	0050667	biological_process	homocysteine metabolic process
A	0051593	biological_process	response to folic acid
A	0060135	biological_process	maternal process involved in female pregnancy
A	0060351	biological_process	cartilage development involved in endochondral bone morphogenesis
A	0070025	molecular_function	carbon monoxide binding
A	0070026	molecular_function	nitric oxide binding
A	0070814	biological_process	hydrogen sulfide biosynthetic process
A	0071456	biological_process	cellular response to hypoxia
A	0072341	molecular_function	modified amino acid binding
A	0097746	biological_process	blood vessel diameter maintenance
A	1904047	molecular_function	S-adenosyl-L-methionine binding
B	0001958	biological_process	endochondral ossification
B	0001974	biological_process	blood vessel remodeling
B	0003824	molecular_function	catalytic activity
B	0004122	molecular_function	cystathionine beta-synthase activity
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006534	biological_process	cysteine metabolic process
B	0006535	biological_process	cysteine biosynthetic process from serine
B	0006563	biological_process	L-serine metabolic process
B	0006565	biological_process	L-serine catabolic process
B	0006801	biological_process	superoxide metabolic process
B	0008652	biological_process	amino acid biosynthetic process
B	0009069	biological_process	serine family amino acid metabolic process
B	0010749	biological_process	regulation of nitric oxide mediated signal transduction
B	0016829	molecular_function	lyase activity
B	0019343	biological_process	cysteine biosynthetic process via cystathionine
B	0019344	biological_process	cysteine biosynthetic process
B	0019346	biological_process	transsulfuration
B	0019448	biological_process	L-cysteine catabolic process
B	0019825	molecular_function	oxygen binding
B	0019899	molecular_function	enzyme binding
B	0020037	molecular_function	heme binding
B	0021587	biological_process	cerebellum morphogenesis
B	0030170	molecular_function	pyridoxal phosphate binding
B	0031625	molecular_function	ubiquitin protein ligase binding
B	0031667	biological_process	response to nutrient levels
B	0042262	biological_process	DNA protection
B	0042802	molecular_function	identical protein binding
B	0042803	molecular_function	protein homodimerization activity
B	0043066	biological_process	negative regulation of apoptotic process
B	0043418	biological_process	homocysteine catabolic process
B	0044272	biological_process	sulfur compound biosynthetic process
B	0046328	biological_process	regulation of JNK cascade
B	0046872	molecular_function	metal ion binding
B	0050421	molecular_function	nitrite reductase (NO-forming) activity
B	0050667	biological_process	homocysteine metabolic process
B	0051593	biological_process	response to folic acid
B	0060135	biological_process	maternal process involved in female pregnancy
B	0060351	biological_process	cartilage development involved in endochondral bone morphogenesis
B	0070025	molecular_function	carbon monoxide binding
B	0070026	molecular_function	nitric oxide binding
B	0070814	biological_process	hydrogen sulfide biosynthetic process
B	0071456	biological_process	cellular response to hypoxia
B	0072341	molecular_function	modified amino acid binding
B	0097746	biological_process	blood vessel diameter maintenance
B	1904047	molecular_function	S-adenosyl-L-methionine binding
C	0001958	biological_process	endochondral ossification
C	0001974	biological_process	blood vessel remodeling
C	0003824	molecular_function	catalytic activity
C	0004122	molecular_function	cystathionine beta-synthase activity
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006534	biological_process	cysteine metabolic process
C	0006535	biological_process	cysteine biosynthetic process from serine
C	0006563	biological_process	L-serine metabolic process
C	0006565	biological_process	L-serine catabolic process
C	0006801	biological_process	superoxide metabolic process
C	0008652	biological_process	amino acid biosynthetic process
C	0009069	biological_process	serine family amino acid metabolic process
C	0010749	biological_process	regulation of nitric oxide mediated signal transduction
C	0016829	molecular_function	lyase activity
C	0019343	biological_process	cysteine biosynthetic process via cystathionine
C	0019344	biological_process	cysteine biosynthetic process
C	0019346	biological_process	transsulfuration
C	0019448	biological_process	L-cysteine catabolic process
C	0019825	molecular_function	oxygen binding
C	0019899	molecular_function	enzyme binding
C	0020037	molecular_function	heme binding
C	0021587	biological_process	cerebellum morphogenesis
C	0030170	molecular_function	pyridoxal phosphate binding
C	0031625	molecular_function	ubiquitin protein ligase binding
C	0031667	biological_process	response to nutrient levels
C	0042262	biological_process	DNA protection
C	0042802	molecular_function	identical protein binding
C	0042803	molecular_function	protein homodimerization activity
C	0043066	biological_process	negative regulation of apoptotic process
C	0043418	biological_process	homocysteine catabolic process
C	0044272	biological_process	sulfur compound biosynthetic process
C	0046328	biological_process	regulation of JNK cascade
C	0046872	molecular_function	metal ion binding
C	0050421	molecular_function	nitrite reductase (NO-forming) activity
C	0050667	biological_process	homocysteine metabolic process
C	0051593	biological_process	response to folic acid
C	0060135	biological_process	maternal process involved in female pregnancy
C	0060351	biological_process	cartilage development involved in endochondral bone morphogenesis
C	0070025	molecular_function	carbon monoxide binding
C	0070026	molecular_function	nitric oxide binding
C	0070814	biological_process	hydrogen sulfide biosynthetic process
C	0071456	biological_process	cellular response to hypoxia
C	0072341	molecular_function	modified amino acid binding
C	0097746	biological_process	blood vessel diameter maintenance
C	1904047	molecular_function	S-adenosyl-L-methionine binding
D	0001958	biological_process	endochondral ossification
D	0001974	biological_process	blood vessel remodeling
D	0003824	molecular_function	catalytic activity
D	0004122	molecular_function	cystathionine beta-synthase activity
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006534	biological_process	cysteine metabolic process
D	0006535	biological_process	cysteine biosynthetic process from serine
D	0006563	biological_process	L-serine metabolic process
D	0006565	biological_process	L-serine catabolic process
D	0006801	biological_process	superoxide metabolic process
D	0008652	biological_process	amino acid biosynthetic process
D	0009069	biological_process	serine family amino acid metabolic process
D	0010749	biological_process	regulation of nitric oxide mediated signal transduction
D	0016829	molecular_function	lyase activity
D	0019343	biological_process	cysteine biosynthetic process via cystathionine
D	0019344	biological_process	cysteine biosynthetic process
D	0019346	biological_process	transsulfuration
D	0019448	biological_process	L-cysteine catabolic process
D	0019825	molecular_function	oxygen binding
D	0019899	molecular_function	enzyme binding
D	0020037	molecular_function	heme binding
D	0021587	biological_process	cerebellum morphogenesis
D	0030170	molecular_function	pyridoxal phosphate binding
D	0031625	molecular_function	ubiquitin protein ligase binding
D	0031667	biological_process	response to nutrient levels
D	0042262	biological_process	DNA protection
D	0042802	molecular_function	identical protein binding
D	0042803	molecular_function	protein homodimerization activity
D	0043066	biological_process	negative regulation of apoptotic process
D	0043418	biological_process	homocysteine catabolic process
D	0044272	biological_process	sulfur compound biosynthetic process
D	0046328	biological_process	regulation of JNK cascade
D	0046872	molecular_function	metal ion binding
D	0050421	molecular_function	nitrite reductase (NO-forming) activity
D	0050667	biological_process	homocysteine metabolic process
D	0051593	biological_process	response to folic acid
D	0060135	biological_process	maternal process involved in female pregnancy
D	0060351	biological_process	cartilage development involved in endochondral bone morphogenesis
D	0070025	molecular_function	carbon monoxide binding
D	0070026	molecular_function	nitric oxide binding
D	0070814	biological_process	hydrogen sulfide biosynthetic process
D	0071456	biological_process	cellular response to hypoxia
D	0072341	molecular_function	modified amino acid binding
D	0097746	biological_process	blood vessel diameter maintenance
D	1904047	molecular_function	S-adenosyl-L-methionine binding

Functional Information from PROSITE/UniProt

site_id	PS00901
Number of Residues	19
Details	CYS_SYNTHASE Cysteine synthase/cystathionine beta-synthase P-phosphate attachment site. KcEffn.AGgSVKdRiSlrM

Chain	Residue	Details
A	LYS108-MET126
B	LYS108-MET126

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	BINDING: axial binding residue => ECO:0000269\|PubMed:11483494, ECO:0000269\|PubMed:12173932

Chain	Residue	Details
B	CYS52
B	HIS65
C	CYS52
C	HIS65

site_id	SWS_FT_FI2
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269\|PubMed:11483494, ECO:0000269\|PubMed:12173932

Chain	Residue	Details
B	ASN149
B	GLY256
B	SER349
C	ASN149
C	GLY256
C	SER349

site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:21406692

Chain	Residue	Details
B	SER27
C	SER27

site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: N6-(pyridoxal phosphate)lysine => ECO:0000269\|PubMed:11483494, ECO:0000269\|PubMed:12173932

Chain	Residue	Details
B	LYS119
C	LYS119

site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:23186163

Chain	Residue	Details
B	SER199
C	SER199

site_id	SWS_FT_FI6
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) => ECO:0000269\|PubMed:17087506

Chain	Residue	Details
B	LYS211
C	LYS211

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	1
Details	M-CSA 713

Chain	Residue	Details
B	LYS119	covalently attached, electron pair acceptor, electron pair donor, nucleofuge, nucleophile, proton acceptor, proton donor, proton relay

site_id	MCSA2
Number of Residues	1
Details	M-CSA 713

Chain	Residue	Details
C	LYS119	covalently attached, electron pair acceptor, electron pair donor, nucleofuge, nucleophile, proton acceptor, proton donor, proton relay

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)