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8S5H

Full-length human cystathionine beta-synthase with C-terminal 6xHis-tag, basal state, helical reconstruction

Functional Information from GO Data
ChainGOidnamespacecontents
A0001958biological_processendochondral ossification
A0001974biological_processblood vessel remodeling
A0003824molecular_functioncatalytic activity
A0004122molecular_functioncystathionine beta-synthase activity
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006534biological_processcysteine metabolic process
A0006535biological_processcysteine biosynthetic process from serine
A0006563biological_processL-serine metabolic process
A0006565biological_processL-serine catabolic process
A0006801biological_processsuperoxide metabolic process
A0008652biological_processamino acid biosynthetic process
A0009069biological_processserine family amino acid metabolic process
A0010749biological_processregulation of nitric oxide mediated signal transduction
A0016829molecular_functionlyase activity
A0019343biological_processcysteine biosynthetic process via cystathionine
A0019344biological_processcysteine biosynthetic process
A0019346biological_processtranssulfuration
A0019448biological_processL-cysteine catabolic process
A0019825molecular_functionoxygen binding
A0019899molecular_functionenzyme binding
A0020037molecular_functionheme binding
A0021587biological_processcerebellum morphogenesis
A0030170molecular_functionpyridoxal phosphate binding
A0031625molecular_functionubiquitin protein ligase binding
A0031667biological_processresponse to nutrient levels
A0042262biological_processDNA protection
A0042802molecular_functionidentical protein binding
A0042803molecular_functionprotein homodimerization activity
A0043066biological_processnegative regulation of apoptotic process
A0043418biological_processhomocysteine catabolic process
A0044272biological_processsulfur compound biosynthetic process
A0046328biological_processregulation of JNK cascade
A0046872molecular_functionmetal ion binding
A0050421molecular_functionnitrite reductase (NO-forming) activity
A0050667biological_processhomocysteine metabolic process
A0051593biological_processresponse to folic acid
A0060135biological_processmaternal process involved in female pregnancy
A0060351biological_processcartilage development involved in endochondral bone morphogenesis
A0070025molecular_functioncarbon monoxide binding
A0070026molecular_functionnitric oxide binding
A0070814biological_processhydrogen sulfide biosynthetic process
A0071456biological_processcellular response to hypoxia
A0072341molecular_functionmodified amino acid binding
A0097746biological_processblood vessel diameter maintenance
A1904047molecular_functionS-adenosyl-L-methionine binding
B0001958biological_processendochondral ossification
B0001974biological_processblood vessel remodeling
B0003824molecular_functioncatalytic activity
B0004122molecular_functioncystathionine beta-synthase activity
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006534biological_processcysteine metabolic process
B0006535biological_processcysteine biosynthetic process from serine
B0006563biological_processL-serine metabolic process
B0006565biological_processL-serine catabolic process
B0006801biological_processsuperoxide metabolic process
B0008652biological_processamino acid biosynthetic process
B0009069biological_processserine family amino acid metabolic process
B0010749biological_processregulation of nitric oxide mediated signal transduction
B0016829molecular_functionlyase activity
B0019343biological_processcysteine biosynthetic process via cystathionine
B0019344biological_processcysteine biosynthetic process
B0019346biological_processtranssulfuration
B0019448biological_processL-cysteine catabolic process
B0019825molecular_functionoxygen binding
B0019899molecular_functionenzyme binding
B0020037molecular_functionheme binding
B0021587biological_processcerebellum morphogenesis
B0030170molecular_functionpyridoxal phosphate binding
B0031625molecular_functionubiquitin protein ligase binding
B0031667biological_processresponse to nutrient levels
B0042262biological_processDNA protection
B0042802molecular_functionidentical protein binding
B0042803molecular_functionprotein homodimerization activity
B0043066biological_processnegative regulation of apoptotic process
B0043418biological_processhomocysteine catabolic process
B0044272biological_processsulfur compound biosynthetic process
B0046328biological_processregulation of JNK cascade
B0046872molecular_functionmetal ion binding
B0050421molecular_functionnitrite reductase (NO-forming) activity
B0050667biological_processhomocysteine metabolic process
B0051593biological_processresponse to folic acid
B0060135biological_processmaternal process involved in female pregnancy
B0060351biological_processcartilage development involved in endochondral bone morphogenesis
B0070025molecular_functioncarbon monoxide binding
B0070026molecular_functionnitric oxide binding
B0070814biological_processhydrogen sulfide biosynthetic process
B0071456biological_processcellular response to hypoxia
B0072341molecular_functionmodified amino acid binding
B0097746biological_processblood vessel diameter maintenance
B1904047molecular_functionS-adenosyl-L-methionine binding
C0001958biological_processendochondral ossification
C0001974biological_processblood vessel remodeling
C0003824molecular_functioncatalytic activity
C0004122molecular_functioncystathionine beta-synthase activity
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0006534biological_processcysteine metabolic process
C0006535biological_processcysteine biosynthetic process from serine
C0006563biological_processL-serine metabolic process
C0006565biological_processL-serine catabolic process
C0006801biological_processsuperoxide metabolic process
C0008652biological_processamino acid biosynthetic process
C0009069biological_processserine family amino acid metabolic process
C0010749biological_processregulation of nitric oxide mediated signal transduction
C0016829molecular_functionlyase activity
C0019343biological_processcysteine biosynthetic process via cystathionine
C0019344biological_processcysteine biosynthetic process
C0019346biological_processtranssulfuration
C0019448biological_processL-cysteine catabolic process
C0019825molecular_functionoxygen binding
C0019899molecular_functionenzyme binding
C0020037molecular_functionheme binding
C0021587biological_processcerebellum morphogenesis
C0030170molecular_functionpyridoxal phosphate binding
C0031625molecular_functionubiquitin protein ligase binding
C0031667biological_processresponse to nutrient levels
C0042262biological_processDNA protection
C0042802molecular_functionidentical protein binding
C0042803molecular_functionprotein homodimerization activity
C0043066biological_processnegative regulation of apoptotic process
C0043418biological_processhomocysteine catabolic process
C0044272biological_processsulfur compound biosynthetic process
C0046328biological_processregulation of JNK cascade
C0046872molecular_functionmetal ion binding
C0050421molecular_functionnitrite reductase (NO-forming) activity
C0050667biological_processhomocysteine metabolic process
C0051593biological_processresponse to folic acid
C0060135biological_processmaternal process involved in female pregnancy
C0060351biological_processcartilage development involved in endochondral bone morphogenesis
C0070025molecular_functioncarbon monoxide binding
C0070026molecular_functionnitric oxide binding
C0070814biological_processhydrogen sulfide biosynthetic process
C0071456biological_processcellular response to hypoxia
C0072341molecular_functionmodified amino acid binding
C0097746biological_processblood vessel diameter maintenance
C1904047molecular_functionS-adenosyl-L-methionine binding
D0001958biological_processendochondral ossification
D0001974biological_processblood vessel remodeling
D0003824molecular_functioncatalytic activity
D0004122molecular_functioncystathionine beta-synthase activity
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0006534biological_processcysteine metabolic process
D0006535biological_processcysteine biosynthetic process from serine
D0006563biological_processL-serine metabolic process
D0006565biological_processL-serine catabolic process
D0006801biological_processsuperoxide metabolic process
D0008652biological_processamino acid biosynthetic process
D0009069biological_processserine family amino acid metabolic process
D0010749biological_processregulation of nitric oxide mediated signal transduction
D0016829molecular_functionlyase activity
D0019343biological_processcysteine biosynthetic process via cystathionine
D0019344biological_processcysteine biosynthetic process
D0019346biological_processtranssulfuration
D0019448biological_processL-cysteine catabolic process
D0019825molecular_functionoxygen binding
D0019899molecular_functionenzyme binding
D0020037molecular_functionheme binding
D0021587biological_processcerebellum morphogenesis
D0030170molecular_functionpyridoxal phosphate binding
D0031625molecular_functionubiquitin protein ligase binding
D0031667biological_processresponse to nutrient levels
D0042262biological_processDNA protection
D0042802molecular_functionidentical protein binding
D0042803molecular_functionprotein homodimerization activity
D0043066biological_processnegative regulation of apoptotic process
D0043418biological_processhomocysteine catabolic process
D0044272biological_processsulfur compound biosynthetic process
D0046328biological_processregulation of JNK cascade
D0046872molecular_functionmetal ion binding
D0050421molecular_functionnitrite reductase (NO-forming) activity
D0050667biological_processhomocysteine metabolic process
D0051593biological_processresponse to folic acid
D0060135biological_processmaternal process involved in female pregnancy
D0060351biological_processcartilage development involved in endochondral bone morphogenesis
D0070025molecular_functioncarbon monoxide binding
D0070026molecular_functionnitric oxide binding
D0070814biological_processhydrogen sulfide biosynthetic process
D0071456biological_processcellular response to hypoxia
D0072341molecular_functionmodified amino acid binding
D0097746biological_processblood vessel diameter maintenance
D1904047molecular_functionS-adenosyl-L-methionine binding
E0001958biological_processendochondral ossification
E0001974biological_processblood vessel remodeling
E0003824molecular_functioncatalytic activity
E0004122molecular_functioncystathionine beta-synthase activity
E0005515molecular_functionprotein binding
E0005634cellular_componentnucleus
E0005737cellular_componentcytoplasm
E0005829cellular_componentcytosol
E0006534biological_processcysteine metabolic process
E0006535biological_processcysteine biosynthetic process from serine
E0006563biological_processL-serine metabolic process
E0006565biological_processL-serine catabolic process
E0006801biological_processsuperoxide metabolic process
E0008652biological_processamino acid biosynthetic process
E0009069biological_processserine family amino acid metabolic process
E0010749biological_processregulation of nitric oxide mediated signal transduction
E0016829molecular_functionlyase activity
E0019343biological_processcysteine biosynthetic process via cystathionine
E0019344biological_processcysteine biosynthetic process
E0019346biological_processtranssulfuration
E0019448biological_processL-cysteine catabolic process
E0019825molecular_functionoxygen binding
E0019899molecular_functionenzyme binding
E0020037molecular_functionheme binding
E0021587biological_processcerebellum morphogenesis
E0030170molecular_functionpyridoxal phosphate binding
E0031625molecular_functionubiquitin protein ligase binding
E0031667biological_processresponse to nutrient levels
E0042262biological_processDNA protection
E0042802molecular_functionidentical protein binding
E0042803molecular_functionprotein homodimerization activity
E0043066biological_processnegative regulation of apoptotic process
E0043418biological_processhomocysteine catabolic process
E0044272biological_processsulfur compound biosynthetic process
E0046328biological_processregulation of JNK cascade
E0046872molecular_functionmetal ion binding
E0050421molecular_functionnitrite reductase (NO-forming) activity
E0050667biological_processhomocysteine metabolic process
E0051593biological_processresponse to folic acid
E0060135biological_processmaternal process involved in female pregnancy
E0060351biological_processcartilage development involved in endochondral bone morphogenesis
E0070025molecular_functioncarbon monoxide binding
E0070026molecular_functionnitric oxide binding
E0070814biological_processhydrogen sulfide biosynthetic process
E0071456biological_processcellular response to hypoxia
E0072341molecular_functionmodified amino acid binding
E0097746biological_processblood vessel diameter maintenance
E1904047molecular_functionS-adenosyl-L-methionine binding
F0001958biological_processendochondral ossification
F0001974biological_processblood vessel remodeling
F0003824molecular_functioncatalytic activity
F0004122molecular_functioncystathionine beta-synthase activity
F0005515molecular_functionprotein binding
F0005634cellular_componentnucleus
F0005737cellular_componentcytoplasm
F0005829cellular_componentcytosol
F0006534biological_processcysteine metabolic process
F0006535biological_processcysteine biosynthetic process from serine
F0006563biological_processL-serine metabolic process
F0006565biological_processL-serine catabolic process
F0006801biological_processsuperoxide metabolic process
F0008652biological_processamino acid biosynthetic process
F0009069biological_processserine family amino acid metabolic process
F0010749biological_processregulation of nitric oxide mediated signal transduction
F0016829molecular_functionlyase activity
F0019343biological_processcysteine biosynthetic process via cystathionine
F0019344biological_processcysteine biosynthetic process
F0019346biological_processtranssulfuration
F0019448biological_processL-cysteine catabolic process
F0019825molecular_functionoxygen binding
F0019899molecular_functionenzyme binding
F0020037molecular_functionheme binding
F0021587biological_processcerebellum morphogenesis
F0030170molecular_functionpyridoxal phosphate binding
F0031625molecular_functionubiquitin protein ligase binding
F0031667biological_processresponse to nutrient levels
F0042262biological_processDNA protection
F0042802molecular_functionidentical protein binding
F0042803molecular_functionprotein homodimerization activity
F0043066biological_processnegative regulation of apoptotic process
F0043418biological_processhomocysteine catabolic process
F0044272biological_processsulfur compound biosynthetic process
F0046328biological_processregulation of JNK cascade
F0046872molecular_functionmetal ion binding
F0050421molecular_functionnitrite reductase (NO-forming) activity
F0050667biological_processhomocysteine metabolic process
F0051593biological_processresponse to folic acid
F0060135biological_processmaternal process involved in female pregnancy
F0060351biological_processcartilage development involved in endochondral bone morphogenesis
F0070025molecular_functioncarbon monoxide binding
F0070026molecular_functionnitric oxide binding
F0070814biological_processhydrogen sulfide biosynthetic process
F0071456biological_processcellular response to hypoxia
F0072341molecular_functionmodified amino acid binding
F0097746biological_processblood vessel diameter maintenance
F1904047molecular_functionS-adenosyl-L-methionine binding
G0001958biological_processendochondral ossification
G0001974biological_processblood vessel remodeling
G0003824molecular_functioncatalytic activity
G0004122molecular_functioncystathionine beta-synthase activity
G0005515molecular_functionprotein binding
G0005634cellular_componentnucleus
G0005737cellular_componentcytoplasm
G0005829cellular_componentcytosol
G0006534biological_processcysteine metabolic process
G0006535biological_processcysteine biosynthetic process from serine
G0006563biological_processL-serine metabolic process
G0006565biological_processL-serine catabolic process
G0006801biological_processsuperoxide metabolic process
G0008652biological_processamino acid biosynthetic process
G0009069biological_processserine family amino acid metabolic process
G0010749biological_processregulation of nitric oxide mediated signal transduction
G0016829molecular_functionlyase activity
G0019343biological_processcysteine biosynthetic process via cystathionine
G0019344biological_processcysteine biosynthetic process
G0019346biological_processtranssulfuration
G0019448biological_processL-cysteine catabolic process
G0019825molecular_functionoxygen binding
G0019899molecular_functionenzyme binding
G0020037molecular_functionheme binding
G0021587biological_processcerebellum morphogenesis
G0030170molecular_functionpyridoxal phosphate binding
G0031625molecular_functionubiquitin protein ligase binding
G0031667biological_processresponse to nutrient levels
G0042262biological_processDNA protection
G0042802molecular_functionidentical protein binding
G0042803molecular_functionprotein homodimerization activity
G0043066biological_processnegative regulation of apoptotic process
G0043418biological_processhomocysteine catabolic process
G0044272biological_processsulfur compound biosynthetic process
G0046328biological_processregulation of JNK cascade
G0046872molecular_functionmetal ion binding
G0050421molecular_functionnitrite reductase (NO-forming) activity
G0050667biological_processhomocysteine metabolic process
G0051593biological_processresponse to folic acid
G0060135biological_processmaternal process involved in female pregnancy
G0060351biological_processcartilage development involved in endochondral bone morphogenesis
G0070025molecular_functioncarbon monoxide binding
G0070026molecular_functionnitric oxide binding
G0070814biological_processhydrogen sulfide biosynthetic process
G0071456biological_processcellular response to hypoxia
G0072341molecular_functionmodified amino acid binding
G0097746biological_processblood vessel diameter maintenance
G1904047molecular_functionS-adenosyl-L-methionine binding
H0001958biological_processendochondral ossification
H0001974biological_processblood vessel remodeling
H0003824molecular_functioncatalytic activity
H0004122molecular_functioncystathionine beta-synthase activity
H0005515molecular_functionprotein binding
H0005634cellular_componentnucleus
H0005737cellular_componentcytoplasm
H0005829cellular_componentcytosol
H0006534biological_processcysteine metabolic process
H0006535biological_processcysteine biosynthetic process from serine
H0006563biological_processL-serine metabolic process
H0006565biological_processL-serine catabolic process
H0006801biological_processsuperoxide metabolic process
H0008652biological_processamino acid biosynthetic process
H0009069biological_processserine family amino acid metabolic process
H0010749biological_processregulation of nitric oxide mediated signal transduction
H0016829molecular_functionlyase activity
H0019343biological_processcysteine biosynthetic process via cystathionine
H0019344biological_processcysteine biosynthetic process
H0019346biological_processtranssulfuration
H0019448biological_processL-cysteine catabolic process
H0019825molecular_functionoxygen binding
H0019899molecular_functionenzyme binding
H0020037molecular_functionheme binding
H0021587biological_processcerebellum morphogenesis
H0030170molecular_functionpyridoxal phosphate binding
H0031625molecular_functionubiquitin protein ligase binding
H0031667biological_processresponse to nutrient levels
H0042262biological_processDNA protection
H0042802molecular_functionidentical protein binding
H0042803molecular_functionprotein homodimerization activity
H0043066biological_processnegative regulation of apoptotic process
H0043418biological_processhomocysteine catabolic process
H0044272biological_processsulfur compound biosynthetic process
H0046328biological_processregulation of JNK cascade
H0046872molecular_functionmetal ion binding
H0050421molecular_functionnitrite reductase (NO-forming) activity
H0050667biological_processhomocysteine metabolic process
H0051593biological_processresponse to folic acid
H0060135biological_processmaternal process involved in female pregnancy
H0060351biological_processcartilage development involved in endochondral bone morphogenesis
H0070025molecular_functioncarbon monoxide binding
H0070026molecular_functionnitric oxide binding
H0070814biological_processhydrogen sulfide biosynthetic process
H0071456biological_processcellular response to hypoxia
H0072341molecular_functionmodified amino acid binding
H0097746biological_processblood vessel diameter maintenance
H1904047molecular_functionS-adenosyl-L-methionine binding
Functional Information from PROSITE/UniProt
site_idPS00901
Number of Residues19
DetailsCYS_SYNTHASE Cysteine synthase/cystathionine beta-synthase P-phosphate attachment site. KcEffn.AGgSVKdRiSlrM
ChainResidueDetails
ALYS108-MET126

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues16
DetailsBINDING: axial binding residue => ECO:0000269|PubMed:11483494, ECO:0000269|PubMed:12173932
ChainResidueDetails
ACYS52
EHIS65
FCYS52
FHIS65
GCYS52
GHIS65
HCYS52
HHIS65
AHIS65
BCYS52
BHIS65
CCYS52
CHIS65
DCYS52
DHIS65
ECYS52

site_idSWS_FT_FI2
Number of Residues24
DetailsBINDING: BINDING => ECO:0000269|PubMed:11483494, ECO:0000269|PubMed:12173932
ChainResidueDetails
AASN149
DASN149
DGLY256
DSER349
EASN149
EGLY256
ESER349
FASN149
FGLY256
FSER349
GASN149
AGLY256
GGLY256
GSER349
HASN149
HGLY256
HSER349
ASER349
BASN149
BGLY256
BSER349
CASN149
CGLY256
CSER349

site_idSWS_FT_FI3
Number of Residues8
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:21406692
ChainResidueDetails
ASER27
BSER27
CSER27
DSER27
ESER27
FSER27
GSER27
HSER27

site_idSWS_FT_FI4
Number of Residues8
DetailsMOD_RES: N6-(pyridoxal phosphate)lysine => ECO:0000269|PubMed:11483494, ECO:0000269|PubMed:12173932
ChainResidueDetails
ALLP119
BLLP119
CLLP119
DLLP119
ELLP119
FLLP119
GLLP119
HLLP119

site_idSWS_FT_FI5
Number of Residues8
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER199
BSER199
CSER199
DSER199
ESER199
FSER199
GSER199
HSER199

site_idSWS_FT_FI6
Number of Residues16
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) => ECO:0000269|PubMed:17087506
ChainResidueDetails
ALYS211
FLYS211
GLYS211
HLYS211
BLYS211
CLYS211
DLYS211
ELYS211

Catalytic Information from CSA
site_idMCSA1
Number of Residues1
DetailsM-CSA 713
ChainResidueDetails
ALLP119covalently attached, electron pair acceptor, electron pair donor, nucleofuge, nucleophile, proton acceptor, proton donor, proton relay

site_idMCSA2
Number of Residues1
DetailsM-CSA 713
ChainResidueDetails
BLLP119covalently attached, electron pair acceptor, electron pair donor, nucleofuge, nucleophile, proton acceptor, proton donor, proton relay

site_idMCSA3
Number of Residues1
DetailsM-CSA 713
ChainResidueDetails
CLLP119covalently attached, electron pair acceptor, electron pair donor, nucleofuge, nucleophile, proton acceptor, proton donor, proton relay

site_idMCSA4
Number of Residues1
DetailsM-CSA 713
ChainResidueDetails
DLLP119covalently attached, electron pair acceptor, electron pair donor, nucleofuge, nucleophile, proton acceptor, proton donor, proton relay

site_idMCSA5
Number of Residues1
DetailsM-CSA 713
ChainResidueDetails
ELLP119covalently attached, electron pair acceptor, electron pair donor, nucleofuge, nucleophile, proton acceptor, proton donor, proton relay

site_idMCSA6
Number of Residues1
DetailsM-CSA 713
ChainResidueDetails
FLLP119covalently attached, electron pair acceptor, electron pair donor, nucleofuge, nucleophile, proton acceptor, proton donor, proton relay

site_idMCSA7
Number of Residues1
DetailsM-CSA 713
ChainResidueDetails
GLLP119covalently attached, electron pair acceptor, electron pair donor, nucleofuge, nucleophile, proton acceptor, proton donor, proton relay

site_idMCSA8
Number of Residues1
DetailsM-CSA 713
ChainResidueDetails
HLLP119covalently attached, electron pair acceptor, electron pair donor, nucleofuge, nucleophile, proton acceptor, proton donor, proton relay

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PDB entries from 2025-06-11

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