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8RK2

Human Replication protein A (RPA; trimeric core) - ssDNA complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0000723biological_processtelomere maintenance
A0000724biological_processdouble-strand break repair via homologous recombination
A0000781cellular_componentchromosome, telomeric region
A0003677molecular_functionDNA binding
A0003684molecular_functiondamaged DNA binding
A0003697molecular_functionsingle-stranded DNA binding
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005662cellular_componentDNA replication factor A complex
A0006260biological_processDNA replication
A0006261biological_processDNA-templated DNA replication
A0006281biological_processDNA repair
A0006284biological_processbase-excision repair
A0006289biological_processnucleotide-excision repair
A0006298biological_processmismatch repair
A0006310biological_processDNA recombination
A0006325biological_processchromatin organization
A0006974biological_processDNA damage response
A0007004biological_processtelomere maintenance via telomerase
A0016605cellular_componentPML body
A0034502biological_processprotein localization to chromosome
A0035861cellular_componentsite of double-strand break
A0043047molecular_functionsingle-stranded telomeric DNA binding
A0046872molecular_functionmetal ion binding
A0051321biological_processmeiotic cell cycle
A0090734cellular_componentsite of DNA damage
A0098505molecular_functionG-rich strand telomeric DNA binding
A0140463molecular_functionchromatin-protein adaptor activity
A1990166biological_processprotein localization to site of double-strand break
B0000723biological_processtelomere maintenance
B0000724biological_processdouble-strand break repair via homologous recombination
B0000781cellular_componentchromosome, telomeric region
B0000785cellular_componentchromatin
B0003677molecular_functionDNA binding
B0003684molecular_functiondamaged DNA binding
B0003697molecular_functionsingle-stranded DNA binding
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005662cellular_componentDNA replication factor A complex
B0006260biological_processDNA replication
B0006281biological_processDNA repair
B0006284biological_processbase-excision repair
B0006289biological_processnucleotide-excision repair
B0006298biological_processmismatch repair
B0006310biological_processDNA recombination
B0010569biological_processregulation of double-strand break repair via homologous recombination
B0016604cellular_componentnuclear body
B0016605cellular_componentPML body
B0019899molecular_functionenzyme binding
B0019903molecular_functionprotein phosphatase binding
B0031571biological_processmitotic G1 DNA damage checkpoint signaling
B0031625molecular_functionubiquitin protein ligase binding
B0034502biological_processprotein localization to chromosome
B0035861cellular_componentsite of double-strand break
B0042162molecular_functiontelomeric DNA binding
B0043229cellular_componentintracellular organelle
B0098505molecular_functionG-rich strand telomeric DNA binding
B2000001biological_processregulation of DNA damage checkpoint
C0000723biological_processtelomere maintenance
C0000724biological_processdouble-strand break repair via homologous recombination
C0003684molecular_functiondamaged DNA binding
C0003697molecular_functionsingle-stranded DNA binding
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005662cellular_componentDNA replication factor A complex
C0006260biological_processDNA replication
C0006281biological_processDNA repair
C0006284biological_processbase-excision repair
C0006289biological_processnucleotide-excision repair
C0006298biological_processmismatch repair
C0006310biological_processDNA recombination
C0007346biological_processregulation of mitotic cell cycle
C0031981cellular_componentnuclear lumen
C0035861cellular_componentsite of double-strand break
C0042127biological_processregulation of cell population proliferation
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsMOD_RES: N-acetylvaline => ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22223895, ECO:0007744|PubMed:22814378
ChainResidueDetails
CVAL2

site_idSWS_FT_FI2
Number of Residues4
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:26474068
ChainResidueDetails
CLYS23
CLYS39
CLYS88

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: Phosphoserine; by PRKDC => ECO:0000269|PubMed:21731742, ECO:0000269|PubMed:26474068
ChainResidueDetails
BSER4
BSER8

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: Phosphothreonine; by PRKDC => ECO:0000269|PubMed:21558276, ECO:0000269|PubMed:26474068, ECO:0000269|PubMed:9139719, ECO:0000269|PubMed:9295339
ChainResidueDetails
BTHR21
ALYS167
ALYS259

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: Phosphoserine; by CDK2 => ECO:0000269|PubMed:1318195, ECO:0000269|PubMed:8246944, ECO:0000269|PubMed:9295339, ECO:0007744|PubMed:20068231
ChainResidueDetails
BSER23

site_idSWS_FT_FI6
Number of Residues1
DetailsMOD_RES: Phosphoserine; by CDK1 => ECO:0000269|PubMed:1318195, ECO:0000269|PubMed:8246944, ECO:0000269|PubMed:9139719, ECO:0000269|PubMed:9295339, ECO:0007744|PubMed:20068231
ChainResidueDetails
BSER29

site_idSWS_FT_FI7
Number of Residues1
DetailsMOD_RES: Phosphoserine; by PRKDC => ECO:0000269|PubMed:26474068, ECO:0000269|PubMed:9139719, ECO:0000269|PubMed:9295339
ChainResidueDetails
BSER33

site_idSWS_FT_FI8
Number of Residues3
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000305|PubMed:26474068
ChainResidueDetails
BLYS37
ALYS458
ALYS553
ALYS88
BLYS38
ALYS220
ALYS244
ALYS267
ALYS331
ALYS410
ALYS431

site_idSWS_FT_FI9
Number of Residues3
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) => ECO:0000269|PubMed:20705237
ChainResidueDetails
ALYS449
ALYS577

site_idSWS_FT_FI10
Number of Residues3
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000269|PubMed:26474068
ChainResidueDetails
ALYS163
ALYS167
ALYS259

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PDB entries from 2024-07-24

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