8QVW

Cryo-EM structure of the peptide binding domain of human SRP68/72

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003723	molecular_function	RNA binding
A	0005047	molecular_function	signal recognition particle binding
A	0005515	molecular_function	protein binding
A	0005730	cellular_component	nucleolus
A	0005737	cellular_component	cytoplasm
A	0005783	cellular_component	endoplasmic reticulum
A	0005786	cellular_component	signal recognition particle, endoplasmic reticulum targeting
A	0005829	cellular_component	cytosol
A	0005840	cellular_component	ribosome
A	0006614	biological_process	SRP-dependent cotranslational protein targeting to membrane
A	0006617	biological_process	SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition
A	0008312	molecular_function	7S RNA binding
A	0009410	biological_process	response to xenobiotic stimulus
A	0019904	molecular_function	protein domain specific binding
A	0030942	molecular_function	endoplasmic reticulum signal peptide binding
A	0043022	molecular_function	ribosome binding
A	0048500	cellular_component	signal recognition particle
A	1990904	cellular_component	ribonucleoprotein complex
B	0003723	molecular_function	RNA binding
B	0005047	molecular_function	signal recognition particle binding
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005783	cellular_component	endoplasmic reticulum
B	0005786	cellular_component	signal recognition particle, endoplasmic reticulum targeting
B	0005829	cellular_component	cytosol
B	0006614	biological_process	SRP-dependent cotranslational protein targeting to membrane
B	0006617	biological_process	SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition
B	0008312	molecular_function	7S RNA binding
B	0030911	molecular_function	TPR domain binding
B	0043022	molecular_function	ribosome binding
B	0048500	cellular_component	signal recognition particle
B	1990904	cellular_component	ribonucleoprotein complex

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	33
Details	Repeat: {"description":"TPR 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00339","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	33
Details	Repeat: {"description":"TPR 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00339","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	33
Details	Repeat: {"description":"TPR 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00339","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	33
Details	Repeat: {"description":"TPR 4","evidences":[{"source":"PROSITE-ProRule","id":"PRU00339","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	154
Details	Region: {"description":"Required for interaction with SRP68","evidences":[{"source":"PubMed","id":"16672232","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28369529","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI6
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate","evidences":[{"source":"PubMed","id":"25114211","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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