8R4A

Cryo-EM structure of the D87G lysozyme amyloid fibril

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003796	molecular_function	lysozyme activity
A	0003824	molecular_function	catalytic activity
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005794	cellular_component	Golgi apparatus
A	0006954	biological_process	inflammatory response
A	0016787	molecular_function	hydrolase activity
A	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
A	0019730	biological_process	antimicrobial humoral response
A	0031640	biological_process	killing of cells of another organism
A	0035578	cellular_component	azurophil granule lumen
A	0035580	cellular_component	specific granule lumen
A	0042742	biological_process	defense response to bacterium
A	0042802	molecular_function	identical protein binding
A	0050829	biological_process	defense response to Gram-negative bacterium
A	0050830	biological_process	defense response to Gram-positive bacterium
A	0070062	cellular_component	extracellular exosome
A	1904724	cellular_component	tertiary granule lumen
B	0003796	molecular_function	lysozyme activity
B	0003824	molecular_function	catalytic activity
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0005794	cellular_component	Golgi apparatus
B	0006954	biological_process	inflammatory response
B	0016787	molecular_function	hydrolase activity
B	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
B	0019730	biological_process	antimicrobial humoral response
B	0031640	biological_process	killing of cells of another organism
B	0035578	cellular_component	azurophil granule lumen
B	0035580	cellular_component	specific granule lumen
B	0042742	biological_process	defense response to bacterium
B	0042802	molecular_function	identical protein binding
B	0050829	biological_process	defense response to Gram-negative bacterium
B	0050830	biological_process	defense response to Gram-positive bacterium
B	0070062	cellular_component	extracellular exosome
B	1904724	cellular_component	tertiary granule lumen
C	0003796	molecular_function	lysozyme activity
C	0003824	molecular_function	catalytic activity
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0005794	cellular_component	Golgi apparatus
C	0006954	biological_process	inflammatory response
C	0016787	molecular_function	hydrolase activity
C	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
C	0019730	biological_process	antimicrobial humoral response
C	0031640	biological_process	killing of cells of another organism
C	0035578	cellular_component	azurophil granule lumen
C	0035580	cellular_component	specific granule lumen
C	0042742	biological_process	defense response to bacterium
C	0042802	molecular_function	identical protein binding
C	0050829	biological_process	defense response to Gram-negative bacterium
C	0050830	biological_process	defense response to Gram-positive bacterium
C	0070062	cellular_component	extracellular exosome
C	1904724	cellular_component	tertiary granule lumen
D	0003796	molecular_function	lysozyme activity
D	0003824	molecular_function	catalytic activity
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
D	0005794	cellular_component	Golgi apparatus
D	0006954	biological_process	inflammatory response
D	0016787	molecular_function	hydrolase activity
D	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
D	0019730	biological_process	antimicrobial humoral response
D	0031640	biological_process	killing of cells of another organism
D	0035578	cellular_component	azurophil granule lumen
D	0035580	cellular_component	specific granule lumen
D	0042742	biological_process	defense response to bacterium
D	0042802	molecular_function	identical protein binding
D	0050829	biological_process	defense response to Gram-negative bacterium
D	0050830	biological_process	defense response to Gram-positive bacterium
D	0070062	cellular_component	extracellular exosome
D	1904724	cellular_component	tertiary granule lumen
E	0003796	molecular_function	lysozyme activity
E	0003824	molecular_function	catalytic activity
E	0005576	cellular_component	extracellular region
E	0005615	cellular_component	extracellular space
E	0005794	cellular_component	Golgi apparatus
E	0006954	biological_process	inflammatory response
E	0016787	molecular_function	hydrolase activity
E	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
E	0019730	biological_process	antimicrobial humoral response
E	0031640	biological_process	killing of cells of another organism
E	0035578	cellular_component	azurophil granule lumen
E	0035580	cellular_component	specific granule lumen
E	0042742	biological_process	defense response to bacterium
E	0042802	molecular_function	identical protein binding
E	0050829	biological_process	defense response to Gram-negative bacterium
E	0050830	biological_process	defense response to Gram-positive bacterium
E	0070062	cellular_component	extracellular exosome
E	1904724	cellular_component	tertiary granule lumen
F	0003796	molecular_function	lysozyme activity
F	0003824	molecular_function	catalytic activity
F	0005576	cellular_component	extracellular region
F	0005615	cellular_component	extracellular space
F	0005794	cellular_component	Golgi apparatus
F	0006954	biological_process	inflammatory response
F	0016787	molecular_function	hydrolase activity
F	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
F	0019730	biological_process	antimicrobial humoral response
F	0031640	biological_process	killing of cells of another organism
F	0035578	cellular_component	azurophil granule lumen
F	0035580	cellular_component	specific granule lumen
F	0042742	biological_process	defense response to bacterium
F	0042802	molecular_function	identical protein binding
F	0050829	biological_process	defense response to Gram-negative bacterium
F	0050830	biological_process	defense response to Gram-positive bacterium
F	0070062	cellular_component	extracellular exosome
F	1904724	cellular_component	tertiary granule lumen
G	0003796	molecular_function	lysozyme activity
G	0003824	molecular_function	catalytic activity
G	0005576	cellular_component	extracellular region
G	0005615	cellular_component	extracellular space
G	0005794	cellular_component	Golgi apparatus
G	0006954	biological_process	inflammatory response
G	0016787	molecular_function	hydrolase activity
G	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
G	0019730	biological_process	antimicrobial humoral response
G	0031640	biological_process	killing of cells of another organism
G	0035578	cellular_component	azurophil granule lumen
G	0035580	cellular_component	specific granule lumen
G	0042742	biological_process	defense response to bacterium
G	0042802	molecular_function	identical protein binding
G	0050829	biological_process	defense response to Gram-negative bacterium
G	0050830	biological_process	defense response to Gram-positive bacterium
G	0070062	cellular_component	extracellular exosome
G	1904724	cellular_component	tertiary granule lumen
H	0003796	molecular_function	lysozyme activity
H	0003824	molecular_function	catalytic activity
H	0005576	cellular_component	extracellular region
H	0005615	cellular_component	extracellular space
H	0005794	cellular_component	Golgi apparatus
H	0006954	biological_process	inflammatory response
H	0016787	molecular_function	hydrolase activity
H	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
H	0019730	biological_process	antimicrobial humoral response
H	0031640	biological_process	killing of cells of another organism
H	0035578	cellular_component	azurophil granule lumen
H	0035580	cellular_component	specific granule lumen
H	0042742	biological_process	defense response to bacterium
H	0042802	molecular_function	identical protein binding
H	0050829	biological_process	defense response to Gram-negative bacterium
H	0050830	biological_process	defense response to Gram-positive bacterium
H	0070062	cellular_component	extracellular exosome
H	1904724	cellular_component	tertiary granule lumen
I	0003796	molecular_function	lysozyme activity
I	0003824	molecular_function	catalytic activity
I	0005576	cellular_component	extracellular region
I	0005615	cellular_component	extracellular space
I	0005794	cellular_component	Golgi apparatus
I	0006954	biological_process	inflammatory response
I	0016787	molecular_function	hydrolase activity
I	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
I	0019730	biological_process	antimicrobial humoral response
I	0031640	biological_process	killing of cells of another organism
I	0035578	cellular_component	azurophil granule lumen
I	0035580	cellular_component	specific granule lumen
I	0042742	biological_process	defense response to bacterium
I	0042802	molecular_function	identical protein binding
I	0050829	biological_process	defense response to Gram-negative bacterium
I	0050830	biological_process	defense response to Gram-positive bacterium
I	0070062	cellular_component	extracellular exosome
I	1904724	cellular_component	tertiary granule lumen

Functional Information from PROSITE/UniProt

site_id	PS00128
Number of Residues	19
Details	GLYCOSYL_HYDROL_F22_1 Glycosyl hydrolases family 22 (GH22) domain signature. ChlsCsaLlqgNIadavaC

Chain	Residue	Details
A	CYS77-CYS95

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1161
Details	Domain: {"description":"C-type lysozyme","evidences":[{"source":"PROSITE-ProRule","id":"PRU00680","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	18
Details	Active site: {}

Chain

Residue

Details

---