8QRS
ASCT2 protomer in lipid nanodiscs with bound glutamine and Na+ ions in the intermediate outward-facing state (iOFS-up)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| B | 0001618 | molecular_function | virus receptor activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006865 | biological_process | amino acid transport |
| B | 0006868 | biological_process | glutamine transport |
| B | 0009925 | cellular_component | basal plasma membrane |
| B | 0010585 | biological_process | glutamine secretion |
| B | 0015171 | molecular_function | amino acid transmembrane transporter activity |
| B | 0015175 | molecular_function | neutral L-amino acid transmembrane transporter activity |
| B | 0015183 | molecular_function | L-aspartate transmembrane transporter activity |
| B | 0015186 | molecular_function | L-glutamine transmembrane transporter activity |
| B | 0015194 | molecular_function | L-serine transmembrane transporter activity |
| B | 0015293 | molecular_function | symporter activity |
| B | 0015297 | molecular_function | antiporter activity |
| B | 0015804 | biological_process | neutral amino acid transport |
| B | 0015825 | biological_process | L-serine transport |
| B | 0016020 | cellular_component | membrane |
| B | 0022834 | molecular_function | ligand-gated channel activity |
| B | 0030218 | biological_process | erythrocyte differentiation |
| B | 0034451 | cellular_component | centriolar satellite |
| B | 0036064 | cellular_component | ciliary basal body |
| B | 0038023 | molecular_function | signaling receptor activity |
| B | 0042470 | cellular_component | melanosome |
| B | 0046718 | biological_process | symbiont entry into host cell |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0070062 | cellular_component | extracellular exosome |
| B | 0070207 | biological_process | protein homotrimerization |
| B | 0140009 | biological_process | L-aspartate import across plasma membrane |
| B | 0150104 | biological_process | transport across blood-brain barrier |
| B | 1903803 | biological_process | L-glutamine import across plasma membrane |
Functional Information from PROSITE/UniProt
| site_id | PS00713 |
| Number of Residues | 15 |
| Details | NA_DICARBOXYL_SYMP_1 Sodium:dicarboxylate symporter family signature 1. P.GElLLrLLRMIIlP |
| Chain | Residue | Details |
| B | PRO92-PRO106 |
| site_id | PS00714 |
| Number of Residues | 24 |
| Details | NA_DICARBOXYL_SYMP_2 Sodium:dicarboxylate symporter family signature 2. PiGaTvNMDGAaLFqcVaaVFIAQ |
| Chain | Residue | Details |
| B | PRO380-GLN403 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 29 |
| Details | Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"29872227","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 56 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 21 |
| Details | Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"29872227","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 33 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 22 |
| Details | Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"29872227","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 23 |
| Details | Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"29872227","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 27 |
| Details | Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"29872227","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 21 |
| Details | Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"29872227","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 63 |
| Details | Intramembrane: {"description":"Discontinuously helical","evidences":[{"source":"PubMed","id":"29872227","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 26 |
| Details | Transmembrane: {"description":"Helical; Name=7","evidences":[{"source":"PubMed","id":"29872227","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 21 |
| Details | Transmembrane: {"description":"Helical; Name=8","evidences":[{"source":"PubMed","id":"29872227","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"O59010","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P43003","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
