Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8RIK

Microtubule-associated kinesin-1 tail complex bound to ADP, single-headed state

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000226	biological_process	microtubule cytoskeleton organization
A	0000278	biological_process	mitotic cell cycle
A	0003924	molecular_function	GTPase activity
A	0005200	molecular_function	structural constituent of cytoskeleton
A	0005525	molecular_function	GTP binding
A	0005737	cellular_component	cytoplasm
A	0005856	cellular_component	cytoskeleton
A	0005874	cellular_component	microtubule
A	0007017	biological_process	microtubule-based process
A	0015630	cellular_component	microtubule cytoskeleton
A	0016787	molecular_function	hydrolase activity
A	0046872	molecular_function	metal ion binding
B	0000166	molecular_function	nucleotide binding
B	0000226	biological_process	microtubule cytoskeleton organization
B	0000278	biological_process	mitotic cell cycle
B	0001764	biological_process	neuron migration
B	0003924	molecular_function	GTPase activity
B	0005200	molecular_function	structural constituent of cytoskeleton
B	0005515	molecular_function	protein binding
B	0005525	molecular_function	GTP binding
B	0005737	cellular_component	cytoplasm
B	0005856	cellular_component	cytoskeleton
B	0005874	cellular_component	microtubule
B	0007017	biological_process	microtubule-based process
B	0046872	molecular_function	metal ion binding
K	0000166	molecular_function	nucleotide binding
K	0003777	molecular_function	microtubule motor activity
K	0005515	molecular_function	protein binding
K	0005524	molecular_function	ATP binding
K	0005737	cellular_component	cytoplasm
K	0005739	cellular_component	mitochondrion
K	0005764	cellular_component	lysosome
K	0005765	cellular_component	lysosomal membrane
K	0005829	cellular_component	cytosol
K	0005856	cellular_component	cytoskeleton
K	0005871	cellular_component	kinesin complex
K	0005874	cellular_component	microtubule
K	0007018	biological_process	microtubule-based movement
K	0007028	biological_process	cytoplasm organization
K	0007411	biological_process	axon guidance
K	0008017	molecular_function	microtubule binding
K	0008574	molecular_function	plus-end-directed microtubule motor activity
K	0016020	cellular_component	membrane
K	0016887	molecular_function	ATP hydrolysis activity
K	0030139	cellular_component	endocytic vesicle
K	0031965	cellular_component	nuclear membrane
K	0031982	cellular_component	vesicle
K	0032230	biological_process	positive regulation of synaptic transmission, GABAergic
K	0032418	biological_process	lysosome localization
K	0032839	cellular_component	dendrite cytoplasm
K	0034451	cellular_component	centriolar satellite
K	0035253	cellular_component	ciliary rootlet
K	0035617	biological_process	stress granule disassembly
K	0042267	biological_process	natural killer cell mediated cytotoxicity
K	0042391	biological_process	regulation of membrane potential
K	0042802	molecular_function	identical protein binding
K	0043005	cellular_component	neuron projection
K	0043268	biological_process	positive regulation of potassium ion transport
K	0044877	molecular_function	protein-containing complex binding
K	0045296	molecular_function	cadherin binding
K	0045335	cellular_component	phagocytic vesicle
K	0047496	biological_process	vesicle transport along microtubule
K	0047497	biological_process	mitochondrion transport along microtubule
K	0048471	cellular_component	perinuclear region of cytoplasm
K	0048489	biological_process	synaptic vesicle transport
K	0051642	biological_process	centrosome localization
K	0071346	biological_process	cellular response to type II interferon
K	0072383	biological_process	plus-end-directed vesicle transport along microtubule
K	0098971	biological_process	anterograde dendritic transport of neurotransmitter receptor complex
K	0098987	biological_process	regulation of modification of synapse structure, modulating synaptic transmission
K	0099524	cellular_component	postsynaptic cytosol
K	0099641	biological_process	anterograde axonal protein transport
K	0101004	cellular_component	cytolytic granule membrane
K	0160040	biological_process	mitocytosis
K	1903078	biological_process	positive regulation of protein localization to plasma membrane
K	1904115	cellular_component	axon cytoplasm
K	1990048	biological_process	anterograde neuronal dense core vesicle transport
K	1990049	biological_process	retrograde neuronal dense core vesicle transport
T	0000166	molecular_function	nucleotide binding
T	0003777	molecular_function	microtubule motor activity
T	0005515	molecular_function	protein binding
T	0005524	molecular_function	ATP binding
T	0005737	cellular_component	cytoplasm
T	0005739	cellular_component	mitochondrion
T	0005764	cellular_component	lysosome
T	0005765	cellular_component	lysosomal membrane
T	0005829	cellular_component	cytosol
T	0005856	cellular_component	cytoskeleton
T	0005871	cellular_component	kinesin complex
T	0005874	cellular_component	microtubule
T	0007018	biological_process	microtubule-based movement
T	0007028	biological_process	cytoplasm organization
T	0007411	biological_process	axon guidance
T	0008017	molecular_function	microtubule binding
T	0008574	molecular_function	plus-end-directed microtubule motor activity
T	0016020	cellular_component	membrane
T	0016887	molecular_function	ATP hydrolysis activity
T	0030139	cellular_component	endocytic vesicle
T	0031965	cellular_component	nuclear membrane
T	0031982	cellular_component	vesicle
T	0032230	biological_process	positive regulation of synaptic transmission, GABAergic
T	0032418	biological_process	lysosome localization
T	0032839	cellular_component	dendrite cytoplasm
T	0034451	cellular_component	centriolar satellite
T	0035253	cellular_component	ciliary rootlet
T	0035617	biological_process	stress granule disassembly
T	0042267	biological_process	natural killer cell mediated cytotoxicity
T	0042391	biological_process	regulation of membrane potential
T	0042802	molecular_function	identical protein binding
T	0043005	cellular_component	neuron projection
T	0043268	biological_process	positive regulation of potassium ion transport
T	0044877	molecular_function	protein-containing complex binding
T	0045296	molecular_function	cadherin binding
T	0045335	cellular_component	phagocytic vesicle
T	0047496	biological_process	vesicle transport along microtubule
T	0047497	biological_process	mitochondrion transport along microtubule
T	0048471	cellular_component	perinuclear region of cytoplasm
T	0048489	biological_process	synaptic vesicle transport
T	0051642	biological_process	centrosome localization
T	0071346	biological_process	cellular response to type II interferon
T	0072383	biological_process	plus-end-directed vesicle transport along microtubule
T	0098971	biological_process	anterograde dendritic transport of neurotransmitter receptor complex
T	0098987	biological_process	regulation of modification of synapse structure, modulating synaptic transmission
T	0099524	cellular_component	postsynaptic cytosol
T	0099641	biological_process	anterograde axonal protein transport
T	0101004	cellular_component	cytolytic granule membrane
T	0160040	biological_process	mitocytosis
T	1903078	biological_process	positive regulation of protein localization to plasma membrane
T	1904115	cellular_component	axon cytoplasm
T	1990048	biological_process	anterograde neuronal dense core vesicle transport
T	1990049	biological_process	retrograde neuronal dense core vesicle transport
t	0000166	molecular_function	nucleotide binding
t	0003777	molecular_function	microtubule motor activity
t	0005515	molecular_function	protein binding
t	0005524	molecular_function	ATP binding
t	0005737	cellular_component	cytoplasm
t	0005739	cellular_component	mitochondrion
t	0005764	cellular_component	lysosome
t	0005765	cellular_component	lysosomal membrane
t	0005829	cellular_component	cytosol
t	0005856	cellular_component	cytoskeleton
t	0005871	cellular_component	kinesin complex
t	0005874	cellular_component	microtubule
t	0007018	biological_process	microtubule-based movement
t	0007028	biological_process	cytoplasm organization
t	0007411	biological_process	axon guidance
t	0008017	molecular_function	microtubule binding
t	0008574	molecular_function	plus-end-directed microtubule motor activity
t	0016020	cellular_component	membrane
t	0016887	molecular_function	ATP hydrolysis activity
t	0030139	cellular_component	endocytic vesicle
t	0031965	cellular_component	nuclear membrane
t	0031982	cellular_component	vesicle
t	0032230	biological_process	positive regulation of synaptic transmission, GABAergic
t	0032418	biological_process	lysosome localization
t	0032839	cellular_component	dendrite cytoplasm
t	0034451	cellular_component	centriolar satellite
t	0035253	cellular_component	ciliary rootlet
t	0035617	biological_process	stress granule disassembly
t	0042267	biological_process	natural killer cell mediated cytotoxicity
t	0042391	biological_process	regulation of membrane potential
t	0042802	molecular_function	identical protein binding
t	0043005	cellular_component	neuron projection
t	0043268	biological_process	positive regulation of potassium ion transport
t	0044877	molecular_function	protein-containing complex binding
t	0045296	molecular_function	cadherin binding
t	0045335	cellular_component	phagocytic vesicle
t	0047496	biological_process	vesicle transport along microtubule
t	0047497	biological_process	mitochondrion transport along microtubule
t	0048471	cellular_component	perinuclear region of cytoplasm
t	0048489	biological_process	synaptic vesicle transport
t	0051642	biological_process	centrosome localization
t	0071346	biological_process	cellular response to type II interferon
t	0072383	biological_process	plus-end-directed vesicle transport along microtubule
t	0098971	biological_process	anterograde dendritic transport of neurotransmitter receptor complex
t	0098987	biological_process	regulation of modification of synapse structure, modulating synaptic transmission
t	0099524	cellular_component	postsynaptic cytosol
t	0099641	biological_process	anterograde axonal protein transport
t	0101004	cellular_component	cytolytic granule membrane
t	0160040	biological_process	mitocytosis
t	1903078	biological_process	positive regulation of protein localization to plasma membrane
t	1904115	cellular_component	axon cytoplasm
t	1990048	biological_process	anterograde neuronal dense core vesicle transport
t	1990049	biological_process	retrograde neuronal dense core vesicle transport

Functional Information from PROSITE/UniProt

site_id	PS00227
Number of Residues	7
Details	TUBULIN Tubulin subunits alpha, beta, and gamma signature. GGGTGSG

Chain	Residue	Details
B	GLY142-GLY148
A	GLY142-GLY148

site_id	PS00228
Number of Residues	4
Details	TUBULIN_B_AUTOREG Tubulin-beta mRNA autoregulation signal. MREI

Chain	Residue	Details
B	MET1-ILE4

site_id	PS00411
Number of Residues	12
Details	KINESIN_MOTOR_1 Kinesin motor domain signature. GKLyLVDLAGSE

Chain	Residue	Details
K	GLY225-GLU236

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	BINDING:

Chain	Residue	Details
K	GLY85
T	GLY85
t	GLY85
B	THR145
B	GLY146
B	ASN206
B	ASN228

site_id	SWS_FT_FI2
Number of Residues	3
Details	MOD_RES: N-acetylalanine => ECO:0007744\|PubMed:19413330, ECO:0007744\|PubMed:22223895, ECO:0007744\|PubMed:22814378

Chain	Residue	Details
K	ALA2
T	ALA2
t	ALA2
A	GLY144
A	THR145
A	THR179
A	ASN206
A	ASN228

site_id	SWS_FT_FI3
Number of Residues	3
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:20068231

Chain	Residue	Details
K	SER933
T	SER933
t	SER933

site_id	SWS_FT_FI4
Number of Residues	3
Details	MOD_RES: Omega-N-methylarginine => ECO:0007744\|PubMed:24129315

Chain	Residue	Details
K	ARG956
T	ARG956
t	ARG956

site_id	SWS_FT_FI5
Number of Residues	6
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744\|PubMed:28112733

Chain	Residue	Details
K	LYS213
A	SER232
T	LYS213
t	LYS213

site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: 3'-nitrotyrosine => ECO:0000250\|UniProtKB:P68373

Chain	Residue	Details
A	TYR282
B	THR292

site_id	SWS_FT_FI7
Number of Residues	1
Details	MOD_RES: Omega-N-methylarginine => ECO:0000250\|UniProtKB:P68363

Chain	Residue	Details
A	ARG339

site_id	SWS_FT_FI8
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:P68373

Chain	Residue	Details
A	SER439

site_id	SWS_FT_FI9
Number of Residues	1
Details	MOD_RES: 5-glutamyl polyglutamate => ECO:0000250\|UniProtKB:P68363

Chain	Residue	Details
A	GLU443

site_id	SWS_FT_FI10
Number of Residues	1
Details	MOD_RES: 5-glutamyl polyglutamate => ECO:0000250\|UniProtKB:P68369

Chain	Residue	Details
A	GLU445
B	LYS326

site_id	SWS_FT_FI11
Number of Residues	1
Details	MOD_RES: 3'-nitrotyrosine => ECO:0000250\|UniProtKB:Q71U36

Chain	Residue	Details
A	TYR451

site_id	SWS_FT_FI12
Number of Residues	3
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250\|UniProtKB:P68363

Chain	Residue	Details
A	LYS326
A	LYS370

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)