8RWK

cryoEM structure of the central Ald4 filament determined by FilamentID

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004029	molecular_function	aldehyde dehydrogenase (NAD+) activity
A	0004030	molecular_function	aldehyde dehydrogenase [NAD(P)+] activity
A	0005739	cellular_component	mitochondrion
A	0005759	cellular_component	mitochondrial matrix
A	0006067	biological_process	ethanol metabolic process
A	0006090	biological_process	pyruvate metabolic process
A	0006740	biological_process	NADPH regeneration
A	0016491	molecular_function	oxidoreductase activity
A	0019413	biological_process	acetate biosynthetic process
A	0042645	cellular_component	mitochondrial nucleoid
B	0004029	molecular_function	aldehyde dehydrogenase (NAD+) activity
B	0004030	molecular_function	aldehyde dehydrogenase [NAD(P)+] activity
B	0005739	cellular_component	mitochondrion
B	0005759	cellular_component	mitochondrial matrix
B	0006067	biological_process	ethanol metabolic process
B	0006090	biological_process	pyruvate metabolic process
B	0006740	biological_process	NADPH regeneration
B	0016491	molecular_function	oxidoreductase activity
B	0019413	biological_process	acetate biosynthetic process
B	0042645	cellular_component	mitochondrial nucleoid
C	0004029	molecular_function	aldehyde dehydrogenase (NAD+) activity
C	0004030	molecular_function	aldehyde dehydrogenase [NAD(P)+] activity
C	0005739	cellular_component	mitochondrion
C	0005759	cellular_component	mitochondrial matrix
C	0006067	biological_process	ethanol metabolic process
C	0006090	biological_process	pyruvate metabolic process
C	0006740	biological_process	NADPH regeneration
C	0016491	molecular_function	oxidoreductase activity
C	0019413	biological_process	acetate biosynthetic process
C	0042645	cellular_component	mitochondrial nucleoid
D	0004029	molecular_function	aldehyde dehydrogenase (NAD+) activity
D	0004030	molecular_function	aldehyde dehydrogenase [NAD(P)+] activity
D	0005739	cellular_component	mitochondrion
D	0005759	cellular_component	mitochondrial matrix
D	0006067	biological_process	ethanol metabolic process
D	0006090	biological_process	pyruvate metabolic process
D	0006740	biological_process	NADPH regeneration
D	0016491	molecular_function	oxidoreductase activity
D	0019413	biological_process	acetate biosynthetic process
D	0042645	cellular_component	mitochondrial nucleoid

Functional Information from PROSITE/UniProt

site_id	PS00070
Number of Residues	12
Details	ALDEHYDE_DEHYDR_CYS Aldehyde dehydrogenases cysteine active site. YyNSGEVCCAGS

Chain	Residue	Details
A	TYR317-SER328

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site_id	PS00687
Number of Residues	8
Details	ALDEHYDE_DEHYDR_GLU Aldehyde dehydrogenases glutamic acid active site. LELGGKSP

Chain	Residue	Details
A	LEU289-PRO296

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU10007, ECO:0000255|PROSITE-ProRule:PRU10008

Chain	Residue	Details
A	GLU290
B	GLU290
C	GLU290
D	GLU290

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	ACT_SITE: Nucleophile => ECO:0000255|PROSITE-ProRule:PRU10007, ECO:0000255|PROSITE-ProRule:PRU10008

Chain	Residue	Details
A	CYS324
B	CYS324
C	CYS324
D	CYS324

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
A	GLY268
B	GLY268
C	GLY268
D	GLY268

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	SITE: Transition state stabilizer => ECO:0000250

Chain	Residue	Details
A	ASN192
B	ASN192
C	ASN192
D	ASN192

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:19779198

Chain	Residue	Details
A	SER96
B	SER96
C	SER96
D	SER96

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:17761666

Chain	Residue	Details
A	THR216
B	THR216
C	THR216
D	THR216

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:17761666, ECO:0007744|PubMed:19779198

Chain	Residue	Details
A	SER500
B	SER500
C	SER500
D	SER500

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