8QCY
Cryo-EM structure of the outward-facing FLVCR2
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005789 | cellular_component | endoplasmic reticulum membrane |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0015220 | molecular_function | choline transmembrane transporter activity |
| A | 0015232 | molecular_function | heme transmembrane transporter activity |
| A | 0015871 | biological_process | choline transport |
| A | 0016020 | cellular_component | membrane |
| A | 0020037 | molecular_function | heme binding |
| A | 0022857 | molecular_function | transmembrane transporter activity |
| A | 0031966 | cellular_component | mitochondrial membrane |
| A | 0034228 | molecular_function | ethanolamine transmembrane transporter activity |
| A | 0034229 | biological_process | ethanolamine transport |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0097037 | biological_process | heme export |
| A | 0150104 | biological_process | transport across blood-brain barrier |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 24 |
| Details | Transmembrane: {"description":"Helical; Name=TM1","evidences":[{"source":"PubMed","id":"38778100","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8QCX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8QCY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8QD0","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 33 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"38778100","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8QCX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8QCY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8QD0","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 27 |
| Details | Transmembrane: {"description":"Helical; Name=TM2","evidences":[{"source":"PubMed","id":"38778100","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8QCX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8QCY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8QD0","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 13 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"38778100","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8QCX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8QCY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8QD0","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 19 |
| Details | Transmembrane: {"description":"Helical; Name=TM3","evidences":[{"source":"PubMed","id":"38778100","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8QCX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8QCY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8QD0","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 28 |
| Details | Transmembrane: {"description":"Helical; Name=TM4","evidences":[{"source":"PubMed","id":"38778100","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8QCX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8QCY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8QD0","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 25 |
| Details | Transmembrane: {"description":"Helical; Name=TM5","evidences":[{"source":"PubMed","id":"38778100","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8QCX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8QCY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8QD0","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 29 |
| Details | Transmembrane: {"description":"Helical; Name=TM6","evidences":[{"source":"PubMed","id":"38778100","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8QCX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8QCY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8QD0","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 30 |
| Details | Transmembrane: {"description":"Helical; Name=TM7","evidences":[{"source":"PubMed","id":"38778100","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8QCX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8QCY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8QD0","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 28 |
| Details | Transmembrane: {"description":"Helical; Name=TM8","evidences":[{"source":"PubMed","id":"38778100","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8QCX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8QCY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8QD0","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 22 |
| Details | Transmembrane: {"description":"Helical; Name=TM9","evidences":[{"source":"PubMed","id":"38778100","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8QCX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8QCY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8QD0","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 29 |
| Details | Transmembrane: {"description":"Helical; Name=TM10","evidences":[{"source":"PubMed","id":"38778100","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8QCX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8QCY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8QD0","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 25 |
| Details | Transmembrane: {"description":"Helical; Name=TM11","evidences":[{"source":"PubMed","id":"38778100","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8QCX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8QCY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8QD0","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 22 |
| Details | Transmembrane: {"description":"Helical; Name=TM12","evidences":[{"source":"PubMed","id":"38778100","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8QCX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8QCY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8QD0","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI15 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"Q91X85","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI16 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"38778100","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8QD0","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
