8S0E

H. sapiens OCCM bound to double stranded DNA

Functional Information from GO Data

Chain	GOid	namespace	contents
2	0000166	molecular_function	nucleotide binding
2	0000228	cellular_component	nuclear chromosome
2	0000727	biological_process	double-strand break repair via break-induced replication
2	0000781	cellular_component	chromosome, telomeric region
2	0000785	cellular_component	chromatin
2	0003677	molecular_function	DNA binding
2	0003678	molecular_function	DNA helicase activity
2	0003688	molecular_function	DNA replication origin binding
2	0003697	molecular_function	single-stranded DNA binding
2	0004386	molecular_function	helicase activity
2	0005515	molecular_function	protein binding
2	0005524	molecular_function	ATP binding
2	0005634	cellular_component	nucleus
2	0005654	cellular_component	nucleoplasm
2	0005664	cellular_component	nuclear origin of replication recognition complex
2	0005694	cellular_component	chromosome
2	0005730	cellular_component	nucleolus
2	0005737	cellular_component	cytoplasm
2	0005829	cellular_component	cytosol
2	0005929	cellular_component	cilium
2	0006260	biological_process	DNA replication
2	0006270	biological_process	DNA replication initiation
2	0006334	biological_process	nucleosome assembly
2	0006915	biological_process	apoptotic process
2	0008270	molecular_function	zinc ion binding
2	0016787	molecular_function	hydrolase activity
2	0016887	molecular_function	ATP hydrolysis activity
2	0017116	molecular_function	single-stranded DNA helicase activity
2	0019899	molecular_function	enzyme binding
2	0030174	biological_process	regulation of DNA-templated DNA replication initiation
2	0042393	molecular_function	histone binding
2	0042555	cellular_component	MCM complex
2	0043138	molecular_function	3'-5' DNA helicase activity
2	0046872	molecular_function	metal ion binding
2	0071162	cellular_component	CMG complex
2	0071353	biological_process	cellular response to interleukin-4
2	0090102	biological_process	cochlea development
2	1902975	biological_process	mitotic DNA replication initiation
3	0000166	molecular_function	nucleotide binding
3	0000727	biological_process	double-strand break repair via break-induced replication
3	0000781	cellular_component	chromosome, telomeric region
3	0003677	molecular_function	DNA binding
3	0003697	molecular_function	single-stranded DNA binding
3	0004386	molecular_function	helicase activity
3	0005515	molecular_function	protein binding
3	0005524	molecular_function	ATP binding
3	0005634	cellular_component	nucleus
3	0005654	cellular_component	nucleoplasm
3	0005658	cellular_component	alpha DNA polymerase:primase complex
3	0005694	cellular_component	chromosome
3	0005730	cellular_component	nucleolus
3	0005737	cellular_component	cytoplasm
3	0006260	biological_process	DNA replication
3	0006270	biological_process	DNA replication initiation
3	0006271	biological_process	DNA strand elongation involved in DNA replication
3	0016020	cellular_component	membrane
3	0016787	molecular_function	hydrolase activity
3	0016887	molecular_function	ATP hydrolysis activity
3	0017116	molecular_function	single-stranded DNA helicase activity
3	0030174	biological_process	regulation of DNA-templated DNA replication initiation
3	0042555	cellular_component	MCM complex
3	0048471	cellular_component	perinuclear region of cytoplasm
3	0071162	cellular_component	CMG complex
3	1902975	biological_process	mitotic DNA replication initiation
4	0000166	molecular_function	nucleotide binding
4	0000727	biological_process	double-strand break repair via break-induced replication
4	0000781	cellular_component	chromosome, telomeric region
4	0003677	molecular_function	DNA binding
4	0003678	molecular_function	DNA helicase activity
4	0003697	molecular_function	single-stranded DNA binding
4	0004386	molecular_function	helicase activity
4	0005515	molecular_function	protein binding
4	0005524	molecular_function	ATP binding
4	0005634	cellular_component	nucleus
4	0005654	cellular_component	nucleoplasm
4	0005694	cellular_component	chromosome
4	0006260	biological_process	DNA replication
4	0006270	biological_process	DNA replication initiation
4	0006271	biological_process	DNA strand elongation involved in DNA replication
4	0016020	cellular_component	membrane
4	0016787	molecular_function	hydrolase activity
4	0016887	molecular_function	ATP hydrolysis activity
4	0017116	molecular_function	single-stranded DNA helicase activity
4	0030174	biological_process	regulation of DNA-templated DNA replication initiation
4	0042555	cellular_component	MCM complex
4	0071162	cellular_component	CMG complex
4	1902975	biological_process	mitotic DNA replication initiation
5	0000166	molecular_function	nucleotide binding
5	0000727	biological_process	double-strand break repair via break-induced replication
5	0000781	cellular_component	chromosome, telomeric region
5	0003677	molecular_function	DNA binding
5	0003688	molecular_function	DNA replication origin binding
5	0003697	molecular_function	single-stranded DNA binding
5	0004386	molecular_function	helicase activity
5	0005515	molecular_function	protein binding
5	0005524	molecular_function	ATP binding
5	0005634	cellular_component	nucleus
5	0005654	cellular_component	nucleoplasm
5	0005694	cellular_component	chromosome
5	0006260	biological_process	DNA replication
5	0006270	biological_process	DNA replication initiation
5	0016020	cellular_component	membrane
5	0016787	molecular_function	hydrolase activity
5	0016887	molecular_function	ATP hydrolysis activity
5	0017116	molecular_function	single-stranded DNA helicase activity
5	0030174	biological_process	regulation of DNA-templated DNA replication initiation
5	0042555	cellular_component	MCM complex
5	0043138	molecular_function	3'-5' DNA helicase activity
5	0071162	cellular_component	CMG complex
6	0000166	molecular_function	nucleotide binding
6	0000727	biological_process	double-strand break repair via break-induced replication
6	0000781	cellular_component	chromosome, telomeric region
6	0003677	molecular_function	DNA binding
6	0003678	molecular_function	DNA helicase activity
6	0003697	molecular_function	single-stranded DNA binding
6	0004386	molecular_function	helicase activity
6	0005515	molecular_function	protein binding
6	0005524	molecular_function	ATP binding
6	0005634	cellular_component	nucleus
6	0005654	cellular_component	nucleoplasm
6	0005694	cellular_component	chromosome
6	0005829	cellular_component	cytosol
6	0006260	biological_process	DNA replication
6	0006270	biological_process	DNA replication initiation
6	0016787	molecular_function	hydrolase activity
6	0016887	molecular_function	ATP hydrolysis activity
6	0030174	biological_process	regulation of DNA-templated DNA replication initiation
6	0042555	cellular_component	MCM complex
6	0042802	molecular_function	identical protein binding
6	0071162	cellular_component	CMG complex
6	1902969	biological_process	mitotic DNA replication
6	1990518	molecular_function	single-stranded 3'-5' DNA helicase activity
7	0000166	molecular_function	nucleotide binding
7	0000727	biological_process	double-strand break repair via break-induced replication
7	0000781	cellular_component	chromosome, telomeric region
7	0000785	cellular_component	chromatin
7	0003677	molecular_function	DNA binding
7	0003678	molecular_function	DNA helicase activity
7	0003697	molecular_function	single-stranded DNA binding
7	0004386	molecular_function	helicase activity
7	0005515	molecular_function	protein binding
7	0005524	molecular_function	ATP binding
7	0005634	cellular_component	nucleus
7	0005654	cellular_component	nucleoplasm
7	0005694	cellular_component	chromosome
7	0005730	cellular_component	nucleolus
7	0006260	biological_process	DNA replication
7	0006270	biological_process	DNA replication initiation
7	0006271	biological_process	DNA strand elongation involved in DNA replication
7	0006974	biological_process	DNA damage response
7	0008283	biological_process	cell population proliferation
7	0009410	biological_process	response to xenobiotic stimulus
7	0016020	cellular_component	membrane
7	0016787	molecular_function	hydrolase activity
7	0016887	molecular_function	ATP hydrolysis activity
7	0017116	molecular_function	single-stranded DNA helicase activity
7	0030174	biological_process	regulation of DNA-templated DNA replication initiation
7	0042325	biological_process	regulation of phosphorylation
7	0042555	cellular_component	MCM complex
7	0071162	cellular_component	CMG complex
7	0071364	biological_process	cellular response to epidermal growth factor stimulus
7	0071466	biological_process	cellular response to xenobiotic stimulus
8	0000076	biological_process	DNA replication checkpoint signaling
8	0000278	biological_process	mitotic cell cycle
8	0000775	cellular_component	chromosome, centromeric region
8	0000776	cellular_component	kinetochore
8	0003677	molecular_function	DNA binding
8	0003682	molecular_function	chromatin binding
8	0005515	molecular_function	protein binding
8	0005634	cellular_component	nucleus
8	0005654	cellular_component	nucleoplasm
8	0005694	cellular_component	chromosome
8	0006260	biological_process	DNA replication
8	0016604	cellular_component	nuclear body
8	0030174	biological_process	regulation of DNA-templated DNA replication initiation
8	0033262	biological_process	regulation of nuclear cell cycle DNA replication
8	0035563	biological_process	positive regulation of chromatin binding
8	0045740	biological_process	positive regulation of DNA replication
8	0045786	biological_process	negative regulation of cell cycle
8	0051301	biological_process	cell division
8	0051315	biological_process	attachment of mitotic spindle microtubules to kinetochore
8	0070182	molecular_function	DNA polymerase binding
8	0071163	biological_process	DNA replication preinitiation complex assembly
8	0072708	biological_process	response to sorbitol
8	2000104	biological_process	negative regulation of DNA-templated DNA replication
8	2000105	biological_process	positive regulation of DNA-templated DNA replication
A	0000166	molecular_function	nucleotide binding
A	0000781	cellular_component	chromosome, telomeric region
A	0000808	cellular_component	origin recognition complex
A	0003677	molecular_function	DNA binding
A	0003682	molecular_function	chromatin binding
A	0003688	molecular_function	DNA replication origin binding
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005664	cellular_component	nuclear origin of replication recognition complex
A	0005829	cellular_component	cytosol
A	0006260	biological_process	DNA replication
A	0006270	biological_process	DNA replication initiation
A	0016887	molecular_function	ATP hydrolysis activity
A	0033314	biological_process	mitotic DNA replication checkpoint signaling
A	0046872	molecular_function	metal ion binding
B	0000122	biological_process	negative regulation of transcription by RNA polymerase II
B	0000781	cellular_component	chromosome, telomeric region
B	0000785	cellular_component	chromatin
B	0000792	cellular_component	heterochromatin
B	0000808	cellular_component	origin recognition complex
B	0000939	cellular_component	inner kinetochore
B	0003688	molecular_function	DNA replication origin binding
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005664	cellular_component	nuclear origin of replication recognition complex
B	0005813	cellular_component	centrosome
B	0006260	biological_process	DNA replication
B	0006270	biological_process	DNA replication initiation
B	0016020	cellular_component	membrane
C	0000781	cellular_component	chromosome, telomeric region
C	0000785	cellular_component	chromatin
C	0000808	cellular_component	origin recognition complex
C	0003677	molecular_function	DNA binding
C	0003688	molecular_function	DNA replication origin binding
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005656	cellular_component	nuclear pre-replicative complex
C	0005664	cellular_component	nuclear origin of replication recognition complex
C	0005694	cellular_component	chromosome
C	0006260	biological_process	DNA replication
C	0006270	biological_process	DNA replication initiation
C	0006275	biological_process	regulation of DNA replication
C	0014009	biological_process	glial cell proliferation
C	0016604	cellular_component	nuclear body
C	0031261	cellular_component	DNA replication preinitiation complex
C	0061351	biological_process	neural precursor cell proliferation
D	0000166	molecular_function	nucleotide binding
D	0000781	cellular_component	chromosome, telomeric region
D	0000808	cellular_component	origin recognition complex
D	0003677	molecular_function	DNA binding
D	0003688	molecular_function	DNA replication origin binding
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005664	cellular_component	nuclear origin of replication recognition complex
D	0005730	cellular_component	nucleolus
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006260	biological_process	DNA replication
D	0006270	biological_process	DNA replication initiation
D	0040038	biological_process	polar body extrusion after meiotic divisions
D	0051258	biological_process	protein polymerization
E	0000166	molecular_function	nucleotide binding
E	0000781	cellular_component	chromosome, telomeric region
E	0000785	cellular_component	chromatin
E	0000808	cellular_component	origin recognition complex
E	0003688	molecular_function	DNA replication origin binding
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005664	cellular_component	nuclear origin of replication recognition complex
E	0005694	cellular_component	chromosome
E	0005829	cellular_component	cytosol
E	0006260	biological_process	DNA replication
E	0006270	biological_process	DNA replication initiation
E	0006275	biological_process	regulation of DNA replication
G	0000076	biological_process	DNA replication checkpoint signaling
G	0000079	biological_process	regulation of cyclin-dependent protein serine/threonine kinase activity
G	0000166	molecular_function	nucleotide binding
G	0000922	cellular_component	spindle pole
G	0003682	molecular_function	chromatin binding
G	0003688	molecular_function	DNA replication origin binding
G	0005515	molecular_function	protein binding
G	0005524	molecular_function	ATP binding
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005730	cellular_component	nucleolus
G	0005737	cellular_component	cytoplasm
G	0005819	cellular_component	spindle
G	0005829	cellular_component	cytosol
G	0006260	biological_process	DNA replication
G	0006270	biological_process	DNA replication initiation
G	0007089	biological_process	traversing start control point of mitotic cell cycle
G	0008156	biological_process	negative regulation of DNA replication
G	0008285	biological_process	negative regulation of cell population proliferation
G	0030071	biological_process	regulation of mitotic metaphase/anaphase transition
G	0032467	biological_process	positive regulation of cytokinesis
G	0033314	biological_process	mitotic DNA replication checkpoint signaling
G	0045171	cellular_component	intercellular bridge
G	0048146	biological_process	positive regulation of fibroblast proliferation
G	0051233	cellular_component	spindle midzone
G	0051301	biological_process	cell division
G	0051984	biological_process	positive regulation of chromosome segregation
G	0072686	cellular_component	mitotic spindle
G	0120283	molecular_function	protein serine/threonine kinase binding
G	1904117	biological_process	cellular response to vasopressin
G	1904385	biological_process	cellular response to angiotensin

Functional Information from PROSITE/UniProt

site_id	PS00847
Number of Residues	9
Details	MCM_1 MCM family signature. GVCCIDEFD

Chain	Residue	Details
7	GLY440-ASP448
5	GLY440-ASP448
4	GLY569-ASP577
2	GLY582-ASP590
6	GLY455-ASP463
3	GLY404-ASP412

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163

Chain	Residue	Details
B	THR116
7	GLY384
7	ALA386
7	LYS387
7	SER388
7	ASN489
7	ARG514
7	ARG604
6	GLU622

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231

Chain	Residue	Details
B	SER122
B	SER138
A	GLU621

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163

Chain	Residue	Details
B	THR226
5	SER605

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
B	SER248
7	SER678
5	LYS696

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163

Chain	Residue	Details
B	SER280
6	SER762

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163

Chain	Residue	Details
7	SER500
A	SER255

---

site_id	SWS_FT_FI7
Number of Residues	3
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733

Chain	Residue	Details
7	LYS15
4	SER34
7	LYS28

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P97311

Chain	Residue	Details
6	SER689

---

site_id	SWS_FT_FI9
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:17525332

Chain	Residue	Details
6	THR791
4	THR110

---

site_id	SWS_FT_FI10
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
4	SER105

---

site_id	SWS_FT_FI11
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163

Chain	Residue	Details
4	SER120
A	SER417
A	SER420

---

site_id	SWS_FT_FI12
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163

Chain	Residue	Details
4	SER131

---

site_id	SWS_FT_FI13
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231

Chain	Residue	Details
4	SER142
4	SER145

---

site_id	SWS_FT_FI14
Number of Residues	2
Details	MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861

Chain	Residue	Details
4	LYS220
4	LYS450

---

site_id	SWS_FT_FI15
Number of Residues	1
Details	MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P49717

Chain	Residue	Details
4	LYS858

---

site_id	SWS_FT_FI16
Number of Residues	3
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733

Chain	Residue	Details
4	LYS439
3	SER734
4	LYS798

---

site_id	SWS_FT_FI17
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000269|PubMed:16899510, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569

Chain	Residue	Details
2	SER139

---

site_id	SWS_FT_FI18
Number of Residues	1
Details	MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861

Chain	Residue	Details
2	LYS216

---

site_id	SWS_FT_FI19
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:21406692

Chain	Residue	Details
2	SER381

---

site_id	SWS_FT_FI20
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733

Chain	Residue	Details
2	LYS178

---