Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8QV3

Structure of the y-Tubulin Small Complex (yTuSC) as part of the native y-Tubulin Ring Complex (yTuRC) capping microtubule minus ends at the spindle pole body

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
Ac	0000070	biological_process	mitotic sister chromatid segregation
Ac	0000166	molecular_function	nucleotide binding
Ac	0000226	biological_process	microtubule cytoskeleton organization
Ac	0000278	biological_process	mitotic cell cycle
Ac	0000280	biological_process	nuclear division
Ac	0003674	molecular_function	molecular_function
Ac	0005200	molecular_function	structural constituent of cytoskeleton
Ac	0005515	molecular_function	protein binding
Ac	0005525	molecular_function	GTP binding
Ac	0005634	cellular_component	nucleus
Ac	0005737	cellular_component	cytoplasm
Ac	0005819	cellular_component	spindle
Ac	0005856	cellular_component	cytoskeleton
Ac	0005874	cellular_component	microtubule
Ac	0007010	biological_process	cytoskeleton organization
Ac	0007017	biological_process	microtubule-based process
Ac	0016787	molecular_function	hydrolase activity
Ac	0030473	biological_process	nuclear migration along microtubule
Ac	0034399	cellular_component	nuclear periphery
Ac	0045143	biological_process	homologous chromosome segregation
Ac	0045298	cellular_component	tubulin complex
Ac	0046872	molecular_function	metal ion binding
Ac	0098863	biological_process	nuclear migration by microtubule mediated pushing forces
Ad	0000070	biological_process	mitotic sister chromatid segregation
Ad	0000166	molecular_function	nucleotide binding
Ad	0000226	biological_process	microtubule cytoskeleton organization
Ad	0000278	biological_process	mitotic cell cycle
Ad	0000280	biological_process	nuclear division
Ad	0003674	molecular_function	molecular_function
Ad	0005200	molecular_function	structural constituent of cytoskeleton
Ad	0005515	molecular_function	protein binding
Ad	0005525	molecular_function	GTP binding
Ad	0005634	cellular_component	nucleus
Ad	0005737	cellular_component	cytoplasm
Ad	0005819	cellular_component	spindle
Ad	0005856	cellular_component	cytoskeleton
Ad	0005874	cellular_component	microtubule
Ad	0007010	biological_process	cytoskeleton organization
Ad	0007017	biological_process	microtubule-based process
Ad	0016787	molecular_function	hydrolase activity
Ad	0030473	biological_process	nuclear migration along microtubule
Ad	0034399	cellular_component	nuclear periphery
Ad	0045143	biological_process	homologous chromosome segregation
Ad	0045298	cellular_component	tubulin complex
Ad	0046872	molecular_function	metal ion binding
Ad	0098863	biological_process	nuclear migration by microtubule mediated pushing forces
Bc	0000022	biological_process	mitotic spindle elongation
Bc	0000070	biological_process	mitotic sister chromatid segregation
Bc	0000166	molecular_function	nucleotide binding
Bc	0000226	biological_process	microtubule cytoskeleton organization
Bc	0000278	biological_process	mitotic cell cycle
Bc	0003924	molecular_function	GTPase activity
Bc	0005200	molecular_function	structural constituent of cytoskeleton
Bc	0005515	molecular_function	protein binding
Bc	0005525	molecular_function	GTP binding
Bc	0005737	cellular_component	cytoplasm
Bc	0005856	cellular_component	cytoskeleton
Bc	0005874	cellular_component	microtubule
Bc	0007010	biological_process	cytoskeleton organization
Bc	0007017	biological_process	microtubule-based process
Bc	0007052	biological_process	mitotic spindle organization
Bc	0031122	biological_process	cytoplasmic microtubule organization
Bc	0045298	cellular_component	tubulin complex
Bc	0046677	biological_process	response to antibiotic
Bc	0046872	molecular_function	metal ion binding
Bc	0090307	biological_process	mitotic spindle assembly
Bc	0090316	biological_process	positive regulation of intracellular protein transport
Bc	0097435	biological_process	supramolecular fiber organization
Bd	0000022	biological_process	mitotic spindle elongation
Bd	0000070	biological_process	mitotic sister chromatid segregation
Bd	0000166	molecular_function	nucleotide binding
Bd	0000226	biological_process	microtubule cytoskeleton organization
Bd	0000278	biological_process	mitotic cell cycle
Bd	0003924	molecular_function	GTPase activity
Bd	0005200	molecular_function	structural constituent of cytoskeleton
Bd	0005515	molecular_function	protein binding
Bd	0005525	molecular_function	GTP binding
Bd	0005737	cellular_component	cytoplasm
Bd	0005856	cellular_component	cytoskeleton
Bd	0005874	cellular_component	microtubule
Bd	0007010	biological_process	cytoskeleton organization
Bd	0007017	biological_process	microtubule-based process
Bd	0007052	biological_process	mitotic spindle organization
Bd	0031122	biological_process	cytoplasmic microtubule organization
Bd	0045298	cellular_component	tubulin complex
Bd	0046677	biological_process	response to antibiotic
Bd	0046872	molecular_function	metal ion binding
Bd	0090307	biological_process	mitotic spindle assembly
Bd	0090316	biological_process	positive regulation of intracellular protein transport
Bd	0097435	biological_process	supramolecular fiber organization
E	0000226	biological_process	microtubule cytoskeleton organization
E	0000278	biological_process	mitotic cell cycle
E	0000922	cellular_component	spindle pole
E	0000930	cellular_component	gamma-tubulin complex
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005815	cellular_component	microtubule organizing center
E	0005816	cellular_component	spindle pole body
E	0005822	cellular_component	inner plaque of spindle pole body
E	0005824	cellular_component	outer plaque of spindle pole body
E	0005874	cellular_component	microtubule
E	0007020	biological_process	microtubule nucleation
E	0008275	cellular_component	gamma-tubulin small complex
E	0010968	biological_process	regulation of microtubule nucleation
E	0031122	biological_process	cytoplasmic microtubule organization
E	0043015	molecular_function	gamma-tubulin binding
E	0044732	cellular_component	mitotic spindle pole body
E	0051011	molecular_function	microtubule minus-end binding
E	0051225	biological_process	spindle assembly
E	0051321	biological_process	meiotic cell cycle
F	0000226	biological_process	microtubule cytoskeleton organization
F	0000278	biological_process	mitotic cell cycle
F	0000922	cellular_component	spindle pole
F	0000930	cellular_component	gamma-tubulin complex
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005815	cellular_component	microtubule organizing center
F	0005816	cellular_component	spindle pole body
F	0005822	cellular_component	inner plaque of spindle pole body
F	0005824	cellular_component	outer plaque of spindle pole body
F	0005874	cellular_component	microtubule
F	0007020	biological_process	microtubule nucleation
F	0007052	biological_process	mitotic spindle organization
F	0008275	cellular_component	gamma-tubulin small complex
F	0010968	biological_process	regulation of microtubule nucleation
F	0031122	biological_process	cytoplasmic microtubule organization
F	0043015	molecular_function	gamma-tubulin binding
F	0051011	molecular_function	microtubule minus-end binding
F	0051225	biological_process	spindle assembly
F	0051321	biological_process	meiotic cell cycle
Sc	0000022	biological_process	mitotic spindle elongation
Sc	0000742	biological_process	karyogamy involved in conjugation with cellular fusion
Sc	0005200	molecular_function	structural constituent of cytoskeleton
Sc	0005515	molecular_function	protein binding
Sc	0005516	molecular_function	calmodulin binding
Sc	0005634	cellular_component	nucleus
Sc	0005816	cellular_component	spindle pole body
Sc	0005822	cellular_component	inner plaque of spindle pole body
Sc	0005823	cellular_component	central plaque of spindle pole body
Sc	0005856	cellular_component	cytoskeleton
Sc	0010968	biological_process	regulation of microtubule nucleation
Sc	0044877	molecular_function	protein-containing complex binding
Sc	0065003	biological_process	protein-containing complex assembly
Sc	0090063	biological_process	positive regulation of microtubule nucleation
Sc	0110120	biological_process	gamma-tubulin complex localization to nuclear side of mitotic spindle pole body
Sc	1902440	biological_process	protein localization to mitotic spindle pole body
Sd	0000022	biological_process	mitotic spindle elongation
Sd	0000742	biological_process	karyogamy involved in conjugation with cellular fusion
Sd	0005200	molecular_function	structural constituent of cytoskeleton
Sd	0005515	molecular_function	protein binding
Sd	0005516	molecular_function	calmodulin binding
Sd	0005634	cellular_component	nucleus
Sd	0005816	cellular_component	spindle pole body
Sd	0005822	cellular_component	inner plaque of spindle pole body
Sd	0005823	cellular_component	central plaque of spindle pole body
Sd	0005856	cellular_component	cytoskeleton
Sd	0010968	biological_process	regulation of microtubule nucleation
Sd	0044877	molecular_function	protein-containing complex binding
Sd	0065003	biological_process	protein-containing complex assembly
Sd	0090063	biological_process	positive regulation of microtubule nucleation
Sd	0110120	biological_process	gamma-tubulin complex localization to nuclear side of mitotic spindle pole body
Sd	1902440	biological_process	protein localization to mitotic spindle pole body
c	0000070	biological_process	mitotic sister chromatid segregation
c	0000166	molecular_function	nucleotide binding
c	0000212	biological_process	meiotic spindle organization
c	0000278	biological_process	mitotic cell cycle
c	0000930	cellular_component	gamma-tubulin complex
c	0000931	cellular_component	gamma-tubulin ring complex
c	0005200	molecular_function	structural constituent of cytoskeleton
c	0005515	molecular_function	protein binding
c	0005525	molecular_function	GTP binding
c	0005634	cellular_component	nucleus
c	0005737	cellular_component	cytoplasm
c	0005816	cellular_component	spindle pole body
c	0005819	cellular_component	spindle
c	0005822	cellular_component	inner plaque of spindle pole body
c	0005824	cellular_component	outer plaque of spindle pole body
c	0005874	cellular_component	microtubule
c	0007017	biological_process	microtubule-based process
c	0007020	biological_process	microtubule nucleation
c	0007052	biological_process	mitotic spindle organization
c	0008275	cellular_component	gamma-tubulin small complex
c	0010968	biological_process	regulation of microtubule nucleation
c	0015630	cellular_component	microtubule cytoskeleton
c	0031122	biological_process	cytoplasmic microtubule organization
c	0051417	biological_process	microtubule nucleation by spindle pole body
c	0140490	molecular_function	microtubule nucleator activity
c	2000767	biological_process	positive regulation of cytoplasmic translation
d	0000070	biological_process	mitotic sister chromatid segregation
d	0000166	molecular_function	nucleotide binding
d	0000212	biological_process	meiotic spindle organization
d	0000278	biological_process	mitotic cell cycle
d	0000930	cellular_component	gamma-tubulin complex
d	0000931	cellular_component	gamma-tubulin ring complex
d	0005200	molecular_function	structural constituent of cytoskeleton
d	0005515	molecular_function	protein binding
d	0005525	molecular_function	GTP binding
d	0005634	cellular_component	nucleus
d	0005737	cellular_component	cytoplasm
d	0005816	cellular_component	spindle pole body
d	0005819	cellular_component	spindle
d	0005822	cellular_component	inner plaque of spindle pole body
d	0005824	cellular_component	outer plaque of spindle pole body
d	0005874	cellular_component	microtubule
d	0007017	biological_process	microtubule-based process
d	0007020	biological_process	microtubule nucleation
d	0007052	biological_process	mitotic spindle organization
d	0008275	cellular_component	gamma-tubulin small complex
d	0010968	biological_process	regulation of microtubule nucleation
d	0015630	cellular_component	microtubule cytoskeleton
d	0031122	biological_process	cytoplasmic microtubule organization
d	0051417	biological_process	microtubule nucleation by spindle pole body
d	0140490	molecular_function	microtubule nucleator activity
d	2000767	biological_process	positive regulation of cytoplasmic translation

Functional Information from PROSITE/UniProt

site_id	PS00227
Number of Residues	7
Details	TUBULIN Tubulin subunits alpha, beta, and gamma signature. AGGTGSG

Chain	Residue	Details
c	ALA143-GLY149
Bd	GLY140-GLY146
Ad	GLY143-GLY149

site_id	PS00228
Number of Residues	4
Details	TUBULIN_B_AUTOREG Tubulin-beta mRNA autoregulation signal. MREI

Chain	Residue	Details
Bd	MET1-ILE4

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	46
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	26
Details	Compositional bias: {"description":"Basic and acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	12
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	2
Details	Active site: {"evidences":[{"source":"PubMed","id":"11739794","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	18
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P68363","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	14
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q13509","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18407956","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		Validation report (PDF)