Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8QZ0

SWR1-hexasome-dimer complex

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000500	cellular_component	RNA polymerase I upstream activating factor complex
A	0000786	cellular_component	nucleosome
A	0003677	molecular_function	DNA binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005694	cellular_component	chromosome
A	0006325	biological_process	chromatin organization
A	0006355	biological_process	regulation of DNA-templated transcription
A	0006878	biological_process	intracellular copper ion homeostasis
A	0008823	molecular_function	cupric reductase (NADH) activity
A	0009060	biological_process	aerobic respiration
A	0009303	biological_process	rRNA transcription
A	0030527	molecular_function	structural constituent of chromatin
A	0042790	biological_process	nucleolar large rRNA transcription by RNA polymerase I
A	0043505	cellular_component	CENP-A containing nucleosome
A	0043935	biological_process	sexual sporulation resulting in formation of a cellular spore
A	0045943	biological_process	positive regulation of transcription by RNA polymerase I
A	0046982	molecular_function	protein heterodimerization activity
A	0070911	biological_process	global genome nucleotide-excision repair
B	0000500	cellular_component	RNA polymerase I upstream activating factor complex
B	0000786	cellular_component	nucleosome
B	0003677	molecular_function	DNA binding
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005694	cellular_component	chromosome
B	0006325	biological_process	chromatin organization
B	0006355	biological_process	regulation of DNA-templated transcription
B	0006878	biological_process	intracellular copper ion homeostasis
B	0008823	molecular_function	cupric reductase (NADH) activity
B	0009060	biological_process	aerobic respiration
B	0009303	biological_process	rRNA transcription
B	0030527	molecular_function	structural constituent of chromatin
B	0042790	biological_process	nucleolar large rRNA transcription by RNA polymerase I
B	0043505	cellular_component	CENP-A containing nucleosome
B	0043935	biological_process	sexual sporulation resulting in formation of a cellular spore
B	0045943	biological_process	positive regulation of transcription by RNA polymerase I
B	0046982	molecular_function	protein heterodimerization activity
B	0070911	biological_process	global genome nucleotide-excision repair
C	0000500	cellular_component	RNA polymerase I upstream activating factor complex
C	0000786	cellular_component	nucleosome
C	0003677	molecular_function	DNA binding
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005694	cellular_component	chromosome
C	0006325	biological_process	chromatin organization
C	0006334	biological_process	nucleosome assembly
C	0006355	biological_process	regulation of DNA-templated transcription
C	0030527	molecular_function	structural constituent of chromatin
C	0042790	biological_process	nucleolar large rRNA transcription by RNA polymerase I
C	0042802	molecular_function	identical protein binding
C	0045943	biological_process	positive regulation of transcription by RNA polymerase I
C	0046982	molecular_function	protein heterodimerization activity
D	0000500	cellular_component	RNA polymerase I upstream activating factor complex
D	0000786	cellular_component	nucleosome
D	0003677	molecular_function	DNA binding
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005694	cellular_component	chromosome
D	0006325	biological_process	chromatin organization
D	0006334	biological_process	nucleosome assembly
D	0006355	biological_process	regulation of DNA-templated transcription
D	0030527	molecular_function	structural constituent of chromatin
D	0042790	biological_process	nucleolar large rRNA transcription by RNA polymerase I
D	0042802	molecular_function	identical protein binding
D	0045943	biological_process	positive regulation of transcription by RNA polymerase I
D	0046982	molecular_function	protein heterodimerization activity
E	0000122	biological_process	negative regulation of transcription by RNA polymerase II
E	0000786	cellular_component	nucleosome
E	0003677	molecular_function	DNA binding
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005694	cellular_component	chromosome
E	0006281	biological_process	DNA repair
E	0006325	biological_process	chromatin organization
E	0006974	biological_process	DNA damage response
E	0030527	molecular_function	structural constituent of chromatin
E	0031298	cellular_component	replication fork protection complex
E	0031507	biological_process	heterochromatin formation
E	0046982	molecular_function	protein heterodimerization activity
G	0000122	biological_process	negative regulation of transcription by RNA polymerase II
G	0000786	cellular_component	nucleosome
G	0003677	molecular_function	DNA binding
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005694	cellular_component	chromosome
G	0006301	biological_process	postreplication repair
G	0006325	biological_process	chromatin organization
G	0006355	biological_process	regulation of DNA-templated transcription
G	0030527	molecular_function	structural constituent of chromatin
G	0046982	molecular_function	protein heterodimerization activity
H	0000122	biological_process	negative regulation of transcription by RNA polymerase II
H	0000786	cellular_component	nucleosome
H	0003677	molecular_function	DNA binding
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005694	cellular_component	chromosome
H	0006301	biological_process	postreplication repair
H	0006325	biological_process	chromatin organization
H	0006355	biological_process	regulation of DNA-templated transcription
H	0030527	molecular_function	structural constituent of chromatin
H	0046982	molecular_function	protein heterodimerization activity
K	0005634	cellular_component	nucleus
K	0006338	biological_process	chromatin remodeling
K	0042393	molecular_function	histone binding
L	0000785	cellular_component	chromatin
L	0000786	cellular_component	nucleosome
L	0000791	cellular_component	euchromatin
L	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
L	0003677	molecular_function	DNA binding
L	0003682	molecular_function	chromatin binding
L	0005515	molecular_function	protein binding
L	0005634	cellular_component	nucleus
L	0005694	cellular_component	chromosome
L	0006325	biological_process	chromatin organization
L	0006338	biological_process	chromatin remodeling
L	0006355	biological_process	regulation of DNA-templated transcription
L	0006357	biological_process	regulation of transcription by RNA polymerase II
L	0006368	biological_process	transcription elongation by RNA polymerase II
L	0006401	biological_process	RNA catabolic process
L	0030466	biological_process	silent mating-type cassette heterochromatin formation
L	0030527	molecular_function	structural constituent of chromatin
L	0031490	molecular_function	chromatin DNA binding
L	0031507	biological_process	heterochromatin formation
L	0042802	molecular_function	identical protein binding
L	0046982	molecular_function	protein heterodimerization activity
L	0070481	biological_process	nuclear-transcribed mRNA catabolic process, non-stop decay
M	0000166	molecular_function	nucleotide binding
M	0000725	biological_process	recombinational repair
M	0000785	cellular_component	chromatin
M	0000812	cellular_component	Swr1 complex
M	0003677	molecular_function	DNA binding
M	0004386	molecular_function	helicase activity
M	0005198	molecular_function	structural molecule activity
M	0005515	molecular_function	protein binding
M	0005524	molecular_function	ATP binding
M	0005634	cellular_component	nucleus
M	0005829	cellular_component	cytosol
M	0006325	biological_process	chromatin organization
M	0006338	biological_process	chromatin remodeling
M	0006355	biological_process	regulation of DNA-templated transcription
M	0016787	molecular_function	hydrolase activity
M	0016887	molecular_function	ATP hydrolysis activity
M	0031492	molecular_function	nucleosomal DNA binding
M	0042393	molecular_function	histone binding
M	0060090	molecular_function	molecular adaptor activity
P	0000785	cellular_component	chromatin
P	0000812	cellular_component	Swr1 complex
P	0003674	molecular_function	molecular_function
P	0005634	cellular_component	nucleus
P	0005829	cellular_component	cytosol
P	0006325	biological_process	chromatin organization
P	0006338	biological_process	chromatin remodeling
P	0006355	biological_process	regulation of DNA-templated transcription
R	0000785	cellular_component	chromatin
R	0000812	cellular_component	Swr1 complex
R	0005515	molecular_function	protein binding
R	0005634	cellular_component	nucleus
R	0005737	cellular_component	cytoplasm
R	0006325	biological_process	chromatin organization
R	0006338	biological_process	chromatin remodeling
R	0006355	biological_process	regulation of DNA-templated transcription
R	0031491	molecular_function	nucleosome binding
R	0034399	cellular_component	nuclear periphery
S	0000785	cellular_component	chromatin
S	0000812	cellular_component	Swr1 complex
S	0005515	molecular_function	protein binding
S	0005634	cellular_component	nucleus
S	0006325	biological_process	chromatin organization
S	0006338	biological_process	chromatin remodeling
S	0006355	biological_process	regulation of DNA-templated transcription
S	0006623	biological_process	protein targeting to vacuole
S	0008270	molecular_function	zinc ion binding
S	0031491	molecular_function	nucleosome binding
S	0046872	molecular_function	metal ion binding
T	0000166	molecular_function	nucleotide binding
T	0000492	biological_process	box C/D snoRNP assembly
T	0000785	cellular_component	chromatin
T	0000812	cellular_component	Swr1 complex
T	0003678	molecular_function	DNA helicase activity
T	0004386	molecular_function	helicase activity
T	0005515	molecular_function	protein binding
T	0005524	molecular_function	ATP binding
T	0005634	cellular_component	nucleus
T	0006281	biological_process	DNA repair
T	0006325	biological_process	chromatin organization
T	0006338	biological_process	chromatin remodeling
T	0006355	biological_process	regulation of DNA-templated transcription
T	0006357	biological_process	regulation of transcription by RNA polymerase II
T	0006974	biological_process	DNA damage response
T	0008094	molecular_function	ATP-dependent activity, acting on DNA
T	0016787	molecular_function	hydrolase activity
T	0016887	molecular_function	ATP hydrolysis activity
T	0031011	cellular_component	Ino80 complex
T	0035267	cellular_component	NuA4 histone acetyltransferase complex
T	0043138	molecular_function	3'-5' DNA helicase activity
T	0043139	molecular_function	5'-3' DNA helicase activity
T	0050821	biological_process	protein stabilization
T	0097255	cellular_component	R2TP complex
T	0110078	cellular_component	TTT Hsp90 cochaperone complex
U	0000166	molecular_function	nucleotide binding
U	0000492	biological_process	box C/D snoRNP assembly
U	0000785	cellular_component	chromatin
U	0000812	cellular_component	Swr1 complex
U	0003678	molecular_function	DNA helicase activity
U	0004386	molecular_function	helicase activity
U	0005515	molecular_function	protein binding
U	0005524	molecular_function	ATP binding
U	0005634	cellular_component	nucleus
U	0005654	cellular_component	nucleoplasm
U	0006281	biological_process	DNA repair
U	0006325	biological_process	chromatin organization
U	0006338	biological_process	chromatin remodeling
U	0006355	biological_process	regulation of DNA-templated transcription
U	0006357	biological_process	regulation of transcription by RNA polymerase II
U	0006364	biological_process	rRNA processing
U	0006974	biological_process	DNA damage response
U	0008094	molecular_function	ATP-dependent activity, acting on DNA
U	0016787	molecular_function	hydrolase activity
U	0016887	molecular_function	ATP hydrolysis activity
U	0031011	cellular_component	Ino80 complex
U	0035267	cellular_component	NuA4 histone acetyltransferase complex
U	0043138	molecular_function	3'-5' DNA helicase activity
U	0043139	molecular_function	5'-3' DNA helicase activity
U	0050821	biological_process	protein stabilization
U	0097255	cellular_component	R2TP complex
U	0110078	cellular_component	TTT Hsp90 cochaperone complex
V	0000166	molecular_function	nucleotide binding
V	0000492	biological_process	box C/D snoRNP assembly
V	0000785	cellular_component	chromatin
V	0000812	cellular_component	Swr1 complex
V	0003678	molecular_function	DNA helicase activity
V	0004386	molecular_function	helicase activity
V	0005515	molecular_function	protein binding
V	0005524	molecular_function	ATP binding
V	0005634	cellular_component	nucleus
V	0006281	biological_process	DNA repair
V	0006325	biological_process	chromatin organization
V	0006338	biological_process	chromatin remodeling
V	0006355	biological_process	regulation of DNA-templated transcription
V	0006357	biological_process	regulation of transcription by RNA polymerase II
V	0006974	biological_process	DNA damage response
V	0008094	molecular_function	ATP-dependent activity, acting on DNA
V	0016787	molecular_function	hydrolase activity
V	0016887	molecular_function	ATP hydrolysis activity
V	0031011	cellular_component	Ino80 complex
V	0035267	cellular_component	NuA4 histone acetyltransferase complex
V	0043138	molecular_function	3'-5' DNA helicase activity
V	0043139	molecular_function	5'-3' DNA helicase activity
V	0050821	biological_process	protein stabilization
V	0097255	cellular_component	R2TP complex
V	0110078	cellular_component	TTT Hsp90 cochaperone complex
W	0000166	molecular_function	nucleotide binding
W	0000492	biological_process	box C/D snoRNP assembly
W	0000785	cellular_component	chromatin
W	0000812	cellular_component	Swr1 complex
W	0003678	molecular_function	DNA helicase activity
W	0004386	molecular_function	helicase activity
W	0005515	molecular_function	protein binding
W	0005524	molecular_function	ATP binding
W	0005634	cellular_component	nucleus
W	0005654	cellular_component	nucleoplasm
W	0006281	biological_process	DNA repair
W	0006325	biological_process	chromatin organization
W	0006338	biological_process	chromatin remodeling
W	0006355	biological_process	regulation of DNA-templated transcription
W	0006357	biological_process	regulation of transcription by RNA polymerase II
W	0006364	biological_process	rRNA processing
W	0006974	biological_process	DNA damage response
W	0008094	molecular_function	ATP-dependent activity, acting on DNA
W	0016787	molecular_function	hydrolase activity
W	0016887	molecular_function	ATP hydrolysis activity
W	0031011	cellular_component	Ino80 complex
W	0035267	cellular_component	NuA4 histone acetyltransferase complex
W	0043138	molecular_function	3'-5' DNA helicase activity
W	0043139	molecular_function	5'-3' DNA helicase activity
W	0050821	biological_process	protein stabilization
W	0097255	cellular_component	R2TP complex
W	0110078	cellular_component	TTT Hsp90 cochaperone complex
X	0000166	molecular_function	nucleotide binding
X	0000492	biological_process	box C/D snoRNP assembly
X	0000785	cellular_component	chromatin
X	0000812	cellular_component	Swr1 complex
X	0003678	molecular_function	DNA helicase activity
X	0004386	molecular_function	helicase activity
X	0005515	molecular_function	protein binding
X	0005524	molecular_function	ATP binding
X	0005634	cellular_component	nucleus
X	0006281	biological_process	DNA repair
X	0006325	biological_process	chromatin organization
X	0006338	biological_process	chromatin remodeling
X	0006355	biological_process	regulation of DNA-templated transcription
X	0006357	biological_process	regulation of transcription by RNA polymerase II
X	0006974	biological_process	DNA damage response
X	0008094	molecular_function	ATP-dependent activity, acting on DNA
X	0016787	molecular_function	hydrolase activity
X	0016887	molecular_function	ATP hydrolysis activity
X	0031011	cellular_component	Ino80 complex
X	0035267	cellular_component	NuA4 histone acetyltransferase complex
X	0043138	molecular_function	3'-5' DNA helicase activity
X	0043139	molecular_function	5'-3' DNA helicase activity
X	0050821	biological_process	protein stabilization
X	0097255	cellular_component	R2TP complex
X	0110078	cellular_component	TTT Hsp90 cochaperone complex
Y	0000166	molecular_function	nucleotide binding
Y	0000492	biological_process	box C/D snoRNP assembly
Y	0000785	cellular_component	chromatin
Y	0000812	cellular_component	Swr1 complex
Y	0003678	molecular_function	DNA helicase activity
Y	0004386	molecular_function	helicase activity
Y	0005515	molecular_function	protein binding
Y	0005524	molecular_function	ATP binding
Y	0005634	cellular_component	nucleus
Y	0005654	cellular_component	nucleoplasm
Y	0006281	biological_process	DNA repair
Y	0006325	biological_process	chromatin organization
Y	0006338	biological_process	chromatin remodeling
Y	0006355	biological_process	regulation of DNA-templated transcription
Y	0006357	biological_process	regulation of transcription by RNA polymerase II
Y	0006364	biological_process	rRNA processing
Y	0006974	biological_process	DNA damage response
Y	0008094	molecular_function	ATP-dependent activity, acting on DNA
Y	0016787	molecular_function	hydrolase activity
Y	0016887	molecular_function	ATP hydrolysis activity
Y	0031011	cellular_component	Ino80 complex
Y	0035267	cellular_component	NuA4 histone acetyltransferase complex
Y	0043138	molecular_function	3'-5' DNA helicase activity
Y	0043139	molecular_function	5'-3' DNA helicase activity
Y	0050821	biological_process	protein stabilization
Y	0097255	cellular_component	R2TP complex
Y	0110078	cellular_component	TTT Hsp90 cochaperone complex
Z	0000785	cellular_component	chromatin
Z	0000812	cellular_component	Swr1 complex
Z	0005515	molecular_function	protein binding
Z	0005634	cellular_component	nucleus
Z	0005737	cellular_component	cytoplasm
Z	0006325	biological_process	chromatin organization
Z	0006338	biological_process	chromatin remodeling
Z	0006355	biological_process	regulation of DNA-templated transcription
Z	0042393	molecular_function	histone binding

Functional Information from PROSITE/UniProt

site_id	PS00014
Number of Residues	4
Details	ER_TARGET Endoplasmic reticulum targeting sequence. SQEL

Chain	Residue	Details
E	SER128-LEU131

site_id	PS00046
Number of Residues	7
Details	HISTONE_H2A Histone H2A signature. AGLqFPV

Chain	Residue	Details
L	ALA28-VAL34
E	ALA22-VAL28

site_id	PS00047
Number of Residues	5
Details	HISTONE_H4 Histone H4 signature. GAKRH

Chain	Residue	Details
C	GLY14-HIS18

site_id	PS00322
Number of Residues	7
Details	HISTONE_H3_1 Histone H3 signature 1. KAPRKQL

Chain	Residue	Details
A	LYS14-LEU20

site_id	PS00357
Number of Residues	23
Details	HISTONE_H2B Histone H2B signature. REIQTavRlILpGELaKHAVSEG

Chain	Residue	Details
G	ARG95-GLY117

site_id	PS00959
Number of Residues	9
Details	HISTONE_H3_2 Histone H3 signature 2. PFqRLVREI

Chain	Residue	Details
A	PRO66-ILE74

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	MOD_RES: N-acetylserine => ECO:0007744\|PubMed:22814378

Chain	Residue	Details
K	SER2
X	GLY79
T	GLY79

site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:18407956, ECO:0007744\|PubMed:19779198

Chain	Residue	Details
K	SER68
K	SER70
T	VAL2
S	CYS259
S	CYS264
S	CYS268
S	HIS272
S	CYS277

site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: N6-acetyllysine => ECO:0000269\|PubMed:11545749, ECO:0000269\|PubMed:15186774

Chain	Residue	Details
H	LYS11
D	LYS16

site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: N6-acetyllysine; alternate => ECO:0000269\|PubMed:11545749, ECO:0000269\|PubMed:15186774, ECO:0000269\|PubMed:16598039, ECO:0000269\|PubMed:19113941

Chain	Residue	Details
H	LYS16
C	LYS77
D	LYS31
D	LYS77

site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: N6-acetyllysine; alternate => ECO:0000269\|PubMed:19113941

Chain	Residue	Details
H	LYS17
E	LYS21
B	LYS23
B	LYS56

site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: N6-butyryllysine; alternate => ECO:0000269\|PubMed:19113941

Chain	Residue	Details
H	LYS21
D	SER60

site_id	SWS_FT_FI7
Number of Residues	1
Details	MOD_RES: N6-methyllysine; alternate => ECO:0000269\|PubMed:19113941

Chain	Residue	Details
H	LYS22
D	SER64

site_id	SWS_FT_FI8
Number of Residues	2
Details	MOD_RES: N6-succinyllysine => ECO:0000269\|PubMed:22389435

Chain	Residue	Details
H	LYS34
H	LYS46

site_id	SWS_FT_FI9
Number of Residues	1
Details	MOD_RES: N6,N6-dimethyllysine => ECO:0000269\|PubMed:19113941

Chain	Residue	Details
H	LYS37
D	LYS91

site_id	SWS_FT_FI10
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO); alternate

Chain	Residue	Details
H	LYS6
H	LYS7

site_id	SWS_FT_FI11
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269\|PubMed:10642555, ECO:0000269\|PubMed:12535538, ECO:0000269\|PubMed:12535539, ECO:0000269\|PubMed:14660635, ECO:0000269\|PubMed:15280549, ECO:0000269\|PubMed:16432255

Chain	Residue	Details
H	LYS123

site_id	SWS_FT_FI12
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO); alternate => ECO:0000305

Chain	Residue	Details
H	LYS16
H	LYS17

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		Validation report (PDF)