8QY5
Structure of interleukin 6.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004896 | molecular_function | cytokine receptor activity |
| A | 0016020 | cellular_component | membrane |
| B | 0005125 | molecular_function | cytokine activity |
| B | 0005138 | molecular_function | interleukin-6 receptor binding |
| B | 0005576 | cellular_component | extracellular region |
| B | 0005615 | cellular_component | extracellular space |
| B | 0006955 | biological_process | immune response |
| B | 0030154 | biological_process | cell differentiation |
| C | 0004896 | molecular_function | cytokine receptor activity |
| C | 0016020 | cellular_component | membrane |
| D | 0004896 | molecular_function | cytokine receptor activity |
| D | 0016020 | cellular_component | membrane |
| E | 0005125 | molecular_function | cytokine activity |
| E | 0005138 | molecular_function | interleukin-6 receptor binding |
| E | 0005576 | cellular_component | extracellular region |
| E | 0005615 | cellular_component | extracellular space |
| E | 0006955 | biological_process | immune response |
| E | 0030154 | biological_process | cell differentiation |
| F | 0004896 | molecular_function | cytokine receptor activity |
| F | 0016020 | cellular_component | membrane |
Functional Information from PROSITE/UniProt
| site_id | PS00254 |
| Number of Residues | 26 |
| Details | INTERLEUKIN_6 Interleukin-6 / G-CSF / MGF signature. CfqsgfneetClvkiitGLleFevyL |
| Chain | Residue | Details |
| B | CYS73-LEU98 |
| site_id | PS01353 |
| Number of Residues | 54 |
| Details | HEMATOPO_REC_L_F2 Long hematopoietin receptor, gp130 family signature. NkvgkSaaavltipsphvtaaysvvnlkafpkdnllw....VeWtppPkpvsk....Yi.LeW |
| Chain | Residue | Details |
| A | ASN402-TRP455 |
| site_id | PS01354 |
| Number of Residues | 42 |
| Details | HEMATOPO_REC_L_F3 Long hematopoietin receptor, soluble alpha chains family signature. LqPDPPanItvtavarnprwLsvtWqdPhSWnssf..YrLrFeL |
| Chain | Residue | Details |
| C | LEU195-LEU236 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 188 |
| Details | Domain: {"description":"Ig-like C2-type"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 186 |
| Details | Domain: {"description":"Fibronectin type-III 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00316","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 200 |
| Details | Domain: {"description":"Fibronectin type-III 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00316","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 180 |
| Details | Domain: {"description":"Fibronectin type-III 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00316","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 186 |
| Details | Domain: {"description":"Fibronectin type-III 4","evidences":[{"source":"PROSITE-ProRule","id":"PRU00316","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 16 |
| Details | Motif: {"description":"WSXWS motif"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 16 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19349973","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine; by FAM20C","evidences":[{"source":"PubMed","id":"26091039","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"1883960","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 2 |
| Details | Site: {"description":"Not glycosylated","evidences":[{"source":"PubMed","id":"10066782","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"10066782","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28060820","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"28060820","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
