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8QSN

Cryo-EM structure of human SLC15A4 monomer in outward open state in PMAL C8

Functional Information from GO Data
ChainGOidnamespacecontents
A0005290molecular_functionL-histidine transmembrane transporter activity
A0005515molecular_functionprotein binding
A0005764cellular_componentlysosome
A0005765cellular_componentlysosomal membrane
A0005768cellular_componentendosome
A0005886cellular_componentplasma membrane
A0006811biological_processmonoatomic ion transport
A0006857biological_processoligopeptide transport
A0010008cellular_componentendosome membrane
A0015031biological_processprotein transport
A0015293molecular_functionsymporter activity
A0015333molecular_functionpeptide:proton symporter activity
A0015647molecular_functionpeptidoglycan transmembrane transporter activity
A0015817biological_processhistidine transport
A0015833biological_processpeptide transport
A0015835biological_processpeptidoglycan transport
A0016020cellular_componentmembrane
A0022857molecular_functiontransmembrane transporter activity
A0031901cellular_componentearly endosome membrane
A0033023biological_processmast cell homeostasis
A0034157biological_processpositive regulation of toll-like receptor 7 signaling pathway
A0034161biological_processpositive regulation of toll-like receptor 8 signaling pathway
A0034165biological_processpositive regulation of toll-like receptor 9 signaling pathway
A0035579cellular_componentspecific granule membrane
A0036020cellular_componentendolysosome membrane
A0045087biological_processinnate immune response
A0045089biological_processpositive regulation of innate immune response
A0048302biological_processregulation of isotype switching to IgG isotypes
A0055085biological_processtransmembrane transport
A0070424biological_processregulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
A0070430biological_processpositive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway
A0070434biological_processpositive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
A0071916molecular_functiondipeptide transmembrane transporter activity
A0089708biological_processL-histidine transmembrane export from vacuole
A0140206biological_processdipeptide import across plasma membrane
A1902600biological_processproton transmembrane transport
Functional Information from PROSITE/UniProt
site_idPS00079
Number of Residues21
DetailsMULTICOPPER_OXIDASE1 Multicopper oxidases signature 1. GlFfFfSgVGsfVgSGLlalV
ChainResidueDetails
AGLY490-VAL510

site_idPS01023
Number of Residues13
DetailsPTR2_2 PTR2 family proton/oligopeptide symporters signature 2. FnwFYWsINLGAI
ChainResidueDetails
APHE195-ILE207

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues240
DetailsTRANSMEM: Helical => ECO:0000255
ChainResidueDetails
AALA49-TRP69
ALEU459-ALA479
AGLY490-VAL510
ATYR535-VAL555
AGLU76-ALA96
AALA105-ALA125
APHE158-PHE178
APHE194-ALA214
APHE222-CYS242
ALEU318-MET338
ATHR363-LEU383
AILE405-LYS425

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q91W98
ChainResidueDetails
ASER279

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER298

219869

PDB entries from 2024-05-15

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