8S5H
Full-length human cystathionine beta-synthase with C-terminal 6xHis-tag, basal state, helical reconstruction
Functional Information from PROSITE/UniProt
site_id | PS00901 |
Number of Residues | 19 |
Details | CYS_SYNTHASE Cysteine synthase/cystathionine beta-synthase P-phosphate attachment site. KcEffn.AGgSVKdRiSlrM |
Chain | Residue | Details |
A | LYS108-MET126 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 16 |
Details | BINDING: axial binding residue => ECO:0000269|PubMed:11483494, ECO:0000269|PubMed:12173932 |
Chain | Residue | Details |
A | CYS52 | |
A | HIS65 | |
B | CYS52 | |
B | HIS65 | |
C | CYS52 | |
C | HIS65 | |
D | CYS52 | |
D | HIS65 | |
E | CYS52 | |
E | HIS65 | |
F | CYS52 | |
F | HIS65 | |
G | CYS52 | |
G | HIS65 | |
H | CYS52 | |
H | HIS65 |
site_id | SWS_FT_FI2 |
Number of Residues | 24 |
Details | BINDING: BINDING => ECO:0000269|PubMed:11483494, ECO:0000269|PubMed:12173932 |
Chain | Residue | Details |
A | ASN149 | |
A | GLY256 | |
A | SER349 | |
B | ASN149 | |
B | GLY256 | |
B | SER349 | |
C | ASN149 | |
C | GLY256 | |
C | SER349 | |
D | ASN149 | |
D | GLY256 | |
D | SER349 | |
E | ASN149 | |
E | GLY256 | |
E | SER349 | |
F | ASN149 | |
F | GLY256 | |
F | SER349 | |
G | ASN149 | |
G | GLY256 | |
G | SER349 | |
H | ASN149 | |
H | GLY256 | |
H | SER349 |
site_id | SWS_FT_FI3 |
Number of Residues | 8 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:21406692 |
Chain | Residue | Details |
A | SER27 | |
B | SER27 | |
C | SER27 | |
D | SER27 | |
E | SER27 | |
F | SER27 | |
G | SER27 | |
H | SER27 |
site_id | SWS_FT_FI4 |
Number of Residues | 8 |
Details | MOD_RES: N6-(pyridoxal phosphate)lysine => ECO:0000269|PubMed:11483494, ECO:0000269|PubMed:12173932 |
Chain | Residue | Details |
A | LLP119 | |
B | LLP119 | |
C | LLP119 | |
D | LLP119 | |
E | LLP119 | |
F | LLP119 | |
G | LLP119 | |
H | LLP119 |
site_id | SWS_FT_FI5 |
Number of Residues | 8 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
Chain | Residue | Details |
A | SER199 | |
B | SER199 | |
C | SER199 | |
D | SER199 | |
E | SER199 | |
F | SER199 | |
G | SER199 | |
H | SER199 |
site_id | SWS_FT_FI6 |
Number of Residues | 16 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) => ECO:0000269|PubMed:17087506 |
Chain | Residue | Details |
A | LYS211 | |
B | LYS211 | |
C | LYS211 | |
D | LYS211 | |
E | LYS211 | |
F | LYS211 | |
G | LYS211 | |
H | LYS211 |
Catalytic Information from CSA
site_id | MCSA1 |
Number of Residues | 1 |
Details | M-CSA 713 |
Chain | Residue | Details |
A | LLP119 | covalently attached, electron pair acceptor, electron pair donor, nucleofuge, nucleophile, proton acceptor, proton donor, proton relay |
site_id | MCSA2 |
Number of Residues | 1 |
Details | M-CSA 713 |
Chain | Residue | Details |
B | LLP119 | covalently attached, electron pair acceptor, electron pair donor, nucleofuge, nucleophile, proton acceptor, proton donor, proton relay |
site_id | MCSA3 |
Number of Residues | 1 |
Details | M-CSA 713 |
Chain | Residue | Details |
C | LLP119 | covalently attached, electron pair acceptor, electron pair donor, nucleofuge, nucleophile, proton acceptor, proton donor, proton relay |
site_id | MCSA4 |
Number of Residues | 1 |
Details | M-CSA 713 |
Chain | Residue | Details |
D | LLP119 | covalently attached, electron pair acceptor, electron pair donor, nucleofuge, nucleophile, proton acceptor, proton donor, proton relay |
site_id | MCSA5 |
Number of Residues | 1 |
Details | M-CSA 713 |
Chain | Residue | Details |
E | LLP119 | covalently attached, electron pair acceptor, electron pair donor, nucleofuge, nucleophile, proton acceptor, proton donor, proton relay |
site_id | MCSA6 |
Number of Residues | 1 |
Details | M-CSA 713 |
Chain | Residue | Details |
F | LLP119 | covalently attached, electron pair acceptor, electron pair donor, nucleofuge, nucleophile, proton acceptor, proton donor, proton relay |
site_id | MCSA7 |
Number of Residues | 1 |
Details | M-CSA 713 |
Chain | Residue | Details |
G | LLP119 | covalently attached, electron pair acceptor, electron pair donor, nucleofuge, nucleophile, proton acceptor, proton donor, proton relay |
site_id | MCSA8 |
Number of Residues | 1 |
Details | M-CSA 713 |
Chain | Residue | Details |
H | LLP119 | covalently attached, electron pair acceptor, electron pair donor, nucleofuge, nucleophile, proton acceptor, proton donor, proton relay |