8RMX
Transglutaminase 3 in complex with DH patient-derived Fab DH63-A02
Functional Information from PROSITE/UniProt
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH |
| Chain | Residue | Details |
| F | TYR197-HIS203 | |
| E | TYR199-HIS205 |
| site_id | PS00547 |
| Number of Residues | 18 |
| Details | TRANSGLUTAMINASES Transglutaminases active site. GQCWVfAGTlnTaLRSLG |
| Chain | Residue | Details |
| A | GLY271-GLY288 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | ACT_SITE: ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU10024 |
| Chain | Residue | Details |
| A | CYS273 | |
| A | HIS331 | |
| A | ASP354 | |
| D | CYS273 | |
| D | HIS331 | |
| D | ASP354 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 28 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:11980702, ECO:0000269|PubMed:12679341 |
| Chain | Residue | Details |
| A | ALA222 | |
| A | ASP325 | |
| A | ASN394 | |
| A | SER416 | |
| A | GLU444 | |
| A | GLU449 | |
| D | ALA222 | |
| D | ASN225 | |
| D | ASN227 | |
| D | ASP228 | |
| D | ASN230 | |
| A | ASN225 | |
| D | ASP302 | |
| D | ASP304 | |
| D | ASN306 | |
| D | SER308 | |
| D | ASP325 | |
| D | ASN394 | |
| D | SER416 | |
| D | GLU444 | |
| D | GLU449 | |
| A | ASN227 | |
| A | ASP228 | |
| A | ASN230 | |
| A | ASP302 | |
| A | ASP304 | |
| A | ASN306 | |
| A | SER308 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | MOD_RES: N-acetylalanine => ECO:0000269|Ref.7 |
| Chain | Residue | Details |
| A | ALA2 | |
| D | ALA2 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:19690332 |
| Chain | Residue | Details |
| A | TYR111 | |
| D | TYR111 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:19690332 |
| Chain | Residue | Details |
| A | THR112 | |
| D | THR112 |
