8RHB
Microtubule-associated kinesin-1 tail complex bound to AMPPNP, single-headed state
This is a non-PDB format compatible entry.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000226 | biological_process | microtubule cytoskeleton organization |
| A | 0000278 | biological_process | mitotic cell cycle |
| A | 0003924 | molecular_function | GTPase activity |
| A | 0005200 | molecular_function | structural constituent of cytoskeleton |
| A | 0005525 | molecular_function | GTP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005856 | cellular_component | cytoskeleton |
| A | 0005874 | cellular_component | microtubule |
| A | 0007017 | biological_process | microtubule-based process |
| A | 0015630 | cellular_component | microtubule cytoskeleton |
| A | 0030182 | biological_process | neuron differentiation |
| B | 0000226 | biological_process | microtubule cytoskeleton organization |
| B | 0000278 | biological_process | mitotic cell cycle |
| B | 0001764 | biological_process | neuron migration |
| B | 0003924 | molecular_function | GTPase activity |
| B | 0005200 | molecular_function | structural constituent of cytoskeleton |
| B | 0005515 | molecular_function | protein binding |
| B | 0005525 | molecular_function | GTP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005856 | cellular_component | cytoskeleton |
| B | 0005874 | cellular_component | microtubule |
| B | 0007017 | biological_process | microtubule-based process |
| K | 0003777 | molecular_function | microtubule motor activity |
| K | 0005515 | molecular_function | protein binding |
| K | 0005524 | molecular_function | ATP binding |
| K | 0005737 | cellular_component | cytoplasm |
| K | 0005765 | cellular_component | lysosomal membrane |
| K | 0005829 | cellular_component | cytosol |
| K | 0005856 | cellular_component | cytoskeleton |
| K | 0005871 | cellular_component | kinesin complex |
| K | 0005874 | cellular_component | microtubule |
| K | 0007018 | biological_process | microtubule-based movement |
| K | 0008017 | molecular_function | microtubule binding |
| K | 0008574 | molecular_function | plus-end-directed microtubule motor activity |
| K | 0016020 | cellular_component | membrane |
| K | 0016887 | molecular_function | ATP hydrolysis activity |
| K | 0031982 | cellular_component | vesicle |
| K | 0032230 | biological_process | positive regulation of synaptic transmission, GABAergic |
| K | 0032418 | biological_process | lysosome localization |
| K | 0032839 | cellular_component | dendrite cytoplasm |
| K | 0035617 | biological_process | stress granule disassembly |
| K | 0042267 | biological_process | natural killer cell mediated cytotoxicity |
| K | 0042391 | biological_process | regulation of membrane potential |
| K | 0042802 | molecular_function | identical protein binding |
| K | 0043268 | biological_process | positive regulation of potassium ion transport |
| K | 0045296 | molecular_function | cadherin binding |
| K | 0047496 | biological_process | vesicle transport along microtubule |
| K | 0048471 | cellular_component | perinuclear region of cytoplasm |
| K | 0048489 | biological_process | synaptic vesicle transport |
| K | 0051642 | biological_process | centrosome localization |
| K | 0098957 | biological_process | anterograde axonal transport of mitochondrion |
| K | 0098971 | biological_process | anterograde dendritic transport of neurotransmitter receptor complex |
| K | 0099641 | biological_process | anterograde axonal protein transport |
| K | 0101004 | cellular_component | cytolytic granule membrane |
| K | 1903078 | biological_process | positive regulation of protein localization to plasma membrane |
| K | 1904115 | cellular_component | axon cytoplasm |
| K | 1990048 | biological_process | anterograde neuronal dense core vesicle transport |
| K | 1990049 | biological_process | retrograde neuronal dense core vesicle transport |
| T | 0003777 | molecular_function | microtubule motor activity |
| T | 0005515 | molecular_function | protein binding |
| T | 0005524 | molecular_function | ATP binding |
| T | 0005737 | cellular_component | cytoplasm |
| T | 0005765 | cellular_component | lysosomal membrane |
| T | 0005829 | cellular_component | cytosol |
| T | 0005856 | cellular_component | cytoskeleton |
| T | 0005871 | cellular_component | kinesin complex |
| T | 0005874 | cellular_component | microtubule |
| T | 0007018 | biological_process | microtubule-based movement |
| T | 0008017 | molecular_function | microtubule binding |
| T | 0008574 | molecular_function | plus-end-directed microtubule motor activity |
| T | 0016020 | cellular_component | membrane |
| T | 0016887 | molecular_function | ATP hydrolysis activity |
| T | 0031982 | cellular_component | vesicle |
| T | 0032230 | biological_process | positive regulation of synaptic transmission, GABAergic |
| T | 0032418 | biological_process | lysosome localization |
| T | 0032839 | cellular_component | dendrite cytoplasm |
| T | 0035617 | biological_process | stress granule disassembly |
| T | 0042267 | biological_process | natural killer cell mediated cytotoxicity |
| T | 0042391 | biological_process | regulation of membrane potential |
| T | 0042802 | molecular_function | identical protein binding |
| T | 0043268 | biological_process | positive regulation of potassium ion transport |
| T | 0045296 | molecular_function | cadherin binding |
| T | 0047496 | biological_process | vesicle transport along microtubule |
| T | 0048471 | cellular_component | perinuclear region of cytoplasm |
| T | 0048489 | biological_process | synaptic vesicle transport |
| T | 0051642 | biological_process | centrosome localization |
| T | 0098957 | biological_process | anterograde axonal transport of mitochondrion |
| T | 0098971 | biological_process | anterograde dendritic transport of neurotransmitter receptor complex |
| T | 0099641 | biological_process | anterograde axonal protein transport |
| T | 0101004 | cellular_component | cytolytic granule membrane |
| T | 1903078 | biological_process | positive regulation of protein localization to plasma membrane |
| T | 1904115 | cellular_component | axon cytoplasm |
| T | 1990048 | biological_process | anterograde neuronal dense core vesicle transport |
| T | 1990049 | biological_process | retrograde neuronal dense core vesicle transport |
Functional Information from PROSITE/UniProt
| site_id | PS00227 |
| Number of Residues | 7 |
| Details | TUBULIN Tubulin subunits alpha, beta, and gamma signature. GGGTGSG |
| Chain | Residue | Details |
| A | GLY142-GLY148 | |
| B | GLY142-GLY148 |
| site_id | PS00228 |
| Number of Residues | 4 |
| Details | TUBULIN_B_AUTOREG Tubulin-beta mRNA autoregulation signal. MREI |
| Chain | Residue | Details |
| B | MET1-ILE4 |
| site_id | PS00411 |
| Number of Residues | 12 |
| Details | KINESIN_MOTOR_1 Kinesin motor domain signature. GKLyLVDLAGSE |
| Chain | Residue | Details |
| K | GLY225-GLU236 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | Motif: {"description":"MREI motif","evidences":[{"source":"UniProtKB","id":"P07437","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 7 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"Q13509","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 18 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P68363","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P99024","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P99024","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine; by CDK1","evidences":[{"source":"UniProtKB","id":"Q13885","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P07437","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Omega-N-methylarginine","evidences":[{"source":"UniProtKB","id":"P07437","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","evidences":[{"source":"UniProtKB","id":"P07437","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"UniProtKB","id":"P07437","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 317 |
| Details | Domain: {"description":"Kinesin motor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00283","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 7 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 2 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 3 |
| Details | Motif: {"description":"MREC motif","evidences":[{"source":"UniProtKB","id":"P68363","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI15 |
| Number of Residues | 1 |
| Details | Active site: {"evidences":[{"source":"UniProtKB","id":"P68363","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI16 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P68363","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI17 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"3'-nitrotyrosine","evidences":[{"source":"UniProtKB","id":"P68373","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI18 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Omega-N-methylarginine","evidences":[{"source":"UniProtKB","id":"P68363","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI19 |
| Number of Residues | 3 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"UniProtKB","id":"P68363","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
