8RWL
Crystal structure of Methanopyrus kandleri malate dehydrogenase mutant 1
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004459 | molecular_function | L-lactate dehydrogenase activity |
| A | 0006089 | biological_process | lactate metabolic process |
| A | 0006090 | biological_process | pyruvate metabolic process |
| A | 0006099 | biological_process | tricarboxylic acid cycle |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0030060 | molecular_function | L-malate dehydrogenase (NAD+) activity |
| A | 0046554 | molecular_function | L-malate dehydrogenase (NADP+) activity |
| B | 0004459 | molecular_function | L-lactate dehydrogenase activity |
| B | 0006089 | biological_process | lactate metabolic process |
| B | 0006090 | biological_process | pyruvate metabolic process |
| B | 0006099 | biological_process | tricarboxylic acid cycle |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0030060 | molecular_function | L-malate dehydrogenase (NAD+) activity |
| B | 0046554 | molecular_function | L-malate dehydrogenase (NADP+) activity |
Functional Information from PROSITE/UniProt
| site_id | PS00064 |
| Number of Residues | 7 |
| Details | L_LDH L-lactate dehydrogenase active site. IGEHGDT |
| Chain | Residue | Details |
| A | ILE175-THR181 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton acceptor => ECO:0000250|UniProtKB:P61889 |
| Chain | Residue | Details |
| A | HIS178 | |
| B | HIS178 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:Q60176 |
| Chain | Residue | Details |
| A | GLY8 | |
| A | ASN98 | |
| A | VAL121 | |
| B | GLY8 | |
| B | ASN98 | |
| B | VAL121 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:P61889 |
| Chain | Residue | Details |
| A | GLN85 | |
| A | ARG91 | |
| A | ASN123 | |
| A | ARG154 | |
| B | GLN85 | |
| B | ARG91 | |
| B | ASN123 | |
| B | ARG154 |
