8R7J

Cryo-EM structure of the human TREX-2 complex

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0000973	biological_process	post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery
B	0003690	molecular_function	double-stranded DNA binding
B	0003723	molecular_function	RNA binding
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005643	cellular_component	nuclear pore
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0006368	biological_process	transcription elongation by RNA polymerase II
B	0006406	biological_process	mRNA export from nucleus
B	0015031	biological_process	protein transport
B	0016973	biological_process	poly(A)+ mRNA export from nucleus
B	0032991	cellular_component	protein-containing complex
B	0044615	cellular_component	nuclear pore nuclear basket
B	0045579	biological_process	positive regulation of B cell differentiation
B	0045814	biological_process	negative regulation of gene expression, epigenetic
B	0045944	biological_process	positive regulation of transcription by RNA polymerase II
B	0048536	biological_process	spleen development
B	0051028	biological_process	mRNA transport
B	0070390	cellular_component	transcription export complex 2
B	1905457	biological_process	negative regulation of lymphoid progenitor cell differentiation
C	0000502	cellular_component	proteasome complex
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005829	cellular_component	cytosol
C	0006406	biological_process	mRNA export from nucleus
C	0006979	biological_process	response to oxidative stress
C	0008021	cellular_component	synaptic vesicle
C	0008541	cellular_component	proteasome regulatory particle, lid subcomplex
C	0010498	biological_process	proteasomal protein catabolic process
C	0032039	cellular_component	integrator complex
C	0032991	cellular_component	protein-containing complex
C	0043130	molecular_function	ubiquitin binding
C	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
C	0043248	biological_process	proteasome assembly
C	0045944	biological_process	positive regulation of transcription by RNA polymerase II
C	0061136	biological_process	regulation of proteasomal protein catabolic process
C	0071357	biological_process	cellular response to type I interferon

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	183
Details	Domain: {"description":"PCI","evidences":[{"source":"PROSITE-ProRule","id":"PRU01185","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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