8QRV
ASCT2 protomer in lipid nanodiscs under low Na+ concentration in the outward-facing state (OFS)
Functional Information from PROSITE/UniProt
| site_id | PS00713 |
| Number of Residues | 15 |
| Details | NA_DICARBOXYL_SYMP_1 Sodium:dicarboxylate symporter family signature 1. P.GElLLrLLRMIIlP |
| Chain | Residue | Details |
| B | PRO92-PRO106 |
| site_id | PS00714 |
| Number of Residues | 24 |
| Details | NA_DICARBOXYL_SYMP_2 Sodium:dicarboxylate symporter family signature 2. PiGaTvNMDGAaLFqcVaaVFIAQ |
| Chain | Residue | Details |
| B | PRO380-GLN403 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 141 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000305 |
| Chain | Residue | Details |
| B | MET1-ALA51 | |
| B | ALA117-TRP130 | |
| B | GLY249-ARG257 | |
| B | THR329-PRO333 | |
| B | GLU365-HIS373 | |
| B | GLN483-MET541 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 29 |
| Details | TRANSMEM: Helical; Name=1 => ECO:0000305|PubMed:29872227 |
| Chain | Residue | Details |
| B | ASN52-LEU81 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 126 |
| Details | TOPO_DOM: Extracellular => ECO:0000305 |
| Chain | Residue | Details |
| B | GLY82-GLU94 | |
| B | GLN154-GLN224 | |
| B | ALA286-ILE306 | |
| B | ILE401-LYS413 | |
| B | LEU448-ASP460 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 21 |
| Details | TRANSMEM: Helical; Name=2 => ECO:0000305|PubMed:29872227 |
| Chain | Residue | Details |
| B | LEU95-ALA116 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 22 |
| Details | TRANSMEM: Helical; Name=3 => ECO:0000305|PubMed:29872227 |
| Chain | Residue | Details |
| B | ALA131-LEU153 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 23 |
| Details | TRANSMEM: Helical; Name=4 => ECO:0000305|PubMed:29872227 |
| Chain | Residue | Details |
| B | GLU225-LEU248 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 27 |
| Details | TRANSMEM: Helical; Name=5 => ECO:0000305|PubMed:29872227 |
| Chain | Residue | Details |
| B | PHE258-VAL285 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 21 |
| Details | TRANSMEM: Helical; Name=6 => ECO:0000305|PubMed:29872227 |
| Chain | Residue | Details |
| B | LEU307-PHE328 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 63 |
| Details | INTRAMEM: Discontinuously helical => ECO:0000305|PubMed:29872227 |
| Chain | Residue | Details |
| B | TYR334-VAL364 | |
| B | ILE414-ASN447 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 26 |
| Details | TRANSMEM: Helical; Name=7 => ECO:0000305|PubMed:29872227 |
| Chain | Residue | Details |
| B | ILE374-PHE400 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 21 |
| Details | TRANSMEM: Helical; Name=8 => ECO:0000305|PubMed:29872227 |
| Chain | Residue | Details |
| B | TRP461-LEU482 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:O59010 |
| Chain | Residue | Details |
| B | GLY382 | |
| B | ASN386 | |
| B | ASN471 | |
| B | ASP475 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:P43003 |
| Chain | Residue | Details |
| B | THR384 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 1 |
| Details | MOD_RES: N-acetylmethionine => ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22814378 |
| Chain | Residue | Details |
| B | MET1 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| B | SER493 |
| site_id | SWS_FT_FI16 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| B | THR494 |
| site_id | SWS_FT_FI17 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332 |
| Chain | Residue | Details |
| B | SER503 |
| site_id | SWS_FT_FI18 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| B | SER535 |
| site_id | SWS_FT_FI19 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| B | SER539 |
| site_id | SWS_FT_FI20 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| B | ASN163 |
| site_id | SWS_FT_FI21 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19349973 |
| Chain | Residue | Details |
| B | ASN212 |
