8QUT

Cryo-EM structure of the heat-irreversible amyloid fibrils of human lysozyme

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003796	molecular_function	lysozyme activity
A	0003824	molecular_function	catalytic activity
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0006954	biological_process	inflammatory response
A	0016787	molecular_function	hydrolase activity
A	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
A	0019730	biological_process	antimicrobial humoral response
A	0031640	biological_process	killing of cells of another organism
A	0035578	cellular_component	azurophil granule lumen
A	0035580	cellular_component	specific granule lumen
A	0042742	biological_process	defense response to bacterium
A	0042802	molecular_function	identical protein binding
A	0050829	biological_process	defense response to Gram-negative bacterium
A	0050830	biological_process	defense response to Gram-positive bacterium
A	0070062	cellular_component	extracellular exosome
A	1904724	cellular_component	tertiary granule lumen
C	0003796	molecular_function	lysozyme activity
C	0003824	molecular_function	catalytic activity
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0006954	biological_process	inflammatory response
C	0016787	molecular_function	hydrolase activity
C	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
C	0019730	biological_process	antimicrobial humoral response
C	0031640	biological_process	killing of cells of another organism
C	0035578	cellular_component	azurophil granule lumen
C	0035580	cellular_component	specific granule lumen
C	0042742	biological_process	defense response to bacterium
C	0042802	molecular_function	identical protein binding
C	0050829	biological_process	defense response to Gram-negative bacterium
C	0050830	biological_process	defense response to Gram-positive bacterium
C	0070062	cellular_component	extracellular exosome
C	1904724	cellular_component	tertiary granule lumen
E	0003796	molecular_function	lysozyme activity
E	0003824	molecular_function	catalytic activity
E	0005576	cellular_component	extracellular region
E	0005615	cellular_component	extracellular space
E	0006954	biological_process	inflammatory response
E	0016787	molecular_function	hydrolase activity
E	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
E	0019730	biological_process	antimicrobial humoral response
E	0031640	biological_process	killing of cells of another organism
E	0035578	cellular_component	azurophil granule lumen
E	0035580	cellular_component	specific granule lumen
E	0042742	biological_process	defense response to bacterium
E	0042802	molecular_function	identical protein binding
E	0050829	biological_process	defense response to Gram-negative bacterium
E	0050830	biological_process	defense response to Gram-positive bacterium
E	0070062	cellular_component	extracellular exosome
E	1904724	cellular_component	tertiary granule lumen
G	0003796	molecular_function	lysozyme activity
G	0003824	molecular_function	catalytic activity
G	0005576	cellular_component	extracellular region
G	0005615	cellular_component	extracellular space
G	0006954	biological_process	inflammatory response
G	0016787	molecular_function	hydrolase activity
G	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
G	0019730	biological_process	antimicrobial humoral response
G	0031640	biological_process	killing of cells of another organism
G	0035578	cellular_component	azurophil granule lumen
G	0035580	cellular_component	specific granule lumen
G	0042742	biological_process	defense response to bacterium
G	0042802	molecular_function	identical protein binding
G	0050829	biological_process	defense response to Gram-negative bacterium
G	0050830	biological_process	defense response to Gram-positive bacterium
G	0070062	cellular_component	extracellular exosome
G	1904724	cellular_component	tertiary granule lumen
I	0003796	molecular_function	lysozyme activity
I	0003824	molecular_function	catalytic activity
I	0005576	cellular_component	extracellular region
I	0005615	cellular_component	extracellular space
I	0006954	biological_process	inflammatory response
I	0016787	molecular_function	hydrolase activity
I	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
I	0019730	biological_process	antimicrobial humoral response
I	0031640	biological_process	killing of cells of another organism
I	0035578	cellular_component	azurophil granule lumen
I	0035580	cellular_component	specific granule lumen
I	0042742	biological_process	defense response to bacterium
I	0042802	molecular_function	identical protein binding
I	0050829	biological_process	defense response to Gram-negative bacterium
I	0050830	biological_process	defense response to Gram-positive bacterium
I	0070062	cellular_component	extracellular exosome
I	1904724	cellular_component	tertiary granule lumen

Functional Information from PROSITE/UniProt

site_id	PS00128
Number of Residues	19
Details	GLYCOSYL_HYDROL_F22_1 Glycosyl hydrolases family 22 (GH22) domain signature. ChlsCsaLlqdNIadavaC

Chain	Residue	Details
A	CYS77-CYS95

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	10
Details	ACT_SITE:

Chain	Residue	Details
A	GLU35
I	ASP53
A	ASP53
C	GLU35
C	ASP53
E	GLU35
E	ASP53
G	GLU35
G	ASP53
I	GLU35

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