8RFA

Arginase 2 in complex with an inhibitor

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000050	biological_process	urea cycle
A	0001657	biological_process	ureteric bud development
A	0002250	biological_process	adaptive immune response
A	0002376	biological_process	immune system process
A	0002829	biological_process	negative regulation of type 2 immune response
A	0004053	molecular_function	arginase activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005759	cellular_component	mitochondrial matrix
A	0006525	biological_process	arginine metabolic process
A	0006809	biological_process	nitric oxide biosynthetic process
A	0006941	biological_process	striated muscle contraction
A	0016787	molecular_function	hydrolase activity
A	0016813	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
A	0030145	molecular_function	manganese ion binding
A	0032651	biological_process	regulation of interleukin-1 beta production
A	0032696	biological_process	negative regulation of interleukin-13 production
A	0032700	biological_process	negative regulation of interleukin-17 production
A	0032720	biological_process	negative regulation of tumor necrosis factor production
A	0045087	biological_process	innate immune response
A	0046872	molecular_function	metal ion binding
A	0051241	biological_process	negative regulation of multicellular organismal process
A	0071641	biological_process	negative regulation of macrophage inflammatory protein 1 alpha production
A	0071644	biological_process	negative regulation of chemokine (C-C motif) ligand 4 production
A	0071650	biological_process	negative regulation of chemokine (C-C motif) ligand 5 production
A	1900425	biological_process	negative regulation of defense response to bacterium
A	1903426	biological_process	regulation of reactive oxygen species biosynthetic process
A	1905403	biological_process	negative regulation of activated CD8-positive, alpha-beta T cell apoptotic process
A	2000562	biological_process	negative regulation of CD4-positive, alpha-beta T cell proliferation
A	2000774	biological_process	positive regulation of cellular senescence
B	0000050	biological_process	urea cycle
B	0001657	biological_process	ureteric bud development
B	0002250	biological_process	adaptive immune response
B	0002376	biological_process	immune system process
B	0002829	biological_process	negative regulation of type 2 immune response
B	0004053	molecular_function	arginase activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005759	cellular_component	mitochondrial matrix
B	0006525	biological_process	arginine metabolic process
B	0006809	biological_process	nitric oxide biosynthetic process
B	0006941	biological_process	striated muscle contraction
B	0016787	molecular_function	hydrolase activity
B	0016813	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
B	0030145	molecular_function	manganese ion binding
B	0032651	biological_process	regulation of interleukin-1 beta production
B	0032696	biological_process	negative regulation of interleukin-13 production
B	0032700	biological_process	negative regulation of interleukin-17 production
B	0032720	biological_process	negative regulation of tumor necrosis factor production
B	0045087	biological_process	innate immune response
B	0046872	molecular_function	metal ion binding
B	0051241	biological_process	negative regulation of multicellular organismal process
B	0071641	biological_process	negative regulation of macrophage inflammatory protein 1 alpha production
B	0071644	biological_process	negative regulation of chemokine (C-C motif) ligand 4 production
B	0071650	biological_process	negative regulation of chemokine (C-C motif) ligand 5 production
B	1900425	biological_process	negative regulation of defense response to bacterium
B	1903426	biological_process	regulation of reactive oxygen species biosynthetic process
B	1905403	biological_process	negative regulation of activated CD8-positive, alpha-beta T cell apoptotic process
B	2000562	biological_process	negative regulation of CD4-positive, alpha-beta T cell proliferation
B	2000774	biological_process	positive regulation of cellular senescence
C	0000050	biological_process	urea cycle
C	0001657	biological_process	ureteric bud development
C	0002250	biological_process	adaptive immune response
C	0002376	biological_process	immune system process
C	0002829	biological_process	negative regulation of type 2 immune response
C	0004053	molecular_function	arginase activity
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0005759	cellular_component	mitochondrial matrix
C	0006525	biological_process	arginine metabolic process
C	0006809	biological_process	nitric oxide biosynthetic process
C	0006941	biological_process	striated muscle contraction
C	0016787	molecular_function	hydrolase activity
C	0016813	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
C	0030145	molecular_function	manganese ion binding
C	0032651	biological_process	regulation of interleukin-1 beta production
C	0032696	biological_process	negative regulation of interleukin-13 production
C	0032700	biological_process	negative regulation of interleukin-17 production
C	0032720	biological_process	negative regulation of tumor necrosis factor production
C	0045087	biological_process	innate immune response
C	0046872	molecular_function	metal ion binding
C	0051241	biological_process	negative regulation of multicellular organismal process
C	0071641	biological_process	negative regulation of macrophage inflammatory protein 1 alpha production
C	0071644	biological_process	negative regulation of chemokine (C-C motif) ligand 4 production
C	0071650	biological_process	negative regulation of chemokine (C-C motif) ligand 5 production
C	1900425	biological_process	negative regulation of defense response to bacterium
C	1903426	biological_process	regulation of reactive oxygen species biosynthetic process
C	1905403	biological_process	negative regulation of activated CD8-positive, alpha-beta T cell apoptotic process
C	2000562	biological_process	negative regulation of CD4-positive, alpha-beta T cell proliferation
C	2000774	biological_process	positive regulation of cellular senescence

Functional Information from PROSITE/UniProt

site_id	PS01053
Number of Residues	22
Details	ARGINASE_1 Arginase family signature. SFDIDafdPtlaPAtgtpvvgG

Chain	Residue	Details
A	SER249-GLY270

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	36
Details	Binding site: {"evidences":[{"source":"PubMed","id":"12859189","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1PQ3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4HZE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4I06","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4IE2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4IE3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4IXU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4IXV","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P53608","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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