Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8RJ4

E. coli adenylate kinase in complex with two ADP molecules and Mg2+ as a result of enzymatic AP4A hydrolysis

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0004017	molecular_function	adenylate kinase activity
A	0004550	molecular_function	nucleoside diphosphate kinase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006172	biological_process	ADP biosynthetic process
A	0009123	biological_process	nucleoside monophosphate metabolic process
A	0009132	biological_process	nucleoside diphosphate metabolic process
A	0009165	biological_process	nucleotide biosynthetic process
A	0015951	biological_process	purine ribonucleotide interconversion
A	0016208	molecular_function	AMP binding
A	0016301	molecular_function	kinase activity
A	0016310	biological_process	phosphorylation
A	0044209	biological_process	AMP salvage
A	0046940	biological_process	nucleoside monophosphate phosphorylation
A	0050145	molecular_function	nucleoside monophosphate kinase activity
B	0000287	molecular_function	magnesium ion binding
B	0004017	molecular_function	adenylate kinase activity
B	0004550	molecular_function	nucleoside diphosphate kinase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006172	biological_process	ADP biosynthetic process
B	0009123	biological_process	nucleoside monophosphate metabolic process
B	0009132	biological_process	nucleoside diphosphate metabolic process
B	0009165	biological_process	nucleotide biosynthetic process
B	0015951	biological_process	purine ribonucleotide interconversion
B	0016208	molecular_function	AMP binding
B	0016301	molecular_function	kinase activity
B	0016310	biological_process	phosphorylation
B	0044209	biological_process	AMP salvage
B	0046940	biological_process	nucleoside monophosphate phosphorylation
B	0050145	molecular_function	nucleoside monophosphate kinase activity
C	0000287	molecular_function	magnesium ion binding
C	0004017	molecular_function	adenylate kinase activity
C	0004550	molecular_function	nucleoside diphosphate kinase activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006172	biological_process	ADP biosynthetic process
C	0009123	biological_process	nucleoside monophosphate metabolic process
C	0009132	biological_process	nucleoside diphosphate metabolic process
C	0009165	biological_process	nucleotide biosynthetic process
C	0015951	biological_process	purine ribonucleotide interconversion
C	0016208	molecular_function	AMP binding
C	0016301	molecular_function	kinase activity
C	0016310	biological_process	phosphorylation
C	0044209	biological_process	AMP salvage
C	0046940	biological_process	nucleoside monophosphate phosphorylation
C	0050145	molecular_function	nucleoside monophosphate kinase activity
D	0000287	molecular_function	magnesium ion binding
D	0004017	molecular_function	adenylate kinase activity
D	0004550	molecular_function	nucleoside diphosphate kinase activity
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006172	biological_process	ADP biosynthetic process
D	0009123	biological_process	nucleoside monophosphate metabolic process
D	0009132	biological_process	nucleoside diphosphate metabolic process
D	0009165	biological_process	nucleotide biosynthetic process
D	0015951	biological_process	purine ribonucleotide interconversion
D	0016208	molecular_function	AMP binding
D	0016301	molecular_function	kinase activity
D	0016310	biological_process	phosphorylation
D	0044209	biological_process	AMP salvage
D	0046940	biological_process	nucleoside monophosphate phosphorylation
D	0050145	molecular_function	nucleoside monophosphate kinase activity

Functional Information from PROSITE/UniProt

site_id	PS00113
Number of Residues	12
Details	ADENYLATE_KINASE Adenylate kinase signature. FLLDGFPRtipQ

Chain	Residue	Details
A	PHE81-GLN92

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	32
Details	BINDING: BINDING => ECO:0000255\|HAMAP-Rule:MF_00235, ECO:0000269\|PubMed:1548697, ECO:0000269\|PubMed:16302237, ECO:0000269\|PubMed:19805185, ECO:0000269\|PubMed:7937733, ECO:0000269\|PubMed:8451239

Chain	Residue	Details
A	GLY10
B	THR31
B	ARG36
B	LYS57
B	GLN92
B	ARG123
B	ARG156
B	LYS200
C	GLY10
C	THR31
C	ARG36
A	THR31
C	LYS57
C	GLN92
C	ARG123
C	ARG156
C	LYS200
D	GLY10
D	THR31
D	ARG36
D	LYS57
D	GLN92
A	ARG36
D	ARG123
D	ARG156
D	LYS200
A	LYS57
A	GLN92
A	ARG123
A	ARG156
A	LYS200
B	GLY10

site_id	SWS_FT_FI2
Number of Residues	8
Details	BINDING: BINDING => ECO:0000255\|HAMAP-Rule:MF_00235, ECO:0000269\|PubMed:1548697, ECO:0000269\|PubMed:19805185, ECO:0000269\|PubMed:8451239

Chain	Residue	Details
A	GLY85
A	ARG167
B	GLY85
B	ARG167
C	GLY85
C	ARG167
D	GLY85
D	ARG167

site_id	SWS_FT_FI3
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269\|PubMed:16302237

Chain	Residue	Details
A	ARG119
B	ARG119
C	ARG119
D	ARG119

site_id	SWS_FT_FI4
Number of Residues	4
Details	BINDING: BINDING => ECO:0000255\|HAMAP-Rule:MF_00235, ECO:0000269\|PubMed:1548697, ECO:0000269\|PubMed:16302237, ECO:0000269\|PubMed:19805185, ECO:0000269\|PubMed:8451239

Chain	Residue	Details
A	VAL132
B	VAL132
C	VAL132
D	VAL132

site_id	SWS_FT_FI5
Number of Residues	4
Details	MOD_RES: N6-acetyllysine => ECO:0000269\|PubMed:18723842

Chain	Residue	Details
A	LYS192
B	LYS192
C	LYS192
D	LYS192

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)