8QCZ
Cryo-EM structure of the outward-facing heme-bound FLVCR2
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005783 | cellular_component | endoplasmic reticulum |
| A | 0005789 | cellular_component | endoplasmic reticulum membrane |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0015220 | molecular_function | choline transmembrane transporter activity |
| A | 0015232 | molecular_function | heme transmembrane transporter activity |
| A | 0015871 | biological_process | choline transport |
| A | 0016020 | cellular_component | membrane |
| A | 0020037 | molecular_function | heme binding |
| A | 0031966 | cellular_component | mitochondrial membrane |
| A | 0034228 | molecular_function | ethanolamine transmembrane transporter activity |
| A | 0034229 | biological_process | ethanolamine transport |
| A | 0097037 | biological_process | heme export |
| A | 0150104 | biological_process | transport across blood-brain barrier |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 160 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:38778100, ECO:0007744|PDB:8QCX, ECO:0007744|PDB:8QCY, ECO:0007744|PDB:8QD0 |
| Chain | Residue | Details |
| A | MET1-SER76 | |
| A | PHE148-GLY149 | |
| A | PHE206-GLU210 | |
| A | PHE272-ASN307 | |
| A | LYS372-THR373 | |
| A | THR430-ILE437 | |
| A | ALA489-LEU526 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 24 |
| Details | TRANSMEM: Helical; Name=TM1 => ECO:0000269|PubMed:38778100, ECO:0007744|PDB:8QCX, ECO:0007744|PDB:8QCY, ECO:0007744|PDB:8QD0 |
| Chain | Residue | Details |
| A | VAL77-GLN101 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 33 |
| Details | TOPO_DOM: Extracellular => ECO:0000269|PubMed:38778100, ECO:0007744|PDB:8QCX, ECO:0007744|PDB:8QCY, ECO:0007744|PDB:8QD0 |
| Chain | Residue | Details |
| A | TRP102-SER119 | |
| A | GLY170-LEU176 | |
| A | VAL237-GLU241 | |
| A | TYR339-GLU342 | |
| A | ASN397-GLY399 | |
| A | TYR464-GLY465 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 27 |
| Details | TRANSMEM: Helical; Name=TM2 => ECO:0000269|PubMed:38778100, ECO:0007744|PDB:8QCX, ECO:0007744|PDB:8QCY, ECO:0007744|PDB:8QD0 |
| Chain | Residue | Details |
| A | ALA120-LYS147 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 19 |
| Details | TRANSMEM: Helical; Name=TM3 => ECO:0000269|PubMed:38778100, ECO:0007744|PDB:8QCX, ECO:0007744|PDB:8QCY, ECO:0007744|PDB:8QD0 |
| Chain | Residue | Details |
| A | LEU150-LEU169 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 28 |
| Details | TRANSMEM: Helical; Name=TM4 => ECO:0000269|PubMed:38778100, ECO:0007744|PDB:8QCX, ECO:0007744|PDB:8QCY, ECO:0007744|PDB:8QD0 |
| Chain | Residue | Details |
| A | PHE177-TRP205 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 25 |
| Details | TRANSMEM: Helical; Name=TM5 => ECO:0000269|PubMed:38778100, ECO:0007744|PDB:8QCX, ECO:0007744|PDB:8QCY, ECO:0007744|PDB:8QD0 |
| Chain | Residue | Details |
| A | VAL211-LEU236 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 29 |
| Details | TRANSMEM: Helical; Name=TM6 => ECO:0000269|PubMed:38778100, ECO:0007744|PDB:8QCX, ECO:0007744|PDB:8QCY, ECO:0007744|PDB:8QD0 |
| Chain | Residue | Details |
| A | ASP242-VAL271 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 30 |
| Details | TRANSMEM: Helical; Name=TM7 => ECO:0000269|PubMed:38778100, ECO:0007744|PDB:8QCX, ECO:0007744|PDB:8QCY, ECO:0007744|PDB:8QD0 |
| Chain | Residue | Details |
| A | LEU308-HIS338 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 28 |
| Details | TRANSMEM: Helical; Name=TM8 => ECO:0000269|PubMed:38778100, ECO:0007744|PDB:8QCX, ECO:0007744|PDB:8QCY, ECO:0007744|PDB:8QD0 |
| Chain | Residue | Details |
| A | GLU343-SER371 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 22 |
| Details | TRANSMEM: Helical; Name=TM9 => ECO:0000269|PubMed:38778100, ECO:0007744|PDB:8QCX, ECO:0007744|PDB:8QCY, ECO:0007744|PDB:8QD0 |
| Chain | Residue | Details |
| A | TYR374-LEU396 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 29 |
| Details | TRANSMEM: Helical; Name=TM10 => ECO:0000269|PubMed:38778100, ECO:0007744|PDB:8QCX, ECO:0007744|PDB:8QCY, ECO:0007744|PDB:8QD0 |
| Chain | Residue | Details |
| A | HIS400-LEU429 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 25 |
| Details | TRANSMEM: Helical; Name=TM11 => ECO:0000269|PubMed:38778100, ECO:0007744|PDB:8QCX, ECO:0007744|PDB:8QCY, ECO:0007744|PDB:8QD0 |
| Chain | Residue | Details |
| A | SER438-ASN463 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 22 |
| Details | TRANSMEM: Helical; Name=TM12 => ECO:0000269|PubMed:38778100, ECO:0007744|PDB:8QCX, ECO:0007744|PDB:8QCY, ECO:0007744|PDB:8QD0 |
| Chain | Residue | Details |
| A | THR466-LYS488 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:32973183 |
| Chain | Residue | Details |
| A | MET1 |
| site_id | SWS_FT_FI16 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:Q91X85 |
| Chain | Residue | Details |
| A | ASN98 | |
| A | TRP102 | |
| A | LEU195 | |
| A | TYR325 |
| site_id | SWS_FT_FI17 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:38778100, ECO:0007744|PDB:8QD0 |
| Chain | Residue | Details |
| A | GLN191 | |
| A | GLN447 |
| site_id | SWS_FT_FI18 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q91X85 |
| Chain | Residue | Details |
| A | SER515 |
