8QPN
LTA4 hydrolase in complex with compound 6(S)
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003723 | molecular_function | RNA binding |
A | 0004177 | molecular_function | aminopeptidase activity |
A | 0004301 | molecular_function | epoxide hydrolase activity |
A | 0004463 | molecular_function | leukotriene-A4 hydrolase activity |
A | 0005515 | molecular_function | protein binding |
A | 0005576 | cellular_component | extracellular region |
A | 0005634 | cellular_component | nucleus |
A | 0005654 | cellular_component | nucleoplasm |
A | 0005737 | cellular_component | cytoplasm |
A | 0005829 | cellular_component | cytosol |
A | 0006508 | biological_process | proteolysis |
A | 0006629 | biological_process | lipid metabolic process |
A | 0006691 | biological_process | leukotriene metabolic process |
A | 0008233 | molecular_function | peptidase activity |
A | 0008237 | molecular_function | metallopeptidase activity |
A | 0008270 | molecular_function | zinc ion binding |
A | 0010043 | biological_process | response to zinc ion |
A | 0019370 | biological_process | leukotriene biosynthetic process |
A | 0019538 | biological_process | protein metabolic process |
A | 0043171 | biological_process | peptide catabolic process |
A | 0043434 | biological_process | response to peptide hormone |
A | 0045148 | molecular_function | tripeptide aminopeptidase activity |
A | 0046872 | molecular_function | metal ion binding |
A | 0060509 | biological_process | type I pneumocyte differentiation |
A | 0070006 | molecular_function | metalloaminopeptidase activity |
A | 0070062 | cellular_component | extracellular exosome |
A | 1904724 | cellular_component | tertiary granule lumen |
A | 1904813 | cellular_component | ficolin-1-rich granule lumen |
Functional Information from PROSITE/UniProt
site_id | PS00142 |
Number of Residues | 10 |
Details | ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. VIAHEISHSW |
Chain | Residue | Details |
A | VAL293-TRP302 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 1 |
Details | ACT_SITE: Proton acceptor => ECO:0000269|PubMed:11675384, ECO:0000305|PubMed:12207002, ECO:0000305|PubMed:24591641, ECO:0007744|PDB:1H19 |
Chain | Residue | Details |
A | GLU297 |
site_id | SWS_FT_FI2 |
Number of Residues | 1 |
Details | ACT_SITE: Proton donor => ECO:0000269|PubMed:11675384, ECO:0000305|PubMed:12207002, ECO:0000305|PubMed:24591641, ECO:0007744|PDB:1H19 |
Chain | Residue | Details |
A | TYR384 |
site_id | SWS_FT_FI3 |
Number of Residues | 3 |
Details | BINDING: BINDING => ECO:0000269|PubMed:18804029 |
Chain | Residue | Details |
A | GLN135 | |
A | PRO267 | |
A | ARG564 |
Chain | Residue | Details |
A | HIS296 | |
A | HIS300 |
Chain | Residue | Details |
A | GLU319 |
site_id | SWS_FT_FI6 |
Number of Residues | 2 |
Details | SITE: Pro-Gly-Pro binding => ECO:0000269|PubMed:24591641 |
Chain | Residue | Details |
A | GLU272 | |
A | GLY563 |
site_id | SWS_FT_FI7 |
Number of Residues | 1 |
Details | SITE: Essential for epoxide hydrolase activity, but not for aminopeptidase activity => ECO:0000269|PubMed:11917124 |
Chain | Residue | Details |
A | ASP376 |
site_id | SWS_FT_FI8 |
Number of Residues | 1 |
Details | SITE: Covalently modified during suicide inhibition by leukotrienes => ECO:0000269|PubMed:7667299 |
Chain | Residue | Details |
A | TYR379 |
site_id | SWS_FT_FI9 |
Number of Residues | 4 |
Details | MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861 |
Chain | Residue | Details |
A | LYS73 | |
A | LYS337 | |
A | LYS414 | |
A | LYS573 |
site_id | SWS_FT_FI10 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:9395533 |
Chain | Residue | Details |
A | SER416 |
Catalytic Information from CSA
site_id | MCSA1 |
Number of Residues | 7 |
Details | M-CSA 166 |
Chain | Residue | Details |
A | GLU272 | electrostatic stabiliser, hydrogen bond acceptor, nucleofuge, nucleophile |
A | HIS296 | metal ligand |
A | GLU297 | electrostatic stabiliser |
A | HIS300 | metal ligand |
A | GLU319 | metal ligand |
A | ASP376 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
A | TYR384 | electrostatic stabiliser |