8S3O
Structure of native human CD109
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001942 | biological_process | hair follicle development |
| A | 0004867 | molecular_function | serine-type endopeptidase inhibitor activity |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0009986 | cellular_component | cell surface |
| A | 0010839 | biological_process | negative regulation of keratinocyte proliferation |
| A | 0016020 | cellular_component | membrane |
| A | 0030414 | molecular_function | peptidase inhibitor activity |
| A | 0030512 | biological_process | negative regulation of transforming growth factor beta receptor signaling pathway |
| A | 0031092 | cellular_component | platelet alpha granule membrane |
| A | 0043616 | biological_process | keratinocyte proliferation |
| A | 0045616 | biological_process | regulation of keratinocyte differentiation |
| A | 0061045 | biological_process | negative regulation of wound healing |
| A | 0072089 | biological_process | stem cell proliferation |
| A | 0072675 | biological_process | osteoclast fusion |
| A | 0098552 | cellular_component | side of membrane |
| A | 2000647 | biological_process | negative regulation of stem cell proliferation |
Functional Information from PROSITE/UniProt
| site_id | PS00477 |
| Number of Residues | 9 |
| Details | ALPHA_2_MACROGLOBULIN Alpha-2-macroglobulin family thiolester region signature. PyGCGEQnM |
| Chain | Residue | Details |
| A | PRO918-MET926 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | LIPID: GPI-anchor amidated alanine => ECO:0000255 |
| Chain | Residue | Details |
| A | ALA1420 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19349973 |
| Chain | Residue | Details |
| A | ASN68 | |
| A | ASN118 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16263699, ECO:0000269|PubMed:16335952 |
| Chain | Residue | Details |
| A | ASN247 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN279 | |
| A | ASN365 | |
| A | ASN645 | |
| A | ASN1086 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19159218 |
| Chain | Residue | Details |
| A | ASN419 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255|PROSITE-ProRule:PRU00498 |
| Chain | Residue | Details |
| A | ASN513 | |
| A | ASN1355 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | CROSSLNK: Isoglutamyl cysteine thioester (Cys-Gln) => ECO:0000250 |
| Chain | Residue | Details |
| A | CYS921 | |
| A | GLN924 |
