8RCZ

Structure of the enoyl-ACP reductase FabV from Pseudomonas aeruginosa with NADH cofactor

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004318	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADH) activity
A	0006629	biological_process	lipid metabolic process
A	0006631	biological_process	fatty acid metabolic process
A	0006633	biological_process	fatty acid biosynthetic process
A	0016491	molecular_function	oxidoreductase activity
A	0050343	molecular_function	trans-2-enoyl-CoA reductase (NADH) activity
A	0051287	molecular_function	NAD binding
B	0004318	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADH) activity
B	0006629	biological_process	lipid metabolic process
B	0006631	biological_process	fatty acid metabolic process
B	0006633	biological_process	fatty acid biosynthetic process
B	0016491	molecular_function	oxidoreductase activity
B	0050343	molecular_function	trans-2-enoyl-CoA reductase (NADH) activity
B	0051287	molecular_function	NAD binding

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: Proton donor => ECO:0000255|HAMAP-Rule:MF_01838

Chain	Residue	Details
A	TYR237
B	TYR237

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site_id	SWS_FT_FI2
Number of Residues	14
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01838

Chain	Residue	Details
A	GLY50
B	ASP113
B	LEU141
B	TYR227
B	LYS246
B	VAL275
A	PHE76
A	ASP113
A	LEU141
A	TYR227
A	LYS246
A	VAL275
B	GLY50
B	PHE76

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site_id	SWS_FT_FI3
Number of Residues	2
Details	SITE: Plays an important role in discriminating NADH against NADPH => ECO:0000255|HAMAP-Rule:MF_01838

Chain	Residue	Details
A	GLU77
B	GLU77

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