8QW0

Human NDPK-C in complex with GDP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004550	molecular_function	nucleoside diphosphate kinase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005741	cellular_component	mitochondrial outer membrane
A	0005829	cellular_component	cytosol
A	0005856	cellular_component	cytoskeleton
A	0006183	biological_process	GTP biosynthetic process
A	0006228	biological_process	UTP biosynthetic process
A	0006235	biological_process	dTTP biosynthetic process
A	0006241	biological_process	CTP biosynthetic process
A	0006281	biological_process	DNA repair
A	0006915	biological_process	apoptotic process
A	0008053	biological_process	mitochondrial fusion
A	0009117	biological_process	nucleotide metabolic process
A	0009142	biological_process	nucleoside triphosphate biosynthetic process
A	0016020	cellular_component	membrane
A	0016301	molecular_function	kinase activity
A	0016740	molecular_function	transferase activity
A	0019003	molecular_function	GDP binding
A	0030552	molecular_function	cAMP binding
A	0034214	biological_process	protein hexamerization
A	0036064	cellular_component	ciliary basal body
A	0042995	cellular_component	cell projection
A	0043531	molecular_function	ADP binding
A	0046872	molecular_function	metal ion binding
A	0070300	molecular_function	phosphatidic acid binding
A	0160204	molecular_function	mitochondrion-mitochondrion outer membrane tether activity
A	1990626	biological_process	mitochondrial outer membrane fusion
B	0000166	molecular_function	nucleotide binding
B	0004550	molecular_function	nucleoside diphosphate kinase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005741	cellular_component	mitochondrial outer membrane
B	0005829	cellular_component	cytosol
B	0005856	cellular_component	cytoskeleton
B	0006183	biological_process	GTP biosynthetic process
B	0006228	biological_process	UTP biosynthetic process
B	0006235	biological_process	dTTP biosynthetic process
B	0006241	biological_process	CTP biosynthetic process
B	0006281	biological_process	DNA repair
B	0006915	biological_process	apoptotic process
B	0008053	biological_process	mitochondrial fusion
B	0009117	biological_process	nucleotide metabolic process
B	0009142	biological_process	nucleoside triphosphate biosynthetic process
B	0016020	cellular_component	membrane
B	0016301	molecular_function	kinase activity
B	0016740	molecular_function	transferase activity
B	0019003	molecular_function	GDP binding
B	0030552	molecular_function	cAMP binding
B	0034214	biological_process	protein hexamerization
B	0036064	cellular_component	ciliary basal body
B	0042995	cellular_component	cell projection
B	0043531	molecular_function	ADP binding
B	0046872	molecular_function	metal ion binding
B	0070300	molecular_function	phosphatidic acid binding
B	0160204	molecular_function	mitochondrion-mitochondrion outer membrane tether activity
B	1990626	biological_process	mitochondrial outer membrane fusion
C	0000166	molecular_function	nucleotide binding
C	0004550	molecular_function	nucleoside diphosphate kinase activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0005741	cellular_component	mitochondrial outer membrane
C	0005829	cellular_component	cytosol
C	0005856	cellular_component	cytoskeleton
C	0006183	biological_process	GTP biosynthetic process
C	0006228	biological_process	UTP biosynthetic process
C	0006235	biological_process	dTTP biosynthetic process
C	0006241	biological_process	CTP biosynthetic process
C	0006281	biological_process	DNA repair
C	0006915	biological_process	apoptotic process
C	0008053	biological_process	mitochondrial fusion
C	0009117	biological_process	nucleotide metabolic process
C	0009142	biological_process	nucleoside triphosphate biosynthetic process
C	0016020	cellular_component	membrane
C	0016301	molecular_function	kinase activity
C	0016740	molecular_function	transferase activity
C	0019003	molecular_function	GDP binding
C	0030552	molecular_function	cAMP binding
C	0034214	biological_process	protein hexamerization
C	0036064	cellular_component	ciliary basal body
C	0042995	cellular_component	cell projection
C	0043531	molecular_function	ADP binding
C	0046872	molecular_function	metal ion binding
C	0070300	molecular_function	phosphatidic acid binding
C	0160204	molecular_function	mitochondrion-mitochondrion outer membrane tether activity
C	1990626	biological_process	mitochondrial outer membrane fusion
D	0000166	molecular_function	nucleotide binding
D	0004550	molecular_function	nucleoside diphosphate kinase activity
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005737	cellular_component	cytoplasm
D	0005739	cellular_component	mitochondrion
D	0005741	cellular_component	mitochondrial outer membrane
D	0005829	cellular_component	cytosol
D	0005856	cellular_component	cytoskeleton
D	0006183	biological_process	GTP biosynthetic process
D	0006228	biological_process	UTP biosynthetic process
D	0006235	biological_process	dTTP biosynthetic process
D	0006241	biological_process	CTP biosynthetic process
D	0006281	biological_process	DNA repair
D	0006915	biological_process	apoptotic process
D	0008053	biological_process	mitochondrial fusion
D	0009117	biological_process	nucleotide metabolic process
D	0009142	biological_process	nucleoside triphosphate biosynthetic process
D	0016020	cellular_component	membrane
D	0016301	molecular_function	kinase activity
D	0016740	molecular_function	transferase activity
D	0019003	molecular_function	GDP binding
D	0030552	molecular_function	cAMP binding
D	0034214	biological_process	protein hexamerization
D	0036064	cellular_component	ciliary basal body
D	0042995	cellular_component	cell projection
D	0043531	molecular_function	ADP binding
D	0046872	molecular_function	metal ion binding
D	0070300	molecular_function	phosphatidic acid binding
D	0160204	molecular_function	mitochondrion-mitochondrion outer membrane tether activity
D	1990626	biological_process	mitochondrial outer membrane fusion
E	0000166	molecular_function	nucleotide binding
E	0004550	molecular_function	nucleoside diphosphate kinase activity
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005737	cellular_component	cytoplasm
E	0005739	cellular_component	mitochondrion
E	0005741	cellular_component	mitochondrial outer membrane
E	0005829	cellular_component	cytosol
E	0005856	cellular_component	cytoskeleton
E	0006183	biological_process	GTP biosynthetic process
E	0006228	biological_process	UTP biosynthetic process
E	0006235	biological_process	dTTP biosynthetic process
E	0006241	biological_process	CTP biosynthetic process
E	0006281	biological_process	DNA repair
E	0006915	biological_process	apoptotic process
E	0008053	biological_process	mitochondrial fusion
E	0009117	biological_process	nucleotide metabolic process
E	0009142	biological_process	nucleoside triphosphate biosynthetic process
E	0016020	cellular_component	membrane
E	0016301	molecular_function	kinase activity
E	0016740	molecular_function	transferase activity
E	0019003	molecular_function	GDP binding
E	0030552	molecular_function	cAMP binding
E	0034214	biological_process	protein hexamerization
E	0036064	cellular_component	ciliary basal body
E	0042995	cellular_component	cell projection
E	0043531	molecular_function	ADP binding
E	0046872	molecular_function	metal ion binding
E	0070300	molecular_function	phosphatidic acid binding
E	0160204	molecular_function	mitochondrion-mitochondrion outer membrane tether activity
E	1990626	biological_process	mitochondrial outer membrane fusion
F	0000166	molecular_function	nucleotide binding
F	0004550	molecular_function	nucleoside diphosphate kinase activity
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0005737	cellular_component	cytoplasm
F	0005739	cellular_component	mitochondrion
F	0005741	cellular_component	mitochondrial outer membrane
F	0005829	cellular_component	cytosol
F	0005856	cellular_component	cytoskeleton
F	0006183	biological_process	GTP biosynthetic process
F	0006228	biological_process	UTP biosynthetic process
F	0006235	biological_process	dTTP biosynthetic process
F	0006241	biological_process	CTP biosynthetic process
F	0006281	biological_process	DNA repair
F	0006915	biological_process	apoptotic process
F	0008053	biological_process	mitochondrial fusion
F	0009117	biological_process	nucleotide metabolic process
F	0009142	biological_process	nucleoside triphosphate biosynthetic process
F	0016020	cellular_component	membrane
F	0016301	molecular_function	kinase activity
F	0016740	molecular_function	transferase activity
F	0019003	molecular_function	GDP binding
F	0030552	molecular_function	cAMP binding
F	0034214	biological_process	protein hexamerization
F	0036064	cellular_component	ciliary basal body
F	0042995	cellular_component	cell projection
F	0043531	molecular_function	ADP binding
F	0046872	molecular_function	metal ion binding
F	0070300	molecular_function	phosphatidic acid binding
F	0160204	molecular_function	mitochondrion-mitochondrion outer membrane tether activity
F	1990626	biological_process	mitochondrial outer membrane fusion
G	0000166	molecular_function	nucleotide binding
G	0004550	molecular_function	nucleoside diphosphate kinase activity
G	0005515	molecular_function	protein binding
G	0005524	molecular_function	ATP binding
G	0005737	cellular_component	cytoplasm
G	0005739	cellular_component	mitochondrion
G	0005741	cellular_component	mitochondrial outer membrane
G	0005829	cellular_component	cytosol
G	0005856	cellular_component	cytoskeleton
G	0006183	biological_process	GTP biosynthetic process
G	0006228	biological_process	UTP biosynthetic process
G	0006235	biological_process	dTTP biosynthetic process
G	0006241	biological_process	CTP biosynthetic process
G	0006281	biological_process	DNA repair
G	0006915	biological_process	apoptotic process
G	0008053	biological_process	mitochondrial fusion
G	0009117	biological_process	nucleotide metabolic process
G	0009142	biological_process	nucleoside triphosphate biosynthetic process
G	0016020	cellular_component	membrane
G	0016301	molecular_function	kinase activity
G	0016740	molecular_function	transferase activity
G	0019003	molecular_function	GDP binding
G	0030552	molecular_function	cAMP binding
G	0034214	biological_process	protein hexamerization
G	0036064	cellular_component	ciliary basal body
G	0042995	cellular_component	cell projection
G	0043531	molecular_function	ADP binding
G	0046872	molecular_function	metal ion binding
G	0070300	molecular_function	phosphatidic acid binding
G	0160204	molecular_function	mitochondrion-mitochondrion outer membrane tether activity
G	1990626	biological_process	mitochondrial outer membrane fusion
H	0000166	molecular_function	nucleotide binding
H	0004550	molecular_function	nucleoside diphosphate kinase activity
H	0005515	molecular_function	protein binding
H	0005524	molecular_function	ATP binding
H	0005737	cellular_component	cytoplasm
H	0005739	cellular_component	mitochondrion
H	0005741	cellular_component	mitochondrial outer membrane
H	0005829	cellular_component	cytosol
H	0005856	cellular_component	cytoskeleton
H	0006183	biological_process	GTP biosynthetic process
H	0006228	biological_process	UTP biosynthetic process
H	0006235	biological_process	dTTP biosynthetic process
H	0006241	biological_process	CTP biosynthetic process
H	0006281	biological_process	DNA repair
H	0006915	biological_process	apoptotic process
H	0008053	biological_process	mitochondrial fusion
H	0009117	biological_process	nucleotide metabolic process
H	0009142	biological_process	nucleoside triphosphate biosynthetic process
H	0016020	cellular_component	membrane
H	0016301	molecular_function	kinase activity
H	0016740	molecular_function	transferase activity
H	0019003	molecular_function	GDP binding
H	0030552	molecular_function	cAMP binding
H	0034214	biological_process	protein hexamerization
H	0036064	cellular_component	ciliary basal body
H	0042995	cellular_component	cell projection
H	0043531	molecular_function	ADP binding
H	0046872	molecular_function	metal ion binding
H	0070300	molecular_function	phosphatidic acid binding
H	0160204	molecular_function	mitochondrion-mitochondrion outer membrane tether activity
H	1990626	biological_process	mitochondrial outer membrane fusion
I	0000166	molecular_function	nucleotide binding
I	0004550	molecular_function	nucleoside diphosphate kinase activity
I	0005515	molecular_function	protein binding
I	0005524	molecular_function	ATP binding
I	0005737	cellular_component	cytoplasm
I	0005739	cellular_component	mitochondrion
I	0005741	cellular_component	mitochondrial outer membrane
I	0005829	cellular_component	cytosol
I	0005856	cellular_component	cytoskeleton
I	0006183	biological_process	GTP biosynthetic process
I	0006228	biological_process	UTP biosynthetic process
I	0006235	biological_process	dTTP biosynthetic process
I	0006241	biological_process	CTP biosynthetic process
I	0006281	biological_process	DNA repair
I	0006915	biological_process	apoptotic process
I	0008053	biological_process	mitochondrial fusion
I	0009117	biological_process	nucleotide metabolic process
I	0009142	biological_process	nucleoside triphosphate biosynthetic process
I	0016020	cellular_component	membrane
I	0016301	molecular_function	kinase activity
I	0016740	molecular_function	transferase activity
I	0019003	molecular_function	GDP binding
I	0030552	molecular_function	cAMP binding
I	0034214	biological_process	protein hexamerization
I	0036064	cellular_component	ciliary basal body
I	0042995	cellular_component	cell projection
I	0043531	molecular_function	ADP binding
I	0046872	molecular_function	metal ion binding
I	0070300	molecular_function	phosphatidic acid binding
I	0160204	molecular_function	mitochondrion-mitochondrion outer membrane tether activity
I	1990626	biological_process	mitochondrial outer membrane fusion
J	0000166	molecular_function	nucleotide binding
J	0004550	molecular_function	nucleoside diphosphate kinase activity
J	0005515	molecular_function	protein binding
J	0005524	molecular_function	ATP binding
J	0005737	cellular_component	cytoplasm
J	0005739	cellular_component	mitochondrion
J	0005741	cellular_component	mitochondrial outer membrane
J	0005829	cellular_component	cytosol
J	0005856	cellular_component	cytoskeleton
J	0006183	biological_process	GTP biosynthetic process
J	0006228	biological_process	UTP biosynthetic process
J	0006235	biological_process	dTTP biosynthetic process
J	0006241	biological_process	CTP biosynthetic process
J	0006281	biological_process	DNA repair
J	0006915	biological_process	apoptotic process
J	0008053	biological_process	mitochondrial fusion
J	0009117	biological_process	nucleotide metabolic process
J	0009142	biological_process	nucleoside triphosphate biosynthetic process
J	0016020	cellular_component	membrane
J	0016301	molecular_function	kinase activity
J	0016740	molecular_function	transferase activity
J	0019003	molecular_function	GDP binding
J	0030552	molecular_function	cAMP binding
J	0034214	biological_process	protein hexamerization
J	0036064	cellular_component	ciliary basal body
J	0042995	cellular_component	cell projection
J	0043531	molecular_function	ADP binding
J	0046872	molecular_function	metal ion binding
J	0070300	molecular_function	phosphatidic acid binding
J	0160204	molecular_function	mitochondrion-mitochondrion outer membrane tether activity
J	1990626	biological_process	mitochondrial outer membrane fusion
K	0000166	molecular_function	nucleotide binding
K	0004550	molecular_function	nucleoside diphosphate kinase activity
K	0005515	molecular_function	protein binding
K	0005524	molecular_function	ATP binding
K	0005737	cellular_component	cytoplasm
K	0005739	cellular_component	mitochondrion
K	0005741	cellular_component	mitochondrial outer membrane
K	0005829	cellular_component	cytosol
K	0005856	cellular_component	cytoskeleton
K	0006183	biological_process	GTP biosynthetic process
K	0006228	biological_process	UTP biosynthetic process
K	0006235	biological_process	dTTP biosynthetic process
K	0006241	biological_process	CTP biosynthetic process
K	0006281	biological_process	DNA repair
K	0006915	biological_process	apoptotic process
K	0008053	biological_process	mitochondrial fusion
K	0009117	biological_process	nucleotide metabolic process
K	0009142	biological_process	nucleoside triphosphate biosynthetic process
K	0016020	cellular_component	membrane
K	0016301	molecular_function	kinase activity
K	0016740	molecular_function	transferase activity
K	0019003	molecular_function	GDP binding
K	0030552	molecular_function	cAMP binding
K	0034214	biological_process	protein hexamerization
K	0036064	cellular_component	ciliary basal body
K	0042995	cellular_component	cell projection
K	0043531	molecular_function	ADP binding
K	0046872	molecular_function	metal ion binding
K	0070300	molecular_function	phosphatidic acid binding
K	0160204	molecular_function	mitochondrion-mitochondrion outer membrane tether activity
K	1990626	biological_process	mitochondrial outer membrane fusion
L	0000166	molecular_function	nucleotide binding
L	0004550	molecular_function	nucleoside diphosphate kinase activity
L	0005515	molecular_function	protein binding
L	0005524	molecular_function	ATP binding
L	0005737	cellular_component	cytoplasm
L	0005739	cellular_component	mitochondrion
L	0005741	cellular_component	mitochondrial outer membrane
L	0005829	cellular_component	cytosol
L	0005856	cellular_component	cytoskeleton
L	0006183	biological_process	GTP biosynthetic process
L	0006228	biological_process	UTP biosynthetic process
L	0006235	biological_process	dTTP biosynthetic process
L	0006241	biological_process	CTP biosynthetic process
L	0006281	biological_process	DNA repair
L	0006915	biological_process	apoptotic process
L	0008053	biological_process	mitochondrial fusion
L	0009117	biological_process	nucleotide metabolic process
L	0009142	biological_process	nucleoside triphosphate biosynthetic process
L	0016020	cellular_component	membrane
L	0016301	molecular_function	kinase activity
L	0016740	molecular_function	transferase activity
L	0019003	molecular_function	GDP binding
L	0030552	molecular_function	cAMP binding
L	0034214	biological_process	protein hexamerization
L	0036064	cellular_component	ciliary basal body
L	0042995	cellular_component	cell projection
L	0043531	molecular_function	ADP binding
L	0046872	molecular_function	metal ion binding
L	0070300	molecular_function	phosphatidic acid binding
L	0160204	molecular_function	mitochondrion-mitochondrion outer membrane tether activity
L	1990626	biological_process	mitochondrial outer membrane fusion

Functional Information from PROSITE/UniProt

site_id	PS00469
Number of Residues	9
Details	NDPK Nucleoside diphosphate kinase (NDPK) active site signature. NliHGSDSV

Chain	Residue	Details
A	ASN132-VAL140

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	ACT_SITE: Pros-phosphohistidine intermediate => ECO:0000250|UniProtKB:P22392

Chain	Residue	Details
A	HIS135
J	HIS135
K	HIS135
L	HIS135
B	HIS135
C	HIS135
D	HIS135
E	HIS135
F	HIS135
G	HIS135
H	HIS135
I	HIS135

---

site_id	SWS_FT_FI2
Number of Residues	72
Details	BINDING: BINDING => ECO:0000269|Ref.5, ECO:0007744|PDB:1ZS6

Chain	Residue	Details
A	LYS29
B	ARG122
B	VAL129
B	ASN132
C	LYS29
C	ARG105
C	THR111
C	ARG122
C	VAL129
C	ASN132
D	LYS29
A	ARG105
D	ARG105
D	THR111
D	ARG122
D	VAL129
D	ASN132
E	LYS29
E	ARG105
E	THR111
E	ARG122
E	VAL129
A	THR111
E	ASN132
F	LYS29
F	ARG105
F	THR111
F	ARG122
F	VAL129
F	ASN132
G	LYS29
G	ARG105
G	THR111
A	ARG122
G	ARG122
G	VAL129
G	ASN132
H	LYS29
H	ARG105
H	THR111
H	ARG122
H	VAL129
H	ASN132
I	LYS29
A	VAL129
I	ARG105
I	THR111
I	ARG122
I	VAL129
I	ASN132
J	LYS29
J	ARG105
J	THR111
J	ARG122
J	VAL129
A	ASN132
J	ASN132
K	LYS29
K	ARG105
K	THR111
K	ARG122
K	VAL129
K	ASN132
L	LYS29
L	ARG105
L	THR111
B	LYS29
L	ARG122
L	VAL129
L	ASN132
B	ARG105
B	THR111

---