Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8RLY

E. coli endonuclease IV complexed with sulfate, catalytic Fe2+

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0003906	molecular_function	DNA-(apurinic or apyrimidinic site) endonuclease activity
A	0004518	molecular_function	nuclease activity
A	0004519	molecular_function	endonuclease activity
A	0005829	cellular_component	cytosol
A	0006281	biological_process	DNA repair
A	0006284	biological_process	base-excision repair
A	0006974	biological_process	DNA damage response
A	0008081	molecular_function	phosphoric diester hydrolase activity
A	0008270	molecular_function	zinc ion binding
A	0008296	molecular_function	3'-5'-DNA exonuclease activity
A	0008833	molecular_function	deoxyribonuclease IV (phage-T4-induced) activity
A	0016787	molecular_function	hydrolase activity
A	0016791	molecular_function	phosphatase activity
A	0046872	molecular_function	metal ion binding
B	0003677	molecular_function	DNA binding
B	0003906	molecular_function	DNA-(apurinic or apyrimidinic site) endonuclease activity
B	0004518	molecular_function	nuclease activity
B	0004519	molecular_function	endonuclease activity
B	0005829	cellular_component	cytosol
B	0006281	biological_process	DNA repair
B	0006284	biological_process	base-excision repair
B	0006974	biological_process	DNA damage response
B	0008081	molecular_function	phosphoric diester hydrolase activity
B	0008270	molecular_function	zinc ion binding
B	0008296	molecular_function	3'-5'-DNA exonuclease activity
B	0008833	molecular_function	deoxyribonuclease IV (phage-T4-induced) activity
B	0016787	molecular_function	hydrolase activity
B	0016791	molecular_function	phosphatase activity
B	0046872	molecular_function	metal ion binding
C	0003677	molecular_function	DNA binding
C	0003906	molecular_function	DNA-(apurinic or apyrimidinic site) endonuclease activity
C	0004518	molecular_function	nuclease activity
C	0004519	molecular_function	endonuclease activity
C	0005829	cellular_component	cytosol
C	0006281	biological_process	DNA repair
C	0006284	biological_process	base-excision repair
C	0006974	biological_process	DNA damage response
C	0008081	molecular_function	phosphoric diester hydrolase activity
C	0008270	molecular_function	zinc ion binding
C	0008296	molecular_function	3'-5'-DNA exonuclease activity
C	0008833	molecular_function	deoxyribonuclease IV (phage-T4-induced) activity
C	0016787	molecular_function	hydrolase activity
C	0016791	molecular_function	phosphatase activity
C	0046872	molecular_function	metal ion binding
D	0003677	molecular_function	DNA binding
D	0003906	molecular_function	DNA-(apurinic or apyrimidinic site) endonuclease activity
D	0004518	molecular_function	nuclease activity
D	0004519	molecular_function	endonuclease activity
D	0005829	cellular_component	cytosol
D	0006281	biological_process	DNA repair
D	0006284	biological_process	base-excision repair
D	0006974	biological_process	DNA damage response
D	0008081	molecular_function	phosphoric diester hydrolase activity
D	0008270	molecular_function	zinc ion binding
D	0008296	molecular_function	3'-5'-DNA exonuclease activity
D	0008833	molecular_function	deoxyribonuclease IV (phage-T4-induced) activity
D	0016787	molecular_function	hydrolase activity
D	0016791	molecular_function	phosphatase activity
D	0046872	molecular_function	metal ion binding
E	0003677	molecular_function	DNA binding
E	0003906	molecular_function	DNA-(apurinic or apyrimidinic site) endonuclease activity
E	0004518	molecular_function	nuclease activity
E	0004519	molecular_function	endonuclease activity
E	0005829	cellular_component	cytosol
E	0006281	biological_process	DNA repair
E	0006284	biological_process	base-excision repair
E	0006974	biological_process	DNA damage response
E	0008081	molecular_function	phosphoric diester hydrolase activity
E	0008270	molecular_function	zinc ion binding
E	0008296	molecular_function	3'-5'-DNA exonuclease activity
E	0008833	molecular_function	deoxyribonuclease IV (phage-T4-induced) activity
E	0016787	molecular_function	hydrolase activity
E	0016791	molecular_function	phosphatase activity
E	0046872	molecular_function	metal ion binding

Functional Information from PROSITE/UniProt

site_id	PS00729
Number of Residues	9
Details	AP_NUCLEASE_F2_1 AP endonucleases family 2 signature 1. HDsYLINLG

Chain	Residue	Details
A	HIS69-GLY77

site_id	PS00730
Number of Residues	8
Details	AP_NUCLEASE_F2_2 AP endonucleases family 2 signature 2. GVCIDTCH

Chain	Residue	Details
A	GLY175-HIS182

site_id	PS00731
Number of Residues	17
Details	AP_NUCLEASE_F2_3 AP endonucleases family 2 signature 3. MHlNDAkstfGsrvDrH

Chain	Residue	Details
A	MET215-HIS231

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	45
Details	Binding site: {}

Chain

Residue

Details

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	11
Details	M-CSA 11

Chain	Residue	Details
A	ARG37	transition state stabiliser
A	HIS231	metal ligand
A	GLU261	metal ligand
A	HIS69	metal ligand
A	TYR72	transition state stabiliser
A	HIS109	metal ligand
A	GLU145	metal ligand
A	ASP179	metal ligand
A	HIS182	metal ligand
A	HIS216	metal ligand
A	ASP229	metal ligand

site_id	MCSA2
Number of Residues	11
Details	M-CSA 11

Chain	Residue	Details
B	ARG37	transition state stabiliser
B	HIS231	metal ligand
B	GLU261	metal ligand
B	HIS69	metal ligand
B	TYR72	transition state stabiliser
B	HIS109	metal ligand
B	GLU145	metal ligand
B	ASP179	metal ligand
B	HIS182	metal ligand
B	HIS216	metal ligand
B	ASP229	metal ligand

site_id	MCSA3
Number of Residues	11
Details	M-CSA 11

Chain	Residue	Details
C	ARG37	transition state stabiliser
C	HIS231	metal ligand
C	GLU261	metal ligand
C	HIS69	metal ligand
C	TYR72	transition state stabiliser
C	HIS109	metal ligand
C	GLU145	metal ligand
C	ASP179	metal ligand
C	HIS182	metal ligand
C	HIS216	metal ligand
C	ASP229	metal ligand

site_id	MCSA4
Number of Residues	11
Details	M-CSA 11

Chain	Residue	Details
D	ARG37	transition state stabiliser
D	HIS231	metal ligand
D	GLU261	metal ligand
D	HIS69	metal ligand
D	TYR72	transition state stabiliser
D	HIS109	metal ligand
D	GLU145	metal ligand
D	ASP179	metal ligand
D	HIS182	metal ligand
D	HIS216	metal ligand
D	ASP229	metal ligand

site_id	MCSA5
Number of Residues	11
Details	M-CSA 11

Chain	Residue	Details
E	ARG37	transition state stabiliser
E	HIS231	metal ligand
E	GLU261	metal ligand
E	HIS69	metal ligand
E	TYR72	transition state stabiliser
E	HIS109	metal ligand
E	GLU145	metal ligand
E	ASP179	metal ligand
E	HIS182	metal ligand
E	HIS216	metal ligand
E	ASP229	metal ligand

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)