Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8RBX

Structure of Integrator-PP2A bound to a paused RNA polymerase II-DSIF-NELF-nucleosome complex

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
a	0005515	molecular_function	protein binding
a	0005634	cellular_component	nucleus
a	0005654	cellular_component	nucleoplasm
a	0016020	cellular_component	membrane
a	0016180	biological_process	snRNA processing
a	0031965	cellular_component	nuclear membrane
a	0032039	cellular_component	integrator complex
a	0034243	biological_process	regulation of transcription elongation by RNA polymerase II
a	0034474	biological_process	U2 snRNA 3'-end processing
a	0160232	cellular_component	INTAC complex
a	0160240	biological_process	RNA polymerase II transcription initiation surveillance
A	0000428	cellular_component	DNA-directed RNA polymerase complex
A	0001172	biological_process	RNA-templated transcription
A	0003676	molecular_function	nucleic acid binding
A	0003677	molecular_function	DNA binding
A	0003899	molecular_function	DNA-directed RNA polymerase activity
A	0003968	molecular_function	RNA-directed RNA polymerase activity
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005694	cellular_component	chromosome
A	0005737	cellular_component	cytoplasm
A	0006351	biological_process	DNA-templated transcription
A	0006366	biological_process	transcription by RNA polymerase II
A	0016740	molecular_function	transferase activity
A	0016779	molecular_function	nucleotidyltransferase activity
A	0016787	molecular_function	hydrolase activity
A	0046872	molecular_function	metal ion binding
b	0016180	biological_process	snRNA processing
b	0032039	cellular_component	integrator complex
B	0003677	molecular_function	DNA binding
B	0003899	molecular_function	DNA-directed RNA polymerase activity
B	0006351	biological_process	DNA-templated transcription
B	0032549	molecular_function	ribonucleoside binding
C	0000428	cellular_component	DNA-directed RNA polymerase complex
C	0003677	molecular_function	DNA binding
C	0003899	molecular_function	DNA-directed RNA polymerase activity
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005665	cellular_component	RNA polymerase II, core complex
C	0006351	biological_process	DNA-templated transcription
C	0006366	biological_process	transcription by RNA polymerase II
C	0006367	biological_process	transcription initiation at RNA polymerase II promoter
C	0006368	biological_process	transcription elongation by RNA polymerase II
C	0046872	molecular_function	metal ion binding
C	0046983	molecular_function	protein dimerization activity
d	0005515	molecular_function	protein binding
d	0005634	cellular_component	nucleus
d	0005654	cellular_component	nucleoplasm
d	0005730	cellular_component	nucleolus
d	0005737	cellular_component	cytoplasm
d	0016180	biological_process	snRNA processing
d	0030674	molecular_function	protein-macromolecule adaptor activity
d	0032039	cellular_component	integrator complex
d	0034243	biological_process	regulation of transcription elongation by RNA polymerase II
d	0160232	cellular_component	INTAC complex
d	0160240	biological_process	RNA polymerase II transcription initiation surveillance
D	0000166	molecular_function	nucleotide binding
D	0006352	biological_process	DNA-templated transcription initiation
D	0030880	cellular_component	RNA polymerase complex
e	0005515	molecular_function	protein binding
e	0005634	cellular_component	nucleus
e	0005654	cellular_component	nucleoplasm
e	0005737	cellular_component	cytoplasm
e	0005829	cellular_component	cytosol
e	0016020	cellular_component	membrane
e	0016180	biological_process	snRNA processing
e	0031965	cellular_component	nuclear membrane
e	0032039	cellular_component	integrator complex
e	0034243	biological_process	regulation of transcription elongation by RNA polymerase II
e	0034472	biological_process	snRNA 3'-end processing
e	0160232	cellular_component	INTAC complex
e	0160240	biological_process	RNA polymerase II transcription initiation surveillance
E	0000428	cellular_component	DNA-directed RNA polymerase complex
E	0003677	molecular_function	DNA binding
E	0003899	molecular_function	DNA-directed RNA polymerase activity
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005665	cellular_component	RNA polymerase II, core complex
E	0005666	cellular_component	RNA polymerase III complex
E	0005736	cellular_component	RNA polymerase I complex
E	0006351	biological_process	DNA-templated transcription
E	0006362	biological_process	transcription elongation by RNA polymerase I
E	0006366	biological_process	transcription by RNA polymerase II
E	0042797	biological_process	tRNA transcription by RNA polymerase III
f	0000785	cellular_component	chromatin
f	0004888	molecular_function	transmembrane signaling receptor activity
f	0005515	molecular_function	protein binding
f	0005634	cellular_component	nucleus
f	0005654	cellular_component	nucleoplasm
f	0005694	cellular_component	chromosome
f	0016180	biological_process	snRNA processing
f	0030674	molecular_function	protein-macromolecule adaptor activity
f	0032039	cellular_component	integrator complex
f	0034243	biological_process	regulation of transcription elongation by RNA polymerase II
f	0034472	biological_process	snRNA 3'-end processing
f	0071168	biological_process	protein localization to chromatin
f	0160232	cellular_component	INTAC complex
f	0160240	biological_process	RNA polymerase II transcription initiation surveillance
F	0000428	cellular_component	DNA-directed RNA polymerase complex
F	0001650	cellular_component	fibrillar center
F	0003677	molecular_function	DNA binding
F	0003899	molecular_function	DNA-directed RNA polymerase activity
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005665	cellular_component	RNA polymerase II, core complex
F	0005666	cellular_component	RNA polymerase III complex
F	0005736	cellular_component	RNA polymerase I complex
F	0006351	biological_process	DNA-templated transcription
F	0006360	biological_process	transcription by RNA polymerase I
F	0006362	biological_process	transcription elongation by RNA polymerase I
F	0006366	biological_process	transcription by RNA polymerase II
F	0006367	biological_process	transcription initiation at RNA polymerase II promoter
F	0006368	biological_process	transcription elongation by RNA polymerase II
F	0006383	biological_process	transcription by RNA polymerase III
F	0006384	biological_process	transcription initiation at RNA polymerase III promoter
F	0006386	biological_process	termination of RNA polymerase III transcription
F	0042797	biological_process	tRNA transcription by RNA polymerase III
g	0000077	biological_process	DNA damage checkpoint signaling
g	0005515	molecular_function	protein binding
g	0005634	cellular_component	nucleus
g	0005654	cellular_component	nucleoplasm
g	0005694	cellular_component	chromosome
g	0005737	cellular_component	cytoplasm
g	0006974	biological_process	DNA damage response
g	0016180	biological_process	snRNA processing
g	0016604	cellular_component	nuclear body
g	0032039	cellular_component	integrator complex
g	0034243	biological_process	regulation of transcription elongation by RNA polymerase II
g	0034472	biological_process	snRNA 3'-end processing
g	0071479	biological_process	cellular response to ionizing radiation
g	0160232	cellular_component	INTAC complex
g	0160240	biological_process	RNA polymerase II transcription initiation surveillance
G	0000428	cellular_component	DNA-directed RNA polymerase complex
G	0003676	molecular_function	nucleic acid binding
G	0005634	cellular_component	nucleus
G	0006351	biological_process	DNA-templated transcription
G	0006352	biological_process	DNA-templated transcription initiation
h	0000785	cellular_component	chromatin
h	0005515	molecular_function	protein binding
h	0005634	cellular_component	nucleus
h	0005654	cellular_component	nucleoplasm
h	0005694	cellular_component	chromosome
h	0016180	biological_process	snRNA processing
h	0032039	cellular_component	integrator complex
h	0034243	biological_process	regulation of transcription elongation by RNA polymerase II
h	0034472	biological_process	snRNA 3'-end processing
h	0071168	biological_process	protein localization to chromatin
h	0160232	cellular_component	INTAC complex
h	0160240	biological_process	RNA polymerase II transcription initiation surveillance
H	0000428	cellular_component	DNA-directed RNA polymerase complex
H	0003899	molecular_function	DNA-directed RNA polymerase activity
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005665	cellular_component	RNA polymerase II, core complex
H	0005666	cellular_component	RNA polymerase III complex
H	0005736	cellular_component	RNA polymerase I complex
H	0006351	biological_process	DNA-templated transcription
i	0005515	molecular_function	protein binding
i	0005634	cellular_component	nucleus
i	0005654	cellular_component	nucleoplasm
i	0005737	cellular_component	cytoplasm
i	0005829	cellular_component	cytosol
i	0016180	biological_process	snRNA processing
i	0030512	biological_process	negative regulation of transforming growth factor beta receptor signaling pathway
i	0032039	cellular_component	integrator complex
i	0034243	biological_process	regulation of transcription elongation by RNA polymerase II
i	0034472	biological_process	snRNA 3'-end processing
i	0090101	biological_process	negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
i	0090287	biological_process	regulation of cellular response to growth factor stimulus
i	0160232	cellular_component	INTAC complex
i	0160240	biological_process	RNA polymerase II transcription initiation surveillance
I	0000428	cellular_component	DNA-directed RNA polymerase complex
I	0001193	biological_process	maintenance of transcriptional fidelity during transcription elongation by RNA polymerase II
I	0003676	molecular_function	nucleic acid binding
I	0003899	molecular_function	DNA-directed RNA polymerase activity
I	0005634	cellular_component	nucleus
I	0005654	cellular_component	nucleoplasm
I	0005665	cellular_component	RNA polymerase II, core complex
I	0005730	cellular_component	nucleolus
I	0006283	biological_process	transcription-coupled nucleotide-excision repair
I	0006351	biological_process	DNA-templated transcription
I	0006366	biological_process	transcription by RNA polymerase II
I	0006367	biological_process	transcription initiation at RNA polymerase II promoter
I	0006368	biological_process	transcription elongation by RNA polymerase II
I	0008270	molecular_function	zinc ion binding
I	0046872	molecular_function	metal ion binding
j	0005515	molecular_function	protein binding
j	0005634	cellular_component	nucleus
j	0005654	cellular_component	nucleoplasm
j	0016180	biological_process	snRNA processing
j	0032039	cellular_component	integrator complex
j	0034243	biological_process	regulation of transcription elongation by RNA polymerase II
j	0160232	cellular_component	INTAC complex
j	0160240	biological_process	RNA polymerase II transcription initiation surveillance
J	0000428	cellular_component	DNA-directed RNA polymerase complex
J	0003677	molecular_function	DNA binding
J	0003899	molecular_function	DNA-directed RNA polymerase activity
J	0005634	cellular_component	nucleus
J	0005665	cellular_component	RNA polymerase II, core complex
J	0006351	biological_process	DNA-templated transcription
J	0008270	molecular_function	zinc ion binding
J	0046872	molecular_function	metal ion binding
k	0004521	molecular_function	RNA endonuclease activity
k	0005515	molecular_function	protein binding
k	0005634	cellular_component	nucleus
k	0005654	cellular_component	nucleoplasm
k	0005737	cellular_component	cytoplasm
k	0005829	cellular_component	cytosol
k	0016180	biological_process	snRNA processing
k	0016787	molecular_function	hydrolase activity
k	0032039	cellular_component	integrator complex
k	0034243	biological_process	regulation of transcription elongation by RNA polymerase II
k	0034472	biological_process	snRNA 3'-end processing
k	0046872	molecular_function	metal ion binding
k	0072562	cellular_component	blood microparticle
k	0160232	cellular_component	INTAC complex
k	0160240	biological_process	RNA polymerase II transcription initiation surveillance
K	0000428	cellular_component	DNA-directed RNA polymerase complex
K	0003677	molecular_function	DNA binding
K	0003899	molecular_function	DNA-directed RNA polymerase activity
K	0005634	cellular_component	nucleus
K	0005665	cellular_component	RNA polymerase II, core complex
K	0006351	biological_process	DNA-templated transcription
K	0006366	biological_process	transcription by RNA polymerase II
K	0046983	molecular_function	protein dimerization activity
L	0000428	cellular_component	DNA-directed RNA polymerase complex
L	0001650	cellular_component	fibrillar center
L	0003677	molecular_function	DNA binding
L	0003899	molecular_function	DNA-directed RNA polymerase activity
L	0005634	cellular_component	nucleus
L	0005654	cellular_component	nucleoplasm
L	0005665	cellular_component	RNA polymerase II, core complex
L	0005666	cellular_component	RNA polymerase III complex
L	0005730	cellular_component	nucleolus
L	0005736	cellular_component	RNA polymerase I complex
L	0006351	biological_process	DNA-templated transcription
L	0006362	biological_process	transcription elongation by RNA polymerase I
L	0006366	biological_process	transcription by RNA polymerase II
L	0006367	biological_process	transcription initiation at RNA polymerase II promoter
L	0006368	biological_process	transcription elongation by RNA polymerase II
L	0006383	biological_process	transcription by RNA polymerase III
L	0006384	biological_process	transcription initiation at RNA polymerase III promoter
L	0006386	biological_process	termination of RNA polymerase III transcription
L	0008270	molecular_function	zinc ion binding
L	0046872	molecular_function	metal ion binding
m	0005515	molecular_function	protein binding
m	0005634	cellular_component	nucleus
m	0005654	cellular_component	nucleoplasm
m	0005737	cellular_component	cytoplasm
m	0007052	biological_process	mitotic spindle organization
m	0007346	biological_process	regulation of mitotic cell cycle
m	0016180	biological_process	snRNA processing
m	0016604	cellular_component	nuclear body
m	0030317	biological_process	flagellated sperm motility
m	0032039	cellular_component	integrator complex
m	0034243	biological_process	regulation of transcription elongation by RNA polymerase II
m	0051301	biological_process	cell division
m	0051642	biological_process	centrosome localization
m	0080154	biological_process	regulation of fertilization
m	0090435	biological_process	protein localization to nuclear envelope
m	0140297	molecular_function	DNA-binding transcription factor binding
m	0160232	cellular_component	INTAC complex
m	0160240	biological_process	RNA polymerase II transcription initiation surveillance
M	0000776	cellular_component	kinetochore
M	0000786	cellular_component	nucleosome
M	0000791	cellular_component	euchromatin
M	0003677	molecular_function	DNA binding
M	0005515	molecular_function	protein binding
M	0005634	cellular_component	nucleus
M	0005654	cellular_component	nucleoplasm
M	0005694	cellular_component	chromosome
M	0007080	biological_process	mitotic metaphase chromosome alignment
M	0030307	biological_process	positive regulation of cell growth
M	0030527	molecular_function	structural constituent of chromatin
M	0031492	molecular_function	nucleosomal DNA binding
M	0031507	biological_process	heterochromatin formation
M	0046982	molecular_function	protein heterodimerization activity
M	0051382	biological_process	kinetochore assembly
n	0005515	molecular_function	protein binding
n	0005634	cellular_component	nucleus
n	0005654	cellular_component	nucleoplasm
n	0016180	biological_process	snRNA processing
n	0032039	cellular_component	integrator complex
n	0034243	biological_process	regulation of transcription elongation by RNA polymerase II
n	0034472	biological_process	snRNA 3'-end processing
n	0046872	molecular_function	metal ion binding
n	0160232	cellular_component	INTAC complex
n	0160240	biological_process	RNA polymerase II transcription initiation surveillance
o	0005634	cellular_component	nucleus
o	0005694	cellular_component	chromosome
o	0016180	biological_process	snRNA processing
o	0032039	cellular_component	integrator complex
o	0034243	biological_process	regulation of transcription elongation by RNA polymerase II
o	0160232	cellular_component	INTAC complex
o	0160240	biological_process	RNA polymerase II transcription initiation surveillance
O	0000781	cellular_component	chromosome, telomeric region
O	0000786	cellular_component	nucleosome
O	0003677	molecular_function	DNA binding
O	0003723	molecular_function	RNA binding
O	0005515	molecular_function	protein binding
O	0005576	cellular_component	extracellular region
O	0005634	cellular_component	nucleus
O	0005654	cellular_component	nucleoplasm
O	0005694	cellular_component	chromosome
O	0006325	biological_process	chromatin organization
O	0006334	biological_process	nucleosome assembly
O	0016020	cellular_component	membrane
O	0030527	molecular_function	structural constituent of chromatin
O	0032200	biological_process	telomere organization
O	0032991	cellular_component	protein-containing complex
O	0045653	biological_process	negative regulation of megakaryocyte differentiation
O	0046982	molecular_function	protein heterodimerization activity
O	0061644	biological_process	protein localization to CENP-A containing chromatin
O	0070062	cellular_component	extracellular exosome
p	0000159	cellular_component	protein phosphatase type 2A complex
p	0000775	cellular_component	chromosome, centromeric region
p	0000785	cellular_component	chromatin
p	0004722	molecular_function	protein serine/threonine phosphatase activity
p	0005515	molecular_function	protein binding
p	0005634	cellular_component	nucleus
p	0005694	cellular_component	chromosome
p	0005737	cellular_component	cytoplasm
p	0005739	cellular_component	mitochondrion
p	0005829	cellular_component	cytosol
p	0007059	biological_process	chromosome segregation
p	0015630	cellular_component	microtubule cytoskeleton
p	0016020	cellular_component	membrane
p	0016180	biological_process	snRNA processing
p	0016328	cellular_component	lateral plasma membrane
p	0019888	molecular_function	protein phosphatase regulator activity
p	0030425	cellular_component	dendrite
p	0034243	biological_process	regulation of transcription elongation by RNA polymerase II
p	0035330	biological_process	regulation of hippo signaling
p	0035331	biological_process	negative regulation of hippo signaling
p	0035556	biological_process	intracellular signal transduction
p	0040008	biological_process	regulation of growth
p	0043005	cellular_component	neuron projection
p	0043025	cellular_component	neuronal cell body
p	0043029	biological_process	T cell homeostasis
p	0045202	cellular_component	synapse
p	0045595	biological_process	regulation of cell differentiation
p	0046982	molecular_function	protein heterodimerization activity
p	0051225	biological_process	spindle assembly
p	0051754	biological_process	meiotic sister chromatid cohesion, centromeric
p	0051898	biological_process	negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
p	0065003	biological_process	protein-containing complex assembly
p	0070062	cellular_component	extracellular exosome
p	0090443	cellular_component	FAR/SIN/STRIPAK complex
p	0098978	cellular_component	glutamatergic synapse
p	0160232	cellular_component	INTAC complex
p	0160240	biological_process	RNA polymerase II transcription initiation surveillance
p	1990405	molecular_function	protein antigen binding
q	0000159	cellular_component	protein phosphatase type 2A complex
q	0000278	biological_process	mitotic cell cycle
q	0000775	cellular_component	chromosome, centromeric region
q	0000785	cellular_component	chromatin
q	0000922	cellular_component	spindle pole
q	0004721	molecular_function	phosphoprotein phosphatase activity
q	0004722	molecular_function	protein serine/threonine phosphatase activity
q	0004725	molecular_function	protein tyrosine phosphatase activity
q	0005515	molecular_function	protein binding
q	0005634	cellular_component	nucleus
q	0005694	cellular_component	chromosome
q	0005737	cellular_component	cytoplasm
q	0005739	cellular_component	mitochondrion
q	0005829	cellular_component	cytosol
q	0005886	cellular_component	plasma membrane
q	0006357	biological_process	regulation of transcription by RNA polymerase II
q	0006470	biological_process	protein dephosphorylation
q	0010288	biological_process	response to lead ion
q	0010719	biological_process	negative regulation of epithelial to mesenchymal transition
q	0015630	cellular_component	microtubule cytoskeleton
q	0016020	cellular_component	membrane
q	0016180	biological_process	snRNA processing
q	0016787	molecular_function	hydrolase activity
q	0031113	biological_process	regulation of microtubule polymerization
q	0034243	biological_process	regulation of transcription elongation by RNA polymerase II
q	0035330	biological_process	regulation of hippo signaling
q	0035331	biological_process	negative regulation of hippo signaling
q	0035556	biological_process	intracellular signal transduction
q	0040008	biological_process	regulation of growth
q	0043029	biological_process	T cell homeostasis
q	0045121	cellular_component	membrane raft
q	0045202	cellular_component	synapse
q	0045595	biological_process	regulation of cell differentiation
q	0046872	molecular_function	metal ion binding
q	0046982	molecular_function	protein heterodimerization activity
q	0048156	molecular_function	tau protein binding
q	0050811	molecular_function	GABA receptor binding
q	0051321	biological_process	meiotic cell cycle
q	0051898	biological_process	negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
q	0070062	cellular_component	extracellular exosome
q	0090090	biological_process	negative regulation of canonical Wnt signaling pathway
q	0090443	cellular_component	FAR/SIN/STRIPAK complex
q	0097706	biological_process	vascular endothelial cell response to oscillatory fluid shear stress
q	0160232	cellular_component	INTAC complex
q	0160240	biological_process	RNA polymerase II transcription initiation surveillance
q	0180006	molecular_function	RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity
q	0180007	molecular_function	RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity
q	0180008	molecular_function	RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity
q	1900227	biological_process	positive regulation of NLRP3 inflammasome complex assembly
q	1904539	biological_process	negative regulation of glycolytic process through fructose-6-phosphate
q	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
Q	0000786	cellular_component	nucleosome
Q	0003677	molecular_function	DNA binding
Q	0005515	molecular_function	protein binding
Q	0005634	cellular_component	nucleus
Q	0005654	cellular_component	nucleoplasm
Q	0005694	cellular_component	chromosome
Q	0006325	biological_process	chromatin organization
Q	0019899	molecular_function	enzyme binding
Q	0030527	molecular_function	structural constituent of chromatin
Q	0031507	biological_process	heterochromatin formation
Q	0046982	molecular_function	protein heterodimerization activity
Q	0070062	cellular_component	extracellular exosome
r	0006406	biological_process	mRNA export from nucleus
r	0008541	cellular_component	proteasome regulatory particle, lid subcomplex
r	0043248	biological_process	proteasome assembly
R	0000786	cellular_component	nucleosome
R	0001530	molecular_function	lipopolysaccharide binding
R	0002227	biological_process	innate immune response in mucosa
R	0003677	molecular_function	DNA binding
R	0005515	molecular_function	protein binding
R	0005615	cellular_component	extracellular space
R	0005634	cellular_component	nucleus
R	0005654	cellular_component	nucleoplasm
R	0005694	cellular_component	chromosome
R	0005886	cellular_component	plasma membrane
R	0006325	biological_process	chromatin organization
R	0006334	biological_process	nucleosome assembly
R	0010804	biological_process	negative regulation of tumor necrosis factor-mediated signaling pathway
R	0019731	biological_process	antibacterial humoral response
R	0030527	molecular_function	structural constituent of chromatin
R	0031640	biological_process	killing of cells of another organism
R	0042742	biological_process	defense response to bacterium
R	0046982	molecular_function	protein heterodimerization activity
R	0050829	biological_process	defense response to Gram-negative bacterium
R	0050830	biological_process	defense response to Gram-positive bacterium
R	0061644	biological_process	protein localization to CENP-A containing chromatin
R	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
S	0000776	cellular_component	kinetochore
S	0000786	cellular_component	nucleosome
S	0000791	cellular_component	euchromatin
S	0003677	molecular_function	DNA binding
S	0005515	molecular_function	protein binding
S	0005634	cellular_component	nucleus
S	0005654	cellular_component	nucleoplasm
S	0005694	cellular_component	chromosome
S	0007080	biological_process	mitotic metaphase chromosome alignment
S	0030307	biological_process	positive regulation of cell growth
S	0030527	molecular_function	structural constituent of chromatin
S	0031492	molecular_function	nucleosomal DNA binding
S	0031507	biological_process	heterochromatin formation
S	0046982	molecular_function	protein heterodimerization activity
S	0051382	biological_process	kinetochore assembly
u	0003682	molecular_function	chromatin binding
u	0005515	molecular_function	protein binding
u	0005634	cellular_component	nucleus
u	0005654	cellular_component	nucleoplasm
u	0006351	biological_process	DNA-templated transcription
u	0016604	cellular_component	nuclear body
u	0032021	cellular_component	NELF complex
u	0034244	biological_process	negative regulation of transcription elongation by RNA polymerase II
u	0045944	biological_process	positive regulation of transcription by RNA polymerase II
u	0060090	molecular_function	molecular adaptor activity
u	0140870	molecular_function	RNA polymerase inhibitor activity
u	0160239	biological_process	transcription pausing by RNA polymerase II
U	0000781	cellular_component	chromosome, telomeric region
U	0000786	cellular_component	nucleosome
U	0003677	molecular_function	DNA binding
U	0003723	molecular_function	RNA binding
U	0005515	molecular_function	protein binding
U	0005576	cellular_component	extracellular region
U	0005634	cellular_component	nucleus
U	0005654	cellular_component	nucleoplasm
U	0005694	cellular_component	chromosome
U	0006325	biological_process	chromatin organization
U	0006334	biological_process	nucleosome assembly
U	0016020	cellular_component	membrane
U	0030527	molecular_function	structural constituent of chromatin
U	0032200	biological_process	telomere organization
U	0032991	cellular_component	protein-containing complex
U	0045653	biological_process	negative regulation of megakaryocyte differentiation
U	0046982	molecular_function	protein heterodimerization activity
U	0061644	biological_process	protein localization to CENP-A containing chromatin
U	0070062	cellular_component	extracellular exosome
v	0003723	molecular_function	RNA binding
v	0005515	molecular_function	protein binding
v	0005634	cellular_component	nucleus
v	0005654	cellular_component	nucleoplasm
v	0005737	cellular_component	cytoplasm
v	0006351	biological_process	DNA-templated transcription
v	0008283	biological_process	cell population proliferation
v	0032021	cellular_component	NELF complex
v	0034244	biological_process	negative regulation of transcription elongation by RNA polymerase II
v	0045892	biological_process	negative regulation of DNA-templated transcription
v	0048863	biological_process	stem cell differentiation
v	0140870	molecular_function	RNA polymerase inhibitor activity
v	0160239	biological_process	transcription pausing by RNA polymerase II
v	2000737	biological_process	negative regulation of stem cell differentiation
V	0000786	cellular_component	nucleosome
V	0003677	molecular_function	DNA binding
V	0005515	molecular_function	protein binding
V	0005634	cellular_component	nucleus
V	0005654	cellular_component	nucleoplasm
V	0005694	cellular_component	chromosome
V	0006325	biological_process	chromatin organization
V	0019899	molecular_function	enzyme binding
V	0030527	molecular_function	structural constituent of chromatin
V	0031507	biological_process	heterochromatin formation
V	0046982	molecular_function	protein heterodimerization activity
V	0070062	cellular_component	extracellular exosome
w	0003723	molecular_function	RNA binding
w	0005515	molecular_function	protein binding
w	0005634	cellular_component	nucleus
w	0005654	cellular_component	nucleoplasm
w	0006351	biological_process	DNA-templated transcription
w	0016020	cellular_component	membrane
w	0016604	cellular_component	nuclear body
w	0032021	cellular_component	NELF complex
w	0034244	biological_process	negative regulation of transcription elongation by RNA polymerase II
w	0045892	biological_process	negative regulation of DNA-templated transcription
w	0140870	molecular_function	RNA polymerase inhibitor activity
w	0160239	biological_process	transcription pausing by RNA polymerase II
W	0000786	cellular_component	nucleosome
W	0001530	molecular_function	lipopolysaccharide binding
W	0002227	biological_process	innate immune response in mucosa
W	0003677	molecular_function	DNA binding
W	0005515	molecular_function	protein binding
W	0005615	cellular_component	extracellular space
W	0005634	cellular_component	nucleus
W	0005654	cellular_component	nucleoplasm
W	0005694	cellular_component	chromosome
W	0005886	cellular_component	plasma membrane
W	0006325	biological_process	chromatin organization
W	0006334	biological_process	nucleosome assembly
W	0010804	biological_process	negative regulation of tumor necrosis factor-mediated signaling pathway
W	0019731	biological_process	antibacterial humoral response
W	0030527	molecular_function	structural constituent of chromatin
W	0031640	biological_process	killing of cells of another organism
W	0042742	biological_process	defense response to bacterium
W	0046982	molecular_function	protein heterodimerization activity
W	0050829	biological_process	defense response to Gram-negative bacterium
W	0050830	biological_process	defense response to Gram-positive bacterium
W	0061644	biological_process	protein localization to CENP-A containing chromatin
W	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
Y	0000428	cellular_component	DNA-directed RNA polymerase complex
Y	0001172	biological_process	RNA-templated transcription
Y	0003676	molecular_function	nucleic acid binding
Y	0003677	molecular_function	DNA binding
Y	0003899	molecular_function	DNA-directed RNA polymerase activity
Y	0003968	molecular_function	RNA-directed RNA polymerase activity
Y	0005634	cellular_component	nucleus
Y	0005654	cellular_component	nucleoplasm
Y	0005694	cellular_component	chromosome
Y	0005737	cellular_component	cytoplasm
Y	0006351	biological_process	DNA-templated transcription
Y	0006366	biological_process	transcription by RNA polymerase II
Y	0016740	molecular_function	transferase activity
Y	0016779	molecular_function	nucleotidyltransferase activity
Y	0016787	molecular_function	hydrolase activity
Y	0046872	molecular_function	metal ion binding
Z	0000122	biological_process	negative regulation of transcription by RNA polymerase II
Z	0003723	molecular_function	RNA binding
Z	0003729	molecular_function	mRNA binding
Z	0005515	molecular_function	protein binding
Z	0005634	cellular_component	nucleus
Z	0005654	cellular_component	nucleoplasm
Z	0006351	biological_process	DNA-templated transcription
Z	0006354	biological_process	DNA-templated transcription elongation
Z	0006357	biological_process	regulation of transcription by RNA polymerase II
Z	0006368	biological_process	transcription elongation by RNA polymerase II
Z	0016239	biological_process	positive regulation of macroautophagy
Z	0019899	molecular_function	enzyme binding
Z	0032044	cellular_component	DSIF complex
Z	0032784	biological_process	regulation of DNA-templated transcription elongation
Z	0032785	biological_process	negative regulation of DNA-templated transcription, elongation
Z	0032786	biological_process	positive regulation of DNA-templated transcription, elongation
Z	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
Z	0034243	biological_process	regulation of transcription elongation by RNA polymerase II
Z	0045944	biological_process	positive regulation of transcription by RNA polymerase II
Z	0046982	molecular_function	protein heterodimerization activity
Z	0140870	molecular_function	RNA polymerase inhibitor activity
Z	0160239	biological_process	transcription pausing by RNA polymerase II

Functional Information from PROSITE/UniProt

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DNDPSDYVEqdDI

Chain	Residue	Details
C	ASP136-ILE148

site_id	PS00019
Number of Residues	10
Details	ACTININ_1 Actinin-type actin-binding domain signature 1. QPeTYYKWDN

Chain	Residue	Details
a	GLN620-ASN629

site_id	PS00039
Number of Residues	9
Details	DEAD_ATP_HELICASE DEAD-box subfamily ATP-dependent helicases signature. MIDEADEfV

Chain	Residue	Details
f	MET627-VAL635

site_id	PS00046
Number of Residues	7
Details	HISTONE_H2A Histone H2A signature. AGLqFPV

Chain	Residue	Details
Q	ALA21-VAL27

site_id	PS00047
Number of Residues	5
Details	HISTONE_H4 Histone H4 signature. GAKRH

Chain	Residue	Details
O	GLY14-HIS18

site_id	PS00115
Number of Residues	7
Details	RNA_POL_II_REPEAT Eukaryotic RNA polymerase II heptapeptide repeat. YSPTSPA

Chain	Residue	Details
A	TYR1593-ALA1599
A	TYR1671-SER1677
A	TYR1678-SER1684
A	TYR1685-SER1691
A	TYR1692-SER1698
A	TYR1699-SER1705
A	TYR1706-SER1712
A	TYR1713-SER1719
A	TYR1720-SER1726
A	TYR1727-SER1733
A	TYR1734-SER1740
A	TYR1615-SER1621
A	TYR1741-ASN1747
A	TYR1748-ASN1754
A	TYR1755-SER1761
A	TYR1762-SER1768
A	TYR1769-ASN1775
A	TYR1776-ASN1782
A	TYR1783-SER1789
A	TYR1790-SER1796
A	TYR1797-SER1803
A	TYR1818-SER1824
A	TYR1622-SER1628
A	TYR1825-SER1831
A	TYR1832-LYS1838
A	TYR1839-SER1845
A	TYR1853-LYS1859
A	TYR1860-LYS1866
A	TYR1867-LYS1873
A	TYR1874-THR1880
A	TYR1888-THR1894
A	TYR1902-LYS1908
A	TYR1909-THR1915
A	TYR1629-ASN1635
A	TYR1916-LYS1922
A	TYR1923-THR1929
A	TYR1930-LYS1936
A	TYR1947-THR1953
A	TYR1636-SER1642
A	TYR1643-SER1649
A	TYR1650-SER1656
A	TYR1657-SER1663
A	TYR1664-SER1670

site_id	PS00125
Number of Residues	6
Details	SER_THR_PHOSPHATASE Serine/threonine specific protein phosphatases signature. LRGNHE

Chain	Residue	Details
q	LEU114-GLU119

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YVCTAPH

Chain	Residue	Details
I	TYR112-HIS118

site_id	PS00322
Number of Residues	7
Details	HISTONE_H3_1 Histone H3 signature 1. KAPRKQL

Chain	Residue	Details
M	LYS15-LEU21

site_id	PS00357
Number of Residues	23
Details	HISTONE_H2B Histone H2B signature. REIQTavRlLLpGELaKHAVSEG

Chain	Residue	Details
R	ARG89-GLY111

site_id	PS00446
Number of Residues	41
Details	RNA_POL_D_30KD RNA polymerases D / 30 to 40 Kd subunits signature. NSIRRvfiaevpiiAidwVqidaNsSvlhDEfIAhRLGLIP

Chain	Residue	Details
C	ASN32-PRO72

site_id	PS00466
Number of Residues	38
Details	ZF_TFIIS_1 Zinc finger TFIIS-type signature. CqkCghkeavffqSHSARaEDAmrlyyvCtaph.CghrW

Chain	Residue	Details
I	CYS86-TRP123

site_id	PS00959
Number of Residues	9
Details	HISTONE_H3_2 Histone H3 signature 2. PFqRLVREI

Chain	Residue	Details
M	PRO66-ILE74

site_id	PS01030
Number of Residues	27
Details	RNA_POL_M_15KD RNA polymerases M / 15 Kd subunits signature. FCQECNNMLypkedkenrillyaCrnC

Chain	Residue	Details
I	PHE16-CYS42

site_id	PS01110
Number of Residues	14
Details	RNA_POL_H_23KD RNA polymerases H / 23 Kd subunits signature. HELVPEHvvMtkEE

Chain	Residue	Details
E	HIS142-GLU155

site_id	PS01111
Number of Residues	15
Details	RNA_POL_K_14KD RNA polymerases K / 14 to 18 Kd subunits signature. TkYErARvLGtRAlQ

Chain	Residue	Details
F	THR58-GLN72

site_id	PS01112
Number of Residues	10
Details	RNA_POL_N_8KD RNA polymerases N / 8 Kd subunits signature. IIPVrCFTCG

Chain	Residue	Details
J	ILE2-GLY11

site_id	PS01154
Number of Residues	32
Details	RNA_POL_L_13KD RNA polymerases L / 13 to 16 Kd subunits signature. InkEdHTLgNiIksqLlkdpqVlfagYkvpHP

Chain	Residue	Details
K	ILE35-PRO66

site_id	PS01166
Number of Residues	13
Details	RNA_POL_BETA RNA polymerases beta chain signature. GdKFASrHGQKGT

Chain	Residue	Details
B	GLY932-THR944

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI23
Number of Residues	25
Details	Zinc finger: {"description":"C4-type","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI24
Number of Residues	42
Details	Zinc finger: {"description":"TFIIS-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00472","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI25
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU10145","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI26
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00472","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI33
Number of Residues	4
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P68431","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI34
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"20850016","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI35
Number of Residues	2
Details	Modified residue: {"description":"N6-methyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P68431","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI36
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"20850016","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI37
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P84243","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI38
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"Q71DI3","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI39
Number of Residues	2
Details	Modified residue: {"description":"N6-glutaryllysine; alternate","evidences":[{"source":"UniProtKB","id":"P84243","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI40
Number of Residues	13
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"PubMed","id":"22389435","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI41
Number of Residues	2
Details	Modified residue: {"description":"N6-propionyllysine; alternate","evidences":[{"source":"PubMed","id":"17267393","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI42
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine; by PAK2","evidences":[{"source":"PubMed","id":"21724829","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17081983","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI43
Number of Residues	2
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"15592455","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI44
Number of Residues	4
Details	Modified residue: {"description":"N6-methacryllysine; alternate","evidences":[{"source":"PubMed","id":"34961760","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI45
Number of Residues	2
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P62806","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI46
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P62806","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI47
Number of Residues	2
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI48
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in UFM1); alternate","evidences":[{"source":"PubMed","id":"30886146","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI49
Number of Residues	4
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","evidences":[{"source":"PubMed","id":"19818714","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI50
Number of Residues	4
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI51
Number of Residues	2
Details	Modified residue: {"description":"N6-benzoyllysine; alternate","evidences":[{"source":"PubMed","id":"30154464","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI52
Number of Residues	2
Details	Modified residue: {"description":"N6-isonicotinyllysine","evidences":[{"source":"PubMed","id":"34545082","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI53
Number of Residues	2
Details	Modified residue: {"description":"N6-crotonyllysine; alternate","evidences":[{"source":"PubMed","id":"21925322","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI54
Number of Residues	4
Details	Modified residue: {"description":"N6-(2-hydroxyisobutyryl)lysine","evidences":[{"source":"PubMed","id":"24681537","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI55
Number of Residues	2
Details	Modified residue: {"description":"N6-glutaryllysine","evidences":[{"source":"PubMed","id":"31542297","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI56
Number of Residues	2
Details	Modified residue: {"description":"N5-methylglutamine","evidences":[{"source":"PubMed","id":"24352239","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI57
Number of Residues	3
Details	Modified residue: {"description":"N6-glutaryllysine; alternate","evidences":[{"source":"PubMed","id":"31542297","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI58
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","evidences":[{"source":"PubMed","id":"22713238","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22980979","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI59
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","evidences":[{"source":"PubMed","id":"15386022","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16359901","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16702407","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25470042","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI60
Number of Residues	3
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"22713238","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22980979","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI61
Number of Residues	2
Details	Modified residue: {"description":"N6-lactoyllysine; alternate","evidences":[{"source":"PubMed","id":"31645732","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI62
Number of Residues	4
Details	Modified residue: {"description":"N6-methyllysine; alternate","evidences":[{"source":"PubMed","id":"16627869","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI63
Number of Residues	2
Details	Modified residue: {"description":"N6-isonicotinyllysine; alternate","evidences":[{"source":"PubMed","id":"34545082","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI64
Number of Residues	2
Details	Modified residue: {"description":"Dimethylated arginine","evidences":[{"source":"UniProtKB","id":"Q96A08","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI65
Number of Residues	4
Details	Modified residue: {"description":"Omega-N-methylarginine","evidences":[{"source":"UniProtKB","id":"Q96A08","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI66
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"Q00729","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI67
Number of Residues	2
Details	Glycosylation: {"description":"O-linked (GlcNAc) serine","evidences":[{"source":"UniProtKB","id":"P62807","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI68
Number of Residues	4
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","evidences":[{"source":"PubMed","id":"16307923","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16627869","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16713563","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI69
Number of Residues	1
Details	Modified residue: {"description":"PolyADP-ribosyl glutamic acid","evidences":[{"source":"UniProtKB","id":"Q64475","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI70
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine; by AMPK","evidences":[{"source":"UniProtKB","id":"Q64475","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI71
Number of Residues	1
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","evidences":[{"source":"PubMed","id":"21726816","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI72
Number of Residues	31
Details	Domain: {"description":"KOW 2"}

Chain

Residue

Details

site_id	SWS_FT_FI73
Number of Residues	31
Details	Domain: {"description":"KOW 3"}

Chain

Residue

Details

site_id	SWS_FT_FI74
Number of Residues	33
Details	Domain: {"description":"KOW 4"}

Chain

Residue

Details

site_id	SWS_FT_FI75
Number of Residues	33
Details	Domain: {"description":"KOW 5"}

Chain

Residue

Details

site_id	SWS_FT_FI76
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"28892040","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5OIK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI77
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"O55201","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI78
Number of Residues	96
Details	Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI79
Number of Residues	39
Details	Repeat: {"description":"HEAT 1"}

Chain

Residue

Details

site_id	SWS_FT_FI80
Number of Residues	34
Details	Repeat: {"description":"HEAT 4"}

Chain

Residue

Details

site_id	SWS_FT_FI81
Number of Residues	36
Details	Repeat: {"description":"HEAT 5"}

Chain

Residue

Details

site_id	SWS_FT_FI82
Number of Residues	38
Details	Repeat: {"description":"HEAT 7"}

Chain

Residue

Details

site_id	SWS_FT_FI83
Number of Residues	38
Details	Repeat: {"description":"HEAT 8"}

Chain

Residue

Details

site_id	SWS_FT_FI84
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate","evidences":[{"source":"PubMed","id":"25114211","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"25218447","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"25755297","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI85
Number of Residues	224
Details	Domain: {"description":"VWFA","evidences":[{"source":"PROSITE-ProRule","id":"PRU00219","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI86
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI87
Number of Residues	38
Details	Repeat: {"description":"TPR 1"}

Chain

Residue

Details

site_id	SWS_FT_FI88
Number of Residues	33
Details	Repeat: {"description":"TPR 3"}

Chain

Residue

Details

site_id	SWS_FT_FI89
Number of Residues	33
Details	Repeat: {"description":"TPR 4"}

Chain

Residue

Details

site_id	SWS_FT_FI90
Number of Residues	5
Details	Motif: {"description":"WFEF motif","evidences":[{"source":"PubMed","id":"32966759","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI91
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q95TS5","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI92
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI93
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q8K2A7","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI94
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"25114211","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI95
Number of Residues	5
Details	Motif: {"description":"HXHXDH motif"}

Chain

Residue

Details

site_id	SWS_FT_FI96
Number of Residues	1
Details	Active site: {"evidences":[{"source":"PubMed","id":"28396433","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32697989","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33548203","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI97
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"33243860","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34762484","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38570683","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7CUN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7PKS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8RBX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8RBZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI98
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"34762484","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38570683","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7PKS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8RBX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8RBZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI99
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"33243860","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34762484","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38570683","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7CUN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7PKS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8RBZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI100
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"33243860","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38570683","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7CUN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8RBZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI101
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"34762484","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7PKS","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI102
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q9VAH9","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI103
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)","evidences":[{"source":"PubMed","id":"36454007","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI104
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"38906142","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI105
Number of Residues	202
Details	Domain: {"description":"VWFA"}

Chain

Residue

Details

site_id	SWS_FT_FI106
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"38823386","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38906142","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8PK5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9EOC","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI107
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"38823386","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9EOC","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI108
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI109
Number of Residues	38
Details	Repeat: {"description":"HEAT 1","evidences":[{"source":"PubMed","id":"38123684","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8SO0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8TTB","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI110
Number of Residues	37
Details	Repeat: {"description":"HEAT 2","evidences":[{"source":"PubMed","id":"38123684","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8SO0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8TTB","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI111
Number of Residues	38
Details	Repeat: {"description":"HEAT 3","evidences":[{"source":"PubMed","id":"38123684","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8SO0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8TTB","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI112
Number of Residues	37
Details	Repeat: {"description":"HEAT 4","evidences":[{"source":"PubMed","id":"38123684","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8SO0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8TTB","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI113
Number of Residues	38
Details	Repeat: {"description":"HEAT 5","evidences":[{"source":"PubMed","id":"38123684","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8SO0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8TTB","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI114
Number of Residues	38
Details	Repeat: {"description":"HEAT 6","evidences":[{"source":"PubMed","id":"38123684","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8SO0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8TTB","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI115
Number of Residues	38
Details	Repeat: {"description":"HEAT 7","evidences":[{"source":"PubMed","id":"38123684","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8SO0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8TTB","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI116
Number of Residues	42
Details	Repeat: {"description":"HEAT 8","evidences":[{"source":"PubMed","id":"38123684","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8SO0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8TTB","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI117
Number of Residues	38
Details	Repeat: {"description":"HEAT 9","evidences":[{"source":"PubMed","id":"38123684","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8SO0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8TTB","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI118
Number of Residues	38
Details	Repeat: {"description":"HEAT 10","evidences":[{"source":"PubMed","id":"38123684","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8SO0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8TTB","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI119
Number of Residues	38
Details	Repeat: {"description":"HEAT 11","evidences":[{"source":"PubMed","id":"38123684","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8SO0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8TTB","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI120
Number of Residues	38
Details	Repeat: {"description":"HEAT 12","evidences":[{"source":"PubMed","id":"38123684","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8SO0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8TTB","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI121
Number of Residues	38
Details	Repeat: {"description":"HEAT 13","evidences":[{"source":"PubMed","id":"38123684","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8SO0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8TTB","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI122
Number of Residues	38
Details	Repeat: {"description":"HEAT 14","evidences":[{"source":"PubMed","id":"38123684","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8SO0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8TTB","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI123
Number of Residues	391
Details	Region: {"description":"PP2A subunit B binding"}

Chain

Residue

Details

site_id	SWS_FT_FI124
Number of Residues	274
Details	Region: {"description":"Polyoma small and medium T antigens Binding"}

Chain

Residue

Details

site_id	SWS_FT_FI125
Number of Residues	154
Details	Region: {"description":"SV40 small T antigen binding"}

Chain

Residue

Details

site_id	SWS_FT_FI126
Number of Residues	1
Details	Active site: {"description":"Proton donor","evidences":[{"source":"UniProtKB","id":"P36873","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI127
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"38123684","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8SO0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8TTB","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI128
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17055435","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33243860","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33633399","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34762484","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7CUN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7K36","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7PKS","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI129
Number of Residues	63
Details	Region: {"description":"NELF-C/D-binding","evidences":[{"source":"PROSITE-ProRule","id":"PRU01183","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI130
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"16964243","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		Validation report (PDF)