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8RCK

CryoEM structure of mTORC1 with a paediatric kidney cancer-associated 1455-EWED-1458 duplication in mTOR, Focused on one protomer copy.

Functional Information from GO Data
ChainGOidnamespacecontents
B0000139cellular_componentGolgi membrane
B0000822molecular_functioninositol hexakisphosphate binding
B0001002molecular_functionRNA polymerase III type 1 promoter sequence-specific DNA binding
B0001003molecular_functionRNA polymerase III type 2 promoter sequence-specific DNA binding
B0001006molecular_functionRNA polymerase III type 3 promoter sequence-specific DNA binding
B0001156molecular_functionTFIIIC-class transcription factor complex binding
B0001558biological_processregulation of cell growth
B0002296biological_processT-helper 1 cell lineage commitment
B0003007biological_processheart morphogenesis
B0003179biological_processheart valve morphogenesis
B0004672molecular_functionprotein kinase activity
B0004674molecular_functionprotein serine/threonine kinase activity
B0004676molecular_function3-phosphoinositide-dependent protein kinase activity
B0004677molecular_functionDNA-dependent protein kinase activity
B0004679molecular_functionAMP-activated protein kinase activity
B0004694molecular_functioneukaryotic translation initiation factor 2alpha kinase activity
B0004711molecular_functionribosomal protein S6 kinase activity
B0004713molecular_functionprotein tyrosine kinase activity
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005634cellular_componentnucleus
B0005635cellular_componentnuclear envelope
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005741cellular_componentmitochondrial outer membrane
B0005764cellular_componentlysosome
B0005765cellular_componentlysosomal membrane
B0005783cellular_componentendoplasmic reticulum
B0005789cellular_componentendoplasmic reticulum membrane
B0005794cellular_componentGolgi apparatus
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0006112biological_processenergy reserve metabolic process
B0006207biological_process'de novo' pyrimidine nucleobase biosynthetic process
B0006338biological_processchromatin remodeling
B0006954biological_processinflammatory response
B0006974biological_processDNA damage response
B0007010biological_processcytoskeleton organization
B0007281biological_processgerm cell development
B0008361biological_processregulation of cell size
B0009267biological_processcellular response to starvation
B0009408biological_processresponse to heat
B0009791biological_processpost-embryonic development
B0010506biological_processregulation of autophagy
B0010507biological_processnegative regulation of autophagy
B0010592biological_processpositive regulation of lamellipodium assembly
B0010718biological_processpositive regulation of epithelial to mesenchymal transition
B0010831biological_processpositive regulation of myotube differentiation
B0012505cellular_componentendomembrane system
B0016020cellular_componentmembrane
B0016236biological_processmacroautophagy
B0016241biological_processregulation of macroautophagy
B0016242biological_processnegative regulation of macroautophagy
B0016605cellular_componentPML body
B0019228biological_processneuronal action potential
B0030030biological_processcell projection organization
B0030307biological_processpositive regulation of cell growth
B0030425cellular_componentdendrite
B0030838biological_processpositive regulation of actin filament polymerization
B0031295biological_processT cell costimulation
B0031410cellular_componentcytoplasmic vesicle
B0031529biological_processruffle organization
B0031641biological_processregulation of myelination
B0031648biological_processprotein destabilization
B0031667biological_processresponse to nutrient levels
B0031669biological_processcellular response to nutrient levels
B0031670biological_processcellular response to nutrient
B0031929biological_processTOR signaling
B0031931cellular_componentTORC1 complex
B0031932cellular_componentTORC2 complex
B0032868biological_processresponse to insulin
B0032869biological_processcellular response to insulin stimulus
B0032956biological_processregulation of actin cytoskeleton organization
B0033173biological_processcalcineurin-NFAT signaling cascade
B0034198biological_processcellular response to amino acid starvation
B0035175molecular_functionhistone H3S10 kinase activity
B0035264biological_processmulticellular organism growth
B0035402molecular_functionhistone H3T11 kinase activity
B0035403molecular_functionhistone H3T6 kinase activity
B0035979molecular_functionhistone H2AXS139 kinase activity
B0038202biological_processTORC1 signaling
B0038203biological_processTORC2 signaling
B0042752biological_processregulation of circadian rhythm
B0042802molecular_functionidentical protein binding
B0043022molecular_functionribosome binding
B0043066biological_processnegative regulation of apoptotic process
B0043200biological_processresponse to amino acid
B0043276biological_processanoikis
B0044022molecular_functionhistone H3S28 kinase activity
B0044023molecular_functionhistone H4S1 kinase activity
B0044024molecular_functionhistone H2AS1 kinase activity
B0044025molecular_functionhistone H2BS14 kinase activity
B0045335cellular_componentphagocytic vesicle
B0045670biological_processregulation of osteoclast differentiation
B0045727biological_processpositive regulation of translation
B0045792biological_processnegative regulation of cell size
B0045821biological_processpositive regulation of glycolytic process
B0045945biological_processpositive regulation of transcription by RNA polymerase III
B0045948biological_processpositive regulation of translational initiation
B0046889biological_processpositive regulation of lipid biosynthetic process
B0048266biological_processbehavioral response to pain
B0048511biological_processrhythmic process
B0048709biological_processoligodendrocyte differentiation
B0048714biological_processpositive regulation of oligodendrocyte differentiation
B0048738biological_processcardiac muscle tissue development
B0050731biological_processpositive regulation of peptidyl-tyrosine phosphorylation
B0050882biological_processvoluntary musculoskeletal movement
B0051128biological_processregulation of cellular component organization
B0051219molecular_functionphosphoprotein binding
B0051247biological_processpositive regulation of protein metabolic process
B0051496biological_processpositive regulation of stress fiber assembly
B0051549biological_processpositive regulation of keratinocyte migration
B0051896biological_processregulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
B0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
B0055006biological_processcardiac cell development
B0055013biological_processcardiac muscle cell development
B0060048biological_processcardiac muscle contraction
B0061431biological_processcellular response to methionine
B0070885biological_processnegative regulation of calcineurin-NFAT signaling cascade
B0071230biological_processcellular response to amino acid stimulus
B0071233biological_processcellular response to L-leucine
B0071456biological_processcellular response to hypoxia
B0071470biological_processcellular response to osmotic stress
B0072354molecular_functionhistone H3T3 kinase activity
B0072371molecular_functionhistone H2AS121 kinase activity
B0072518molecular_functionRho-dependent protein serine/threonine kinase activity
B0080135biological_processregulation of cellular response to stress
B0090559biological_processregulation of membrane permeability
B0106310molecular_functionprotein serine kinase activity
B0140823molecular_functionhistone H2BS36 kinase activity
B0140855molecular_functionhistone H3S57 kinase activity
B0140857molecular_functionhistone H3T45 kinase activity
B1900034biological_processregulation of cellular response to heat
B1900181biological_processnegative regulation of protein localization to nucleus
B1901796biological_processregulation of signal transduction by p53 class mediator
B1901838biological_processpositive regulation of transcription of nucleolar large rRNA by RNA polymerase I
B1903691biological_processpositive regulation of wound healing, spreading of epidermal cells
B1904059biological_processregulation of locomotor rhythm
B1904690biological_processpositive regulation of cytoplasmic translational initiation
B1905671biological_processregulation of lysosome organization
B1905672biological_processnegative regulation of lysosome organization
B1905857biological_processpositive regulation of pentose-phosphate shunt
B1990244molecular_functionhistone H2AT120 kinase activity
B1990253biological_processcellular response to leucine starvation
B2000785biological_processregulation of autophagosome assembly
E0005515molecular_functionprotein binding
E0005654cellular_componentnucleoplasm
E0005737cellular_componentcytoplasm
E0005764cellular_componentlysosome
E0005765cellular_componentlysosomal membrane
E0005829cellular_componentcytosol
E0006974biological_processDNA damage response
E0007010biological_processcytoskeleton organization
E0010507biological_processnegative regulation of autophagy
E0016020cellular_componentmembrane
E0030307biological_processpositive regulation of cell growth
E0030674molecular_functionprotein-macromolecule adaptor activity
E0030838biological_processpositive regulation of actin filament polymerization
E0031669biological_processcellular response to nutrient levels
E0031929biological_processTOR signaling
E0031931cellular_componentTORC1 complex
E0031932cellular_componentTORC2 complex
E0032008biological_processpositive regulation of TOR signaling
E0032956biological_processregulation of actin cytoskeleton organization
E0038202biological_processTORC1 signaling
E0038203biological_processTORC2 signaling
E0043066biological_processnegative regulation of apoptotic process
E0043539molecular_functionprotein serine/threonine kinase activator activity
E0045821biological_processpositive regulation of glycolytic process
E0046889biological_processpositive regulation of lipid biosynthetic process
E0050731biological_processpositive regulation of peptidyl-tyrosine phosphorylation
E0071456biological_processcellular response to hypoxia
E0071470biological_processcellular response to osmotic stress
E1905857biological_processpositive regulation of pentose-phosphate shunt
X0000082biological_processG1/S transition of mitotic cell cycle
X0005515molecular_functionprotein binding
X0005634cellular_componentnucleus
X0005737cellular_componentcytoplasm
X0005829cellular_componentcytosol
X0008190molecular_functioneukaryotic initiation factor 4E binding
X0017148biological_processnegative regulation of translation
X0030371molecular_functiontranslation repressor activity
X0031369molecular_functiontranslation initiation factor binding
X0031929biological_processTOR signaling
X0045931biological_processpositive regulation of mitotic cell cycle
X0045947biological_processnegative regulation of translational initiation
Y0001558biological_processregulation of cell growth
Y0001938biological_processpositive regulation of endothelial cell proliferation
Y0005515molecular_functionprotein binding
Y0005654cellular_componentnucleoplasm
Y0005737cellular_componentcytoplasm
Y0005764cellular_componentlysosome
Y0005765cellular_componentlysosomal membrane
Y0005829cellular_componentcytosol
Y0006974biological_processDNA damage response
Y0008361biological_processregulation of cell size
Y0009267biological_processcellular response to starvation
Y0009410biological_processresponse to xenobiotic stimulus
Y0010494cellular_componentcytoplasmic stress granule
Y0010506biological_processregulation of autophagy
Y0010507biological_processnegative regulation of autophagy
Y0010800biological_processpositive regulation of peptidyl-threonine phosphorylation
Y0016020cellular_componentmembrane
Y0019901molecular_functionprotein kinase binding
Y0030291molecular_functionprotein serine/threonine kinase inhibitor activity
Y0030295molecular_functionprotein kinase activator activity
Y0030307biological_processpositive regulation of cell growth
Y0030425cellular_componentdendrite
Y0030674molecular_functionprotein-macromolecule adaptor activity
Y0031267molecular_functionsmall GTPase binding
Y0031669biological_processcellular response to nutrient levels
Y0031929biological_processTOR signaling
Y0031931cellular_componentTORC1 complex
Y0032008biological_processpositive regulation of TOR signaling
Y0033138biological_processpositive regulation of peptidyl-serine phosphorylation
Y0035176biological_processsocial behavior
Y0038202biological_processTORC1 signaling
Y0043025cellular_componentneuronal cell body
Y0044877molecular_functionprotein-containing complex binding
Y0045672biological_processpositive regulation of osteoclast differentiation
Y0045821biological_processpositive regulation of glycolytic process
Y0045945biological_processpositive regulation of transcription by RNA polymerase III
Y0046889biological_processpositive regulation of lipid biosynthetic process
Y0071230biological_processcellular response to amino acid stimulus
Y0071233biological_processcellular response to L-leucine
Y0071333biological_processcellular response to glucose stimulus
Y0071456biological_processcellular response to hypoxia
Y0071470biological_processcellular response to osmotic stress
Y0071889molecular_function14-3-3 protein binding
Y0140767molecular_functionenzyme-substrate adaptor activity
Y1900087biological_processpositive regulation of G1/S transition of mitotic cell cycle
Y1901331biological_processpositive regulation of odontoblast differentiation
Y1905857biological_processpositive regulation of pentose-phosphate shunt
Functional Information from PROSITE/UniProt
site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. MYTGgeDcTARIWDL
ChainResidueDetails
EMET100-LEU114

site_idPS00915
Number of Residues15
DetailsPI3_4_KINASE_1 Phosphatidylinositol 3- and 4-kinases signature 1. LKgh.EDLRQDervmQ
ChainResidueDetails
BLEU2186-GLN2200

site_idPS00916
Number of Residues21
DetailsPI3_4_KINASE_2 Phosphatidylinositol 3- and 4-kinases signature 2. SlAvmsMvgYILgLgDRHpsN
ChainResidueDetails
BSER2323-ASN2343

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsMOD_RES: N-acetylserine => ECO:0000269|PubMed:12665801, ECO:0007744|PubMed:22814378
ChainResidueDetails
XSER2
BMET2345
BILE2356
YSER122
YSER836
YSER982
BTYR2225
BGLY2238
BTRP2239
BVAL2240
BTHR2245

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: Phosphothreonine; by MTOR => ECO:0000269|PubMed:12747827, ECO:0000269|PubMed:22578813, ECO:0000269|PubMed:29236692, ECO:0000269|PubMed:29750193, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163
ChainResidueDetails
XTHR37
BASN2343
BASP2357

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163
ChainResidueDetails
XTHR41

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q60876
ChainResidueDetails
XSER44
XSER96

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: Phosphothreonine; by MTOR => ECO:0000269|PubMed:12747827, ECO:0000269|PubMed:22578813, ECO:0000269|PubMed:29236692, ECO:0000269|PubMed:29750193, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332
ChainResidueDetails
XTHR46

site_idSWS_FT_FI6
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:18220336, ECO:0007744|PubMed:18669648
ChainResidueDetails
XTHR50

site_idSWS_FT_FI7
Number of Residues1
DetailsMOD_RES: Phosphotyrosine => ECO:0007744|PubMed:18669648
ChainResidueDetails
XTYR54

site_idSWS_FT_FI8
Number of Residues1
DetailsMOD_RES: Phosphoserine; by DYRK2, MAPK1, MAPK3 and MTOR => ECO:0000269|PubMed:12588975, ECO:0000269|PubMed:12747827, ECO:0000269|PubMed:22578813, ECO:0000269|PubMed:25702871, ECO:0000269|PubMed:29750193, ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569
ChainResidueDetails
XSER65

site_idSWS_FT_FI9
Number of Residues1
DetailsMOD_RES: Phosphothreonine; by MTOR => ECO:0000269|PubMed:12747827, ECO:0000269|PubMed:22578813, ECO:0000269|PubMed:25702871, ECO:0000269|PubMed:29750193, ECO:0007744|PubMed:18220336, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569
ChainResidueDetails
XTHR70

site_idSWS_FT_FI10
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:24275569
ChainResidueDetails
XTHR77

site_idSWS_FT_FI11
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648
ChainResidueDetails
XSER83

site_idSWS_FT_FI12
Number of Residues1
DetailsMOD_RES: Phosphoserine; by DYRK2 => ECO:0000269|PubMed:12588975, ECO:0007744|PubMed:18220336, ECO:0007744|PubMed:23186163
ChainResidueDetails
XSER101

site_idSWS_FT_FI13
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:12588975, ECO:0007744|PubMed:17525332, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163
ChainResidueDetails
XSER112

site_idSWS_FT_FI14
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000305|PubMed:22578813
ChainResidueDetails
XLYS57

site_idSWS_FT_FI15
Number of Residues1
DetailsMOD_RES: N6-acetyllysine => ECO:0000269|PubMed:30197302, ECO:0000269|PubMed:32561715
ChainResidueDetails
YLYS1097

site_idSWS_FT_FI16
Number of Residues1
DetailsCARBOHYD: O-linked (GlcNAc) threonine => ECO:0000269|PubMed:37541260
ChainResidueDetails
YTHR700

site_idSWS_FT_FI17
Number of Residues3
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000305|PubMed:35927303
ChainResidueDetails
YLYS932
YLYS948

227344

PDB entries from 2024-11-13

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