8RFM
Human NOQ1 enzyme in complex with NADH by serial crystallography
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 28 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:10543876, ECO:0000269|PubMed:10706635, ECO:0000269|PubMed:11735396 |
| Chain | Residue | Details |
| A | HIS12 | |
| B | GLN67 | |
| B | LEU104 | |
| B | THR148 | |
| B | TYR156 | |
| B | ARG201 | |
| C | HIS12 | |
| C | PHE18 | |
| C | GLN67 | |
| C | LEU104 | |
| C | THR148 | |
| A | PHE18 | |
| C | TYR156 | |
| C | ARG201 | |
| D | HIS12 | |
| D | PHE18 | |
| D | GLN67 | |
| D | LEU104 | |
| D | THR148 | |
| D | TYR156 | |
| D | ARG201 | |
| A | GLN67 | |
| A | LEU104 | |
| A | THR148 | |
| A | TYR156 | |
| A | ARG201 | |
| B | HIS12 | |
| B | PHE18 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | ALA126 | |
| B | ALA126 | |
| C | ALA126 | |
| D | ALA126 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER82 | |
| B | SER82 | |
| C | SER82 | |
| D | SER82 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 12 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 |
| Chain | Residue | Details |
| A | LYS250 | |
| D | LYS250 | |
| D | LYS251 | |
| A | LYS251 | |
| B | LYS250 | |
| B | LYS251 | |
| C | LYS250 | |
| C | LYS251 |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 3 |
| Details | M-CSA 3 |
| Chain | Residue | Details |
| A | GLY150 | electrostatic stabiliser, hydrogen bond donor |
| A | TYR156 | electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay |
| A | HIS162 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay |
| site_id | MCSA2 |
| Number of Residues | 3 |
| Details | M-CSA 3 |
| Chain | Residue | Details |
| B | GLY150 | electrostatic stabiliser, hydrogen bond donor |
| B | TYR156 | electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay |
| B | HIS162 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay |
| site_id | MCSA3 |
| Number of Residues | 3 |
| Details | M-CSA 3 |
| Chain | Residue | Details |
| C | GLY150 | electrostatic stabiliser, hydrogen bond donor |
| C | TYR156 | electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay |
| C | HIS162 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay |
| site_id | MCSA4 |
| Number of Residues | 3 |
| Details | M-CSA 3 |
| Chain | Residue | Details |
| D | GLY150 | electrostatic stabiliser, hydrogen bond donor |
| D | TYR156 | electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay |
| D | HIS162 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay |
