8QR1

Cryo-EM structure of the human Tip60 complex

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000786	cellular_component	nucleosome
A	0000812	cellular_component	Swr1 complex
A	0003677	molecular_function	DNA binding
A	0003682	molecular_function	chromatin binding
A	0004386	molecular_function	helicase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0006281	biological_process	DNA repair
A	0006325	biological_process	chromatin organization
A	0016607	cellular_component	nuclear speck
A	0016787	molecular_function	hydrolase activity
A	0035267	cellular_component	NuA4 histone acetyltransferase complex
A	0042981	biological_process	regulation of apoptotic process
A	0045893	biological_process	positive regulation of DNA-templated transcription
A	0051726	biological_process	regulation of cell cycle
A	1905168	biological_process	positive regulation of double-strand break repair via homologous recombination
A	1990405	molecular_function	protein antigen binding
A	2000779	biological_process	regulation of double-strand break repair
B	0000166	molecular_function	nucleotide binding
B	0000776	cellular_component	kinetochore
B	0000785	cellular_component	chromatin
B	0000786	cellular_component	nucleosome
B	0001738	biological_process	morphogenesis of a polarized epithelium
B	0005200	molecular_function	structural constituent of cytoskeleton
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005615	cellular_component	extracellular space
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005856	cellular_component	cytoskeleton
B	0005884	cellular_component	actin filament
B	0005886	cellular_component	plasma membrane
B	0005903	cellular_component	brush border
B	0005911	cellular_component	cell-cell junction
B	0005912	cellular_component	adherens junction
B	0005925	cellular_component	focal adhesion
B	0006338	biological_process	chromatin remodeling
B	0006357	biological_process	regulation of transcription by RNA polymerase II
B	0007010	biological_process	cytoskeleton organization
B	0007163	biological_process	establishment or maintenance of cell polarity
B	0007409	biological_process	axonogenesis
B	0008284	biological_process	positive regulation of cell population proliferation
B	0015629	cellular_component	actin cytoskeleton
B	0016020	cellular_component	membrane
B	0016363	cellular_component	nuclear matrix
B	0016514	cellular_component	SWI/SNF complex
B	0016586	cellular_component	RSC-type complex
B	0016787	molecular_function	hydrolase activity
B	0016887	molecular_function	ATP hydrolysis activity
B	0019894	molecular_function	kinesin binding
B	0019901	molecular_function	protein kinase binding
B	0021762	biological_process	substantia nigra development
B	0030027	cellular_component	lamellipodium
B	0030071	biological_process	regulation of mitotic metaphase/anaphase transition
B	0030235	molecular_function	nitric-oxide synthase regulator activity
B	0030424	cellular_component	axon
B	0030863	cellular_component	cortical cytoskeleton
B	0030957	molecular_function	Tat protein binding
B	0031492	molecular_function	nucleosomal DNA binding
B	0031982	cellular_component	vesicle
B	0032991	cellular_component	protein-containing complex
B	0034333	biological_process	adherens junction assembly
B	0035060	cellular_component	brahma complex
B	0035267	cellular_component	NuA4 histone acetyltransferase complex
B	0035633	biological_process	maintenance of blood-brain barrier
B	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
B	0042802	molecular_function	identical protein binding
B	0042981	biological_process	regulation of apoptotic process
B	0043296	cellular_component	apical junction complex
B	0044305	cellular_component	calyx of Held
B	0045176	biological_process	apical protein localization
B	0045202	cellular_component	synapse
B	0045582	biological_process	positive regulation of T cell differentiation
B	0045596	biological_process	negative regulation of cell differentiation
B	0045597	biological_process	positive regulation of cell differentiation
B	0045663	biological_process	positive regulation of myoblast differentiation
B	0045893	biological_process	positive regulation of DNA-templated transcription
B	0048156	molecular_function	tau protein binding
B	0048870	biological_process	cell motility
B	0050998	molecular_function	nitric-oxide synthase binding
B	0051621	biological_process	regulation of norepinephrine uptake
B	0051623	biological_process	positive regulation of norepinephrine uptake
B	0051726	biological_process	regulation of cell cycle
B	0070062	cellular_component	extracellular exosome
B	0070160	cellular_component	tight junction
B	0070316	biological_process	regulation of G0 to G1 transition
B	0070527	biological_process	platelet aggregation
B	0071564	cellular_component	npBAF complex
B	0071565	cellular_component	nBAF complex
B	0071896	biological_process	protein localization to adherens junction
B	0072562	cellular_component	blood microparticle
B	0072749	biological_process	cellular response to cytochalasin B
B	0097433	cellular_component	dense body
B	0098685	cellular_component	Schaffer collateral - CA1 synapse
B	0098793	cellular_component	presynapse
B	0098871	cellular_component	postsynaptic actin cytoskeleton
B	0098973	molecular_function	structural constituent of postsynaptic actin cytoskeleton
B	0098974	biological_process	postsynaptic actin cytoskeleton organization
B	0098978	cellular_component	glutamatergic synapse
B	0140092	cellular_component	bBAF complex
B	0140288	cellular_component	GBAF complex
B	0141108	molecular_function	transporter regulator activity
B	0150111	biological_process	regulation of transepithelial transport
B	1900242	biological_process	regulation of synaptic vesicle endocytosis
B	1902459	biological_process	positive regulation of stem cell population maintenance
B	1903076	biological_process	regulation of protein localization to plasma membrane
B	1905168	biological_process	positive regulation of double-strand break repair via homologous recombination
B	1990904	cellular_component	ribonucleoprotein complex
B	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
B	2000779	biological_process	regulation of double-strand break repair
B	2000781	biological_process	positive regulation of double-strand break repair
B	2000819	biological_process	regulation of nucleotide-excision repair
C	0000122	biological_process	negative regulation of transcription by RNA polymerase II
C	0000724	biological_process	double-strand break repair via homologous recombination
C	0000786	cellular_component	nucleosome
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005730	cellular_component	nucleolus
C	0005737	cellular_component	cytoplasm
C	0006303	biological_process	double-strand break repair via nonhomologous end joining
C	0006325	biological_process	chromatin organization
C	0006351	biological_process	DNA-templated transcription
C	0006357	biological_process	regulation of transcription by RNA polymerase II
C	0007283	biological_process	spermatogenesis
C	0007286	biological_process	spermatid development
C	0016604	cellular_component	nuclear body
C	0030154	biological_process	cell differentiation
C	0031965	cellular_component	nuclear membrane
C	0032777	cellular_component	piccolo histone acetyltransferase complex
C	0035092	biological_process	sperm DNA condensation
C	0035267	cellular_component	NuA4 histone acetyltransferase complex
C	0035861	cellular_component	site of double-strand break
C	0042981	biological_process	regulation of apoptotic process
C	0045814	biological_process	negative regulation of gene expression, epigenetic
C	0045892	biological_process	negative regulation of DNA-templated transcription
C	0045893	biological_process	positive regulation of DNA-templated transcription
C	0045944	biological_process	positive regulation of transcription by RNA polymerase II
C	0051726	biological_process	regulation of cell cycle
C	0140463	molecular_function	chromatin-protein adaptor activity
C	0140767	molecular_function	enzyme-substrate adaptor activity
C	1905168	biological_process	positive regulation of double-strand break repair via homologous recombination
C	2000779	biological_process	regulation of double-strand break repair
D	0000166	molecular_function	nucleotide binding
D	0000492	biological_process	box C/D snoRNP assembly
D	0000723	biological_process	telomere maintenance
D	0000786	cellular_component	nucleosome
D	0000791	cellular_component	euchromatin
D	0000812	cellular_component	Swr1 complex
D	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
D	0000979	molecular_function	RNA polymerase II core promoter sequence-specific DNA binding
D	0001094	molecular_function	TFIID-class transcription factor complex binding
D	0003678	molecular_function	DNA helicase activity
D	0003714	molecular_function	transcription corepressor activity
D	0004386	molecular_function	helicase activity
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005737	cellular_component	cytoplasm
D	0005813	cellular_component	centrosome
D	0005829	cellular_component	cytosol
D	0006275	biological_process	regulation of DNA replication
D	0006281	biological_process	DNA repair
D	0006282	biological_process	regulation of DNA repair
D	0006310	biological_process	DNA recombination
D	0006325	biological_process	chromatin organization
D	0006338	biological_process	chromatin remodeling
D	0006355	biological_process	regulation of DNA-templated transcription
D	0006357	biological_process	regulation of transcription by RNA polymerase II
D	0006457	biological_process	protein folding
D	0006974	biological_process	DNA damage response
D	0008013	molecular_function	beta-catenin binding
D	0008094	molecular_function	ATP-dependent activity, acting on DNA
D	0016020	cellular_component	membrane
D	0016363	cellular_component	nuclear matrix
D	0016787	molecular_function	hydrolase activity
D	0016887	molecular_function	ATP hydrolysis activity
D	0017025	molecular_function	TBP-class protein binding
D	0031011	cellular_component	Ino80 complex
D	0031490	molecular_function	chromatin DNA binding
D	0033044	biological_process	regulation of chromosome organization
D	0034644	biological_process	cellular response to UV
D	0035267	cellular_component	NuA4 histone acetyltransferase complex
D	0036064	cellular_component	ciliary basal body
D	0042802	molecular_function	identical protein binding
D	0042803	molecular_function	protein homodimerization activity
D	0042981	biological_process	regulation of apoptotic process
D	0043531	molecular_function	ADP binding
D	0045739	biological_process	positive regulation of DNA repair
D	0045892	biological_process	negative regulation of DNA-templated transcription
D	0045893	biological_process	positive regulation of DNA-templated transcription
D	0045944	biological_process	positive regulation of transcription by RNA polymerase II
D	0045995	biological_process	regulation of embryonic development
D	0050821	biological_process	protein stabilization
D	0051082	molecular_function	unfolded protein binding
D	0051117	molecular_function	ATPase binding
D	0051726	biological_process	regulation of cell cycle
D	0060382	biological_process	regulation of DNA strand elongation
D	0070062	cellular_component	extracellular exosome
D	0071169	biological_process	establishment of protein localization to chromatin
D	0071339	cellular_component	MLL1 complex
D	0071392	biological_process	cellular response to estradiol stimulus
D	0090090	biological_process	negative regulation of canonical Wnt signaling pathway
D	0090671	biological_process	telomerase RNA localization to Cajal body
D	0097255	cellular_component	R2TP complex
D	0101031	cellular_component	protein folding chaperone complex
D	0120293	cellular_component	dynein axonemal particle
D	0140585	molecular_function	promoter-enhancer loop anchoring activity
D	1904507	biological_process	positive regulation of telomere maintenance in response to DNA damage
D	1905168	biological_process	positive regulation of double-strand break repair via homologous recombination
D	1990062	cellular_component	RPAP3/R2TP/prefoldin-like complex
D	1990904	cellular_component	ribonucleoprotein complex
D	2000779	biological_process	regulation of double-strand break repair
E	0000166	molecular_function	nucleotide binding
E	0000492	biological_process	box C/D snoRNP assembly
E	0000723	biological_process	telomere maintenance
E	0000786	cellular_component	nucleosome
E	0000812	cellular_component	Swr1 complex
E	0001094	molecular_function	TFIID-class transcription factor complex binding
E	0003678	molecular_function	DNA helicase activity
E	0003713	molecular_function	transcription coactivator activity
E	0004386	molecular_function	helicase activity
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005737	cellular_component	cytoplasm
E	0005813	cellular_component	centrosome
E	0005829	cellular_component	cytosol
E	0005856	cellular_component	cytoskeleton
E	0006275	biological_process	regulation of DNA replication
E	0006281	biological_process	DNA repair
E	0006282	biological_process	regulation of DNA repair
E	0006310	biological_process	DNA recombination
E	0006325	biological_process	chromatin organization
E	0006338	biological_process	chromatin remodeling
E	0006355	biological_process	regulation of DNA-templated transcription
E	0006357	biological_process	regulation of transcription by RNA polymerase II
E	0006974	biological_process	DNA damage response
E	0007283	biological_process	spermatogenesis
E	0008094	molecular_function	ATP-dependent activity, acting on DNA
E	0016020	cellular_component	membrane
E	0016363	cellular_component	nuclear matrix
E	0016607	cellular_component	nuclear speck
E	0016787	molecular_function	hydrolase activity
E	0016887	molecular_function	ATP hydrolysis activity
E	0017025	molecular_function	TBP-class protein binding
E	0031011	cellular_component	Ino80 complex
E	0033044	biological_process	regulation of chromosome organization
E	0035267	cellular_component	NuA4 histone acetyltransferase complex
E	0036064	cellular_component	ciliary basal body
E	0042981	biological_process	regulation of apoptotic process
E	0043531	molecular_function	ADP binding
E	0045296	molecular_function	cadherin binding
E	0045739	biological_process	positive regulation of DNA repair
E	0045893	biological_process	positive regulation of DNA-templated transcription
E	0045995	biological_process	regulation of embryonic development
E	0050821	biological_process	protein stabilization
E	0051117	molecular_function	ATPase binding
E	0051301	biological_process	cell division
E	0051726	biological_process	regulation of cell cycle
E	0060382	biological_process	regulation of DNA strand elongation
E	0070062	cellular_component	extracellular exosome
E	0071339	cellular_component	MLL1 complex
E	0090263	biological_process	positive regulation of canonical Wnt signaling pathway
E	0090671	biological_process	telomerase RNA localization to Cajal body
E	0097255	cellular_component	R2TP complex
E	0101031	cellular_component	protein folding chaperone complex
E	0120293	cellular_component	dynein axonemal particle
E	1904507	biological_process	positive regulation of telomere maintenance in response to DNA damage
E	1905168	biological_process	positive regulation of double-strand break repair via homologous recombination
E	1990062	cellular_component	RPAP3/R2TP/prefoldin-like complex
E	1990904	cellular_component	ribonucleoprotein complex
E	2000779	biological_process	regulation of double-strand break repair
F	0000122	biological_process	negative regulation of transcription by RNA polymerase II
F	0000786	cellular_component	nucleosome
F	0000812	cellular_component	Swr1 complex
F	0003714	molecular_function	transcription corepressor activity
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005657	cellular_component	replication fork
F	0005694	cellular_component	chromosome
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0006281	biological_process	DNA repair
F	0006325	biological_process	chromatin organization
F	0006338	biological_process	chromatin remodeling
F	0006355	biological_process	regulation of DNA-templated transcription
F	0035267	cellular_component	NuA4 histone acetyltransferase complex
F	0042307	biological_process	positive regulation of protein import into nucleus
F	0042981	biological_process	regulation of apoptotic process
F	0045471	biological_process	response to ethanol
F	0045892	biological_process	negative regulation of DNA-templated transcription
F	0045893	biological_process	positive regulation of DNA-templated transcription
F	0051726	biological_process	regulation of cell cycle
F	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
F	1905168	biological_process	positive regulation of double-strand break repair via homologous recombination
F	2000779	biological_process	regulation of double-strand break repair
G	0000166	molecular_function	nucleotide binding
G	0000776	cellular_component	kinetochore
G	0000785	cellular_component	chromatin
G	0000786	cellular_component	nucleosome
G	0001738	biological_process	morphogenesis of a polarized epithelium
G	0005200	molecular_function	structural constituent of cytoskeleton
G	0005515	molecular_function	protein binding
G	0005524	molecular_function	ATP binding
G	0005615	cellular_component	extracellular space
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0005856	cellular_component	cytoskeleton
G	0005884	cellular_component	actin filament
G	0005886	cellular_component	plasma membrane
G	0005903	cellular_component	brush border
G	0005911	cellular_component	cell-cell junction
G	0005912	cellular_component	adherens junction
G	0005925	cellular_component	focal adhesion
G	0006338	biological_process	chromatin remodeling
G	0006357	biological_process	regulation of transcription by RNA polymerase II
G	0007010	biological_process	cytoskeleton organization
G	0007163	biological_process	establishment or maintenance of cell polarity
G	0007409	biological_process	axonogenesis
G	0008284	biological_process	positive regulation of cell population proliferation
G	0015629	cellular_component	actin cytoskeleton
G	0016020	cellular_component	membrane
G	0016363	cellular_component	nuclear matrix
G	0016514	cellular_component	SWI/SNF complex
G	0016586	cellular_component	RSC-type complex
G	0016787	molecular_function	hydrolase activity
G	0016887	molecular_function	ATP hydrolysis activity
G	0019894	molecular_function	kinesin binding
G	0019901	molecular_function	protein kinase binding
G	0021762	biological_process	substantia nigra development
G	0030027	cellular_component	lamellipodium
G	0030071	biological_process	regulation of mitotic metaphase/anaphase transition
G	0030235	molecular_function	nitric-oxide synthase regulator activity
G	0030424	cellular_component	axon
G	0030863	cellular_component	cortical cytoskeleton
G	0030957	molecular_function	Tat protein binding
G	0031492	molecular_function	nucleosomal DNA binding
G	0031982	cellular_component	vesicle
G	0032991	cellular_component	protein-containing complex
G	0034333	biological_process	adherens junction assembly
G	0035060	cellular_component	brahma complex
G	0035267	cellular_component	NuA4 histone acetyltransferase complex
G	0035633	biological_process	maintenance of blood-brain barrier
G	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
G	0042802	molecular_function	identical protein binding
G	0042981	biological_process	regulation of apoptotic process
G	0043296	cellular_component	apical junction complex
G	0044305	cellular_component	calyx of Held
G	0045176	biological_process	apical protein localization
G	0045202	cellular_component	synapse
G	0045582	biological_process	positive regulation of T cell differentiation
G	0045596	biological_process	negative regulation of cell differentiation
G	0045597	biological_process	positive regulation of cell differentiation
G	0045663	biological_process	positive regulation of myoblast differentiation
G	0045893	biological_process	positive regulation of DNA-templated transcription
G	0048156	molecular_function	tau protein binding
G	0048870	biological_process	cell motility
G	0050998	molecular_function	nitric-oxide synthase binding
G	0051621	biological_process	regulation of norepinephrine uptake
G	0051623	biological_process	positive regulation of norepinephrine uptake
G	0051726	biological_process	regulation of cell cycle
G	0070062	cellular_component	extracellular exosome
G	0070160	cellular_component	tight junction
G	0070316	biological_process	regulation of G0 to G1 transition
G	0070527	biological_process	platelet aggregation
G	0071564	cellular_component	npBAF complex
G	0071565	cellular_component	nBAF complex
G	0071896	biological_process	protein localization to adherens junction
G	0072562	cellular_component	blood microparticle
G	0072749	biological_process	cellular response to cytochalasin B
G	0097433	cellular_component	dense body
G	0098685	cellular_component	Schaffer collateral - CA1 synapse
G	0098793	cellular_component	presynapse
G	0098871	cellular_component	postsynaptic actin cytoskeleton
G	0098973	molecular_function	structural constituent of postsynaptic actin cytoskeleton
G	0098974	biological_process	postsynaptic actin cytoskeleton organization
G	0098978	cellular_component	glutamatergic synapse
G	0140092	cellular_component	bBAF complex
G	0140288	cellular_component	GBAF complex
G	0141108	molecular_function	transporter regulator activity
G	0150111	biological_process	regulation of transepithelial transport
G	1900242	biological_process	regulation of synaptic vesicle endocytosis
G	1902459	biological_process	positive regulation of stem cell population maintenance
G	1903076	biological_process	regulation of protein localization to plasma membrane
G	1905168	biological_process	positive regulation of double-strand break repair via homologous recombination
G	1990904	cellular_component	ribonucleoprotein complex
G	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
G	2000779	biological_process	regulation of double-strand break repair
G	2000781	biological_process	positive regulation of double-strand break repair
G	2000819	biological_process	regulation of nucleotide-excision repair
H	0000166	molecular_function	nucleotide binding
H	0000492	biological_process	box C/D snoRNP assembly
H	0000723	biological_process	telomere maintenance
H	0000786	cellular_component	nucleosome
H	0000791	cellular_component	euchromatin
H	0000812	cellular_component	Swr1 complex
H	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
H	0000979	molecular_function	RNA polymerase II core promoter sequence-specific DNA binding
H	0001094	molecular_function	TFIID-class transcription factor complex binding
H	0003678	molecular_function	DNA helicase activity
H	0003714	molecular_function	transcription corepressor activity
H	0004386	molecular_function	helicase activity
H	0005515	molecular_function	protein binding
H	0005524	molecular_function	ATP binding
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005737	cellular_component	cytoplasm
H	0005813	cellular_component	centrosome
H	0005829	cellular_component	cytosol
H	0006275	biological_process	regulation of DNA replication
H	0006281	biological_process	DNA repair
H	0006282	biological_process	regulation of DNA repair
H	0006310	biological_process	DNA recombination
H	0006325	biological_process	chromatin organization
H	0006338	biological_process	chromatin remodeling
H	0006355	biological_process	regulation of DNA-templated transcription
H	0006357	biological_process	regulation of transcription by RNA polymerase II
H	0006457	biological_process	protein folding
H	0006974	biological_process	DNA damage response
H	0008013	molecular_function	beta-catenin binding
H	0008094	molecular_function	ATP-dependent activity, acting on DNA
H	0016020	cellular_component	membrane
H	0016363	cellular_component	nuclear matrix
H	0016787	molecular_function	hydrolase activity
H	0016887	molecular_function	ATP hydrolysis activity
H	0017025	molecular_function	TBP-class protein binding
H	0031011	cellular_component	Ino80 complex
H	0031490	molecular_function	chromatin DNA binding
H	0033044	biological_process	regulation of chromosome organization
H	0034644	biological_process	cellular response to UV
H	0035267	cellular_component	NuA4 histone acetyltransferase complex
H	0036064	cellular_component	ciliary basal body
H	0042802	molecular_function	identical protein binding
H	0042803	molecular_function	protein homodimerization activity
H	0042981	biological_process	regulation of apoptotic process
H	0043531	molecular_function	ADP binding
H	0045739	biological_process	positive regulation of DNA repair
H	0045892	biological_process	negative regulation of DNA-templated transcription
H	0045893	biological_process	positive regulation of DNA-templated transcription
H	0045944	biological_process	positive regulation of transcription by RNA polymerase II
H	0045995	biological_process	regulation of embryonic development
H	0050821	biological_process	protein stabilization
H	0051082	molecular_function	unfolded protein binding
H	0051117	molecular_function	ATPase binding
H	0051726	biological_process	regulation of cell cycle
H	0060382	biological_process	regulation of DNA strand elongation
H	0070062	cellular_component	extracellular exosome
H	0071169	biological_process	establishment of protein localization to chromatin
H	0071339	cellular_component	MLL1 complex
H	0071392	biological_process	cellular response to estradiol stimulus
H	0090090	biological_process	negative regulation of canonical Wnt signaling pathway
H	0090671	biological_process	telomerase RNA localization to Cajal body
H	0097255	cellular_component	R2TP complex
H	0101031	cellular_component	protein folding chaperone complex
H	0120293	cellular_component	dynein axonemal particle
H	0140585	molecular_function	promoter-enhancer loop anchoring activity
H	1904507	biological_process	positive regulation of telomere maintenance in response to DNA damage
H	1905168	biological_process	positive regulation of double-strand break repair via homologous recombination
H	1990062	cellular_component	RPAP3/R2TP/prefoldin-like complex
H	1990904	cellular_component	ribonucleoprotein complex
H	2000779	biological_process	regulation of double-strand break repair
I	0000166	molecular_function	nucleotide binding
I	0000492	biological_process	box C/D snoRNP assembly
I	0000723	biological_process	telomere maintenance
I	0000786	cellular_component	nucleosome
I	0000812	cellular_component	Swr1 complex
I	0001094	molecular_function	TFIID-class transcription factor complex binding
I	0003678	molecular_function	DNA helicase activity
I	0003713	molecular_function	transcription coactivator activity
I	0004386	molecular_function	helicase activity
I	0005515	molecular_function	protein binding
I	0005524	molecular_function	ATP binding
I	0005634	cellular_component	nucleus
I	0005654	cellular_component	nucleoplasm
I	0005737	cellular_component	cytoplasm
I	0005813	cellular_component	centrosome
I	0005829	cellular_component	cytosol
I	0005856	cellular_component	cytoskeleton
I	0006275	biological_process	regulation of DNA replication
I	0006281	biological_process	DNA repair
I	0006282	biological_process	regulation of DNA repair
I	0006310	biological_process	DNA recombination
I	0006325	biological_process	chromatin organization
I	0006338	biological_process	chromatin remodeling
I	0006355	biological_process	regulation of DNA-templated transcription
I	0006357	biological_process	regulation of transcription by RNA polymerase II
I	0006974	biological_process	DNA damage response
I	0007283	biological_process	spermatogenesis
I	0008094	molecular_function	ATP-dependent activity, acting on DNA
I	0016020	cellular_component	membrane
I	0016363	cellular_component	nuclear matrix
I	0016607	cellular_component	nuclear speck
I	0016787	molecular_function	hydrolase activity
I	0016887	molecular_function	ATP hydrolysis activity
I	0017025	molecular_function	TBP-class protein binding
I	0031011	cellular_component	Ino80 complex
I	0033044	biological_process	regulation of chromosome organization
I	0035267	cellular_component	NuA4 histone acetyltransferase complex
I	0036064	cellular_component	ciliary basal body
I	0042981	biological_process	regulation of apoptotic process
I	0043531	molecular_function	ADP binding
I	0045296	molecular_function	cadherin binding
I	0045739	biological_process	positive regulation of DNA repair
I	0045893	biological_process	positive regulation of DNA-templated transcription
I	0045995	biological_process	regulation of embryonic development
I	0050821	biological_process	protein stabilization
I	0051117	molecular_function	ATPase binding
I	0051301	biological_process	cell division
I	0051726	biological_process	regulation of cell cycle
I	0060382	biological_process	regulation of DNA strand elongation
I	0070062	cellular_component	extracellular exosome
I	0071339	cellular_component	MLL1 complex
I	0090263	biological_process	positive regulation of canonical Wnt signaling pathway
I	0090671	biological_process	telomerase RNA localization to Cajal body
I	0097255	cellular_component	R2TP complex
I	0101031	cellular_component	protein folding chaperone complex
I	0120293	cellular_component	dynein axonemal particle
I	1904507	biological_process	positive regulation of telomere maintenance in response to DNA damage
I	1905168	biological_process	positive regulation of double-strand break repair via homologous recombination
I	1990062	cellular_component	RPAP3/R2TP/prefoldin-like complex
I	1990904	cellular_component	ribonucleoprotein complex
I	2000779	biological_process	regulation of double-strand break repair
J	0000166	molecular_function	nucleotide binding
J	0000492	biological_process	box C/D snoRNP assembly
J	0000723	biological_process	telomere maintenance
J	0000786	cellular_component	nucleosome
J	0000791	cellular_component	euchromatin
J	0000812	cellular_component	Swr1 complex
J	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
J	0000979	molecular_function	RNA polymerase II core promoter sequence-specific DNA binding
J	0001094	molecular_function	TFIID-class transcription factor complex binding
J	0003678	molecular_function	DNA helicase activity
J	0003714	molecular_function	transcription corepressor activity
J	0004386	molecular_function	helicase activity
J	0005515	molecular_function	protein binding
J	0005524	molecular_function	ATP binding
J	0005634	cellular_component	nucleus
J	0005654	cellular_component	nucleoplasm
J	0005737	cellular_component	cytoplasm
J	0005813	cellular_component	centrosome
J	0005829	cellular_component	cytosol
J	0006275	biological_process	regulation of DNA replication
J	0006281	biological_process	DNA repair
J	0006282	biological_process	regulation of DNA repair
J	0006310	biological_process	DNA recombination
J	0006325	biological_process	chromatin organization
J	0006338	biological_process	chromatin remodeling
J	0006355	biological_process	regulation of DNA-templated transcription
J	0006357	biological_process	regulation of transcription by RNA polymerase II
J	0006457	biological_process	protein folding
J	0006974	biological_process	DNA damage response
J	0008013	molecular_function	beta-catenin binding
J	0008094	molecular_function	ATP-dependent activity, acting on DNA
J	0016020	cellular_component	membrane
J	0016363	cellular_component	nuclear matrix
J	0016787	molecular_function	hydrolase activity
J	0016887	molecular_function	ATP hydrolysis activity
J	0017025	molecular_function	TBP-class protein binding
J	0031011	cellular_component	Ino80 complex
J	0031490	molecular_function	chromatin DNA binding
J	0033044	biological_process	regulation of chromosome organization
J	0034644	biological_process	cellular response to UV
J	0035267	cellular_component	NuA4 histone acetyltransferase complex
J	0036064	cellular_component	ciliary basal body
J	0042802	molecular_function	identical protein binding
J	0042803	molecular_function	protein homodimerization activity
J	0042981	biological_process	regulation of apoptotic process
J	0043531	molecular_function	ADP binding
J	0045739	biological_process	positive regulation of DNA repair
J	0045892	biological_process	negative regulation of DNA-templated transcription
J	0045893	biological_process	positive regulation of DNA-templated transcription
J	0045944	biological_process	positive regulation of transcription by RNA polymerase II
J	0045995	biological_process	regulation of embryonic development
J	0050821	biological_process	protein stabilization
J	0051082	molecular_function	unfolded protein binding
J	0051117	molecular_function	ATPase binding
J	0051726	biological_process	regulation of cell cycle
J	0060382	biological_process	regulation of DNA strand elongation
J	0070062	cellular_component	extracellular exosome
J	0071169	biological_process	establishment of protein localization to chromatin
J	0071339	cellular_component	MLL1 complex
J	0071392	biological_process	cellular response to estradiol stimulus
J	0090090	biological_process	negative regulation of canonical Wnt signaling pathway
J	0090671	biological_process	telomerase RNA localization to Cajal body
J	0097255	cellular_component	R2TP complex
J	0101031	cellular_component	protein folding chaperone complex
J	0120293	cellular_component	dynein axonemal particle
J	0140585	molecular_function	promoter-enhancer loop anchoring activity
J	1904507	biological_process	positive regulation of telomere maintenance in response to DNA damage
J	1905168	biological_process	positive regulation of double-strand break repair via homologous recombination
J	1990062	cellular_component	RPAP3/R2TP/prefoldin-like complex
J	1990904	cellular_component	ribonucleoprotein complex
J	2000779	biological_process	regulation of double-strand break repair
K	0000723	biological_process	telomere maintenance
K	0000776	cellular_component	kinetochore
K	0000785	cellular_component	chromatin
K	0000786	cellular_component	nucleosome
K	0001825	biological_process	blastocyst formation
K	0003407	biological_process	neural retina development
K	0003682	molecular_function	chromatin binding
K	0003713	molecular_function	transcription coactivator activity
K	0005515	molecular_function	protein binding
K	0005634	cellular_component	nucleus
K	0005654	cellular_component	nucleoplasm
K	0005886	cellular_component	plasma membrane
K	0006275	biological_process	regulation of DNA replication
K	0006281	biological_process	DNA repair
K	0006282	biological_process	regulation of DNA repair
K	0006310	biological_process	DNA recombination
K	0006325	biological_process	chromatin organization
K	0006338	biological_process	chromatin remodeling
K	0006355	biological_process	regulation of DNA-templated transcription
K	0006357	biological_process	regulation of transcription by RNA polymerase II
K	0006974	biological_process	DNA damage response
K	0007165	biological_process	signal transduction
K	0007399	biological_process	nervous system development
K	0008284	biological_process	positive regulation of cell population proliferation
K	0016363	cellular_component	nuclear matrix
K	0016514	cellular_component	SWI/SNF complex
K	0016586	cellular_component	RSC-type complex
K	0021510	biological_process	spinal cord development
K	0030071	biological_process	regulation of mitotic metaphase/anaphase transition
K	0031011	cellular_component	Ino80 complex
K	0031492	molecular_function	nucleosomal DNA binding
K	0032991	cellular_component	protein-containing complex
K	0033044	biological_process	regulation of chromosome organization
K	0035060	cellular_component	brahma complex
K	0035267	cellular_component	NuA4 histone acetyltransferase complex
K	0042981	biological_process	regulation of apoptotic process
K	0045582	biological_process	positive regulation of T cell differentiation
K	0045596	biological_process	negative regulation of cell differentiation
K	0045597	biological_process	positive regulation of cell differentiation
K	0045663	biological_process	positive regulation of myoblast differentiation
K	0045739	biological_process	positive regulation of DNA repair
K	0045893	biological_process	positive regulation of DNA-templated transcription
K	0045995	biological_process	regulation of embryonic development
K	0048731	biological_process	system development
K	0051726	biological_process	regulation of cell cycle
K	0060382	biological_process	regulation of DNA strand elongation
K	0070316	biological_process	regulation of G0 to G1 transition
K	0071564	cellular_component	npBAF complex
K	0140288	cellular_component	GBAF complex
K	1902459	biological_process	positive regulation of stem cell population maintenance
K	1904507	biological_process	positive regulation of telomere maintenance in response to DNA damage
K	1905168	biological_process	positive regulation of double-strand break repair via homologous recombination
K	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
K	2000779	biological_process	regulation of double-strand break repair
K	2000781	biological_process	positive regulation of double-strand break repair
K	2000819	biological_process	regulation of nucleotide-excision repair
L	0000166	molecular_function	nucleotide binding
L	0000492	biological_process	box C/D snoRNP assembly
L	0000723	biological_process	telomere maintenance
L	0000786	cellular_component	nucleosome
L	0000812	cellular_component	Swr1 complex
L	0001094	molecular_function	TFIID-class transcription factor complex binding
L	0003678	molecular_function	DNA helicase activity
L	0003713	molecular_function	transcription coactivator activity
L	0004386	molecular_function	helicase activity
L	0005515	molecular_function	protein binding
L	0005524	molecular_function	ATP binding
L	0005634	cellular_component	nucleus
L	0005654	cellular_component	nucleoplasm
L	0005737	cellular_component	cytoplasm
L	0005813	cellular_component	centrosome
L	0005829	cellular_component	cytosol
L	0005856	cellular_component	cytoskeleton
L	0006275	biological_process	regulation of DNA replication
L	0006281	biological_process	DNA repair
L	0006282	biological_process	regulation of DNA repair
L	0006310	biological_process	DNA recombination
L	0006325	biological_process	chromatin organization
L	0006338	biological_process	chromatin remodeling
L	0006355	biological_process	regulation of DNA-templated transcription
L	0006357	biological_process	regulation of transcription by RNA polymerase II
L	0006974	biological_process	DNA damage response
L	0007283	biological_process	spermatogenesis
L	0008094	molecular_function	ATP-dependent activity, acting on DNA
L	0016020	cellular_component	membrane
L	0016363	cellular_component	nuclear matrix
L	0016607	cellular_component	nuclear speck
L	0016787	molecular_function	hydrolase activity
L	0016887	molecular_function	ATP hydrolysis activity
L	0017025	molecular_function	TBP-class protein binding
L	0031011	cellular_component	Ino80 complex
L	0033044	biological_process	regulation of chromosome organization
L	0035267	cellular_component	NuA4 histone acetyltransferase complex
L	0036064	cellular_component	ciliary basal body
L	0042981	biological_process	regulation of apoptotic process
L	0043531	molecular_function	ADP binding
L	0045296	molecular_function	cadherin binding
L	0045739	biological_process	positive regulation of DNA repair
L	0045893	biological_process	positive regulation of DNA-templated transcription
L	0045995	biological_process	regulation of embryonic development
L	0050821	biological_process	protein stabilization
L	0051117	molecular_function	ATPase binding
L	0051301	biological_process	cell division
L	0051726	biological_process	regulation of cell cycle
L	0060382	biological_process	regulation of DNA strand elongation
L	0070062	cellular_component	extracellular exosome
L	0071339	cellular_component	MLL1 complex
L	0090263	biological_process	positive regulation of canonical Wnt signaling pathway
L	0090671	biological_process	telomerase RNA localization to Cajal body
L	0097255	cellular_component	R2TP complex
L	0101031	cellular_component	protein folding chaperone complex
L	0120293	cellular_component	dynein axonemal particle
L	1904507	biological_process	positive regulation of telomere maintenance in response to DNA damage
L	1905168	biological_process	positive regulation of double-strand break repair via homologous recombination
L	1990062	cellular_component	RPAP3/R2TP/prefoldin-like complex
L	1990904	cellular_component	ribonucleoprotein complex
L	2000779	biological_process	regulation of double-strand break repair
S	0000122	biological_process	negative regulation of transcription by RNA polymerase II
S	0000786	cellular_component	nucleosome
S	0003677	molecular_function	DNA binding
S	0005515	molecular_function	protein binding
S	0005634	cellular_component	nucleus
S	0005654	cellular_component	nucleoplasm
S	0006325	biological_process	chromatin organization
S	0006338	biological_process	chromatin remodeling
S	0006355	biological_process	regulation of DNA-templated transcription
S	0016607	cellular_component	nuclear speck
S	0032991	cellular_component	protein-containing complex
S	0035019	biological_process	somatic stem cell population maintenance
S	0035267	cellular_component	NuA4 histone acetyltransferase complex
S	0042393	molecular_function	histone binding
S	0042981	biological_process	regulation of apoptotic process
S	0045815	biological_process	transcription initiation-coupled chromatin remodeling
S	0045893	biological_process	positive regulation of DNA-templated transcription
S	0051726	biological_process	regulation of cell cycle
S	0140713	molecular_function	histone chaperone activity
S	1905168	biological_process	positive regulation of double-strand break repair via homologous recombination
S	2000779	biological_process	regulation of double-strand break repair

Functional Information from PROSITE/UniProt

site_id	PS00141
Number of Residues	12
Details	ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. LILDSGATHTTA

Chain	Residue	Details
K	LEU168-ALA179

---

site_id	PS00406
Number of Residues	11
Details	ACTINS_1 Actins signature 1. YVGDEAQs.KRG

Chain	Residue	Details
B	TYR53-GLY63

---

site_id	PS00432
Number of Residues	9
Details	ACTINS_2 Actins signature 2. WISKqEYEE

Chain	Residue	Details
K	TRP410-GLU418
B	TRP356-GLU364

---

site_id	PS01132
Number of Residues	13
Details	ACTINS_ACT_LIKE Actins and actin-related proteins signature. LLTEApLNPkaNR

Chain	Residue	Details
B	LEU104-ARG116

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	72
Details	Domain: {"description":"HSA","evidences":[{"source":"PROSITE-ProRule","id":"PRU00549","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	165
Details	Domain: {"description":"Helicase ATP-binding","evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	157
Details	Domain: {"description":"Helicase C-terminal","evidences":[{"source":"PROSITE-ProRule","id":"PRU00542","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	3
Details	Motif: {"description":"DEAH box-like"}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	7
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	50
Details	Domain: {"description":"SANT"}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	14
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	10
Details	Compositional bias: {"description":"Pro residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	1
Details	Modified residue: {"description":"N-acetylmethionine","evidences":[{"source":"PubMed","id":"36173861","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	1
Details	Modified residue: {"description":"N-acetylaspartate; in Actin, cytoplasmic 1, N-terminally processed","evidences":[{"source":"PubMed","id":"29581253","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30028079","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"JUN-2005","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V."]}},{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22223895","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"25944712","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	2
Details	Modified residue: {"description":"Methionine (R)-sulfoxide","evidences":[{"source":"PubMed","id":"29343822","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	2
Details	Modified residue: {"description":"Tele-methylhistidine","evidences":[{"source":"PubMed","id":"30526847","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30626964","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30785395","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31388018","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32503840","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	2
Details	Modified residue: {"description":"N6-methyllysine","evidences":[{"source":"PubMed","id":"23673617","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	1
Details	Cross-link: {"description":"(Microbial infection) Isoglutamyl lysine isopeptide (Lys-Glu) (interchain with E-270); by Vibrio toxins RtxA and VgrG1","evidences":[{"source":"PubMed","id":"19015515","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	4
Details	Cross-link: {"description":"(Microbial infection) Isoglutamyl lysine isopeptide (Glu-Lys) (interchain with K-50); by Vibrio toxins RtxA and VgrG1","evidences":[{"source":"PubMed","id":"19015515","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17081983","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI18
Number of Residues	21
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI19
Number of Residues	3
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI20
Number of Residues	21
Details	Binding site: {}

Chain

Residue

Details

---