8S4M

Crystal structure of Mycobacterium tuberculosis cytochrome P450 CYP125 in complex with an inhibitor

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004497	molecular_function	monooxygenase activity
A	0005506	molecular_function	iron ion binding
A	0006629	biological_process	lipid metabolic process
A	0006707	biological_process	cholesterol catabolic process
A	0008202	biological_process	steroid metabolic process
A	0008203	biological_process	cholesterol metabolic process
A	0008395	molecular_function	steroid hydroxylase activity
A	0016042	biological_process	lipid catabolic process
A	0016491	molecular_function	oxidoreductase activity
A	0016705	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
A	0020037	molecular_function	heme binding
A	0036199	molecular_function	cholest-4-en-3-one 26-monooxygenase activity
A	0046872	molecular_function	metal ion binding
A	0051701	biological_process	biological process involved in interaction with host
B	0004497	molecular_function	monooxygenase activity
B	0005506	molecular_function	iron ion binding
B	0006629	biological_process	lipid metabolic process
B	0006707	biological_process	cholesterol catabolic process
B	0008202	biological_process	steroid metabolic process
B	0008203	biological_process	cholesterol metabolic process
B	0008395	molecular_function	steroid hydroxylase activity
B	0016042	biological_process	lipid catabolic process
B	0016491	molecular_function	oxidoreductase activity
B	0016705	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
B	0020037	molecular_function	heme binding
B	0036199	molecular_function	cholest-4-en-3-one 26-monooxygenase activity
B	0046872	molecular_function	metal ion binding
B	0051701	biological_process	biological process involved in interaction with host
C	0004497	molecular_function	monooxygenase activity
C	0005506	molecular_function	iron ion binding
C	0006629	biological_process	lipid metabolic process
C	0006707	biological_process	cholesterol catabolic process
C	0008202	biological_process	steroid metabolic process
C	0008203	biological_process	cholesterol metabolic process
C	0008395	molecular_function	steroid hydroxylase activity
C	0016042	biological_process	lipid catabolic process
C	0016491	molecular_function	oxidoreductase activity
C	0016705	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
C	0020037	molecular_function	heme binding
C	0036199	molecular_function	cholest-4-en-3-one 26-monooxygenase activity
C	0046872	molecular_function	metal ion binding
C	0051701	biological_process	biological process involved in interaction with host

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"19846552","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3IW1","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	Binding site: {"description":"axial binding residue","evidences":[{"source":"PubMed","id":"20545858","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2X5L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2X5W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2XC3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2XN8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3IVY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3IW0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3IW1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3IW2","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---