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8RHK

Yeast 20S proteasome in complex with a linear oxindole epoxyketone (compound 6)

This is a non-PDB format compatible entry.
Functional Information from GO Data
ChainGOidnamespacecontents
a0000502cellular_componentproteasome complex
a0003674molecular_functionmolecular_function
a0005515molecular_functionprotein binding
a0005634cellular_componentnucleus
a0005737cellular_componentcytoplasm
a0005829cellular_componentcytosol
a0010499biological_processproteasomal ubiquitin-independent protein catabolic process
a0019774cellular_componentproteasome core complex, beta-subunit complex
a0034515cellular_componentproteasome storage granule
a0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
a0043248biological_processproteasome assembly
A0000502cellular_componentproteasome complex
A0003674molecular_functionmolecular_function
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0010499biological_processproteasomal ubiquitin-independent protein catabolic process
A0019773cellular_componentproteasome core complex, alpha-subunit complex
A0034515cellular_componentproteasome storage granule
A0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
b0000502cellular_componentproteasome complex
b0004175molecular_functionendopeptidase activity
b0004298molecular_functionthreonine-type endopeptidase activity
b0005515molecular_functionprotein binding
b0005634cellular_componentnucleus
b0005737cellular_componentcytoplasm
b0005829cellular_componentcytosol
b0006508biological_processproteolysis
b0010499biological_processproteasomal ubiquitin-independent protein catabolic process
b0019774cellular_componentproteasome core complex, beta-subunit complex
b0034515cellular_componentproteasome storage granule
b0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
B0000502cellular_componentproteasome complex
B0003674molecular_functionmolecular_function
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0010499biological_processproteasomal ubiquitin-independent protein catabolic process
B0019773cellular_componentproteasome core complex, alpha-subunit complex
B0034515cellular_componentproteasome storage granule
B0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
B0080129biological_processproteasome core complex assembly
C0000502cellular_componentproteasome complex
C0003674molecular_functionmolecular_function
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0005739cellular_componentmitochondrion
C0010499biological_processproteasomal ubiquitin-independent protein catabolic process
C0019773cellular_componentproteasome core complex, alpha-subunit complex
C0034515cellular_componentproteasome storage granule
C0042175cellular_componentnuclear outer membrane-endoplasmic reticulum membrane network
C0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
D0000502cellular_componentproteasome complex
D0003674molecular_functionmolecular_function
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005737cellular_componentcytoplasm
D0010499biological_processproteasomal ubiquitin-independent protein catabolic process
D0019773cellular_componentproteasome core complex, alpha-subunit complex
D0034515cellular_componentproteasome storage granule
D0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
E0000502cellular_componentproteasome complex
E0003674molecular_functionmolecular_function
E0005515molecular_functionprotein binding
E0005634cellular_componentnucleus
E0005737cellular_componentcytoplasm
E0010499biological_processproteasomal ubiquitin-independent protein catabolic process
E0019773cellular_componentproteasome core complex, alpha-subunit complex
E0034515cellular_componentproteasome storage granule
E0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
F0000502cellular_componentproteasome complex
F0003729molecular_functionmRNA binding
F0005515molecular_functionprotein binding
F0005634cellular_componentnucleus
F0005737cellular_componentcytoplasm
F0010499biological_processproteasomal ubiquitin-independent protein catabolic process
F0019773cellular_componentproteasome core complex, alpha-subunit complex
F0034515cellular_componentproteasome storage granule
F0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
G0000502cellular_componentproteasome complex
G0003674molecular_functionmolecular_function
G0005515molecular_functionprotein binding
G0005634cellular_componentnucleus
G0005737cellular_componentcytoplasm
G0005739cellular_componentmitochondrion
G0010499biological_processproteasomal ubiquitin-independent protein catabolic process
G0019773cellular_componentproteasome core complex, alpha-subunit complex
G0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
I0000502cellular_componentproteasome complex
I0005515molecular_functionprotein binding
I0005634cellular_componentnucleus
I0005737cellular_componentcytoplasm
I0005829cellular_componentcytosol
I0010499biological_processproteasomal ubiquitin-independent protein catabolic process
I0019774cellular_componentproteasome core complex, beta-subunit complex
I0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
I0061133molecular_functionendopeptidase activator activity
J0000502cellular_componentproteasome complex
J0005515molecular_functionprotein binding
J0005634cellular_componentnucleus
J0005737cellular_componentcytoplasm
J0005789cellular_componentendoplasmic reticulum membrane
J0005829cellular_componentcytosol
J0010499biological_processproteasomal ubiquitin-independent protein catabolic process
J0019774cellular_componentproteasome core complex, beta-subunit complex
J0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
J0061133molecular_functionendopeptidase activator activity
L0000502cellular_componentproteasome complex
L0003674molecular_functionmolecular_function
L0005515molecular_functionprotein binding
L0005634cellular_componentnucleus
L0005737cellular_componentcytoplasm
L0005829cellular_componentcytosol
L0010499biological_processproteasomal ubiquitin-independent protein catabolic process
L0019774cellular_componentproteasome core complex, beta-subunit complex
L0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
M0000502cellular_componentproteasome complex
M0003674molecular_functionmolecular_function
M0005515molecular_functionprotein binding
M0005634cellular_componentnucleus
M0005737cellular_componentcytoplasm
M0005829cellular_componentcytosol
M0010499biological_processproteasomal ubiquitin-independent protein catabolic process
M0019774cellular_componentproteasome core complex, beta-subunit complex
M0034515cellular_componentproteasome storage granule
M0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
M0043248biological_processproteasome assembly
N0000502cellular_componentproteasome complex
N0004175molecular_functionendopeptidase activity
N0004298molecular_functionthreonine-type endopeptidase activity
N0005515molecular_functionprotein binding
N0005634cellular_componentnucleus
N0005737cellular_componentcytoplasm
N0005829cellular_componentcytosol
N0006508biological_processproteolysis
N0010499biological_processproteasomal ubiquitin-independent protein catabolic process
N0019774cellular_componentproteasome core complex, beta-subunit complex
N0034515cellular_componentproteasome storage granule
N0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
O0000502cellular_componentproteasome complex
O0003674molecular_functionmolecular_function
O0005515molecular_functionprotein binding
O0005634cellular_componentnucleus
O0005737cellular_componentcytoplasm
O0010499biological_processproteasomal ubiquitin-independent protein catabolic process
O0019773cellular_componentproteasome core complex, alpha-subunit complex
O0034515cellular_componentproteasome storage granule
O0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
P0000502cellular_componentproteasome complex
P0003674molecular_functionmolecular_function
P0005515molecular_functionprotein binding
P0005634cellular_componentnucleus
P0005737cellular_componentcytoplasm
P0005829cellular_componentcytosol
P0010499biological_processproteasomal ubiquitin-independent protein catabolic process
P0019773cellular_componentproteasome core complex, alpha-subunit complex
P0034515cellular_componentproteasome storage granule
P0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
P0080129biological_processproteasome core complex assembly
Q0000502cellular_componentproteasome complex
Q0003674molecular_functionmolecular_function
Q0005515molecular_functionprotein binding
Q0005634cellular_componentnucleus
Q0005737cellular_componentcytoplasm
Q0005739cellular_componentmitochondrion
Q0010499biological_processproteasomal ubiquitin-independent protein catabolic process
Q0019773cellular_componentproteasome core complex, alpha-subunit complex
Q0034515cellular_componentproteasome storage granule
Q0042175cellular_componentnuclear outer membrane-endoplasmic reticulum membrane network
Q0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
R0000502cellular_componentproteasome complex
R0003674molecular_functionmolecular_function
R0005515molecular_functionprotein binding
R0005634cellular_componentnucleus
R0005737cellular_componentcytoplasm
R0010499biological_processproteasomal ubiquitin-independent protein catabolic process
R0019773cellular_componentproteasome core complex, alpha-subunit complex
R0034515cellular_componentproteasome storage granule
R0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
S0000502cellular_componentproteasome complex
S0003674molecular_functionmolecular_function
S0005515molecular_functionprotein binding
S0005634cellular_componentnucleus
S0005737cellular_componentcytoplasm
S0010499biological_processproteasomal ubiquitin-independent protein catabolic process
S0019773cellular_componentproteasome core complex, alpha-subunit complex
S0034515cellular_componentproteasome storage granule
S0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
T0000502cellular_componentproteasome complex
T0003729molecular_functionmRNA binding
T0005515molecular_functionprotein binding
T0005634cellular_componentnucleus
T0005737cellular_componentcytoplasm
T0010499biological_processproteasomal ubiquitin-independent protein catabolic process
T0019773cellular_componentproteasome core complex, alpha-subunit complex
T0034515cellular_componentproteasome storage granule
T0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
U0000502cellular_componentproteasome complex
U0003674molecular_functionmolecular_function
U0005515molecular_functionprotein binding
U0005634cellular_componentnucleus
U0005737cellular_componentcytoplasm
U0005739cellular_componentmitochondrion
U0010499biological_processproteasomal ubiquitin-independent protein catabolic process
U0019773cellular_componentproteasome core complex, alpha-subunit complex
U0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
W0000502cellular_componentproteasome complex
W0005515molecular_functionprotein binding
W0005634cellular_componentnucleus
W0005737cellular_componentcytoplasm
W0005829cellular_componentcytosol
W0010499biological_processproteasomal ubiquitin-independent protein catabolic process
W0019774cellular_componentproteasome core complex, beta-subunit complex
W0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
W0061133molecular_functionendopeptidase activator activity
X0000502cellular_componentproteasome complex
X0005515molecular_functionprotein binding
X0005634cellular_componentnucleus
X0005737cellular_componentcytoplasm
X0005789cellular_componentendoplasmic reticulum membrane
X0005829cellular_componentcytosol
X0010499biological_processproteasomal ubiquitin-independent protein catabolic process
X0019774cellular_componentproteasome core complex, beta-subunit complex
X0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
X0061133molecular_functionendopeptidase activator activity
Z0000502cellular_componentproteasome complex
Z0003674molecular_functionmolecular_function
Z0005515molecular_functionprotein binding
Z0005634cellular_componentnucleus
Z0005737cellular_componentcytoplasm
Z0005829cellular_componentcytosol
Z0010499biological_processproteasomal ubiquitin-independent protein catabolic process
Z0019774cellular_componentproteasome core complex, beta-subunit complex
Z0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
Functional Information from PROSITE/UniProt
site_idPS00388
Number of Residues23
DetailsPROTEASOME_ALPHA_1 Proteasome alpha-type subunits signature. YdrhiTiFSPeGRlyQVEYAfkA
ChainResidueDetails
GTYR3-ALA25
CTYR2-ALA24
DTYR0-ALA22
BTYR5-SER27
ETYR5-ALA27
ATYR5-ALA27
FTYR4-ALA26

site_idPS00854
Number of Residues48
DetailsPROTEASOME_BETA_1 Proteasome beta-type subunits signature. ISMkYdnGVIIAADnlgsygsllrfngve.RlipvgdntvvgisGdiSD
ChainResidueDetails
aILE12-ASP59
KLEU9-ASP56
CVAL32-ASP79
LLEU13-ASP60
BILE35-ASP82
JLEU5-ASP52
bMET9-ASP56
IVAL12-ASP58
HVAL9-ASP56

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0007744|PubMed:22106047
ChainResidueDetails
ALYS108
SSER13
OLYS108
BLYS230
PLYS99
PLYS198
PLYS230

site_idSWS_FT_FI2
Number of Residues4
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0007744|PubMed:22106047
ChainResidueDetails
ELYS190
RSER48
SLYS190

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:17330950, ECO:0007744|PubMed:18407956, ECO:0007744|PubMed:19779198
ChainResidueDetails
DSER243
RSER243
ULYS223

Catalytic Information from CSA
site_idMCSA1
Number of Residues8
DetailsM-CSA 177
ChainResidueDetails
HTHR6covalently attached, hydrogen bond acceptor, hydrogen bond donor, nucleofuge, nucleophile, proton acceptor, proton donor
HASP22activator, steric locator
HARG24activator
HLYS38activator, electrostatic stabiliser
HGLY52electrostatic stabiliser
HSER134activator, electrostatic stabiliser
HASP171activator, steric locator
HSER174activator, electrostatic stabiliser

site_idMCSA2
Number of Residues8
DetailsM-CSA 177
ChainResidueDetails
VTHR6covalently attached, hydrogen bond acceptor, hydrogen bond donor, nucleofuge, nucleophile, proton acceptor, proton donor
VASP22activator, steric locator
VARG24activator
VLYS38activator, electrostatic stabiliser
VGLY52electrostatic stabiliser
VSER134activator, electrostatic stabiliser
VASP171activator, steric locator
VSER174activator, electrostatic stabiliser

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PDB entries from 2024-07-24

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