8RIZ

Microtubule-associated kinesin-1 tail complex bound to ADP, two-headed state

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000226	biological_process	microtubule cytoskeleton organization
A	0000278	biological_process	mitotic cell cycle
A	0003924	molecular_function	GTPase activity
A	0005200	molecular_function	structural constituent of cytoskeleton
A	0005525	molecular_function	GTP binding
A	0005737	cellular_component	cytoplasm
A	0005856	cellular_component	cytoskeleton
A	0005874	cellular_component	microtubule
A	0007017	biological_process	microtubule-based process
A	0015630	cellular_component	microtubule cytoskeleton
A	0016787	molecular_function	hydrolase activity
A	0046872	molecular_function	metal ion binding
B	0000166	molecular_function	nucleotide binding
B	0000226	biological_process	microtubule cytoskeleton organization
B	0000278	biological_process	mitotic cell cycle
B	0001764	biological_process	neuron migration
B	0003924	molecular_function	GTPase activity
B	0005200	molecular_function	structural constituent of cytoskeleton
B	0005515	molecular_function	protein binding
B	0005525	molecular_function	GTP binding
B	0005737	cellular_component	cytoplasm
B	0005856	cellular_component	cytoskeleton
B	0005874	cellular_component	microtubule
B	0007017	biological_process	microtubule-based process
B	0046872	molecular_function	metal ion binding
K	0000166	molecular_function	nucleotide binding
K	0003777	molecular_function	microtubule motor activity
K	0005515	molecular_function	protein binding
K	0005524	molecular_function	ATP binding
K	0005737	cellular_component	cytoplasm
K	0005739	cellular_component	mitochondrion
K	0005764	cellular_component	lysosome
K	0005765	cellular_component	lysosomal membrane
K	0005829	cellular_component	cytosol
K	0005856	cellular_component	cytoskeleton
K	0005871	cellular_component	kinesin complex
K	0005874	cellular_component	microtubule
K	0007018	biological_process	microtubule-based movement
K	0007028	biological_process	cytoplasm organization
K	0007411	biological_process	axon guidance
K	0008017	molecular_function	microtubule binding
K	0008574	molecular_function	plus-end-directed microtubule motor activity
K	0016020	cellular_component	membrane
K	0016887	molecular_function	ATP hydrolysis activity
K	0030139	cellular_component	endocytic vesicle
K	0031965	cellular_component	nuclear membrane
K	0031982	cellular_component	vesicle
K	0032230	biological_process	positive regulation of synaptic transmission, GABAergic
K	0032418	biological_process	lysosome localization
K	0032839	cellular_component	dendrite cytoplasm
K	0034451	cellular_component	centriolar satellite
K	0035253	cellular_component	ciliary rootlet
K	0035617	biological_process	stress granule disassembly
K	0042267	biological_process	natural killer cell mediated cytotoxicity
K	0042391	biological_process	regulation of membrane potential
K	0042802	molecular_function	identical protein binding
K	0043005	cellular_component	neuron projection
K	0043268	biological_process	positive regulation of potassium ion transport
K	0044877	molecular_function	protein-containing complex binding
K	0045296	molecular_function	cadherin binding
K	0045335	cellular_component	phagocytic vesicle
K	0047496	biological_process	vesicle transport along microtubule
K	0047497	biological_process	mitochondrion transport along microtubule
K	0048471	cellular_component	perinuclear region of cytoplasm
K	0048489	biological_process	synaptic vesicle transport
K	0051642	biological_process	centrosome localization
K	0071346	biological_process	cellular response to type II interferon
K	0072383	biological_process	plus-end-directed vesicle transport along microtubule
K	0098971	biological_process	anterograde dendritic transport of neurotransmitter receptor complex
K	0098987	biological_process	regulation of modification of synapse structure, modulating synaptic transmission
K	0099524	cellular_component	postsynaptic cytosol
K	0099641	biological_process	anterograde axonal protein transport
K	0101004	cellular_component	cytolytic granule membrane
K	0160040	biological_process	mitocytosis
K	1903078	biological_process	positive regulation of protein localization to plasma membrane
K	1904115	cellular_component	axon cytoplasm
K	1990048	biological_process	anterograde neuronal dense core vesicle transport
K	1990049	biological_process	retrograde neuronal dense core vesicle transport
L	0000166	molecular_function	nucleotide binding
L	0003777	molecular_function	microtubule motor activity
L	0005515	molecular_function	protein binding
L	0005524	molecular_function	ATP binding
L	0005737	cellular_component	cytoplasm
L	0005739	cellular_component	mitochondrion
L	0005764	cellular_component	lysosome
L	0005765	cellular_component	lysosomal membrane
L	0005829	cellular_component	cytosol
L	0005856	cellular_component	cytoskeleton
L	0005871	cellular_component	kinesin complex
L	0005874	cellular_component	microtubule
L	0007018	biological_process	microtubule-based movement
L	0007028	biological_process	cytoplasm organization
L	0007411	biological_process	axon guidance
L	0008017	molecular_function	microtubule binding
L	0008574	molecular_function	plus-end-directed microtubule motor activity
L	0016020	cellular_component	membrane
L	0016887	molecular_function	ATP hydrolysis activity
L	0030139	cellular_component	endocytic vesicle
L	0031965	cellular_component	nuclear membrane
L	0031982	cellular_component	vesicle
L	0032230	biological_process	positive regulation of synaptic transmission, GABAergic
L	0032418	biological_process	lysosome localization
L	0032839	cellular_component	dendrite cytoplasm
L	0034451	cellular_component	centriolar satellite
L	0035253	cellular_component	ciliary rootlet
L	0035617	biological_process	stress granule disassembly
L	0042267	biological_process	natural killer cell mediated cytotoxicity
L	0042391	biological_process	regulation of membrane potential
L	0042802	molecular_function	identical protein binding
L	0043005	cellular_component	neuron projection
L	0043268	biological_process	positive regulation of potassium ion transport
L	0044877	molecular_function	protein-containing complex binding
L	0045296	molecular_function	cadherin binding
L	0045335	cellular_component	phagocytic vesicle
L	0047496	biological_process	vesicle transport along microtubule
L	0047497	biological_process	mitochondrion transport along microtubule
L	0048471	cellular_component	perinuclear region of cytoplasm
L	0048489	biological_process	synaptic vesicle transport
L	0051642	biological_process	centrosome localization
L	0071346	biological_process	cellular response to type II interferon
L	0072383	biological_process	plus-end-directed vesicle transport along microtubule
L	0098971	biological_process	anterograde dendritic transport of neurotransmitter receptor complex
L	0098987	biological_process	regulation of modification of synapse structure, modulating synaptic transmission
L	0099524	cellular_component	postsynaptic cytosol
L	0099641	biological_process	anterograde axonal protein transport
L	0101004	cellular_component	cytolytic granule membrane
L	0160040	biological_process	mitocytosis
L	1903078	biological_process	positive regulation of protein localization to plasma membrane
L	1904115	cellular_component	axon cytoplasm
L	1990048	biological_process	anterograde neuronal dense core vesicle transport
L	1990049	biological_process	retrograde neuronal dense core vesicle transport
T	0000166	molecular_function	nucleotide binding
T	0003777	molecular_function	microtubule motor activity
T	0005515	molecular_function	protein binding
T	0005524	molecular_function	ATP binding
T	0005737	cellular_component	cytoplasm
T	0005739	cellular_component	mitochondrion
T	0005764	cellular_component	lysosome
T	0005765	cellular_component	lysosomal membrane
T	0005829	cellular_component	cytosol
T	0005856	cellular_component	cytoskeleton
T	0005871	cellular_component	kinesin complex
T	0005874	cellular_component	microtubule
T	0007018	biological_process	microtubule-based movement
T	0007028	biological_process	cytoplasm organization
T	0007411	biological_process	axon guidance
T	0008017	molecular_function	microtubule binding
T	0008574	molecular_function	plus-end-directed microtubule motor activity
T	0016020	cellular_component	membrane
T	0016887	molecular_function	ATP hydrolysis activity
T	0030139	cellular_component	endocytic vesicle
T	0031965	cellular_component	nuclear membrane
T	0031982	cellular_component	vesicle
T	0032230	biological_process	positive regulation of synaptic transmission, GABAergic
T	0032418	biological_process	lysosome localization
T	0032839	cellular_component	dendrite cytoplasm
T	0034451	cellular_component	centriolar satellite
T	0035253	cellular_component	ciliary rootlet
T	0035617	biological_process	stress granule disassembly
T	0042267	biological_process	natural killer cell mediated cytotoxicity
T	0042391	biological_process	regulation of membrane potential
T	0042802	molecular_function	identical protein binding
T	0043005	cellular_component	neuron projection
T	0043268	biological_process	positive regulation of potassium ion transport
T	0044877	molecular_function	protein-containing complex binding
T	0045296	molecular_function	cadherin binding
T	0045335	cellular_component	phagocytic vesicle
T	0047496	biological_process	vesicle transport along microtubule
T	0047497	biological_process	mitochondrion transport along microtubule
T	0048471	cellular_component	perinuclear region of cytoplasm
T	0048489	biological_process	synaptic vesicle transport
T	0051642	biological_process	centrosome localization
T	0071346	biological_process	cellular response to type II interferon
T	0072383	biological_process	plus-end-directed vesicle transport along microtubule
T	0098971	biological_process	anterograde dendritic transport of neurotransmitter receptor complex
T	0098987	biological_process	regulation of modification of synapse structure, modulating synaptic transmission
T	0099524	cellular_component	postsynaptic cytosol
T	0099641	biological_process	anterograde axonal protein transport
T	0101004	cellular_component	cytolytic granule membrane
T	0160040	biological_process	mitocytosis
T	1903078	biological_process	positive regulation of protein localization to plasma membrane
T	1904115	cellular_component	axon cytoplasm
T	1990048	biological_process	anterograde neuronal dense core vesicle transport
T	1990049	biological_process	retrograde neuronal dense core vesicle transport

Functional Information from PROSITE/UniProt

site_id	PS00227
Number of Residues	7
Details	TUBULIN Tubulin subunits alpha, beta, and gamma signature. GGGTGSG

Chain	Residue	Details
A	GLY142-GLY148
B	GLY142-GLY148

---

site_id	PS00228
Number of Residues	4
Details	TUBULIN_B_AUTOREG Tubulin-beta mRNA autoregulation signal. MREI

Chain	Residue	Details
B	MET1-ILE4

---

site_id	PS00411
Number of Residues	12
Details	KINESIN_MOTOR_1 Kinesin motor domain signature. GKLyLVDLAGSE

Chain	Residue	Details
K	GLY225-GLU236

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	Motif: {"description":"MREI motif","evidences":[{"source":"UniProtKB","id":"P07437","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	7
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q13509","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	18
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P68363","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P99024","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P99024","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine; by CDK1","evidences":[{"source":"UniProtKB","id":"Q13885","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P07437","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	Modified residue: {"description":"Omega-N-methylarginine","evidences":[{"source":"UniProtKB","id":"P07437","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	1
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","evidences":[{"source":"UniProtKB","id":"P07437","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"UniProtKB","id":"P07437","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	3
Details	Motif: {"description":"MREC motif","evidences":[{"source":"UniProtKB","id":"P68363","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	1
Details	Active site: {"evidences":[{"source":"UniProtKB","id":"P68363","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P68363","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	1
Details	Modified residue: {"description":"3'-nitrotyrosine","evidences":[{"source":"UniProtKB","id":"P68373","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	1
Details	Modified residue: {"description":"Omega-N-methylarginine","evidences":[{"source":"UniProtKB","id":"P68363","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	3
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"UniProtKB","id":"P68363","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	14
Details	Binding site: {}

Chain

Residue

Details

---

site_id	SWS_FT_FI18
Number of Residues	4
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---