8RCR
human TRPM4 in SMA apo
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 492 |
| Details | TRANSMEM: Helical => ECO:0000269|PubMed:29211723, ECO:0000269|PubMed:29217581 |
| Chain | Residue | Details |
| A | PHE783-VAL803 | |
| B | LEU887-PHE910 | |
| B | PHE931-LEU951 | |
| B | VAL1020-ILE1040 | |
| C | PHE783-VAL803 | |
| C | LEU815-GLY835 | |
| C | TRP864-THR884 | |
| C | LEU887-PHE910 | |
| C | PHE931-LEU951 | |
| C | VAL1020-ILE1040 | |
| D | PHE783-VAL803 | |
| A | LEU815-GLY835 | |
| D | LEU815-GLY835 | |
| D | TRP864-THR884 | |
| D | LEU887-PHE910 | |
| D | PHE931-LEU951 | |
| D | VAL1020-ILE1040 | |
| A | TRP864-THR884 | |
| A | LEU887-PHE910 | |
| A | PHE931-LEU951 | |
| A | VAL1020-ILE1040 | |
| B | PHE783-VAL803 | |
| B | LEU815-GLY835 | |
| B | TRP864-THR884 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 224 |
| Details | TOPO_DOM: Extracellular => ECO:0000269|PubMed:29211723, ECO:0000269|PubMed:29217581 |
| Chain | Residue | Details |
| A | ASP804-GLU814 | |
| C | PRO885-GLY886 | |
| C | LEU952-LEU963 | |
| C | VAL985-LEU1019 | |
| D | ASP804-GLU814 | |
| D | PRO885-GLY886 | |
| D | LEU952-LEU963 | |
| D | VAL985-LEU1019 | |
| A | PRO885-GLY886 | |
| A | LEU952-LEU963 | |
| A | VAL985-LEU1019 | |
| B | ASP804-GLU814 | |
| B | PRO885-GLY886 | |
| B | LEU952-LEU963 | |
| B | VAL985-LEU1019 | |
| C | ASP804-GLU814 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 184 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:29211723, ECO:0000269|PubMed:29217581 |
| Chain | Residue | Details |
| A | GLY836-SER863 | |
| A | THR911-VAL930 | |
| B | GLY836-SER863 | |
| B | THR911-VAL930 | |
| C | GLY836-SER863 | |
| C | THR911-VAL930 | |
| D | GLY836-SER863 | |
| D | THR911-VAL930 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 80 |
| Details | INTRAMEM: Pore-forming => ECO:0000269|PubMed:29211723, ECO:0000269|PubMed:29217581 |
| Chain | Residue | Details |
| A | ARG964-ASP984 | |
| B | ARG964-ASP984 | |
| C | ARG964-ASP984 | |
| D | ARG964-ASP984 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 8 |
| Details | BINDING: in other chain => ECO:0000250|UniProtKB:Q7TN37 |
| Chain | Residue | Details |
| A | ARG421 | |
| A | GLY448 | |
| B | ARG421 | |
| B | GLY448 | |
| C | ARG421 | |
| C | GLY448 | |
| D | ARG421 | |
| D | GLY448 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:29217581, ECO:0007744|PDB:6BQV |
| Chain | Residue | Details |
| A | GLU828 | |
| B | GLU828 | |
| C | GLU828 | |
| D | GLU828 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:29217581, ECO:0000269|PubMed:38750366, ECO:0007744|PDB:6BQV, ECO:0007744|PDB:9B92 |
| Chain | Residue | Details |
| A | GLN831 | |
| A | ASN865 | |
| B | GLN831 | |
| B | ASN865 | |
| C | GLN831 | |
| C | ASN865 | |
| D | GLN831 | |
| D | ASN865 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:38750366, ECO:0000305|PubMed:29217581, ECO:0007744|PDB:6BQV, ECO:0007744|PDB:9B92 |
| Chain | Residue | Details |
| A | ASP868 | |
| B | ASP868 | |
| C | ASP868 | |
| D | ASP868 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 8 |
| Details | MOD_RES: Phosphoserine; by PKC => ECO:0000305|PubMed:15590641 |
| Chain | Residue | Details |
| A | SER1145 | |
| A | SER1152 | |
| B | SER1145 | |
| B | SER1152 | |
| C | SER1145 | |
| C | SER1152 | |
| D | SER1145 | |
| D | SER1152 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 4 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:29217581 |
| Chain | Residue | Details |
| A | ASN992 | |
| B | ASN992 | |
| C | ASN992 | |
| D | ASN992 |
