8R8T
Cryo-EM structure of the inward-facing ethanolamine-bound FLVCR1
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001568 | biological_process | blood vessel development |
| A | 0001701 | biological_process | in utero embryonic development |
| A | 0005515 | molecular_function | protein binding |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005743 | cellular_component | mitochondrial inner membrane |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006783 | biological_process | heme biosynthetic process |
| A | 0006839 | biological_process | mitochondrial transport |
| A | 0006879 | biological_process | intracellular iron ion homeostasis |
| A | 0008654 | biological_process | phospholipid biosynthetic process |
| A | 0015220 | molecular_function | choline transmembrane transporter activity |
| A | 0015232 | molecular_function | heme transmembrane transporter activity |
| A | 0015871 | biological_process | choline transport |
| A | 0015886 | biological_process | heme transport |
| A | 0016020 | cellular_component | membrane |
| A | 0020037 | molecular_function | heme binding |
| A | 0022857 | molecular_function | transmembrane transporter activity |
| A | 0030218 | biological_process | erythrocyte differentiation |
| A | 0031966 | cellular_component | mitochondrial membrane |
| A | 0034228 | molecular_function | ethanolamine transmembrane transporter activity |
| A | 0034229 | biological_process | ethanolamine transport |
| A | 0035108 | biological_process | limb morphogenesis |
| A | 0035264 | biological_process | multicellular organism growth |
| A | 0042733 | biological_process | embryonic digit morphogenesis |
| A | 0043249 | biological_process | erythrocyte maturation |
| A | 0046620 | biological_process | regulation of organ growth |
| A | 0048536 | biological_process | spleen development |
| A | 0048704 | biological_process | embryonic skeletal system morphogenesis |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0060323 | biological_process | head morphogenesis |
| A | 0097037 | biological_process | heme export |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 188 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:38693265, ECO:0000269|PubMed:38778100, ECO:0007744|PDB:8QCS, ECO:0007744|PDB:8QCT, ECO:0007744|PDB:8R8T, ECO:0007744|PDB:8UBW, ECO:0007744|PDB:8UBX, ECO:0007744|PDB:8UBZ |
| Chain | Residue | Details |
| A | MET1-PRO99 | |
| A | ARG171-GLY172 | |
| A | PHE229-GLU233 | |
| A | PHE296-ASN331 | |
| A | LYS396-THR397 | |
| A | THR454-THR461 | |
| A | SER513-ILE555 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 24 |
| Details | TRANSMEM: Helical; Name=TM1 => ECO:0000269|PubMed:38693265, ECO:0000269|PubMed:38778100, ECO:0007744|PDB:8QCS, ECO:0007744|PDB:8QCT, ECO:0007744|PDB:8R8T, ECO:0007744|PDB:8UBW, ECO:0007744|PDB:8UBX, ECO:0007744|PDB:8UBZ |
| Chain | Residue | Details |
| A | LEU100-GLN124 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 34 |
| Details | TOPO_DOM: Extracellular => ECO:0000269|PubMed:38693265, ECO:0000269|PubMed:38778100, ECO:0007744|PDB:8QCS, ECO:0007744|PDB:8QCT, ECO:0007744|PDB:8R8T, ECO:0007744|PDB:8UBW, ECO:0007744|PDB:8UBX, ECO:0007744|PDB:8UBZ |
| Chain | Residue | Details |
| A | TRP125-THR142 | |
| A | GLY193-LEU199 | |
| A | VAL260-ASN265 | |
| A | TYR363-GLU366 | |
| A | ASP421-ARG423 | |
| A | TYR488-GLY489 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 27 |
| Details | TRANSMEM: Helical; Name=TM2 => ECO:0000269|PubMed:38693265, ECO:0000269|PubMed:38778100, ECO:0007744|PDB:8QCS, ECO:0007744|PDB:8QCT, ECO:0007744|PDB:8R8T, ECO:0007744|PDB:8UBW, ECO:0007744|PDB:8UBX, ECO:0007744|PDB:8UBZ |
| Chain | Residue | Details |
| A | LEU143-THR170 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 19 |
| Details | TRANSMEM: Helical; Name=TM3 => ECO:0000269|PubMed:38693265, ECO:0000269|PubMed:38778100, ECO:0007744|PDB:8QCS, ECO:0007744|PDB:8QCT, ECO:0007744|PDB:8R8T, ECO:0007744|PDB:8UBW, ECO:0007744|PDB:8UBX, ECO:0007744|PDB:8UBZ |
| Chain | Residue | Details |
| A | LEU173-CYS192 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 28 |
| Details | TRANSMEM: Helical; Name=TM4 => ECO:0000269|PubMed:38693265, ECO:0000269|PubMed:38778100, ECO:0007744|PDB:8QCS, ECO:0007744|PDB:8QCT, ECO:0007744|PDB:8R8T, ECO:0007744|PDB:8UBW, ECO:0007744|PDB:8UBX, ECO:0007744|PDB:8UBZ |
| Chain | Residue | Details |
| A | PHE200-TRP228 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 25 |
| Details | TRANSMEM: Helical; Name=TM5 => ECO:0000269|PubMed:38693265, ECO:0000269|PubMed:38778100, ECO:0007744|PDB:8QCS, ECO:0007744|PDB:8QCT, ECO:0007744|PDB:8R8T, ECO:0007744|PDB:8UBW, ECO:0007744|PDB:8UBX, ECO:0007744|PDB:8UBZ |
| Chain | Residue | Details |
| A | VAL234-LEU259 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 29 |
| Details | TRANSMEM: Helical; Name=TM6 => ECO:0000269|PubMed:38693265, ECO:0000269|PubMed:38778100, ECO:0007744|PDB:8QCS, ECO:0007744|PDB:8QCT, ECO:0007744|PDB:8R8T, ECO:0007744|PDB:8UBW, ECO:0007744|PDB:8UBX, ECO:0007744|PDB:8UBZ |
| Chain | Residue | Details |
| A | ASP266-ALA295 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 30 |
| Details | TRANSMEM: Helical; Name=TM7 => ECO:0000269|PubMed:38693265, ECO:0000269|PubMed:38778100, ECO:0007744|PDB:8QCS, ECO:0007744|PDB:8QCT, ECO:0007744|PDB:8R8T, ECO:0007744|PDB:8UBW, ECO:0007744|PDB:8UBX, ECO:0007744|PDB:8UBZ |
| Chain | Residue | Details |
| A | ILE332-TYR362 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 28 |
| Details | TRANSMEM: Helical; Name=TM8 => ECO:0000269|PubMed:38693265, ECO:0000269|PubMed:38778100, ECO:0007744|PDB:8QCS, ECO:0007744|PDB:8QCT, ECO:0007744|PDB:8R8T, ECO:0007744|PDB:8UBW, ECO:0007744|PDB:8UBX, ECO:0007744|PDB:8UBZ |
| Chain | Residue | Details |
| A | GLU367-THR395 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 22 |
| Details | TRANSMEM: Helical; Name=TM9 => ECO:0000269|PubMed:38693265, ECO:0000269|PubMed:38778100, ECO:0007744|PDB:8QCS, ECO:0007744|PDB:8QCT, ECO:0007744|PDB:8R8T, ECO:0007744|PDB:8UBW, ECO:0007744|PDB:8UBX, ECO:0007744|PDB:8UBZ |
| Chain | Residue | Details |
| A | TYR398-LEU420 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 29 |
| Details | TRANSMEM: Helical; Name=TM10 => ECO:0000269|PubMed:38693265, ECO:0000269|PubMed:38778100, ECO:0007744|PDB:8QCS, ECO:0007744|PDB:8QCT, ECO:0007744|PDB:8R8T, ECO:0007744|PDB:8UBW, ECO:0007744|PDB:8UBX, ECO:0007744|PDB:8UBZ |
| Chain | Residue | Details |
| A | TYR424-ILE453 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 25 |
| Details | TRANSMEM: Helical; Name=TM11 => ECO:0000269|PubMed:38693265, ECO:0000269|PubMed:38778100, ECO:0007744|PDB:8QCS, ECO:0007744|PDB:8QCT, ECO:0007744|PDB:8R8T, ECO:0007744|PDB:8UBW, ECO:0007744|PDB:8UBX, ECO:0007744|PDB:8UBZ |
| Chain | Residue | Details |
| A | SER462-ASP487 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 22 |
| Details | TRANSMEM: Helical; Name=TM12 => ECO:0000269|PubMed:38693265, ECO:0000269|PubMed:38778100, ECO:0007744|PDB:8QCS, ECO:0007744|PDB:8QCT, ECO:0007744|PDB:8R8T, ECO:0007744|PDB:8UBW, ECO:0007744|PDB:8UBX, ECO:0007744|PDB:8UBZ |
| Chain | Residue | Details |
| A | PRO490-LYS512 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:38693265, ECO:0000269|PubMed:38778100, ECO:0007744|PDB:8R8T, ECO:0007744|PDB:8UBX |
| Chain | Residue | Details |
| A | GLN214 |
| site_id | SWS_FT_FI16 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:38693265, ECO:0007744|PDB:8R8T, ECO:0007744|PDB:8UBX |
| Chain | Residue | Details |
| A | GLN471 |
| site_id | SWS_FT_FI17 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332 |
| Chain | Residue | Details |
| A | SER56 |
| site_id | SWS_FT_FI18 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER536 |
| site_id | SWS_FT_FI19 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN265 |
