8S4D
Crystal structure of a peptidergic GPCR in complex with a small synthetic G protein-biased agonist
This is a non-PDB format compatible entry.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004930 | molecular_function | G protein-coupled receptor activity |
| A | 0005506 | molecular_function | iron ion binding |
| A | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| A | 0009055 | molecular_function | electron transfer activity |
| A | 0016020 | cellular_component | membrane |
| A | 0020037 | molecular_function | heme binding |
| A | 0022900 | biological_process | electron transport chain |
| A | 0042597 | cellular_component | periplasmic space |
| A | 0046872 | molecular_function | metal ion binding |
Functional Information from PROSITE/UniProt
| site_id | PS00237 |
| Number of Residues | 17 |
| Details | G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. ASVfCLTGLSFDRYLaI |
| Chain | Residue | Details |
| A | ALA115-ILE131 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 23 |
| Details | TRANSMEM: Helical; Name=1 => ECO:0000269|PubMed:35817871, ECO:0007744|PDB:7W0O |
| Chain | Residue | Details |
| A | ILE31-PHE54 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 29 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000305 |
| Chain | Residue | Details |
| A | ARG55-ALA64 | |
| A | ASP126-GLY146 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 21 |
| Details | TRANSMEM: Helical; Name=2 => ECO:0000269|PubMed:35817871, ECO:0007744|PDB:7W0O |
| Chain | Residue | Details |
| A | ASP65-ALA86 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 63 |
| Details | TOPO_DOM: Extracellular => ECO:0000305 |
| Chain | Residue | Details |
| A | VAL87-THR99 | |
| A | MET165-GLU198 | |
| A | TYR271-ASN289 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 25 |
| Details | TRANSMEM: Helical; Name=3 => ECO:0000269|PubMed:35817871, ECO:0007744|PDB:7W0O |
| Chain | Residue | Details |
| A | PHE100-PHE125 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 17 |
| Details | TRANSMEM: Helical; Name=4 => ECO:0000269|PubMed:35817871, ECO:0007744|PDB:7W0O |
| Chain | Residue | Details |
| A | ALA147-VAL164 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 24 |
| Details | TRANSMEM: Helical; Name=5 => ECO:0000269|PubMed:35817871, ECO:0007744|PDB:7W0O |
| Chain | Residue | Details |
| A | VAL199-PHE223 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 23 |
| Details | TRANSMEM: Helical; Name=6 => ECO:0000269|PubMed:35817871, ECO:0007744|PDB:7W0O |
| Chain | Residue | Details |
| A | LEU247-LEU270 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 22 |
| Details | TRANSMEM: Helical; Name=7 => ECO:0000269|PubMed:35817871, ECO:0007744|PDB:7W0O |
| Chain | Residue | Details |
| A | ILE290-PHE312 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | SITE: Required for APELA and APLN/apelin-13 interaction and signaling => ECO:0000269|PubMed:35817871, ECO:0000269|PubMed:38428423 |
| Chain | Residue | Details |
| A | TRP85 | |
| A | ARG168 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN15 | |
| A | ASN175 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 1 |
| Details | BINDING: axial binding residue |
| Chain | Residue | Details |
| A | TRP1007 |
