Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8R7C

MutSbeta bound to compound CHDI-00915542 in the canonical DNA-mismatch bound form

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000287	molecular_function	magnesium ion binding
A	0000400	molecular_function	four-way junction DNA binding
A	0000781	cellular_component	chromosome, telomeric region
A	0001701	biological_process	in utero embryonic development
A	0002204	biological_process	somatic recombination of immunoglobulin genes involved in immune response
A	0003677	molecular_function	DNA binding
A	0003682	molecular_function	chromatin binding
A	0003684	molecular_function	damaged DNA binding
A	0003690	molecular_function	double-stranded DNA binding
A	0003697	molecular_function	single-stranded DNA binding
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005694	cellular_component	chromosome
A	0006119	biological_process	oxidative phosphorylation
A	0006281	biological_process	DNA repair
A	0006298	biological_process	mismatch repair
A	0006301	biological_process	postreplication repair
A	0006302	biological_process	double-strand break repair
A	0006312	biological_process	mitotic recombination
A	0006974	biological_process	DNA damage response
A	0007281	biological_process	germ cell development
A	0008047	molecular_function	enzyme activator activity
A	0008094	molecular_function	ATP-dependent activity, acting on DNA
A	0008340	biological_process	determination of adult lifespan
A	0008584	biological_process	male gonad development
A	0008630	biological_process	intrinsic apoptotic signaling pathway in response to DNA damage
A	0010165	biological_process	response to X-ray
A	0010224	biological_process	response to UV-B
A	0016020	cellular_component	membrane
A	0016446	biological_process	somatic hypermutation of immunoglobulin genes
A	0016447	biological_process	somatic recombination of immunoglobulin gene segments
A	0016887	molecular_function	ATP hydrolysis activity
A	0019237	molecular_function	centromeric DNA binding
A	0019724	biological_process	B cell mediated immunity
A	0030183	biological_process	B cell differentiation
A	0030983	molecular_function	mismatched DNA binding
A	0031573	biological_process	mitotic intra-S DNA damage checkpoint signaling
A	0032137	molecular_function	guanine/thymine mispair binding
A	0032139	molecular_function	dinucleotide insertion or deletion binding
A	0032142	molecular_function	single guanine insertion binding
A	0032143	molecular_function	single thymine insertion binding
A	0032181	molecular_function	dinucleotide repeat insertion binding
A	0032301	cellular_component	MutSalpha complex
A	0032302	cellular_component	MutSbeta complex
A	0032357	molecular_function	oxidized purine DNA binding
A	0032405	molecular_function	MutLalpha complex binding
A	0042771	biological_process	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
A	0042803	molecular_function	protein homodimerization activity
A	0043524	biological_process	negative regulation of neuron apoptotic process
A	0043531	molecular_function	ADP binding
A	0043570	biological_process	maintenance of DNA repeat elements
A	0045190	biological_process	isotype switching
A	0045910	biological_process	negative regulation of DNA recombination
A	0048298	biological_process	positive regulation of isotype switching to IgA isotypes
A	0048304	biological_process	positive regulation of isotype switching to IgG isotypes
A	0051726	biological_process	regulation of cell cycle
A	0140664	molecular_function	ATP-dependent DNA damage sensor activity
B	0005524	molecular_function	ATP binding
B	0006298	biological_process	mismatch repair
B	0030983	molecular_function	mismatched DNA binding
B	0140664	molecular_function	ATP-dependent DNA damage sensor activity
E	0000166	molecular_function	nucleotide binding
E	0000287	molecular_function	magnesium ion binding
E	0000400	molecular_function	four-way junction DNA binding
E	0000781	cellular_component	chromosome, telomeric region
E	0001701	biological_process	in utero embryonic development
E	0002204	biological_process	somatic recombination of immunoglobulin genes involved in immune response
E	0003677	molecular_function	DNA binding
E	0003682	molecular_function	chromatin binding
E	0003684	molecular_function	damaged DNA binding
E	0003690	molecular_function	double-stranded DNA binding
E	0003697	molecular_function	single-stranded DNA binding
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005694	cellular_component	chromosome
E	0006119	biological_process	oxidative phosphorylation
E	0006281	biological_process	DNA repair
E	0006298	biological_process	mismatch repair
E	0006301	biological_process	postreplication repair
E	0006302	biological_process	double-strand break repair
E	0006312	biological_process	mitotic recombination
E	0006974	biological_process	DNA damage response
E	0007281	biological_process	germ cell development
E	0008047	molecular_function	enzyme activator activity
E	0008094	molecular_function	ATP-dependent activity, acting on DNA
E	0008340	biological_process	determination of adult lifespan
E	0008584	biological_process	male gonad development
E	0008630	biological_process	intrinsic apoptotic signaling pathway in response to DNA damage
E	0010165	biological_process	response to X-ray
E	0010224	biological_process	response to UV-B
E	0016020	cellular_component	membrane
E	0016446	biological_process	somatic hypermutation of immunoglobulin genes
E	0016447	biological_process	somatic recombination of immunoglobulin gene segments
E	0016887	molecular_function	ATP hydrolysis activity
E	0019237	molecular_function	centromeric DNA binding
E	0019724	biological_process	B cell mediated immunity
E	0030183	biological_process	B cell differentiation
E	0030983	molecular_function	mismatched DNA binding
E	0031573	biological_process	mitotic intra-S DNA damage checkpoint signaling
E	0032137	molecular_function	guanine/thymine mispair binding
E	0032139	molecular_function	dinucleotide insertion or deletion binding
E	0032142	molecular_function	single guanine insertion binding
E	0032143	molecular_function	single thymine insertion binding
E	0032181	molecular_function	dinucleotide repeat insertion binding
E	0032301	cellular_component	MutSalpha complex
E	0032302	cellular_component	MutSbeta complex
E	0032357	molecular_function	oxidized purine DNA binding
E	0032405	molecular_function	MutLalpha complex binding
E	0042771	biological_process	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
E	0042803	molecular_function	protein homodimerization activity
E	0043524	biological_process	negative regulation of neuron apoptotic process
E	0043531	molecular_function	ADP binding
E	0043570	biological_process	maintenance of DNA repeat elements
E	0045190	biological_process	isotype switching
E	0045910	biological_process	negative regulation of DNA recombination
E	0048298	biological_process	positive regulation of isotype switching to IgA isotypes
E	0048304	biological_process	positive regulation of isotype switching to IgG isotypes
E	0051726	biological_process	regulation of cell cycle
E	0140664	molecular_function	ATP-dependent DNA damage sensor activity
F	0005524	molecular_function	ATP binding
F	0006298	biological_process	mismatch repair
F	0030983	molecular_function	mismatched DNA binding
F	0140664	molecular_function	ATP-dependent DNA damage sensor activity

Functional Information from PROSITE/UniProt

site_id	PS00486
Number of Residues	17
Details	DNA_MISMATCH_REPAIR_2 DNA mismatch repair proteins mutS family signature. SLiIiDELGRGTstydG

Chain	Residue	Details
A	SER743-GLY759
B	SER970-GLY986

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	BINDING: BINDING => ECO:0000255

Chain	Residue	Details
B	GLY896
F	GLY896

site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0007744\|PubMed:20068231, ECO:0007744\|PubMed:21406692

Chain	Residue	Details
B	THR1099
F	THR1099

site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: N6-acetyllysine => ECO:0007744\|PubMed:19608861

Chain	Residue	Details
A	LYS555
E	LYS555

site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: N6-acetyllysine => ECO:0000250\|UniProtKB:P43247

Chain	Residue	Details
A	LYS567
E	LYS567

site_id	SWS_FT_FI5
Number of Residues	8
Details	MOD_RES: N6-acetyllysine => ECO:0000269\|PubMed:24882211

Chain	Residue	Details
A	LYS845
A	LYS847
A	LYS871
A	LYS892
E	LYS845
E	LYS847
E	LYS871
E	LYS892

site_id	SWS_FT_FI6
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:23186163

Chain	Residue	Details
A	SER921
E	SER921

site_id	SWS_FT_FI7
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744\|PubMed:28112733

Chain	Residue	Details
A	LYS430
E	LYS430

site_id	SWS_FT_FI8
Number of Residues	10
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269\|PubMed:24882211

Chain	Residue	Details
E	LYS892
A	LYS845
A	LYS847
A	LYS871
A	LYS892
E	LYS845
E	LYS847
E	LYS871

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)