8QNO
Crystal structure of S-adenosyl-L-homocysteine hydrolase treated at 368 K from Pyrococcus furiosus in complex with inosine
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004013 | molecular_function | adenosylhomocysteinase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006730 | biological_process | one-carbon metabolic process |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0033353 | biological_process | S-adenosylmethionine cycle |
| A | 0071269 | biological_process | L-homocysteine biosynthetic process |
| B | 0004013 | molecular_function | adenosylhomocysteinase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006730 | biological_process | one-carbon metabolic process |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0033353 | biological_process | S-adenosylmethionine cycle |
| B | 0071269 | biological_process | L-homocysteine biosynthetic process |
Functional Information from PROSITE/UniProt
| site_id | PS00738 |
| Number of Residues | 15 |
| Details | ADOHCYASE_1 S-adenosyl-L-homocysteine hydrolase signature 1. ASNpLSTQDdVVAAL |
| Chain | Residue | Details |
| A | ALA78-LEU92 |
| site_id | PS00739 |
| Number of Residues | 17 |
| Details | ADOHCYASE_2 S-adenosyl-L-homocysteine hydrolase signature 2. GKnvvVvGYGwCGRGi.A |
| Chain | Residue | Details |
| A | GLY210-ALA226 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 22 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00563 |
| Chain | Residue | Details |
| A | ASP128 | |
| A | ALA296 | |
| A | ASN343 | |
| B | ASP128 | |
| B | GLU153 | |
| B | THR154 | |
| B | LYS183 | |
| B | ASP187 | |
| B | ASN188 | |
| B | GLY217 | |
| B | GLU240 | |
| A | GLU153 | |
| B | ASN275 | |
| B | ALA296 | |
| B | ASN343 | |
| A | THR154 | |
| A | LYS183 | |
| A | ASP187 | |
| A | ASN188 | |
| A | GLY217 | |
| A | GLU240 | |
| A | ASN275 |
